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BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients.

Abstract：

:This study was conducted to determine the frequency of the most common fusion genes in Mexican pediatric patients with acute lymphoblastic leukemia (ALL). Molecular analysis using RT-PCR was carried out in 53-blood samples: 52 patients with de novo ALL and one with relapsed ALL. The ETV6-RUNX1 fusion was found in 7 cases (13.5%), BCR-ABL fusion was detected in 2 cases (3.8%), and 6 patients (11.5%) expressed the chimeric gene E2A-PBX1. The prevalence of E2A-PBX1 is one of the highest that has been described thus far in childhood ALL. Furthermore, we detected both the BCR-ABL, and E2A-PBX1 fusion in the relapsed patient. With regards to the immunophenotype, ETV6-RUNX1 was expressed in both pre-B and T-cell cases, while the presence of E2A-PBX1 and BCR-ABL was associated with the pre-B ALL phenotype. The prevalence of E2A-PBX1 in Mexican pediatric cases supports the existence of ethnic differences in the frequency of molecular markers of ALL.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Jiménez-Morales S,Miranda-Peralta E,Saldaña-Alvarez Y,Perez-Vera P,Paredes-Aguilera R,Rivera-Luna R,Velázquez-Cruz R,Ramírez-Bello J,Carnevale A,Orozco L

doi

10.1016/j.leukres.2008.03.021

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1518-22

issue

10

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(08)00155-0

journal_volume

32

pub_type

杂志文章

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