当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Intensive chemotherapy of poor prognosis myelodysplastic syndromes (MDS) and acute myeloid leukemia following MDS with idarubicin and cytarabine.

Intensive chemotherapy of poor prognosis myelodysplastic syndromes (MDS) and acute myeloid leukemia following MDS with idarubicin and cytarabine.

Abstract：

:Forty patients with high risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) preceded by MDS were treated with intensive induction and consolidation chemotherapy in a prospective multicenter pilot study. They were given two cycles of cytarabine 100 mg/m with 12-h intervals on days 1-7 and idarubicin 12 mg/m2 on days 5-7, both intravenously. Patients who were in remission after these two cycles were given two further cycles of cytarabine on days 1-5 and idarubicin on day 5. No maintenance treatment was given. Eleven out of 19 MDS patients (58%) and 10 out of 21 AML patients (48%), in total 21 out of 40 patients (53%), entered remission. Eight patients underwent allogeneic bone marrow transplantation. The follow-up time was 13-48 (median 33) months. At the time of the analysis, seven patients survived, four patients with MDS all of whom had been treated with bone marrow transplantation (three in continuous remission), and three patients with AML treated with chemotherapy only (two in continuous remission). The median survival of the patients treated with chemotherapy only was 12 months, with the median progression-free survival being 8 months. In view of the poor prognostic factors of the patients, the remission rate was satisfactory, but the responses as well as the survival were short. The post-remission treatment needs to be improved.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Ruutu T,Hänninen A,Järventie G,Koistinen P,Koivunen E,Kätkä K,Nousiainen T,Oksanen K,Pelliniemi TT,Remes K,Timonen T,Volin L,Elonen E

doi

10.1016/s0145-2126(96)00116-6

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

133-8

issue

2

eissn

0145-2126

issn

1873-5835

pii

S0145212696001166

journal_volume

21

pub_type

临床试验,杂志文章,多中心研究

相关文献

LEUKEMIA RESEARCH文献大全
  • Serum double monoclonal components and hematological malignancies: only a casual association? Review of 34 cases.

    abstract：:A double monoclonal component (MC) detected in the serum and/or urine represents a very rare occurrence (2-6% of monoclonal gammopathies). In this study, we report 34 patients with double serum MCs, focusing on the associated diseases. The diagnosis was made using high-resolution serum protein electrophoresis and immu...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.05.008

    authors： Guastafierro S,Ferrara MG,Sica A,Parascandola RR,Santangelo S,Falcone U

    更新日期：2012-10-01 00:00:00

  • YM155 suppresses cell proliferation and induces cell death in human adult T-cell leukemia/lymphoma cells.

    abstract：:Adult T-cell leukemia (ATL) is an aggressive malignancy of peripheral T cells infected with human T-cell leukemia virus type 1 (HTLV-1). The prognosis of patients with aggressive ATL remains poor because ATL cells acquire resistance to conventional cytotoxic agents. Therefore, development of novel agents is urgently n...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2015.10.012

    authors： Sasaki R,Ito S,Asahi M,Ishida Y

    更新日期：2015-12-01 00:00:00

  • No parental origin bias for the rearranged chromosomes in myeloid leukemias associated with t(9;22), t(8;21) and t(15;17).

    abstract：:We investigated parental origin of rearranged chromosomes 9 and 22 (9q + and 22q -) in five patients with Ph-positive chronic myeloid leukemia (CML) using the C-banding and silver-staining methods of nucleolus organizer regions, respectively; of rearranged chromosome 21 (21q +) in seven patients with t(8;21)-positive ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(98)00069-1

    authors： Nakamura H,Itoyama T,Niikawa N,Sadamori N,Tomonaga M

    更新日期：1998-09-01 00:00:00

  • The deacetylase inhibitor LAQ824 induces notch signalling in haematopoietic progenitor cells.

    abstract：:AML progenitor cells (AML-PC) undergo significant apoptosis in response to the deacetylase inhibitor (DACi) LAQ824 and lose the replating capacity which was not observed with the DACi valproic acid. Treatment of normal hematopoietic progenitor cells (HPC) with LAQ824 resulted in (i) inhibition of differentiation, (ii)...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2010.06.024

    authors： Schwarz K,Romanski A,Puccetti E,Wietbrauk S,Vogel A,Keller M,Scott JW,Serve H,Bug G

    更新日期：2011-01-01 00:00:00

  • Clinico-hematological profile and thrombotic/hemorrhagic events in 150 chinese patients with essential thrombocythemia.

    abstract：:Essential thrombocythemia (ET) is an uncommon chronic myeloproliferative disorder with no cure. Patients with ET are at risk of different complications, and currently there are no optimal prognostic standards to predict severe post-diagnosis complications such as thrombosis and hemorrhage. In this study, we retrospect...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2018.03.013

    authors： Zhou D,Chen W,Cheng H,Qiao JL,Zhu LL,Li ZY,Xu KL

    更新日期：2018-06-01 00:00:00

  • Real-world costs of chronic lymphocytic leukaemia in the Netherlands.

    abstract：:We performed a comprehensive cost calculation identifying the main cost drivers of treatment of chronic lymphocytic leukaemia in daily practice. In our observational study 160 patient charts were reviewed repeatedly to assess the treatment strategies from diagnosis till the study end. Ninety-seven patients (61%) recei...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.10.029

    authors： Holtzer-Goor KM,Bouwmans-Frijters CA,Schaafsma MR,de Weerdt O,Joosten P,Posthuma EF,Wittebol S,Huijgens PC,Mattijssen EJ,Vreugdenhil G,Visser H,Peters WG,Erjavec Z,Wijermans PW,Daenen SM,van der Hem KG,van Oers MH,Groot

    更新日期：2014-01-01 00:00:00

  • Stimulation of HTLV-I expression by subtoxic dose of 3-methylcholanthrene.

    abstract：:In vivo infection by HTLV-I is characterized by the lack of virus expression in the host's infected cells and in most cases it is clinically inapparent. The present study shows that exposure of HTLV-I-infected human T-cells to a maximal non-toxic dose of 3-MC remarkably enhances virus expression. This stimulatory effe...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(93)90098-6

    authors： Feldman G,Aboud M

    更新日期：1993-05-01 00:00:00

  • Allogeneic hematopoietic cell transplantation in T-cell prolymphocytic leukemia: A single-center experience.

    abstract：BACKGROUND:T- cell prolymphocytic leukemia (T- PLL) is a rare aggressive hematological malignancy. Alemtuzumab, an anti-CD52 humanized monoclonal antibody, is the treatment of choice for remission induction. Allogeneic hematopoietic cell transplantation (allo-HCT) has been described to induce durable remissions and imp...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2018.01.009

    authors： Dholaria BR,Ayala E,Sokol L,Nishihori T,Chavez JC,Hussaini M,Kumar A,Kharfan-Dabaja MA

    更新日期：2018-04-01 00:00:00

  • Levels of CAF7 (CD98) expression correlate with the complete remission duration in childhood acute leukemia.

    abstract：:The levels of expression of the activation antigen CD98 were studied by mAB CAF7 in 51 newly diagnosed consecutive cases of childhood acute lymphoblastic leukemia aged from 1 to 13 years. The mean follow-up was 8 months. A wide range of CAF7 expression was observed, the highest mean fluorescence intensity exceeding th...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00114-x

    authors： Taskov H,Pashov A,ffmitrova E,Yordanova M,Serbinova M

    更新日期：1996-01-01 00:00:00

  • Blinatumomab administered concurrently with oral tyrosine kinase inhibitor therapy is a well-tolerated consolidation strategy and eradicates measurable residual disease in adults with Philadelphia chromosome positive acute lymphoblastic leukemia.

    abstract：:Incorporation of ABL-targeted oral tyrosine kinase inhibitors (TKIs) into frontline therapeutic regimens has improved outcomes for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). However, patients with persistent minimal residual disease (MRD) exhibit increased risk of relapse. Co...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2019.02.009

    authors： King AC,Pappacena JJ,Tallman MS,Park JH,Geyer MB

    更新日期：2019-04-01 00:00:00

  • Decreased blood flow to rat bone marrow, bone, spleen, and liver in acute leukemia.

    abstract：:An acute promyelocytic leukemia in the rat (BNML) has been used in model studies on pathogenesis and therapy of human acute myeloid leukemia. The blood supply to bone marrow during BNML development has hitherto not been examined, even though in general, blood flow to hematopoietic tissues might affect drug treatment a...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(93)90071-r

    authors： Iversen PO,Thing-Mortensen B,Nicolaysen G,Benestad HB

    更新日期：1993-08-01 00:00:00

  • Hierarchical regulation of interleukin production: induction of interleukin 6 (IL-6) production from bone marrow cells and marrow stromal cells by interleukin 3 (IL-3).

    abstract：:IL-3 stimulated the production of IL-6 from a bone marrow-adherent cell population, macrophages and from hemopoietic supportive stromal cell lines. It also induced IL-6 production from a stem cell-enriched population of bone marrow cells which did not produce IL-6 without stimulation. In contrast, stimulation with IL-...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(91)90180-2

    authors： Miyashita M,Sugimoto K,Suzuki J,Taniguchi S,Aramaki K,Mori KJ

    更新日期：1991-01-01 00:00:00

  • Purine metabolism in relation to leukemia and lymphoid cell differentiation.

    abstract：:A number of inborn errors of purine metabolism have been associated with immunodeficiency diseases. From studies to the possible mechanism(s) leading to the defects in the immune system, it appeared that the accumulation of deoxyATP and deoxyGTP and the subsequent inhibition of ribonucleotide reductase played an impor...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/0145-2126(83)90042-5

    authors： van Laarhoven JP,de Bruyn CH

    更新日期：1983-01-01 00:00:00

  • Molecular mechanisms of resistance of leukemia to imatinib mesylate.

    abstract：:Despite high rates of hematologic and cytogenetic responses to imatinib therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of Ph-positive leukemia. The high frequency of BCR-ABL mutations and amplifications represents the high degree of heterogeneity in patients wi...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.leukres.2003.10.007

    authors： Tauchi T,Ohyashiki K

    更新日期：2004-05-01 00:00:00

  • Combined treatment of 3-hydroxyflavone and imatinib mesylate increases apoptotic cell death of imatinib mesylate-resistant leukemia cells.

    abstract：:Imatinib mesylate, a Bcr/Abl tyrosine kinase inhibitor, is widely used in treating chronic myeloid leukemia. However, drug-resistance of leukemia cells becomes an emergent problem. Herein, various flavonoids were screened for applicability in leukemia treatment, and 3-hydroxyflavone (3-HF) was found to be most effecti...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.05.018

    authors： Kim JH,Song M,Kang GH,Lee ER,Choi HY,Lee C,Kim JH,Kim Y,Koo BN,Cho SG

    更新日期：2012-09-01 00:00:00

  • A phase I study of induction chemotherapy for older patients with newly diagnosed acute myeloid leukemia (AML) using mitoxantrone, etoposide, and the MDR modulator PSC 833: a southwest oncology group study 9617.

    abstract：:Older patients with acute myelogenous leukemia (AML) have overexpression of P-glycoprotein (Pgp+), and this has been shown to correlate quantitatively with therapeutic outcome. Since Pgp-mediated efflux of cytotoxic drugs can be inhibited by the cyclosporine analogue, PSC 833, we investigated the use of this agent wit...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0145-2126(00)00024-2

    authors： Chauncey TR,Rankin C,Anderson JE,Chen I,Kopecky KJ,Godwin JE,Kalaycio ME,Moore DF,Shurafa MS,Petersdorf SH,Kraut EH,Leith CP,Head DR,Luthardt FW,Willman CL,Appelbaum FR

    更新日期：2000-07-01 00:00:00

  • Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP.

    abstract：BACKGROUND:Little is known on racial differences in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this retrospective study is to compare characteristics, prognostic factors and outcomes of Asian and Western patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and pred...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.01.002

    authors： Castillo JJ,Sinclair N,Beltrán BE,Song MK,Ilic I,Leppa S,Nurmi H,Seki R,Uccella S,Li JM,Treaba DO,Stachurski D,Butera JN

    更新日期：2013-04-01 00:00:00

  • Quality of life of patients with acute myeloid leukaemia.

    abstract：:In a prospective study of 27 patients with acute myeloid leukaemia (AML) quality of life was studied using three different instruments, Life Ingredient Profile, Karnofsky Performance Scale and Vitagram. The course of the disease was followed during the induction period, remission, relapse and in the terminal phase. We...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(94)90028-0

    authors： Stalfelt AM

    更新日期：1994-04-01 00:00:00

  • Incidence and prognostic relevance of CD34 expression in acute myeloblastic leukemia: analysis of 141 cases.

    abstract：:In 141 adult patients with diagnosis of acute myeloid leukemia the overall expression and intensity of expression of CD34 antigen on leukemic cells was investigated. Myeloid blasts were tested by applying direct immunofluorescence staining using anti-CD34 fluorescein monoclonal antibody in flow cytometry. CD34 antigen...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(97)00015-5

    authors： Raspadori D,Lauria F,Ventura MA,Rondelli D,Visani G,de Vivo A,Tura S

    更新日期：1997-07-01 00:00:00

  • RAF-1/MEK/ERK pathway regulates ATRA-induced differentiation in acute promyelocytic leukemia cells through C/EBPβ, C/EBPε and PU.1.

    abstract：:MEK/ERK signal pathway was required for the differentiation of granulocytes, megakaryocytes and erythrocytes. Recently, MEK/ERK cascade was reported to be involved in all-trans retinoic acid (ATRA) induced differentiation in acute promyelocytic leukemia (APL) cells. However, the upstream and downstream molecules of ME...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2016.03.008

    authors： Weng XQ,Sheng Y,Ge DZ,Wu J,Shi L,Cai X

    更新日期：2016-06-01 00:00:00

  • Impaired cell-mediated immunity to cytomegalovirus (CMV) in leukemic children with prolonged CMV viruria.

    abstract：:To determine the role of cell-mediated immunity (CMI) to cytomegalovirus (CMV) in leukemic children after CMV infection, CMI to CMV antigen was studied using CMV-specific lymphocyte blastogenic responses (LBR) and interferon (IFN) production. Four children, who continuously secreted CMV in urine more than 2 years afte...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(94)90086-8

    authors： Ihara T,Yasuda N,Isaji M,Torigoe S,Ito M,Kamiya H,Sakurai M

    更新日期：1994-07-01 00:00:00

  • Molecular monitoring of responses to DLI and DLI + IFN treatment of post-SCT relapses in patients with CML.

    abstract：:We monitored DLI treatment of 13 post-SCT relapses using quantitative competitive (QC) RT-PCR for BCR-ABL (sensitivity 10(-5)) and compared responses to DLI alone and DLI in combination with interferon-alpha (IFN). Ten relapses (one blast crisis, five cytogenetic and four molecular) were treated with DLI+IFN, three re...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(02)00280-1

    authors： Moravcová J,Nádvorníková S,Zmeková V,Michalová K,Brezinová J,Lukásová M,Vítek A,Hrabánek J,Gasová Z,Sedlácek P,Starý J

    更新日期：2003-08-01 00:00:00

  • Differential effect of heat shock on RNA metabolism in human Burkitt's lymphoma B-cell lines.

    abstract：:Thermal stress induces expression of a family of heat shock proteins which may regulate the synthesis of various cellular genes. We investigated the effect of heat shock on polyadenylation in Epstein-Barr Virus (EBV) negative and EBV transformed human Burkitt's lymphoma (BL) B-cell lines. Incubation of the BL B-cell l...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00063-1

    authors： Kumar A,Kurl RN,Kryworuchko M,Diaz-Mitoma F,Sharma S

    更新日期：1995-11-01 00:00:00

  • XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells.

    abstract：:To further understand the role of XIAP in acute myeloid leukemia (AML), we suppressed XIAP expression by antisense oligonucleotides and determined the effect on gene expression profiles and biological pathways. XIAP inhibition upregulated expression of proteasome genes in a manner similar to the proteasome inhibitor b...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.04.018

    authors： Carter BZ,Mak DH,Wang Z,Ma W,Mak PY,Andreeff M,Davis RE

    更新日期：2013-08-01 00:00:00

  • Establishment and characterization of a B-cell line from a patient with acute lymphoblastic leukemia.

    abstract：:A permanent lymphoblastoid cell line was established from the peripheral blood of a child with acute lymphoblastic leukemia. The cell line, designated SDK, grows in a stationary suspension culture, forming aggregates, in RPMI medium supplemented with 10% FCS, with a doubling time of 50-60 h. Immunologic markers and cy...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(85)90025-6

    authors： Kottaridis S,Perez S,Kokkinopoulos D,Delinassios JG,Pangalis GA,Cosmidis H,Goula I,Papamichail M

    更新日期：1985-01-01 00:00:00

  • Effects of X-irradiation, ovariohysterectomy and estradiol-17 beta on incidence, benign/malignant ratio and multiplicity of rat mammary neoplasms--a preliminary report.

    abstract：:An overview is given of the effects of X-irradiation, ovariohysterectomy and estradiol-17 beta administration on mammary tumorigenesis in females of 3 rat strains, viz. the WAG/Rij, BN/BiRij and SD. The 3 rat strains differed significantly in their spontaneous mammary tumor incidence. Female SD rats had the highest in...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(86)90292-4

    authors： Solleveld HA,van Zwieten MJ,Broerse JJ,Hollander CF

    更新日期：1986-01-01 00:00:00

  • A cytogenetic model predicts relapse risk and survival in patients with acute myeloid leukemia undergoing hematopoietic stem cell transplantation in morphologic complete remission.

    abstract：:Up to 30% of patients with acute myeloid leukemia (AML) and abnormal cytogenetics have persistent cytogenetic abnormalities (pCytAbnl) at morphologic complete remission (mCR). We hypothesized that the prognostic significance of pCytAbnl in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) i...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.leukres.2014.11.007

    authors： Rashidi A,Cashen AF

    更新日期：2015-01-01 00:00:00

  • Expression of the testis-specific gene, TSGA10, in Iranian patients with acute lymphoblastic leukemia (ALL).

    abstract：:Testis-specific gene antigen (TSGA10) is expressed in fetus, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detection of minimal residual disease (MRD). This gene is considered as a member of cancer-testis (CT) genes. We previously demonstrated TSGA10 ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.11.012

    authors： Mobasheri MB,Modarressi MH,Shabani M,Asgarian H,Sharifian RA,Vossough P,Shokri F

    更新日期：2006-07-01 00:00:00

  • The expression of PRAME in chronic lymphoproliferative disorders.

    abstract：:The PRAME gene encodes an antigen recognized by autologous T lymphocytes and is expressed in trophoblasts, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detecting MRD. We demonstrate expression of PRAME by RT-PCR in the peripheral blood or bone marrow...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(02)00217-5

    authors： Proto-Siqueira R,Falcão RP,de Souza CA,Ismael SJ,Zago MA

    更新日期：2003-05-01 00:00:00

  • Phase 2 study of gandotinib (LY2784544) in patients with myeloproliferative neoplasms.

    abstract：BACKGROUND:The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are associated with increases in janus kinase 2 (JAK2) signaling, often resulting from the JAK2 V617F mutation. LY2784544 (gandotinib) is a potent, selective, small-molecule inhibitor of JAK2 that has potential dose-dependent selectivit...

    journal_title：Leukemia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.leukres.2018.06.014

    authors： Berdeja J,Palandri F,Baer MR,Quick D,Kiladjian JJ,Martinelli G,Verma A,Hamid O,Walgren R,Pitou C,Li PL,Gerds AT

    更新日期：2018-08-01 00:00:00