Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo.

abstract：:Vascular endothelial growth factor (VEGF) is pathognomonically elevated in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome. However, its source of overproduction is unclear. As clinical improvement is almost always associated with VEGF reduction after...

journal_title：Leukemia research

authors： Wang C,Huang XF,Cai QQ,Cao XX,Cai H,Zhou D,Li J

更新日期：2016-11-01 00:00:00

abstract：:In this study we investigated the Ara-CTP-forming capacity of leukemic cells in different phases of the cell cycle. Cells from two leukemic cell lines and leukemic bone marrow cells from patients and rats (BNML model) with acute myelocytic leukemia were separated according to cell cycle phase by means of an albumin de...

journal_title：Leukemia research

authors： Richel DJ,Colly LP,Arentsen-Honders MW,Starrenburg CW,Willemze R

更新日期：1990-01-01 00:00:00

abstract：:A variety of genetic and epigenetic abnormalities were characterized over the last years in Hodgkin and Reed-Sternberg (H-RS) cells of classic Hodgkin Lymphoma (cHL). It was speculated that simultaneous inhibition of multiple signalling pathways might be a promising strategy to target this tumor entity. In the present...

journal_title：Leukemia research

authors： Hartlapp I,Pallasch C,Weibert G,Kemkers A,Hummel M,Re D

更新日期：2009-07-01 00:00:00

abstract：:Murine erythroleukemia (MEL) cells undergo erythroid differentiation in vitro when treated with hexamethylene bisacetamide (HMBA). To identify genes involved in the commitment of MEL cells to differentiate, we screened a cDNA library constructed from HMBA-induced cells by differential hybridization and isolated GTPase...

journal_title：Leukemia research

authors： Vanegas N,García-Sacristán A,López-Fernández LA,Párraga M,del Mazo J,Hernández P,Schvartzman JB,Krimer DB

更新日期：2003-07-01 00:00:00

abstract：:Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cases of CML in late C...

journal_title：Leukemia research

authors： Breccia M,Cannella L,Stefanizzi C,Santopietro M,De Cuia R,Diverio D,Alimena G

更新日期：2009-05-01 00:00:00

abstract：:The impact of genetic aberrations on rituximab-based therapeutic regimens has been intensely studied in chronic lymphocytic leukemia (CLL). According to the current consensus chemoimmunotherapy consisting of rituximab and DNA-damaging drugs is not suitable for patients with TP53 defects. In our study, we focused on CL...

journal_title：Leukemia research

authors： Spunarova M,Tom N,Pavlova S,Mraz M,Brychtova Y,Doubek M,Panovska A,Skuhrova Francova H,Brzobohata A,Pospisilova S,Mayer J,Trbusek M

更新日期：2019-06-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) plays a major role in the homeostasis of cellular protein. We demonstrate that each of the major hematologic diseases (AML, ALL, and MDS) has a specific and different plasma profile of UPS protein and enzymatic activities. While high levels of proteasome and ubiquitin proteins and...

journal_title：Leukemia research

authors： Ma W,Kantarjian H,Zhang X,Wang X,Estrov Z,O'Brien S,Albitar M

更新日期：2011-04-01 00:00:00

abstract：:Total body irradiation (TBI) has traditionally been used in the conditioning regimen for allogenetic hematopoietic stem cell transplantation (alloHCT) from an unrelated donor (u-HCT). However, patients are increasingly receiving a fludarabine-based conditioning regimen without TBI, as it seemed less toxic than TBI. We...

journal_title：Leukemia research

authors： Kim H,Lee KH,Kim I,Sohn SK,Jung CW,Joo YD,Kim SH,Kim BS,Choi JH,Kwak JY,Kim MK,Bae SH,Shin HJ,Won JH,Lee WS,Oh S,Kim HJ,Park JH,Korean Society of Blood and Marrow Transplantation.

更新日期：2014-07-01 00:00:00

abstract：:To clarify whether expression of the programmed cell death 5 (PDCD5) gene in leukemic cells is abnormal, real-time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) was used to examine its expression in marrow cells from leukemia patients. We found lower PDCD5 in both AML and CML marrow cells th...

journal_title：Leukemia research

authors： Ruan GR,Qin YZ,Chen SS,Li JL,Ma X,Chang Y,Wang YZ,Fu JY,Liu YR

更新日期：2006-09-01 00:00:00

abstract：:To increase our knowledge of the pathogenesis of tumour recurrence, cell membrane phenotypes were determined on bone marrow and extramedullary tumour cells at diagnosis and at relapse in 24 children with lymphoid malignancies. There were 19 patients with acute lymphoblastic leukemia and five with non-Hodgkin's lymphom...

journal_title：Leukemia research

authors： Lauer S,Piaskowski V,Camitta B,Casper J

更新日期：1982-01-01 00:00:00

abstract：:The pre-B lymphoma in SL/Kh mice is a polygenic trait involving a number of host genes. In prelymphoma-stage bone marrow, transient pre-B cell expansion is induced by a host locus, Bomb1, and later followed by the emergence of a monoclonal population with a similar phenotype. To determine whether these pre-B cells rep...

journal_title：Leukemia research

authors： Hiratsuka T,Tsuruyama T,Kaszynski R,Kometani K,Minato N,Nakamura T,Tamaki K,Hiai H

更新日期：2008-02-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is rare in Asians living in Asia and possibly in US Asians. In contrast, CLL is the most common leukemia in whites. The basis for this ethnic and geographic variation is unknown. We compared average annual age-adjusted incidence rates (AAIR) of CLL diagnosed from 1972 to 1995 among L...

journal_title：Leukemia research

authors： Gale RP,Cozen W,Goodman MT,Wang FF,Bernstein L

更新日期：2000-08-01 00:00:00

abstract：:Bone marrow cells of five patients with acute myeloid leukemia were fractionated by means of counterflow centrifugation (elutriation). The different fractions were enriched with cells belonging to subsequent stages of the cell cycle. Cytokinetic evaluation of these cell fractions was performed by [3H]thymidine autorad...

journal_title：Leukemia research

authors： Vierwinden G,Drenthe-Schonk AM,Plas AM,Linssen PC,Pennings AH,Holdrinet RS,van Egmond J,Wessels JM,Haanen CA

更新日期：1982-01-01 00:00:00

abstract：:We performed a comprehensive cost calculation identifying the main cost drivers of treatment of chronic lymphocytic leukaemia in daily practice. In our observational study 160 patient charts were reviewed repeatedly to assess the treatment strategies from diagnosis till the study end. Ninety-seven patients (61%) recei...

journal_title：Leukemia research

authors： Holtzer-Goor KM,Bouwmans-Frijters CA,Schaafsma MR,de Weerdt O,Joosten P,Posthuma EF,Wittebol S,Huijgens PC,Mattijssen EJ,Vreugdenhil G,Visser H,Peters WG,Erjavec Z,Wijermans PW,Daenen SM,van der Hem KG,van Oers MH,Groot

更新日期：2014-01-01 00:00:00

abstract：:The methylation inhibitor decitabine (DAC) has great therapeutic value for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, DAC monotherapy is associated with relatively low rates of overall response and complete remission. Previous studies have shown promising results for combination treatmen...

journal_title：Leukemia research

authors： Geng S,Yao H,Weng J,Tong J,Huang X,Wu P,Deng C,Li M,Lu Z,Du X

更新日期：2016-05-01 00:00:00

abstract：:Inhibition of cyclooxygenase 2 (COX-2) by the selective COX-2 inhibitor celecoxib has been suggested as potentially useful for B-cell lymphoma therapy. However, additional pharmacological activities of celecoxib have been discovered and have challenged the notion that its antitumor effects are mediated primarily via t...

journal_title：Leukemia research

authors： Chen ST,Thomas S,Gaffney KJ,Louie SG,Petasis NA,Schönthal AH

更新日期：2010-02-01 00:00:00

abstract：:Primary cardiac lymphoma (PCL) is a rare and usually fatal neoplasm, which may cause syncope, arrhythmia, heart failure and pericardial effusion as presenting clinical complaints. A case of PCL in a 72-year-old man with moderate aortic stenosis is presented. The patient was investigated because of pericardial effusion...

journal_title：Leukemia research

authors： Rolla G,Bertero MT,Pastena G,Tartaglia N,Corradi F,Casabona R,Motta M,Caligaris-Cappio F

更新日期：2002-01-01 00:00:00

abstract：:Despite initial remissions, most patients with Ph chromosome positive (Ph(+)) acute leukemia (AL) become refractory to tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib. This study was designed to determine if targeting the interleukin-3 receptor (IL-3R) with a diphtheria toxin fusion protein (DT(388)IL...

journal_title：Leukemia research

authors： Kim HP,Frankel AE,Hogge DE

更新日期：2010-08-01 00:00:00

abstract：:A t(14;18) translocation is closely associated with the follicular lymphoma but is also seen in diffuse B cell lymphomas with a previous history of a follicular lymphoma as well as de novo diffuse lymphomas. Estimation of the frequency of t(14;18) in follicular lymphoma vary widely from 33 to 89%. Furthermore, no exte...

journal_title：Leukemia research

authors： Sayhan N,Tuzuner N,Aki H,Demir G,Berkarda B

更新日期：2000-06-01 00:00:00

abstract：:We report single institution outcome of brief, intensive ara-C-based chemotherapy using bone marrow transplantation as primary intensification for untreated adult patients with acute lymphoblastic leukemia (ALL). Overall disease-free and overall survival were inferior to those reported with prolonged chemotherapy mode...

journal_title：Leukemia research

authors： Sotomayor EM,Piantadosi S,Miller CB,Karp JE,Jones RJ,Rowley SD,Kaufmann SH,Braine H,Burke PJ,Gore SD

更新日期：2002-05-01 00:00:00

abstract：:Helix-loop-helix (HLH) transcription factors are involved in cellular growth and differentiation. The Id (inhibitor of DNA binding and differentiation) HLH proteins, in a dominantly negative fashion, regulate transcriptional activities of basic HLH proteins. We examined by northern hybridization the expression of Id2 ...

journal_title：Leukemia research

authors： Ishiguro A,Spirin K,Shiohara M,Tobler A,Norton JD,Rigolet M,Shimbo T,Koeffler HP

更新日期：1995-12-01 00:00:00

abstract：:Little information is available about the risk factors and means to improve the survival rate of acute leukemia in a rare but often fatal complication after liver transplantation (LT). We report the development of AML-M2 in one of the 764 patients who underwent liver transplantation at our center, and review the liter...

journal_title：Leukemia research

authors： Jiang N,Li H,Wang GS,Zhang J,Zhang JF,Yi SH,Yang Y,Cai CJ,Lu MQ,Chen GH

更新日期：2009-10-01 00:00:00

abstract：:Adults with acute lymphoblastic leukemia (ALL) in first complete remission (CR1) may be treated either with ongoing systemic chemotherapy or with allogeneic hematopoietic cell transplantation (alloHCT). Despite the presence of phase III trials to support clinical decision-making, we hypothesized that physicians who tr...

journal_title：Leukemia research

authors： Paulson K,Szwajcer D,Raymond CB,Seftel MD

更新日期：2014-02-01 00:00:00

abstract：:We monitored DLI treatment of 13 post-SCT relapses using quantitative competitive (QC) RT-PCR for BCR-ABL (sensitivity 10(-5)) and compared responses to DLI alone and DLI in combination with interferon-alpha (IFN). Ten relapses (one blast crisis, five cytogenetic and four molecular) were treated with DLI+IFN, three re...

journal_title：Leukemia research

authors： Moravcová J,Nádvorníková S,Zmeková V,Michalová K,Brezinová J,Lukásová M,Vítek A,Hrabánek J,Gasová Z,Sedlácek P,Starý J

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:For most cases of idiopathic acquired sideroblastic anemia (IASA), the molecular pathogenesis is unknown, despite the consistent morphological signature of abundant pathological ringed sideroblasts with their characteristic iron-engorged mitochondria. Moderately elevated free erythrocyte protoporphyrin (FEP)...

journal_title：Leukemia research

authors： Steensma DP,Hecksel KA,Porcher JC,Lasho TL

更新日期：2007-05-01 00:00:00

abstract：:Media conditioned by regenerating murine bone marrow cells contain a stimulator of haemopoietic stem cell proliferation. Fractionated cell populations have been examined for production of this stimulatory activity in order to characterize its cellular source. The stimulator is produced by adherent, phagocytic, radiore...

journal_title：Leukemia research

authors： Wright EG,Ali AM,Riches AC,Lord BI

更新日期：1982-01-01 00:00:00

abstract：:The development of the leukemia-lymphoma complex was studied in AKR/J (H-2k) mice using flow cytometry and staining with acridine orange. Investigation of cytokinetics and of cellular RNA content showed that during the neonatal period all mice had a significant increase of S phase cells in the thymus, bone marrow, lym...

journal_title：Leukemia research

authors： Wustrow TP,Andreeff M,Fernandes G,Good RA

更新日期：1985-01-01 00:00:00

abstract：:Immunophenotypic classification of the acute leukemias (AcL) is of well documented value in those of lymphoid or uncertain origin and of increasing importance in those of nonlymphoid origin. Most of these studies have been performed on viable cell suspensions. To study the efficacy of a simpler immunohistochemical app...

journal_title：Leukemia research

authors： Vago JF,Hurtubise PE,Martelo OJ,Swerdlow SH

更新日期：1987-01-01 00:00:00

abstract：:Checkpoint genes code for a family of proteins which sense DNA damage in eukaryotic cells. They play an important role in the control of the cell cycle. The human CHK2 is a homolog of the yeast G(2) checkpoint kinases known as CDS1 and RAD53. The CHK2 may be a tumor suppressor gene because it was found to be mutated i...

journal_title：Leukemia research

authors： Hofmann WK,Miller CW,Tsukasaki K,Tavor S,Ikezoe T,Hoelzer D,Takeuchi S,Koeffler HP

更新日期：2001-04-01 00:00:00

abstract：:CD200 is a relatively ubiquitously expressed molecule that plays a role in cancer immune evasion through interaction with its receptors. High expression levels of CD200 have been described in different human malignancies. For example, CD200 has been shown to be targeted after RAS/RAF/MEK/ERK activation in melanoma. He...

journal_title：Leukemia research

authors： Conticello C,Giuffrida R,Parrinello N,Buccheri S,Adamo L,Sciuto MR,Colarossi C,Aiello E,Chiarenza A,Romano A,Salomone E,Gulisano M,Giustolisi R,Di Raimondo F

更新日期：2013-12-01 00:00:00