Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT).

Abstract:

:We investigated the role of Src family kinases (SFKs) in the regulation of STAT activation in myeloid leukemia cells. Two of 6 AML cell lines displayed constitutive STAT5 activation, whereas four cell lines had constitutive SFK activity. Treatment with the SFK inhibitors suppressed STAT5 activation and decreased viability. Akt phosphorylation and Mcl-1 expression decreased after SFK inhibition accompanied by apoptosis induction. In primary AML specimens, SFK inhibitors suppressed proliferation in 5 of 14 specimens. These data indicate that Src-STAT5 and Src-Akt pathways are integral survival signal pathways in AML cells. Src inhibition may represent a novel treatment strategy for investigation in AML.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Ozawa Y,Williams AH,Estes ML,Matsushita N,Boschelli F,Jove R,List AF

doi

10.1016/j.leukres.2007.11.032

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

893-903

issue

6

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(07)00467-5

journal_volume

32

pub_type

杂志文章
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    journal_title:Leukemia research

    pub_type: 杂志文章,评审

    doi:10.1016/0145-2126(92)90099-s

    authors: Jacobs A

    更新日期:1992-01-01 00:00:00

  • Blinatumomab administered concurrently with oral tyrosine kinase inhibitor therapy is a well-tolerated consolidation strategy and eradicates measurable residual disease in adults with Philadelphia chromosome positive acute lymphoblastic leukemia.

    abstract::Incorporation of ABL-targeted oral tyrosine kinase inhibitors (TKIs) into frontline therapeutic regimens has improved outcomes for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). However, patients with persistent minimal residual disease (MRD) exhibit increased risk of relapse. Co...

    journal_title:Leukemia research

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    doi:10.1016/j.leukres.2019.02.009

    authors: King AC,Pappacena JJ,Tallman MS,Park JH,Geyer MB

    更新日期:2019-04-01 00:00:00

  • Involvement of NF-kappaB and glutathione in cytotoxic effects of nitric oxide and taxol on human leukemia cells.

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    journal_title:Leukemia research

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    doi:10.1016/j.leukres.2005.06.021

    authors: Santos-Silva MC,Freitas MS,Assreuy J

    更新日期:2006-02-01 00:00:00

  • Incorporation of nucleic acid and protein precursors in enriched populations of proliferating normal and leukemic cells.

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    journal_title:Leukemia research

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    doi:10.1016/0145-2126(82)90098-4

    authors: Burghouts JT,Plas AM,Salden MH,Wessels HM

    更新日期:1982-01-01 00:00:00

  • Histone deacetylase inhibition restores cisplatin sensitivity of Hodgkin's lymphoma cells.

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    journal_title:Leukemia research

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    doi:10.1016/j.leukres.2012.02.021

    authors: Kewitz S,Bernig T,Staege MS

    更新日期:2012-06-01 00:00:00

  • Bone marrow niche in the myelodysplastic syndromes.

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    journal_title:Leukemia research

    pub_type: 杂志文章,评审

    doi:10.1016/j.leukres.2015.06.017

    authors: Cogle CR,Saki N,Khodadi E,Li J,Shahjahani M,Azizidoost S

    更新日期:2015-10-01 00:00:00

  • The correlation of adenosine deaminase and purine nucleoside phosphorylase activities in human lymphocytes subpopulations and in various lymphoid malignancies.

    abstract::Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) were measured in normal human and in malignant lymphoid cells. Thymocytes had high ADA activity (21.2 +/- 6.8 10(3) nM/h/mg) and low PNP activity (1.2 +/- 0.6), whereas T peripheral blood lymphocytes (PBL) had low ADA activity (1.20 +/- 0.22) and high...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(82)90027-3

    authors: Demeocq F,Viallard JL,Boumsell L,Richard Y,Chassagne J,Plagne R,Lemerle J,Bernard A

    更新日期:1982-01-01 00:00:00

  • Twice daily fludarabine/Ara-C associated to idarubicin, G-CSF and ATRA is an effective salvage regimen in non-promyelocytic acute myeloid leukemia.

    abstract::Preclinical data suggest that all-trans retinoic acid (ATRA) synergizing with granulocyte colony stimulating factor (G-CSF), can improve the effectiveness of chemotherapy in acute myeloid leukemia (AML). Fludarabine 15 mg/m(2) is the minimum dose able to optimize intensification with fludarabine-arabinosylcytosine reg...

    journal_title:Leukemia research

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.leukres.2008.12.014

    authors: Montillo M,Ricci F,Tedeschi A,Cafro AM,Nosari AM,Nichelatti M,Marbello L,Morra E

    更新日期:2009-08-01 00:00:00

  • Evidence for the in vivo production of interleukin-3 in lethally irradiated mice transplanted with syngeneic murine splenocytes.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(89)90138-0

    authors: Hirokawa M,Takatsu H,Chubachi A,Kudo K,Takahashi T,Yoshida K,Miura AB

    更新日期:1989-01-01 00:00:00

  • Changes in antigen expression on differentiating HL60 cells treated with dimethylsulphoxide, all-trans retinoic acid, alpha1,25-dihydroxyvitamin D3 or 12-O-tetradecanoyl phorbol-13-acetate.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/s0145-2126(98)00041-1

    authors: Trayner ID,Bustorff T,Etches AE,Mufti GJ,Foss Y,Farzaneh F

    更新日期:1998-06-01 00:00:00

  • Unusual course of an acute lymphoblastic leukemia case with i(9q) as a sole cytogenetic abnormality.

    abstract::Chromosomal changes are necessary in determining the classification, prognosis and using the appropriate therapeutic regimen in acute leukemia. Isochromosomes are uncommon chromosome aberations in childhood acute lymphoblastic leukemia (ALL) and the effect of i(9q) is not well established. We present an 8-year-old mal...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/j.leukres.2006.02.018

    authors: Cogulu O,Karapinar DY,Karaca E,Aydinok Y,Ozkinay F

    更新日期:2006-11-01 00:00:00

  • The deacetylase inhibitor LAQ824 induces notch signalling in haematopoietic progenitor cells.

    abstract::AML progenitor cells (AML-PC) undergo significant apoptosis in response to the deacetylase inhibitor (DACi) LAQ824 and lose the replating capacity which was not observed with the DACi valproic acid. Treatment of normal hematopoietic progenitor cells (HPC) with LAQ824 resulted in (i) inhibition of differentiation, (ii)...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/j.leukres.2010.06.024

    authors: Schwarz K,Romanski A,Puccetti E,Wietbrauk S,Vogel A,Keller M,Scott JW,Serve H,Bug G

    更新日期:2011-01-01 00:00:00

  • MiR-15a/16 regulates the growth of myeloma cells, angiogenesis and antitumor immunity by inhibiting Bcl-2, VEGF-A and IL-17 expression in multiple myeloma.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/j.leukres.2016.08.013

    authors: Li Y,Zhang B,Li W,Wang L,Yan Z,Li H,Yao Y,Yao R,Xu K,Li Z

    更新日期:2016-10-01 00:00:00

  • Effects of cytapheresis on cell cycle distribution of peripheral blood and bone marrow cells in some hematological malignancies.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(87)90186-x

    authors: Kotelnikov VM,Kasatkina VV,Dultsina SM,Sarytcheva TG,Kalinin NN,Kovaleva LG,Poljanskaja AM,Isajev VG,Khoroshko ND,Lishmanova NG

    更新日期:1987-01-01 00:00:00

  • Clonality analysis of childhood ALL in remission: no evidence of clonal hematopoiesis.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(94)90121-x

    authors: Busque L,Ilaria R Jr,Tantravahi R,Weinstein H,Gilliland DG

    更新日期:1994-02-01 00:00:00

  • Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL).

    abstract::Flow cytometry is commonly used to establish the diagnosis of chronic lymphocytic leukemia (CLL). A defined combination of antibodies discriminates between normal B cells and CLL cells (coexpression of CD5, CD19, and CD23). The receptor tyrosine-like orphan receptor one (ROR1) is an embryonic glycoprotein involved in ...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/j.leukres.2011.04.006

    authors: Uhrmacher S,Schmidt C,Erdfelder F,Poll-Wolbeck SJ,Gehrke I,Hallek M,Kreuzer KA

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  • Reciprocal alterations of GMP reductase and IMP dehydrogenase activities during differentiation in HL-60 leukemia cells.

    abstract::The study was undertaken to elucidate the regulatory roles of GMP reductase (GMPR) and IMP dehydrogenase (IMPDH) on purine interconversion during differentiation. Treatment of HL-60 cells with retinoic acid (1 microM) induced granulocytic differentiation which was accompanied with a 2.4-fold increase in GMPR and 55% d...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(92)90002-o

    authors: Nakamura H,Natsumeda Y,Nagai M,Takahara J,Irino S,Weber G

    更新日期:1992-06-01 00:00:00

  • Ph-negative acute lymphocytic leukemia occurring after interferon therapy for Ph-positive chronic myelocytic leukemia.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/s0145-2126(02)00175-3

    authors: Zhang X,Ji L,Liu S,Wang J

    更新日期:2003-04-01 00:00:00

  • Saturation of intracellular cytosine arabinoside triphosphate accumulation in human leukemic blast cells.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(90)90035-8

    authors: Jamieson GP,Snook MB,Wiley JS

    更新日期:1990-01-01 00:00:00

  • CDKN2A deletions in acute lymphoblastic leukemia of adolescents and young adults: an array CGH study.

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    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/j.leukres.2008.01.014

    authors: Usvasalo A,Savola S,Räty R,Vettenranta K,Harila-Saari A,Koistinen P,Savolainen ER,Elonen E,Saarinen-Pihkala UM,Knuutila S

    更新日期:2008-08-01 00:00:00

  • Mitoxantrone and prolonged infusion gemcitabine as salvage therapy in patients with acute myelogenous leukemia.

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    journal_title:Leukemia research

    pub_type: 临床试验,杂志文章

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    authors: Apostolidou E,Estey E,Cortes J,Garcia-Manero G,Faderl S,Thomas D,Tsimberidou A,Kantarjian H,Giles FJ

    更新日期:2003-04-01 00:00:00

  • The addition of daunorubicin to imatinib mesylate in combination with cytarabine improves the response rate and the survival of patients with myeloid blast crisis chronic myelogenous leukemia (AFR01 study).

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    journal_title:Leukemia research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.leukres.2010.11.004

    authors: Deau B,Nicolini FE,Guilhot J,Huguet F,Guerci A,Legros L,Pautas C,Berthou C,Guyotat D,Cony-Makhoul P,Gardembas M,Michallet M,Hayette S,Cayuela JM,Weiss IR,Réa D,Castaigne S,Mahon FX,Guilhot F,Rousselot P

    更新日期:2011-06-01 00:00:00

  • Characteristics of the inhibition of human promyelocytic leukaemia HL60 cell growth by S-D-lactoylglutathione in vitro.

    abstract::The mechanism of the inhibition of proliferation of human leukaemia 60 (HL60) cells by S-D-lactoylglutathione in vitro was investigated. The median inhibitory concentration IC50 value was 66 microM (95% C.I. 50-87 microM; n = 18). The inhibition of leukaemia cell growth required exposure of HL60 cells to S-D-lactoylgl...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(93)90017-f

    authors: Edwards L,Clelland JD,Thornalley PJ

    更新日期:1993-04-01 00:00:00

  • ALL masquerading as AUL.

    abstract::Of 597 cases of acute leukaemia in adults (greater than 16 years) seen at St. Bartholomew's Hospital, London, between May 1973 and January 1982, 412 were diagnosed as AML, 103 as ALL and 58 as Philadelphia chromosome positive blast crisis of CML (13 presenting as acute leukaemia and 45 having a prior chronic phase). T...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(83)90067-x

    authors: Greaves MF,Bell R,Amess J,Lister TA

    更新日期:1983-01-01 00:00:00

  • The relationship between the site of breakpoints within the bcr gene and thrombopoiesis of Philadelphia-positive chronic myelocytic leukemia.

    abstract::We determined the position of the breakpoint within the bcr gene in 22 patients with Philadelphia-positive chronic myelocytic leukemia using conventional Southern-blots and analyzed its relationship to thrombopoiesis. After DNA digestion with restriction endonucleases (Hind III, Bam HI and Bgl II), we localized the br...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(91)90113-8

    authors: Inokuchi K,Futaki M,Yamada T,Tanabe Y,Dan K,Shinohara T,Kuriya S,Nomura T

    更新日期:1991-01-01 00:00:00

  • Aspiration biopsy-nucleic acid diagnosis of thyroid malignant lymphoma by vectorette PCR: experience of eight cases.

    abstract::The usefulness of a new method to detect B-cell monoclonality named VR, which is a combination of the digestion with restriction enzymes and vectorette PCR, in aspiration biopsy-nucleic acid diagnosis (ABND) of thyroid malignant lymphoma was investigated. ABND was performed in 12 patients in whom malignant lymphoma wa...

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    pub_type: 杂志文章

    doi:10.1016/j.leukres.2007.03.019

    authors: Takano T,Asahi S,Matsuzuka F,Hidaka Y,Yoshida H,Miyauchi A

    更新日期:2008-01-01 00:00:00

  • Characterization of acute myeloid leukemia with del(9q) - Impact of the genes in the minimally deleted region.

    abstract::Acute myeloid leukemia is an aggressive disease that arises from clonal expansion of malignant hematopoietic precursor cells of the bone marrow. Deletions on the long arm of chromosome 9 (del(9q)) are observed in 2% of acute myeloid leukemia patients. Our deletion analysis in a cohort of 31 del(9q) acute myeloid leuke...

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    pub_type: 杂志文章

    doi:10.1016/j.leukres.2018.11.007

    authors: Naarmann-de Vries IS,Sackmann Y,Klein F,Ostareck-Lederer A,Ostareck DH,Jost E,Ehninger G,Brümmendorf TH,Marx G,Röllig C,Thiede C,Crysandt M

    更新日期:2019-01-01 00:00:00

  • Dasatinib is safe and effective in unselected chronic myeloid leukaemia elderly patients resistant/intolerant to imatinib.

    abstract::To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher ...

    journal_title:Leukemia research

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.leukres.2011.05.015

    authors: Latagliata R,Breccia M,Castagnetti F,Stagno F,Luciano L,Gozzini A,Ulisciani S,Cavazzini F,Annunziata M,Sorà F,Rossi AR,Pregno P,Montefusco E,Abruzzese E,Crisà E,Musto P,Tiribelli M,Binotto G,Occhini U,Feo C,Vigner

    更新日期:2011-09-01 00:00:00

  • Neurotoxicity of stem cell mobilization chemotherapy with vinorelbine in myeloma patients after bortezomib treatment.

    abstract::Vinorelbine chemotherapy with G-CSF stimulation is the standard mobilization regimen in Switzerland for multiple myeloma patients. However, with the increasing use of bortezomib during induction treatment, adding the neurotoxic compound vinorelbine for mobilization may aggravate bortezomib-induced polyneuropathy. In t...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/j.leukres.2015.03.015

    authors: Keller S,Seipel K,Novak U,Mueller BU,Taleghani BM,Leibundgut K,Pabst T

    更新日期:2015-07-01 00:00:00

  • Changes in thymidine kinase activity during differentiation of HL-60 leukemic cells.

    abstract::Induction of granulocyte maturation in HL-60 leukemic cells by DMSO (1.2%) or RA (1 microM) is accompanied by a 50-60% decrease in cellular thymidine kinase activity. Similarly, the differentiation of HL-60 cells into monocyte-macrophage phenotype by the addition of PMA is paralleled by a 60-80% suppression of thymidi...

    journal_title:Leukemia research

    pub_type: 杂志文章

    doi:10.1016/0145-2126(87)90079-8

    authors: Borelli TJ,Miyamoto S,Wertheimer SJ,Wu JM

    更新日期:1987-01-01 00:00:00