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Aven overexpression: association with poor prognosis in childhood acute lymphoblastic leukemia.

Abstract：

:Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients >or=10 years old or <1 year (P=0.003), and in patients with unfavorable cytogenetic abnormalities (P<0.001). Aven expression was also significantly higher in relapsed patients in the standard-risk group. Aven overexpression was an independent poor prognostic factor. These findings demonstrate that Aven expression can predict prognosis in childhood ALL.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Choi J,Hwang YK,Sung KW,Kim DH,Yoo KH,Jung HL,Koo HH

doi

10.1016/j.leukres.2005.11.001

keywords:

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

1019-25

issue

8

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(05)00426-1

journal_volume

30

pub_type

杂志文章

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