Abstract:
:We describe changes in antigen expression on HL60 cells with differentiation into granulocytes induced by all-trans retinoic acid (ATRA) or dimethylsulphoxide (DMSO), into monocytes by alpha1,25-dihydroxyvitamin D3 (D3), or into macrophages by 12-O-tetradecanoyl phorbol-13-acetate (TPA). Undifferentiated cells expressed CD13, CD14 (at a low level), CD15, CDw17, CD32, CD33, CD49e, CD63, CD64, CDw65, CD71 and CD87 antigens and bound the unclustered mAb D171 and Mo5. Differentiated and undifferentiated cells were negative for CD16, CD34, CD61, CD66abcde, CD68, CD88, CDw90 and CD93. Four panels of markers were identified whose expression changes significantly following differentiation. CD15, CD49e, CD63, CDw65, CD71 and mAb D171 and IGR-2,1A6 for DMSO; CD13, CD15, CDw17, CD49e, CD63, CDw65, CD71, CD87, CDw92 and mAb D171 and IGR-2,1A6 for ATRA; CD14, CD31, CD35, CD71, CD87, CDw92 and mAb D171 and BRIC18 for D3; CDw12, CD13, CD15, CD31, CD35, CD49e, CD71, CD87, CDw92 and mAb D171 for TPA. These will be useful for analyzing the pathways that regulate differentiation, whether the observed changes are consequences of differentiation or more direct effects of the inducers. HL60 cells provide a model for investigating the regulation of these antigens.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Trayner ID,Bustorff T,Etches AE,Mufti GJ,Foss Y,Farzaneh Fdoi
10.1016/s0145-2126(98)00041-1subject
Has Abstractpub_date
1998-06-01 00:00:00pages
537-47issue
6eissn
0145-2126issn
1873-5835pii
S0145212698000411journal_volume
22pub_type
杂志文章abstract::Prospective data are needed to ascertain the impact of iron chelation therapy in patients with myelodysplastic syndromes. The present 5-year prospective registry analysis was conducted to compare clinical outcomes between chelated and nonchelated patients with lower-risk myelodysplastic syndromes and transfusional iro...
journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90011-u
更新日期:1992-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.11.005
更新日期:2018-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(91)90121-9
更新日期:1991-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(82)90010-8
更新日期:1982-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.leukres.2004.01.008
更新日期:2004-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(99)00101-0
更新日期:1999-10-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.08.001
更新日期:2006-03-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00129-1
更新日期:2002-03-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2016.01.013
更新日期:2016-03-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2018.11.018
更新日期:2019-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.03.010
更新日期:2009-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(03)00216-9
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pub_type: 临床试验,杂志文章
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更新日期:2000-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.leukres.2009.03.047
更新日期:2009-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.11.012
更新日期:2006-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)90004-3
更新日期:1994-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.03.009
更新日期:2007-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(00)00019-9
更新日期:2000-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90117-2
更新日期:1987-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(89)90010-6
更新日期:1989-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.07.022
更新日期:2013-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.04.017
更新日期:2005-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(02)00175-3
更新日期:2003-04-01 00:00:00
abstract::Ectopic expression of LMO2 occurs in approximately 45% of T-lineage acute lymphoblastic leukemias (T-ALL), sometimes in association with chromosomal translocations. Recently, a lymphoproliferative disorder developed in two participants in a gene therapy trial due to LMO2 activation via integration of the retroviral ve...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.05.013
更新日期:2005-01-01 00:00:00