Abstract：
:In vivo infection by HTLV-I is characterized by the lack of virus expression in the host's infected cells and in most cases it is clinically inapparent. The present study shows that exposure of HTLV-I-infected human T-cells to a maximal non-toxic dose of 3-MC remarkably enhances virus expression. This stimulatory effect was demonstrated by showing elevated levels of viral RNA and proteins within the cells and increased virus release to the culture medium. The enhanced virus expression was found to increase the ability of the treated cells to infect normal human peripheral lymphocytes in co-culture. Such data point to the possibility that initiation of a pathogenic process in HTLV-I-infected individuals might result from activating the expression of the latent provirus by environmental carcinogens.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Feldman G,Aboud Mdoi
10.1016/0145-2126(93)90098-6subject
Has Abstractpub_date
1993-05-01 00:00:00pages
429-35issue
5eissn
0145-2126issn
1873-5835journal_volume
17pub_type
杂志文章abstract：:During 2004-2006, two hypomethylating agents (HMAs) were approved for the treatment of myelodysplastic syndromes (MDS) in the United States. We assessed the impact of HMAs on the cost of care and survival of MDS patients, by constructing a cohort of patients who were diagnosed during 2001-2007 (n=6556, age ≥66.5 years...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.07.020
更新日期：2012-11-01 00:00:00
abstract：:Treatment failure of patients with acute myelogenous leukemia (AML) is frequently due to the development of multidrug resistance phenotype blasts. We have expressed a fusion protein consisting of human granulocyte-macrophage colony stimulating factor (GMCSF) fused to the N-terminus of a lectin-deficient ricin toxin B ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(97)00043-x
更新日期：1997-07-01 00:00:00
abstract：:We assessed plasma cell proliferation (by propidium iodide index, PC-PI) and apoptosis (by annexin-V index PC-AI) for the estimation of overall survival (OS) in multiple myeloma (MM) patients. 181 patients with newly diagnosed MM were assessed, treated using conventional chemotherapy. The values best discriminating pa...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2010.04.015
更新日期：2011-01-01 00:00:00
abstract：:The ability of pH-sensitive liposomes and immunoliposomes to deliver synthetic antisense oligonucleotides (oligos) into human myeloid and lymphoid leukaemia cells was examined. The cellular uptake of an 18mer anti-myb oligonucleotide encapsulated in liposomes was from three- to five-fold higher than that of 32P-oligos...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(96)00062-8
更新日期：1996-11-01 00:00:00
abstract：:Myelodysplastic syndrome (MDS) are a heterogeneous group of clonal disease characterized by insufficiency of bone marrow, increase of apoptosis and increased risk of acute leukemia progression. Proteins related to the mitotic spindle (AURKA, AURKB, TPX2), to the mitotic checkpoint (MAD2, CDC20) and the regulation of t...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.11.013
更新日期：2018-01-01 00:00:00
abstract：:We have utilized the MTT assay to measure the metabolic activity of cells from the bone marrow of 55 patients with acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) and non-clonal disease. Doubling dilutions of cells were exposed to MTT for 3-4 h. The mean optical density of the formazan produced by each c...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(95)00163-8
更新日期：1996-05-01 00:00:00
abstract：:Although recent advances in chemotherapy have markedly improved outcome of acute lymphoblastic leukemia (ALL), infantile ALL with MLL gene rearrangements (MLL+ALL) is refractory to chemotherapy. We have shown that specific cytokines FLT3 ligand and TGFβ1 both of which are produced from bone marrow stromal cells synerg...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2018.11.001
更新日期：2018-12-01 00:00:00
abstract：:We have recently described that a variant of L1210 leukemia cell (L1210/LN-1) originally fused with Lesch-Nyhan fibroblast is highly immunogenic for inducing tumor-specific transplantation immunity in (BALB/cxDBA/2)F1 mice. This finding has clearly been confirmed in the present study by in-vitro cell-mediated cytotoxi...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90316-9
更新日期：1985-01-01 00:00:00
abstract：:Treatment of CMML remains a clinical challenge, with no drug demonstrating clear clinical benefit. Even if azacitidine is approved in the treatment of CMML, its role remains disputed. We report a cohort of 76 CMML patients (according to WHO classification) treated with azacitidine in 3 programs (French AZA compassiona...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.leukres.2013.01.004
更新日期：2013-06-01 00:00:00
abstract：:Incidence and outcomes of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are not well established at the population level, especially since the widespread use of immunophenotyping. We studied the epidemiology of CLL in Manitoba (Canada) by combining data from a centralized flow cytometry facility and th...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.06.013
更新日期：2009-11-01 00:00:00
abstract：:Survivin is a newly discovered inhibitor of the apoptosis protein, IAP, expressed during development and in human cancers. The effector cell protease receptor-1 (EPR-1) gene is oriented in the opposite direction on the same DNA double strand. Thus, the Survivin and EPR-1 (Survivin/EPR-1) genes exist in a head-to-head ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(00)00065-5
更新日期：2000-11-01 00:00:00
abstract：:Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients >or=10...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.11.001
更新日期：2006-08-01 00:00:00
abstract：:Dimethyl sulfoxide (DMSO) is a widely used prototypical chemical inducer of cell differentiation. In the present study, the effects of DMSO on susceptibility of human myeloid leukemia U937 cells towards ligation of distinct death receptors (DRs) were investigated. DMSO sensitized cells towards induction of apoptosis b...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.05.016
更新日期：2006-01-01 00:00:00
abstract：:Granulocytic sarcoma (GS) is a rare extra-medullary tumor and usually involves the skin, soft tissue, and lymph nodes. GS is found in 8% of acute myeloid leukemia (AML) patients, especially patients with t(8;21)AML. It has been suggested that GS is a poor prognostic factor in t(8;21)AML. Compared to t(8;21)AML, GS is ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.11.003
更新日期：2006-08-01 00:00:00
abstract：:Rearrangements in MLL (MLL-r) are common within very young children with leukemia and affect the prognosis and treatment. Previous studies have suggested the use of the NG2 molecule as a marker for MLL-r but these studies were performed using a small number of infants. We analyzed 148 patients (all less than 24 months...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2011.03.006
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Chylomicrons carry in the bloodstream dietary fats absorbed the intestine for storage in the body tissues such as adipose and muscle. The two-step chylomicron metabolism consists in lipolysis by lipoprotein lipase on vessel walls and hepatic uptake of triglyceride-depleted remnants. Chylomicron metabolism is...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(02)00087-5
更新日期：2003-02-01 00:00:00
abstract：:Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in folate metabolism and DNA methylation. Studies on MTHFR polymorphism in leukemia have largely focused on the protective role of MTHFR polymorphism in acute lymphoblastic leukemia (ALL). We evaluated the C677T and A1298C polymorphisms using the TaqMan...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.10.016
更新日期：2007-09-01 00:00:00
abstract：:Mutations in Janus kinase 2 (JAK2) are implicated in the pathogenesis of Philadelphia-chromosome negative myeloproliferative neoplasms, including primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2V61...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2017.08.010
更新日期：2017-10-01 00:00:00
abstract：:Based on Bcl-X(L) overexpression studies we identified type I and type II follicular lymphoma cell lines in response to TRAIL. We demonstrate here that either amount of caspase-8 activation or Bid cleavage could not define the dependence on mitochondria. Furthermore, an inhibitor of NF-kappaB, PDTC, enabled TRAIL to a...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.09.025
更新日期：2009-06-01 00:00:00
abstract：:We studied 98 female patients in remission (2-240 months) from childhood ALL to determine the clonality status of their hematopoiesis. Thirty-one (31.6%) were heterozygous at the PGK locus for the BstX1 endonuclease restriction site, permitting X-linked clonality assays to be performed. Two patients were in relapse at...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90121-x
更新日期：1994-02-01 00:00:00
abstract：:Our retrospective analysis explored the role of leukemia cutis (LC) in disease progression of chronic myelomonocytic leukemia (CMML). Of 108 patients with CMML, 11 patients (10.2%) had LC including its equivalent (2 patients). Four of these patients developed acute myeloid leukemia (AML) within 0-4 months. The remaini...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2011.05.003
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:Bortezomib-dexamethasone-thalidomide has been reported to be effective in newly-diagnosed multiple myeloma (MM) with an overall response rate of 92% and a CR rate of 18% (Alexanian et al, Hematology 2007;12(3):235-9), but this regimen has not been tested in the Chinese patients. We report here our results tes...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.04.006
更新日期：2009-12-01 00:00:00
abstract：:Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-kappaB), which is a target molecule of these kin...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.01.008
更新日期：2005-08-01 00:00:00
abstract：:Although clinical experience and in vitro data provide evidence of an anti-leukemic activity of T cells, there are few examples of recognition of leukemic cells by tumor-specific T cells in vitro. Tumor antigens encoded by the MAGE genes are useful tools to study this recognition. We tested the sensitivity to recognit...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(00)00053-9
更新日期：2000-10-01 00:00:00
abstract：:To determine the incidence of haematological malignancies in French Polynesia from 1990 to 1995, we collected cases from the local cancer registry, sanitary evacuation files and all the histopathology and clinical biology laboratories. All leukaemias, non Hodgkin's lymphomas, and multiple myelomas incidence was slight...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(98)00186-6
更新日期：1999-04-01 00:00:00
abstract：:Outcome of adult acute lymphoblastic leukemia (ALL) with central nervous system (CNS) involvement is not clearly defined. We studied 104 patients presenting with CNS involvement at diagnosis among 1493 patients (7%) included into the LALA trials, and 109 patients presenting CNS disease at the time of first relapse amo...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2008.04.011
更新日期：2008-11-01 00:00:00
abstract：:The effect of prostaglandin E2 (PGE2) on the reduction of c-myc expression during the differentiation of the human leukemic cell line, HL-60, was examined. PGE2, a potent inducer of intracellular cyclic AMP (cAMP) in HL-60 cells, augmented monocyte-associated cell surface antigens induced by human gamma-interferon (IF...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(88)90090-2
更新日期：1988-01-01 00:00:00
abstract：:We have previously shown that heparin and heparan sulfate stimulate the growth of human erythroleukemia cells in vitro in the presence of serum or plasma. To determine whether heparin and other glycosaminoglycans (GAGs) are involved in the growth of leukemia cells, effects of GAGs on the growth of three leukemia cell ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90164-3
更新日期：1994-11-01 00:00:00
abstract：:FLT3 is a receptor tyrosine kinase involved in the survival of hematopoietic stem cells, and mutations of FLT3 have been reported to be of prognostic significance. This is the first study of FLT3 mutations in pediatric non-promyelocytic AML patients that received the same treatment scheme in single institute. FLT3 int...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2004.11.006
更新日期：2005-06-01 00:00:00
abstract：:A novel bivalent single chain fusion protein, Bic3, was assembled consisting of the catalytic and translocation domains of diphtheria toxin (DT(390)) fused to two repeating sFv molecules recognizing human CD3 epsilon of the human T-cell receptor. Historically, problems with these constructs include low yield, toxicity...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2004.08.006
更新日期：2005-03-01 00:00:00
