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Multilineage cell involvement in Ph1-negative, bcr-negative chronic myeloid leukemia.

Abstract：

:We report a case of Ph1-negative, bcr-negative CML-BC, in which the primary leukemic cells displayed T-related antigens (CD7, CD4) in addition to HLA-DR and CD25 determinants. No B-lymphoid, myeloid and megakaryoblastic surface antigens were detected. In spite of this phenotype, DNA analysis revealed a germ-line configuration of the T-cell receptor beta chain gene region. Moreover, in-vitro culture studies demonstrated a proliferative response of the blast cell population to natural and recombinant myeloid-related factors, while no proliferative signal was observed in the presence of IL-2. The myeloid lineage was further demonstrated by the expression of myeloid-associated antigens on cultured blast cells, which still retained the CD7 antigen. Finally, cytogenetic analysis revealed a monosomy 7 which is usually associated with a stem cell leukemia. These results support the hypothesis that Ph1-negative, bcr-negative CML is characterized by the involvement of a multipotent stem cell capable of multilineage expression and indicate that differentiative and proliferative assays provide a further tool towards a more precise recognition of hematological disorders of uncertain origin.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Callea V,Morabito F,Lista P,Pegoraro L,Cambrin GR,Guerrasio A,Saglio G,Tassinari A,Fierro MT,Iacopino P

doi

10.1016/0145-2126(88)90097-5

subject

Has Abstract,Author List Incomplete

pub_date

1988-01-01 00:00:00

pages

637-45

issue

8

eissn

0145-2126

issn

1873-5835

journal_volume

12

pub_type

杂志文章

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