Abstract:
:Ectopic expression of LMO2 occurs in approximately 45% of T-lineage acute lymphoblastic leukemias (T-ALL), sometimes in association with chromosomal translocations. Recently, a lymphoproliferative disorder developed in two participants in a gene therapy trial due to LMO2 activation via integration of the retroviral vector. To investigate these regulatory disruptions, we analyzed the promoter region and identified a tissue-specific repressor. The fragment containing this element could also produce tissue-specific suppression of transcription from the SV40 promoter. This suppression involves histone acetylation which can be relieved with Trichostatin A (TSA). The negative element is in a region consistently removed from LMO2 in the known chromosomal translocations.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Hammond SM,Crable SC,Anderson KPdoi
10.1016/j.leukres.2004.05.013keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
89-97issue
1eissn
0145-2126issn
1873-5835pii
S0145212604002152journal_volume
29pub_type
杂志文章abstract::The resistance to all trans retinoic acid (ATRA) differentiating treatment is a consequence, in most of the cases, of either increased catabolism or down regulation of ATRA uptake. Recently, we have shown that ATRA efficiency to differentiate HL-60 cells was enhanced about 30 times after its incorporation into Low Den...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(00)00019-9
更新日期:2000-06-01 00:00:00
abstract::Defective apoptosis is a hallmark of the progression of B chronic lymphocytic leukaemia (B-CLL). Smac-mimetics have been shown to induce apoptosis in several tumours. We describe the in vitro pro-apoptotic activity and regulation of the molecular pathway induced by new Smac-mimetics in B-CLL. The cytotoxic effect was ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.03.016
更新日期:2013-07-01 00:00:00
abstract::Regulation of pluripotent stem cell (CFU-S) proliferation kinetics by humoral factors is now well documented. However, the mechanism of choice of CFU-S differentiation pathways is still a controversial issue. We suggest that long-range humoral factors (pluripoietins) are capable of preferentially channelling CFU-S tow...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90041-9
更新日期:1984-01-01 00:00:00
abstract::The immunologic phenotype of the lymphocytes of 100 patients with chronic lymphocytic leukaemia (CLL) was investigated. Peripheral blood lymphocytes (PBL) were examined in all cases; in 46 patients with lymphadenopathy, a lymph node was biopsied and the histologic and immunologic patterns were assessed: 24 had a lymph...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90063-4
更新日期:1987-01-01 00:00:00
abstract::Replication of the Friend spleen focus forming virus (SFFV) in C3H/HeJ or C57BL/6J mouse continuous bone marrow cultures is associated with an increased cumulative production of pluripotential/hematopoietic stem cells (CFUs), granulocyte-macrophage progenitor cells (GM-CFUc), and total granulocytes, compared to uninfe...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90133-9
更新日期:1983-01-01 00:00:00
abstract::We recently confirmed that ciclopirox olamine inhibits Wnt/beta catenin signalling in myeloma. Griseofulvin (GF) has similar chemical features as compared to ciclopirox olamine. In this study the anti-tumor effect of GF was investigated. GF demonstrated a major apoptotic activity in various human and murine myeloma an...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2010.10.008
更新日期:2011-08-01 00:00:00
abstract::We studied differentiation inducing effects of retinoic acid (RA), 1 alpha, 25-dihydroxyvitamin D3 (D3) and interferons (IFNs), alone and in combination, on fresh myeloid leukemic cells from 8 patients. RA not only induced the differentiation of leukemic cells in 5/8 cases, but potentiated differentiation by IFNs eith...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(90)90072-h
更新日期:1990-01-01 00:00:00
abstract::The National Comprehensive Cancer Network (NCCN) defines the following types of acute myeloid leukemia (AML) as favorable-risk: acute promyelocytic leukemia with t(15;17) (APL); AML with core-binding factor (CBF) rearrangements, including t(8;21) and inv(16) or t(16;16) without mutations in KIT (CBF-KITwt); and AML wi...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.12.012
更新日期:2018-02-01 00:00:00
abstract::We report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. The cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at di...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00152-7
更新日期:2002-06-01 00:00:00
abstract::Chronic B-lymphocytic leukemia (B-CLL) cells may be regulated by immune functions. In an attempt to analyze such functions, helper factors (IL-1 alpha, IL-1 beta and IL-6), T-cell products (sCD4 and sCD8) and sIL-2R and beta 2-microglobulin were measured in serum of patients at different stages of the disease. Patient...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90009-v
更新日期:1992-06-01 00:00:00
abstract::Epstein-Barr virus (EBV) can induce a broad spectrum of hematological diseases, especially in immune deficient patients. We assayed for receptor for EBV (EBVR) using fluoresceinated viral particles on 44 human hematopoietic cell lines derived from patients with T, B, and non-T, non-B acute lymphocytic leukemia (ALL), ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90085-2
更新日期:1985-01-01 00:00:00
abstract::We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m(2) q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-r...
journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.leukres.2013.01.001
更新日期:2013-05-01 00:00:00
abstract::Thermal stress induces expression of a family of heat shock proteins which may regulate the synthesis of various cellular genes. We investigated the effect of heat shock on polyadenylation in Epstein-Barr Virus (EBV) negative and EBV transformed human Burkitt's lymphoma (BL) B-cell lines. Incubation of the BL B-cell l...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00063-1
更新日期:1995-11-01 00:00:00
abstract::Introduction of the maturation index (MI) as a measure for the degree of maturation improved the subtyping of acute myeloid leukemia (AML). A comparison is made here between the MI and the results of surface marker analysis with a panel of monoclonal antibodies (McAb) in the immunofluorescence technique. The McAb appl...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90100-5
更新日期:1983-01-01 00:00:00
abstract::The treatment of acute myeloid leukemia (AML) did not evolve profoundly in the last decades. Some improvement has been made for acute lymphoblastic leukemia (ALL). Emerging new treatment modalities, such as immunotherapy, are now beginning to be available for acute leukemia, mostly for patients suffering from ALL. Thi...
journal_title:Leukemia research
pub_type: 杂志文章,评审
doi:10.1016/j.leukres.2017.06.011
更新日期:2017-09-01 00:00:00
abstract::We have earlier shown that VP-16 combined with Cyclosporin A (CsA) produces tumor specific immunity to L1210 leukemia in BDF/1 mice [Slater LM, Sweet P, Stupecky M, Reynolds JT. Cyclosporin A/VP-16 produced immunity to L1210 leukemia: the participation of cytotoxic CD(8) T-lymphocytes, Clin Immunol Immunopathol 1995;7...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00105-9
更新日期:2002-02-01 00:00:00
abstract::Leukemia cells enriched from peripheral blood of a patient with myelogenous leukemia were induced to differentiate with a purified T cell lymphokine neuroleukin. With sufficient neuroleukin concentrations, cells with macrophage-like morphology were identified among the developing adherent cells. After 2-5 days, approx...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(98)00129-5
更新日期:1999-01-01 00:00:00
abstract::Fifty-three patients with Ph positive chronic myeloid leukaemia in blastic phase were studied. Additional abnormalities were found in 29 (55%) patients and were more common in myeloid (64%) than lymphoid (45%) blast crisis. The most frequent were +Ph (32%), +8 (28%), +19 (19%), +20 (9%) and +21 (9%). i(17q) (9%) was a...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)90023-x
更新日期:1994-05-01 00:00:00
abstract::Dasatinib was approved for the treatment of chronic phase (CP) chronic myeloid leukemia (CML) patients in first line therapy based on the demonstration of efficacy and safety reported in patients enrolled in clinical trials. We describe a multicentric Italian "real-life" experience of dasatinib used as frontline treat...
journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.leukres.2015.11.008
更新日期:2016-01-01 00:00:00
abstract::Two white European males are reported with adult T-cell leukemia (ATL), a disease first described in Japan, but recently also in the U.K. and U.S.A. Both patients presented with lymphadenopathy, but without a mediastinal mass. In addition, one patient had skin infiltrates and the other had hepatosplenomegaly. Morpholo...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90055-3
更新日期:1983-01-01 00:00:00
abstract::Methods for ex vivo purging of neoplastic cells from harvested marrow are being developed to increase the efficacy of autologous transplantation. One approach is selective photosensitization, using sensitizing compounds and light radiation. Pyrene-containing fatty acids and lipids are potent photosensitizers, e.g. 12-...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(92)90170-c
更新日期:1992-01-01 00:00:00
abstract::Useful prognostic markers for patients with diffuse large B cell lymphoma (DLBCL) have been reported. To identify which biomarker best predicts the prognosis of patients with DLBCL, we performed a retrospective study that included 319 DLBCL patients who had received rituximab, cyclophosphamide, doxorubicin, vincristin...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.08.016
更新日期:2015-08-29 00:00:00
abstract::Internal tandem duplications (ITDs) of the FLT3 gene occur in approximately 20-30% of acute myeloid leukemia (AML) patients. We investigated if FLT3 ITDs could be used as minimal residual disease (MRD) markers for AML patients. Patient-specific polymerase chain reaction (PCR) assays for FLT3 ITDs were developed for fo...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00087-x
更新日期:2001-12-01 00:00:00
abstract::We report a case of Ph1-negative, bcr-negative CML-BC, in which the primary leukemic cells displayed T-related antigens (CD7, CD4) in addition to HLA-DR and CD25 determinants. No B-lymphoid, myeloid and megakaryoblastic surface antigens were detected. In spite of this phenotype, DNA analysis revealed a germ-line confi...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(88)90097-5
更新日期:1988-01-01 00:00:00
abstract::Ten patients with acute nonlymphocytic leukemia (ANLL) received bromodeoxyuridine (BrdU) at 100 mg/M2 intravenously over 1 h. BrdU is incorporated into the DNA by S-phase cells and was detected by using a monoclonal anti-BrdU antibody in the bone marrow aspirate (BM) and biopsy specimens obtained at the end of the inf...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90160-3
更新日期:1987-01-01 00:00:00
abstract::Recent studies have identified SOX11 as a novel diagnostic marker for mantle cell lymphoma (MCL). We quantified SOX11 by a truly mRNA specific qPCR assay in longitudinal peripheral blood samples from 20 patients and evidenced a close relationship of SOX11 expression and clinical status of the patients. In eight patien...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.04.007
更新日期:2014-08-01 00:00:00
abstract::There is resurgent interest in glucocorticoids (GCs) in the treatment of poor prognosis chronic lymphocytic leukemia (CLL). Little is known however on how GCs induce apoptosis in CLL. Methylprednisolone (MP) induces apoptosis in ZAP-70 positive CLL more readily than in ZAP-70 negative CLL, which is in contrast to the ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.02.022
更新日期:2009-10-01 00:00:00
abstract::The treatment of acute leukemia is still challenging due in part to the development of resistance and relapse. This chemotherapeutics resistance is established by clonal selection of resistant variants of the cancer cells. Recently, a horizontal transfer of chemo-resistance among cancer cells via extracellular vesicle...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.09.014
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Telomerase disfunction leads to short telometric overhangs, potentially resulting in chromosome instability. AIMS:To better understand the role of overhang length in the progression of myelodysplastic syndrome (MDS). METHODS:Bone marrow samples of 62 Chinese MDS patients were screened for TERT and TERC gen...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.06.011
更新日期:2013-10-01 00:00:00
abstract::Effects of the HDAC inhibitor LBH-589 (panobinostat) on fludarabine lethality toward acute myeloid leukemia (AML) cells were examined in vitro and in vivo. LBH-589 pretreatment sensitized U937, HL-60, and primary leukemia cells to fludarabine while blocking NF-κB activation accompanied by XIAP down-regulation and JNK ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.10.020
更新日期:2012-04-01 00:00:00