Myelodysplastic syndrome in childhood: report of two cases with deletion of chromosome 4 and the Philadelphia chromosome.


:We report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. The cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at different moments of the disease. One patient showed the Ph chromosome at disease transformation and the other at diagnosis. The different breakpoints at 4q and the presence of Ph could be a marker of this form of MDS. The association of clinical and hematological findings suggests the possibility of a new group of pediatric MDS.


Leuk Res


Leukemia research


Dalla Torre CA,de Martino Lee ML,Yoshimoto M,Lopes LF,Melo LN,Caminada de Toledo SR,Duffles Andrade JA





Has Abstract


2002-06-01 00:00:00














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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2002-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Arunasree KM,Roy KR,Anilkumar K,Aparna A,Reddy GV,Reddanna P

    更新日期:2008-06-01 00:00:00

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    journal_title:Leukemia research

    pub_type: 杂志文章


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    更新日期:2009-06-01 00:00:00

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    更新日期:2010-10-01 00:00:00

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    journal_title:Leukemia research

    pub_type: 杂志文章


    authors: Andrivon W,Saucier JM,Auclair C,Monneret C,Florent JC,Guillosson JJ,Nafziger J

    更新日期:1996-02-01 00:00:00

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    journal_title:Leukemia research

    pub_type: 杂志文章


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    更新日期:1998-05-01 00:00:00