Abstract:
:Vascular endothelial growth factor (VEGF) is pathognomonically elevated in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome. However, its source of overproduction is unclear. As clinical improvement is almost always associated with VEGF reduction after anti-plasma cell therapy, its increase at diagnosis has been attributed to the underlying monoclonal gammopathy, although direct evidence is still lacking. In the current study, we systemically measured VEGF levels in POEMS patients, before and after treatment. Bone marrow plasma cells showed remarkable VEGF expression, in both mRNA and protein levels, which decreased gradually in response to therapy. Of note, statistically linear correlations were observed between serum and bone marrow plasma cell VEGF levels (mRNA vs. serum, rho 0.343, p=0.003; protein vs. serum, rho 0.644, p<0.0001), supporting bone marrow plasma cells as the main source of circulating VEGF. Intriguingly, immunophenotyping revealed that bone marrow plasma cells were polyclonal in most patients at diagnosis. A clear monoclonal population, coexistent with polytypic cells, was only detectable in 11 cases (18%), in which comparable intracellular VEGF expression was observed between these two plasma cell populations (p=0.594), while monoclonal cells showed higher intracellular interleukin-6 expression (p=0.006). These patients had more serum monoclonal protein, less post-therapeutic complete remission, and inferior overall (p=0.027) and progression-free survival (p=0.002). Collectively, bone marrow plasma cells, mainly polyclonal population, are the major source of VEGF overproduction in POEMS patients.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Wang C,Huang XF,Cai QQ,Cao XX,Cai H,Zhou D,Li Jdoi
10.1016/j.leukres.2016.09.017subject
Has Abstractpub_date
2016-11-01 00:00:00pages
78-84eissn
0145-2126issn
1873-5835pii
S0145-2126(16)30209-0journal_volume
50pub_type
杂志文章abstract::In acute lymphoblastic leukemia (ALL) patients, automated fluorescence fragment analysis (ALF) has been reported to improve the monoclonality detection rate of immunoglobulin heavy chain genes (IgH) polymerase chain reaction (PCR) analysis. This study performed complementary determining region (CDR) I and III PCR on s...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00025-x
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders, with very different prognosis in given individuals; age and comorbidities are emerging as relevant patient-related factors influencing clinical outcome in MDS. Our aim was to evaluate the impact of age, comorbidities and disease s...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.05.007
更新日期:2015-08-01 00:00:00
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doi:10.1016/j.leukres.2005.08.001
更新日期:2006-03-01 00:00:00
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journal_title:Leukemia research
pub_type: 历史文章,杂志文章
doi:10.1016/j.leukres.2016.10.007
更新日期:2016-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2009.03.010
更新日期:2009-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00029-n
更新日期:1995-08-01 00:00:00
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journal_title:Leukemia research
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更新日期:2013-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2014-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
doi:10.1016/s0145-2126(98)00102-7
更新日期:1998-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.08.016
更新日期:2015-08-29 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.04.016
更新日期:2004-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-03-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(01)00181-3
更新日期:2002-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.07.015
更新日期:2012-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.03.013
更新日期:2014-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(99)00128-9
更新日期:1999-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90081-x
更新日期:1984-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(98)00068-x
更新日期:1998-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2013.04.018
更新日期:2013-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 信件
doi:10.1016/j.leukres.2005.11.025
更新日期:2006-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00083-6
更新日期:1995-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.leukres.2011.03.006
更新日期:2011-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00163-8
更新日期:1996-05-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2015.10.012
更新日期:2015-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.03.017
更新日期:2011-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.05.020
更新日期:2007-04-01 00:00:00
abstract::Malignant B-1 cells derived from NZB mice, a murine model of chronic lymphocytic leukemia, produce significantly higher levels of IL-10 mRNA than normal B-1 or B cells. IL-10 may act as an autocrine growth factor for malignant B-1 cells. By addition of antisense oligodeoxynucleotides specific for IL-10 mRNA, we were a...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(94)00129-x
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:The use of intensive pediatric protocols for the treatment of ALL is being extended to older adults. AIM OF THE STUDY:Analysis of the efficacy and toxicity results of pediatric DFCP vs. classic Hyper-CVAD protocol for the treatment of patients with ALL < 50 Y. PATIENTS AND METHODS:A retrospective single ce...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2017.06.010
更新日期:2017-09-01 00:00:00