Cutaneous manifestations in CMML: Indication of disease acceleration or transformation to AML and review of the literature.

abstract：:A synthetic pentadecapeptide preparation, env 406-420, with an amino acid sequence deduced from the envelope glycoprotein gene of human T cell leukemia virus type I (HTLV I), was used as the antigen in an enzyme immunoassay for immunoglobulin G antibodies, exploring its usefulness for seroepidemiological purposes. The...

journal_title：Leukemia research

authors： Blomberg J,Fölsch G,Nilsson I,Fäldt R

更新日期：1985-01-01 00:00:00

abstract：:The direct effect of the feline leukaemia virus (FeLV) on erythroid colony formation in vitro was investigated. Bone marrow mononuclear cells (BMMC) from FeLV-naïve, specific-pathogen-free (SPF), adult cats were inoculated with FeLVs of characterized strains and biologically cloned subgroups and the subsequent develop...

journal_title：Leukemia research

authors： Rojko JL,Cheney CM,Gasper PW,Hamilton KL,Hoover EA,Mathes LE,Kociba GJ

更新日期：1986-01-01 00:00:00

abstract：:Two AML patients, whose leukemic clonogenic cells totally reacted to the anti-lactofucopentaose III S4-7 monoclonal antibody (MoAb), underwent autologous bone marrow transplantation, in first complete remission, after in-vitro purging with S4-7 MoAb and complement. After ablative chemotherapy (BAVC regimen) and reinfu...

journal_title：Leukemia research

authors： Ferrero D,De Fabritiis P,Amadori S,De Felice L,Gallo E,Meloni G,Pregno P,Pulsoni A,Simone F,Tarella C

更新日期：1987-01-01 00:00:00

abstract：:As a part of our continuing efforts to develop gene therapy for acute myelogenous leukemia (AML), this study was undertaken to evaluate the possibility of using autologous bone marrow stromal fibroblasts (BMSFs) as a target cell population. Autologous BMSFs in AML were isolated from the stromal layers of long-term bon...

journal_title：Leukemia research

authors： Min YH,Li GX,Jang JH,Suh HC,Kim JS,Cheong JW,Lee ST,Hahn JS,Ko YW

更新日期：2002-04-01 00:00:00

abstract：:Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells. Ongoing protein synthase does not seem to be required for the initial induction of IL-8 gene expression. However, the rate of transient induction kinetics was modulated by cyclohexim...

journal_title：Leukemia research

authors： Meier RW,Niklaus G,Fey MF,Tobler A

更新日期：1995-07-01 00:00:00

abstract：:We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m(2) q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-r...

journal_title：Leukemia research

authors： Hassanein M,Atenafu EG,Schuh AC,Yee KW,Minden MD,Schimmer AD,Gupta V,Brandwein JM

更新日期：2013-05-01 00:00:00

abstract：:We describe changes in antigen expression on HL60 cells with differentiation into granulocytes induced by all-trans retinoic acid (ATRA) or dimethylsulphoxide (DMSO), into monocytes by alpha1,25-dihydroxyvitamin D3 (D3), or into macrophages by 12-O-tetradecanoyl phorbol-13-acetate (TPA). Undifferentiated cells express...

journal_title：Leukemia research

authors： Trayner ID,Bustorff T,Etches AE,Mufti GJ,Foss Y,Farzaneh F

更新日期：1998-06-01 00:00:00

abstract：:MEK/ERK signal pathway was required for the differentiation of granulocytes, megakaryocytes and erythrocytes. Recently, MEK/ERK cascade was reported to be involved in all-trans retinoic acid (ATRA) induced differentiation in acute promyelocytic leukemia (APL) cells. However, the upstream and downstream molecules of ME...

journal_title：Leukemia research

authors： Weng XQ,Sheng Y,Ge DZ,Wu J,Shi L,Cai X

更新日期：2016-06-01 00:00:00

abstract：:A variety of genetic and epigenetic abnormalities were characterized over the last years in Hodgkin and Reed-Sternberg (H-RS) cells of classic Hodgkin Lymphoma (cHL). It was speculated that simultaneous inhibition of multiple signalling pathways might be a promising strategy to target this tumor entity. In the present...

journal_title：Leukemia research

authors： Hartlapp I,Pallasch C,Weibert G,Kemkers A,Hummel M,Re D

更新日期：2009-07-01 00:00:00

abstract：:We report on the clinico-biological characteristics of 20 cases of gammadelta T cell large granular lymphocyte (LGL) leukemia. All the data were compared to that of 196 cases with alphabeta T cell subtype, which represents the majority of T cell LGL leukemias. Clinical findings were quite similar in the two groups reg...

journal_title：Leukemia research

authors： Bourgault-Rouxel AS,Loughran TP Jr,Zambello R,Epling-Burnette PK,Semenzato G,Donadieu J,Amiot L,Fest T,Lamy T

更新日期：2008-01-01 00:00:00

abstract：:In a previous study we reported that a new anthracycline derivative (moflomycin) exhibited a higher antileukemic activity compared to other anthracyclines, such as daunorubicin and doxorubicin. To explain the superior antileukemic effect of moflomycin and to disclose a possible structure-activity relationship, we inve...

journal_title：Leukemia research

authors： Andrivon W,Saucier JM,Auclair C,Monneret C,Florent JC,Guillosson JJ,Nafziger J

更新日期：1996-02-01 00:00:00

abstract：:The results of allogeneic marrow transplantation in 75 patients with acute lymphoblastic leukemia and 63 patients with acute non-lymphoblastic leukemia in relapse are reviewed. The effects of various chemotherapeutic regimens added to the basic regimen of cyclophosphamide (Cy) 60 mg/kg given on each of two successive ...

journal_title：Leukemia research

authors： Badger C,Buckner CD,Thomas ED,Clift RA,Sanders JE,Stewart PS,Storb R,Sullivan KM,Shulman H,Flournoy N

更新日期：1982-01-01 00:00:00

abstract：:The Bcl-2 protein inhibits apoptosis (programmed cell death) of hematopoietic stem cells induced by a variety of noxious stimuli, thus mediating chemoresistance and decreasing chemosensitivity. Higher Bcl-2 expression correlates to an adverse outcome following therapy for acute myeloid leukemia (AML). The current stud...

journal_title：Leukemia research

authors： Moon JH,Sohn SK,Lee MH,Jang JH,Kim K,Jung CW,Kim DH

更新日期：2010-02-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) are a heterogeneous group of clonal disease characterized by insufficiency of bone marrow, increase of apoptosis and increased risk of acute leukemia progression. Proteins related to the mitotic spindle (AURKA, AURKB, TPX2), to the mitotic checkpoint (MAD2, CDC20) and the regulation of t...

journal_title：Leukemia research

authors： Borges DP,Dos Santos AWA,Paier CRK,Ribeiro HL Júnior,Costa MB,Farias IR,de Oliveira RTG,França IGDF,Cavalcante GM,Magalhães SMM,Pinheiro RF

更新日期：2018-01-01 00:00:00

abstract：:2',5'-oligoadenylate synthetase (OAS) has been implicated in the effects of interferons (INF) and steroid hormones on cell growth and differentiation. We studied the combined effects in vitro of hormones and INF on OAS activity in cells from 10 patients with chronic lymphocytic leukemia. IFN enhanced OAS activity in a...

journal_title：Leukemia research

authors： Triozzi PL,Avery KB,Abou-Issa HM,Chou TC

更新日期：1989-01-01 00:00:00

abstract：:We wondered whether there was any association between the extent of increased angiogenesis and IgV(H) gene mutational status, expression of CD38 and ZAP-70 in early B-cell chronic lymphocytic leukemia (CLL) patients. Circulating levels of vascular endothelial growth factor (VEGF) correlated positively with ZAP-70-expr...

journal_title：Leukemia research

authors： Molica S,Cutrona G,Vitelli G,Mirabelli R,Molica M,Digiesi G,Ribatti D,Ferrarini M,Vacca A

更新日期：2007-11-01 00:00:00

abstract：:Fifty-three patients with Ph positive chronic myeloid leukaemia in blastic phase were studied. Additional abnormalities were found in 29 (55%) patients and were more common in myeloid (64%) than lymphoid (45%) blast crisis. The most frequent were +Ph (32%), +8 (28%), +19 (19%), +20 (9%) and +21 (9%). i(17q) (9%) was a...

journal_title：Leukemia research

authors： Nanjangud G,Kadam PR,Saikia T,Bhisey AN,Kumar A,Gopal R,Chopra H,Nair CN,Advani SH

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Chylomicrons carry in the bloodstream dietary fats absorbed the intestine for storage in the body tissues such as adipose and muscle. The two-step chylomicron metabolism consists in lipolysis by lipoprotein lipase on vessel walls and hepatic uptake of triglyceride-depleted remnants. Chylomicron metabolism is...

journal_title：Leukemia research

authors： Gonçalves RP,Hungria VT,Chiattone CS,Pozzi DB,Maranhão RC

更新日期：2003-02-01 00:00:00

abstract：:Forty patients with high risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) preceded by MDS were treated with intensive induction and consolidation chemotherapy in a prospective multicenter pilot study. They were given two cycles of cytarabine 100 mg/m with 12-h intervals on days 1-7 and idarubicin 12...

journal_title：Leukemia research

authors： Ruutu T,Hänninen A,Järventie G,Koistinen P,Koivunen E,Kätkä K,Nousiainen T,Oksanen K,Pelliniemi TT,Remes K,Timonen T,Volin L,Elonen E

更新日期：1997-02-01 00:00:00

abstract：:A wide range of different agents are capable of inducing the onset of HL-60 differentiation along the myeloid lineage. The diversity of these agents has made the analysis of the molecular mechanisms involved in the regulation of the onset and progress of terminal differentiation in these cells difficult. We have adapt...

journal_title：Leukemia research

authors： Darling DC,Linskens MH,Farzaneh F

更新日期：1989-01-01 00:00:00

abstract：:The human lymphoblastoid leukemic cell line (CCRF-CEM) was induced to differentiate with phorbol 12-myristate 13-acetate (PMA). During differentiation, assessed by monitoring the cluster of differentiation (CD) profile, the prosome (proteasomes, multi-catalytic proteinase) distribution and composition were studied by ...

journal_title：Leukemia research

authors： Baz A,Henry L,Chateau MT,Scherrer K,Bureau JP

更新日期：1997-11-01 00:00:00

abstract：:The effect of prostaglandin E2 (PGE2) on the reduction of c-myc expression during the differentiation of the human leukemic cell line, HL-60, was examined. PGE2, a potent inducer of intracellular cyclic AMP (cAMP) in HL-60 cells, augmented monocyte-associated cell surface antigens induced by human gamma-interferon (IF...

journal_title：Leukemia research

authors： Matsui T,Nakao Y,Koizumi T,Katakami Y,Takahashi R,Mihara K,Sugiyama T,Fujita T

更新日期：1988-01-01 00:00:00

abstract：:Secondary acute lymphoblastic leukemia (s-ALL) is rare and poorly defined and data regarding outcomes post-transplant are lacking. Here, we report a detailed analysis of s-ALL at our Institution. Among 211 eligible patients with ALL from 2006 to 2017, 30 (14%) were defined as s-ALL and the remaining as primary ALL (p-...

journal_title：Leukemia research

authors： Ferraro F,Gao F,Stockerl-Goldstein K,Westervelt P,DiPersio JF,Ghobadi A

更新日期：2018-09-01 00:00:00

abstract：:Homoharringtonine combined aclarubicin and cytarabine (HAA) has been demonstrated to achieve a high remission rate and provide a survival advantage in acute myeloid leukemia (AML). To investigate whether HAA is an ideal induction regimen for t(8;21)AML, we retrospectively analyzed the data of 140 patients from the las...

journal_title：Leukemia research

authors： Zhu HH,Jiang H,Jiang Q,Jia JS,Qin YZ,Huang XJ

更新日期：2016-05-01 00:00:00

abstract：:Leukotrienes and lipoxins are bioactive lipoxygenase products formed by leukocytes alone or in collaboration with other cells. While the physiological role of lipoxins remains to be clarified, accumulating evidence shows that leukotrienes are important mediators in asthma and inflammation. Consequently, recent clinica...

journal_title：Leukemia research

authors： Stenke L,Reizenstein P,Lindgren JA

更新日期：1994-10-01 00:00:00

abstract：:An acute promyelocytic leukemia in the rat (BNML) has been used in model studies on pathogenesis and therapy of human acute myeloid leukemia. The blood supply to bone marrow during BNML development has hitherto not been examined, even though in general, blood flow to hematopoietic tissues might affect drug treatment a...

journal_title：Leukemia research

authors： Iversen PO,Thing-Mortensen B,Nicolaysen G,Benestad HB

更新日期：1993-08-01 00:00:00

abstract：:A single somatic mutation, V617F, in the pseudokinase domain of the Jak2 is the primary cause of many chronic myeloproliferative diseases. As valine 617 of Jak2 is conserved as valine 678 of Tyk2, we examined the effect of a homologous mutation in Tyk2 (V678F Tyk2) on cell growth. V678F Tyk2 augmented the transcriptio...

journal_title：Leukemia research

authors： Shide K,Shimoda K,Kamezaki K,Kakumitsu H,Kumano T,Numata A,Ishikawa F,Takenaka K,Yamamoto K,Matsuda T,Harada M

更新日期：2007-08-01 00:00:00

abstract：:A retrospective cytogenetic study was performed to determine whether non-random chromosome aberrations were related to the outcome of marrow transplantation for advanced stage acute leukemia (AL) and chronic myelogenous leukemia (CML). The patients were registered on SWOG-8612, a randomized comparison of busulphan and...

journal_title：Leukemia research

authors： Slovak ML,Kopecky KJ,Wolman SR,Henslee-Downey JP,Appelbaum FR,Forman SJ,Blume KG

更新日期：1995-06-01 00:00:00

abstract：:We have recently described that a variant of L1210 leukemia cell (L1210/LN-1) originally fused with Lesch-Nyhan fibroblast is highly immunogenic for inducing tumor-specific transplantation immunity in (BALB/cxDBA/2)F1 mice. This finding has clearly been confirmed in the present study by in-vitro cell-mediated cytotoxi...

journal_title：Leukemia research

authors： Kawashima K,Isobe K,Nagase F,Yokochi T,Nagura E,Hasegawa Y,Morishita H,Yamada K,Nakashima I

更新日期：1985-01-01 00:00:00

abstract：:One of the major limitations of DNA flow cytometry (FCM) in hematologic malignancies is the lack of information about the proliferation activity of subpopulations of the heterogeneous bone marrow (BM) compartment. We studied the S-phase DNA content of immunophenotypically defined BM subpopulations (CD2+; CD19+; CD2/CD...

journal_title：Leukemia research

authors： Brons P,Pennings A,Haanen C,Wessels H,Boezeman J

更新日期：1991-01-01 00:00:00