Abstract:
:Outcomes in patients with secondary acute myeloid leukemia (sAML) (including therapy related myeloid neoplasms and AML with myelodysplasia related changes (MRC)) are poor. Patients treated with hypomethylating agents (HMAs) for antecedent hematological malignancy (AHM) have suboptimal responses to induction chemotherapy upon transformation to AML. We investigated outcomes after various induction strategies in patients with sAML who had prior HMA exposure. We identified 242 patients with sAML who had prior HMA treatment for AHM and later received induction chemotherapy upon AML transformation and divided into 3 cohorts based on induction regimen: (A) CLAG/M (B) 7 + 3 and (C) CPX-351. The CR/CRi rate was 53% in cohort A, 32% in cohort B and 41.2% in cohort C (p = 0.005 between cohort A and B) (p = 0.329 between cohorts A and C) (p = 0.402 between cohorts B and C). The early death rates were not significantly different among the three cohorts (p = 0.200). In patients who received ≤4 cycles of HMAs prior to AML transformation, response rates to CPX-351 were higher (64.3%) with a trend toward better overall survival (OS) (19.9 vs. 5.5 months) compared to >4 cycles (p = 0.092). There was no significant difference in median OS among the 3 groups: cohort A (7.27 months), cohort B (7.63 months) and cohort C (7.07 months) (p = 0.887). We demonstrate that CLAG/M and CPX-351 yield higher CR/CRi rates compared to 7 + 3 in patients with sAML after HMA failure. Median OS remains poor and did not differ among the 3 groups, illustrating the unmet need for more efficacious therapy for sAML patients following HMA failure.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Talati C,Goldberg AD,Przespolewski A,Chan O,Ali NA,Kim J,Famulare C,Sallman D,Padron E,Kuykendall A,Lancet JE,Wang E,Tallman MS,Komrokji R,Sweet Kdoi
10.1016/j.leukres.2020.106367subject
Has Abstractpub_date
2020-06-01 00:00:00pages
106367eissn
0145-2126issn
1873-5835pii
S0145-2126(20)30072-2journal_volume
93pub_type
杂志文章,多中心研究abstract::The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-va...
journal_title:Leukemia research
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abstract::Gain-of-function mutations in the proto-oncogene c-kit that induce constitutive kinase activity of its product, KIT protein, are characteristic of human mast cell disease and are believed to play a central role in mast cell leukemia oncogenesis, proliferation and survival. Nuclear overexpression of the Wnt effector be...
journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(86)90237-7
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2007.03.034
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(98)00129-5
更新日期:1999-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.11.008
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.10.004
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.11.003
更新日期:2006-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章,meta分析,评审
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(00)00019-9
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abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.01.006
更新日期:2009-02-20 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2019.02.005
更新日期:2019-04-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2008.12.015
更新日期:2009-09-01 00:00:00