Myelodysplastic syndrome in childhood: report of two cases with deletion of chromosome 4 and the Philadelphia chromosome.

Abstract:

:We report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. The cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at different moments of the disease. One patient showed the Ph chromosome at disease transformation and the other at diagnosis. The different breakpoints at 4q and the presence of Ph could be a marker of this form of MDS. The association of clinical and hematological findings suggests the possibility of a new group of pediatric MDS.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Dalla Torre CA,de Martino Lee ML,Yoshimoto M,Lopes LF,Melo LN,Caminada de Toledo SR,Duffles Andrade JA

doi

10.1016/s0145-2126(01)00152-7

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

533-8

issue

6

eissn

0145-2126

issn

1873-5835

pii

S0145212601001527

journal_volume

26

pub_type

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