Abstract:
BACKGROUND:The use of intensive pediatric protocols for the treatment of ALL is being extended to older adults. AIM OF THE STUDY:Analysis of the efficacy and toxicity results of pediatric DFCP vs. classic Hyper-CVAD protocol for the treatment of patients with ALL < 50 Y. PATIENTS AND METHODS:A retrospective single center comparative analysis of DFCP & classic Hyper-CVAD for first line treatment of patients with ALL < 50 Y. RESULTS:73 patients were included, 43 received DFCP and 30 received Hyper-CVAD protocol. CR rate was 90.7% for DFCP vs. 83.7 for Hyper-CVAD (p 0.7). 3 Y Leukemia free survival was 57.4% (70.9% for DFCP vs. 41.6% Hyper-CVAD P 0.1) while 3Y OS was 62.6%% for the whole group, 72.6% DFCP vs. 48.5% Hyper-CVAD, P 0.04. Those with age <21 Y, had significantly longer 3 Y LFS and OS (P 0.04, 0.02, respectively). TOXICITY:pancreatitis occurred in 5 patients with DFCP and it was related to Asparginase and in 1 patient on Hyper-CVAD related to gall stones. Osteonecrosis affected 5 patients on DFCP. IN CONCLUSION:pediatric protocols are feasible in patients younger than 50 Y and they are more active than classic adult protocols. Although modifications of adult protocols may improve their results, this had to be investigated in randomized controlled trials.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Alabdulwahab AS,Elsayed HG,Sherisher MA,Zeeneldin A,Alghamdi K,Elbjeirami WMdoi
10.1016/j.leukres.2017.06.010subject
Has Abstractpub_date
2017-09-01 00:00:00pages
58-62eissn
0145-2126issn
1873-5835pii
S0145-2126(17)30463-0journal_volume
60pub_type
杂志文章abstract::Recombinant TNF was capable of inducing differentiation of human leukemic ML-1 cells in the monocytic pathway. Recombinant interleukin 6 did not have the activity but it could significantly increase the activity of recombinant TNF. Both of these molecules were found to play a similar role in PWM-induced conditioned me...
journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2010.06.024
更新日期:2011-01-01 00:00:00
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2007.03.018
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2006.11.018
更新日期:2007-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90001-8
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pub_type: 杂志文章
doi:10.1016/0145-2126(94)90004-3
更新日期:1994-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.04.025
更新日期:2012-09-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.11.001
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.07.025
更新日期:2007-05-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(84)90101-2
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2010.06.012
更新日期:2010-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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