Abstract：
:Zerumbone (ZER) is a potential anticancer natural compound, isolated from Zingiber zerumbet Smith. In this investigation, the anticancer properties of ZER were evaluated on cancer cells of T-acute lymphoblastic leukemia, CEM-ss. The results showed that ZER has cytotoxic effect against CEM-ss cells with an IC(50) of 8.4 ± 1.9 μg/ml (coefficient of variation < 30%). Comparatively, 5-fluorouracil (positive control), imposed an inhibitory effect on CEM-ss cells with an IC(50) of 1.94 ± 0.06 μg/ml. Scanning electron microscopy (SEM) results revealed abnormalities such as membrane blebbing, holes and cytoplasmic extrusions, all of which are characteristics of apoptosis. In addition, ZER has increased the number of TUNEL-positive stain and the cellular level of caspase-3, the hallmarks of apoptosis, on treated CEM-ss cells. It could be concluded that, ZER was able to produce apoptosis on T-acute lymphoblastic leukemia, CEM-ss. The current findings suggest that ZER might be helpful for improving the usefulness of anticancer agents in the therapy of leukemia.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Abdelwahab SI,Abdul AB,Mohan S,Taha MM,Syam S,Ibrahim MY,Mariod AAdoi
10.1016/j.leukres.2010.07.025subject
Has Abstractpub_date
2011-02-01 00:00:00pages
268-71issue
2eissn
0145-2126issn
1873-5835pii
S0145-2126(10)00368-1journal_volume
35pub_type
杂志文章abstract：:The monoclonal antibody AGF2.3 identifies a nuclear envelope protein expressed at high levels in most transformed cell lines and weakly expressed in or absent from normal tissues and primary cell cultures. Here we report that expression of AGF2.3 antigen relates to the maturation status of cells. When HL60 cells were ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(86)90235-3
更新日期：1986-01-01 00:00:00
abstract：:In a recent phase I study, a combination of gemcitabine at 10 mg/(m(2)min) for 12 h and mitoxantrone 12 mg/m(2) daily for 3 days, achieved a complete remission (CR) in 3 of 12 (25%) patients with refractory leukemia. A pilot assessment of this regimen was conducted to determine its tolerability in patients with refrac...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/s0145-2126(02)00171-6
更新日期：2003-04-01 00:00:00
abstract：:Smoking is associated with both acute myeloid leukemia (AML) and lung cancer. We therefore searched our database for concomitant presentation of AML and lung cancer. Among 775 AML cases and 5225 lung cancer cases presenting to Roswell Park Cancer Institute between the years January 1992 and May 2008 we found 12 (1.5% ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.12.016
更新日期：2009-09-01 00:00:00
abstract：:Many evidences have shown that dietary intake of cruciferous vegetables could protect against the risk of various types of malignancies. Benzyl isothiocyanate (BITC), one of the compounds from cruciferous vegetables, had shown induced cell cycle arrest and apoptosis in cancer cells. However, there is no available info...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.01.030
更新日期：2009-11-01 00:00:00
abstract：:In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MD...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.10.012
更新日期：2007-04-01 00:00:00
abstract：:Human promyelocytic leukemia cells (HL-60) mature into functional granulocytes in response to in vitro treatment with several classes of chemical agents. Compounds that increase intracellular adenosine 3':5' -cyclic monophosphate induce a modified program of maturation in which the cells demonstrate functional propert...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90311-x
更新日期：1985-01-01 00:00:00
abstract：:Osteogenic growth peptide (OGP) is a peptide exerting regulatory effects on the bone and on bone marrow. The carboxy-terminal pentapeptide (OGP10-14) is the biologically active portion of OGP. We evaluated OGP10-14 hematopoietic activity performing colony-forming tests on human stem cells derived by bone marrow, perip...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(02)00008-5
更新日期：2002-09-01 00:00:00
abstract：:The effect of VM-26, a topoisomerase II targeting drug, on IW32 murine erythroleukemia cells was investigated. The VM-26 induced IW32 cells to differentiate at a non-toxic but cytostatic concentration (0.01 microgram/ml). More than 40% of the cells were induced to synthesize hemoglobin, and cells were arrested in G2/M...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(95)00144-1
更新日期：1996-03-01 00:00:00
abstract：:A primary mitochondrial defect may be pivotal in the pathogenesis of acquired idiopathic sideroblastic anemia (AISA). The mitochondrial respiratory chain is involved in mitochondrial iron uptake and supply of ferrous iron (Fe2+) for heme synthesis. Mitochondrial DNA (mtDNA) comes into play because several subunits of ...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/s0145-2126(99)00160-5
更新日期：2000-02-01 00:00:00
abstract：:MDS is primarily a disease of the elderly. Cases who give a history of exposure to X-rays, cytotoxic drugs or leukaemogenic chemicals may be younger. Many cases of MDS present because of an incidental blood count. The most prominent clinical features are those of anaemia, neutropenia, thrombocytopenia. Because haemopo...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/0145-2126(92)90106-h
更新日期：1992-01-01 00:00:00
abstract：:Septins are proteins associated with crucial steps in cell division and cellular integrity. In humans, 14 septin genes have been identified, of which five (SEPT2, SEPT5, SEPT6, SEPT9, and SEPT11) are known to participate in reciprocal translocations with the MLL gene in myeloid neoplasias. We have recently shown a sig...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.08.018
更新日期：2010-05-01 00:00:00
abstract：:The involvement of histone lysine methyltransferases (HMT) in carcinogenesis is not well understood. Here, we describe a dose-dependent growth and survival inhibitory effects of BIX-01294, a specific inhibitor of euchromatic HMT2, in promyelocytic leukemia HL-60 and NB4 cells. BIX-01294 combined with all-trans retinoi...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2014.04.003
更新日期：2014-07-01 00:00:00
abstract：:Leukemic cell apoptosis may be enhanced by appropriate oxidative stress. We report here the mechanism of Jurkat cell apoptosis by monochloramine (NH(2)Cl), a neutrophil-derived oxidant. NH(2)Cl induced caspase-dependent apoptosis, which was preceded by cytochrome c and Smac/Diablo release from mitochondria. Within 10m...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.07.009
更新日期：2009-01-01 00:00:00
abstract：:Although the earliest sites of hematopoietic cell and endothelial cell differentiation in the yolk sac blood islands were identified about 100 years ago, cells with hemangioblast properties have not yet been identified in vivo. Endothelial cells differentiate from angioblasts in the embryo and from endothelial progeni...
journal_title：Leukemia research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.leukres.2006.10.014
更新日期：2007-04-01 00:00:00
abstract：:During 2004-2006, two hypomethylating agents (HMAs) were approved for the treatment of myelodysplastic syndromes (MDS) in the United States. We assessed the impact of HMAs on the cost of care and survival of MDS patients, by constructing a cohort of patients who were diagnosed during 2001-2007 (n=6556, age ≥66.5 years...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.07.020
更新日期：2012-11-01 00:00:00
abstract：:The biological progression of chronic myeloid leukaemia is often associated with secondary cytogenetic abnormalities but the molecular mechanisms underlying this progression are poorly understood. This study explores the association of c-myc gene amplification with the progression of chronic myeloid leukaemia in fourt...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(98)00097-6
更新日期：1998-10-01 00:00:00
abstract：:Selective inhibition of the BCR/ABL tyrosine kinase by imatinib (STI571, Glivec/Gleevec) is the therapeutic strategy in patients with chronic myelogenous leukemia (CML). Despite significant hematologic and cytogenetic responses with imatinib, mainly due to the mutations in the Abl kinase domain, resistance occurs in p...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.11.007
更新日期：2008-06-01 00:00:00
abstract：:Homoharringtonine combined aclarubicin and cytarabine (HAA) has been demonstrated to achieve a high remission rate and provide a survival advantage in acute myeloid leukemia (AML). To investigate whether HAA is an ideal induction regimen for t(8;21)AML, we retrospectively analyzed the data of 140 patients from the las...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2016.02.012
更新日期：2016-05-01 00:00:00
abstract：:Incidence and outcomes of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are not well established at the population level, especially since the widespread use of immunophenotyping. We studied the epidemiology of CLL in Manitoba (Canada) by combining data from a centralized flow cytometry facility and th...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.06.013
更新日期：2009-11-01 00:00:00
abstract：:Endonucleases capable of producing internucleosomal DNA cleavage are one of the key enzymes in apoptosis. We examined endonuclease activities contained in nuclei of CD34+ and erythroid cells in the bone marrow (BM) from 12 patients with the myelodysplastic syndromes. The levels of Mg(2+)-dependent and acidic endonucle...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(97)00041-6
更新日期：1997-08-01 00:00:00
abstract：:The role of hemin induction of K562 in inositol phospholipid metabolism has not been previously studied. K562 cells were induced to synthesize hemoglobin upon addition of bovine hemin to the culture media. The phospholipid content of K562 was determined before and after the addition of hemin. The results of this study...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90055-x
更新日期：1991-01-01 00:00:00
abstract：:We describe a 79-year-old man who had massive pleural effusion and a proliferation of prolymphocytic leukemia cells in the peripheral blood, bone marrow, and pleural effusion fluid. Immunophenotyping of leukemia cells revealed either CD3+CD4+CD8-CD25+ or CD3+CD4+CD8+CD25+. The antibody against human T-cell lymphotropi...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.02.029
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND/AIMS:Multiple myeloma (MM) is caused by proliferation of clonal plasma cells (cPCs) in bone marrow (BM), associated with numerical and functional defects in immune subsets. An impairment of B cell compartment is involved in onset/progression of the disease. METHODS:By flow cytometry, we studied distribution...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2016.08.008
更新日期：2016-10-01 00:00:00
abstract：:Spider venoms are a rich source of bioactive compounds with therapeutic potential. In traditional Chinese medicine, spiders and spider venoms have been used in the treatment of various ailments. In the present study, the venom of the spider Macrothele raveni potently suppressed cell growth in the myelogenous leukemia ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.02.025
更新日期：2012-08-01 00:00:00
abstract：:CD13/aminopeptidase-N, an enzyme expressed by myeloid cells, may be important in the regulation and signalling pathways that control myeloid growth and differentiation. In this study we have used the myeloid leukaemic cell line HL60, and its ability to differentiate when induced by all-trans-retinoic acid (ATRA), to s...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90045-0
更新日期：1994-08-01 00:00:00
abstract：:Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. We report here that OPN gene is transactivated by Tax protein of human T-cell leukemia virus type 1 (HTLV-1). Northern blot showed enhanced OPN gene expression in cells stably expressing Tax....
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.08.028
更新日期：2010-06-01 00:00:00
abstract：:Osteogenic growth peptide (OGP) increases blood and bone marrow cellularity in mice, and enhances engraftment of bone marrow transplant. Carboxy-terminal pentapeptide (OGP10-14) holds several properties of full-length polypeptide. We evaluated whether synthetic OGP-derived pentapeptide (sOGP10-14) has some activity on...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(01)00091-1
更新日期：2002-01-01 00:00:00
abstract：:Infant leukemia cells with 46XY,t(11; 17)(q23; p13) karyotype and a hybrid pre B myeloid phenotype (HLA-DR, (Ia), B4 and My7-positive and CALLA and T11-negative) and immunoglobulin heavy chain gene rearrangement were maintained in long-term culture for over 10 months. The in-vitro survival and growth of the leukemia c...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(86)90253-5
更新日期：1986-01-01 00:00:00
abstract：:The aim of this study is to detect the biologic and/or prognostic significance of survivin (S) and effector protease receptor 1: EPR-1 (E) expression in acute leukemias (34 ALL and 40 AML) by using RT-PCR. S and E expressions were found in 83.8 and 20.3% of the cases, respectively. S was detected in 90%, 76.5% and E w...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.01.005
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:The median survival of patients with chronic myelogenous leukemia in myeloid blast crisis (MBC-CML) is poor even for patients treated with tyrosine kinase inhibitors (TKIs). DESIGN AND METHODS:We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM (imatinib mesylate, 600 mg/d) an...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.leukres.2010.11.004
更新日期：2011-06-01 00:00:00
