Abstract:
:The simultaneous occurrence of two specific acquired chromosomal abnormalities in chronic or acute leukaemias is rare. Inherited chromosomal abnormalities are also rare events in the general population. In chronic myeloid leukaemia (CML), characterised by the t(9;22)(q34;q11), the inv(16)(p13q22) has been described associated with the acceleration of disease or onset of blast crisis. We report on a patient with chronic phase of CML and both acquired t(9;22)(q34;q11) and inherited inv(16)(p13q22), who obtained a complete remission of the disease after bone marrow transplant. Therefore, it is worth to comment that an additional chromosomal abnormality in disease does not obligatory mean transformation of the disease to a more aggressive form, since chromosomal abnormalities are also seen in normal individuals.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Silva PM,Lourenço GJ,Bognone RA,Delamain MT,Pinto-Junior W,Lima CSdoi
10.1016/j.leukres.2005.06.003keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
115-7issue
1eissn
0145-2126issn
1873-5835pii
S0145-2126(05)00217-1journal_volume
30pub_type
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doi:10.1016/j.leukres.2005.01.003
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