Age and comorbidities deeply impact on clinical outcome of patients with myelodysplastic syndromes.

abstract：BACKGROUND:The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are associated with increases in janus kinase 2 (JAK2) signaling, often resulting from the JAK2 V617F mutation. LY2784544 (gandotinib) is a potent, selective, small-molecule inhibitor of JAK2 that has potential dose-dependent selectivit...

journal_title：Leukemia research

authors： Berdeja J,Palandri F,Baer MR,Quick D,Kiladjian JJ,Martinelli G,Verma A,Hamid O,Walgren R,Pitou C,Li PL,Gerds AT

更新日期：2018-08-01 00:00:00

abstract：:Peripheral blood and/or bone marrow lymphoblasts from 25 patients with acute lymphoblastic leukemia (ALL) were tested with a panel of monoclonal antibodies (MoAbs) and conventional hematopoietic markers by three different laboratories. The results were analysed to evaluate the reproducibility of ALL phenotype determin...

journal_title：Leukemia research

authors： Sobol RE,Mick R,LeBien TW,Ozer H,Minowada J,Anderson K,Ellison RR,Cuttner J,Morrison A,Richards F 2nd

更新日期：1986-01-01 00:00:00

abstract：INTRODUCTION:The seven in absentia homolog 2 (SIAH2) protein plays a significant role in human cancer by regulating hypoxia-inducible factor-a (HIF-1α); however, its role in T-cell acute lymphoblastic leukemia (T-ALL) is less clear. METHODS:Immunofluorescence evaluation of SIAH2 protein expression and location were co...

journal_title：Leukemia research

authors： Chen H,Wang N,Yang G,Guo Y,Shen Y,Wang X,Zhang P,Xu Y

更新日期：2016-03-01 00:00:00

abstract：:Primary cardiac lymphoma (PCL) is a rare and usually fatal neoplasm, which may cause syncope, arrhythmia, heart failure and pericardial effusion as presenting clinical complaints. A case of PCL in a 72-year-old man with moderate aortic stenosis is presented. The patient was investigated because of pericardial effusion...

journal_title：Leukemia research

authors： Rolla G,Bertero MT,Pastena G,Tartaglia N,Corradi F,Casabona R,Motta M,Caligaris-Cappio F

更新日期：2002-01-01 00:00:00

abstract：:We evaluated the cytotoxicity of dimethylsphingosine (DMS) against four human leukemia cell lines: two acute (HL60 and a multi-drug resistance MDR-positive derivative HL60-dox) and two blast crisis chronic myelogenous leukemias (JFP1, from a treatment refractory patient and K562), and against blasts isolated from 11 l...

journal_title：Leukemia research

authors： Jendiroba DB,Klostergaard J,Keyhani A,Pagliaro L,Freireich EJ

更新日期：2002-03-01 00:00:00

abstract：:TCL-1 expression is variable in CLL, and no study has examined its association with treatment response. We measured TCL-1 protein in CLL cells from 51 patients who then received pentostatin, cyclophosphamide, and rituximab. TCL-1 expression did not correlate with any pre-treatment characteristics. Lower TCL-1 levels w...

journal_title：Leukemia research

authors： Browning RL,Geyer SM,Johnson AJ,Jelinek DF,Tschumper RC,Call TG,Shanafelt TD,Zent CS,Bone ND,Dewald GW,Lin TS,Heerema NA,Grever MR,Kay NE,Byrd JC,Lucas DM

更新日期：2007-12-01 00:00:00

abstract：:We wondered whether there was any association between the extent of increased angiogenesis and IgV(H) gene mutational status, expression of CD38 and ZAP-70 in early B-cell chronic lymphocytic leukemia (CLL) patients. Circulating levels of vascular endothelial growth factor (VEGF) correlated positively with ZAP-70-expr...

journal_title：Leukemia research

authors： Molica S,Cutrona G,Vitelli G,Mirabelli R,Molica M,Digiesi G,Ribatti D,Ferrarini M,Vacca A

更新日期：2007-11-01 00:00:00

abstract：:C-kit, a tyrosine kinase receptor, is expressed on most myeloid blasts and is thought to be important in the pathogenesis of AML. Activation of the c-kit receptor leads to phosphorylation and activation of downstream signaling proteins, which are important for cell survival and proliferation. Here, we discuss the prog...

journal_title：Leukemia research

authors： Advani AS,Rodriguez C,Jin T,Jawde RA,Saber W,Baz R,Kalaycio M,Sobecks R,Sekeres M,Tripp B,Hsi E

更新日期：2008-06-01 00:00:00

abstract：:We examined the symptoms and referral rates to specialized palliative care and psychosocial oncology services of patients with acute leukemia. The Memorial Symptom Assessment Scale (MSAS) was completed by 249 adult patients with acute leukemia. Patients reported a median of 9 physical and 2 psychological symptoms, and...

journal_title：Leukemia research

authors： Zimmermann C,Yuen D,Mischitelle A,Minden MD,Brandwein JM,Schimmer A,Gagliese L,Lo C,Rydall A,Rodin G

更新日期：2013-07-01 00:00:00

abstract：:In vivo infection by HTLV-I is characterized by the lack of virus expression in the host's infected cells and in most cases it is clinically inapparent. The present study shows that exposure of HTLV-I-infected human T-cells to a maximal non-toxic dose of 3-MC remarkably enhances virus expression. This stimulatory effe...

journal_title：Leukemia research

authors： Feldman G,Aboud M

更新日期：1993-05-01 00:00:00

abstract：:Chlorambucil-induced apoptosis was assessed by three different flow cytometric methods in B-cell chronic lymphocytic leukaemia (B-CLL) cells cultured in vitro and the results were compared with those derived from the morphological assessment of the same samples. Spontaneous apoptosis was consistently observed in the c...

journal_title：Leukemia research

authors： Pepper C,Thomas A,Tucker H,Hoy T,Bentley P

更新日期：1998-05-01 00:00:00

abstract：:The functional behavior of hematopoietic stem cell (HSC) and progenitors in chronic myelomonocytic leukemia (CMML) and on disease progression is little known. We performed cell proliferation, apoptosis, hematopoietic colony forming/replating and differentiation potential studies in the purified subpopulations of Lin(-...

journal_title：Leukemia research

authors： Sun Q,So CC,Yip SF,Wan TS,Ma SK,Chan LC

更新日期：2008-09-01 00:00:00

abstract：:Aggressive systemic mastocytosis (ASM) is a hematopoietic neoplasm characterized by infiltration of visceral organs by neoplastic mast cells (MCs) with consecutive organopathy and respective clinical and laboratory findings (so called C-Findings). Whereas, it is generally appreciated that patients with ASM are candida...

journal_title：Leukemia research

authors： Hauswirth AW,Simonitsch-Klupp I,Uffmann M,Koller E,Sperr WR,Lechner K,Valent P

更新日期：2004-03-01 00:00:00

abstract：:Ml cells were labeled in vitro with [3H]thymidine and injected into the peritoneal cavity of syngeneic mice. After several days the peritoneal cells were harvested and [3H]labeled cells were determined by autoradiography. The inoculated isotope-labeled Ml cells differentiated in the peritoneal cavity and lipopolysacch...

journal_title：Leukemia research

authors： Honma Y,Hayashi M,Kasukabe T,Hozumi M

更新日期：1982-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression at the post-transcriptional level through its sequence complementation with target mRNAs. An individual miRNA species can simultaneously influence the expression of multiple genes and conversely, several miRNAs can synchronously contro...

journal_title：Leukemia research

authors： Mazan-Mamczarz K,Gartenhaus RB

更新日期：2013-11-01 00:00:00

abstract：:Leukemic cell lines have become important tools for studies of disease providing a monoclonal cell population that can be extensively expanded in vitro while preserving leukemic cellular characteristics. However, studies of chronic lymphocytic leukemia (CLL) have been impeded in part by the lack of continuous human ce...

journal_title：Leukemia research

authors： Kellner J,Wierda W,Shpall E,Keating M,McNiece I

更新日期：2016-01-01 00:00:00

abstract：:Forty-three patients were studied to determine whether light chain gene rearrangements may occur in hematopoietic cells not pertaining to the B-lineage. In only one patient, affected by T-cell lymphoblastic lymphoma, one kappa light chain allele was rearranged. Neither at the protein level nor at the RNA level the rea...

journal_title：Leukemia research

authors： Moretti L,Mariano MT,Donelli A,Montagnani G,Sarti M,Grantini M,Di Prisco U,Torelli U,Narni F

更新日期：1991-01-01 00:00:00

abstract：:The biological progression of chronic myeloid leukaemia is often associated with secondary cytogenetic abnormalities but the molecular mechanisms underlying this progression are poorly understood. This study explores the association of c-myc gene amplification with the progression of chronic myeloid leukaemia in fourt...

journal_title：Leukemia research

authors： Jennings BA,Mills KI

更新日期：1998-10-01 00:00:00

abstract：:Regulation of pluripotent stem cell (CFU-S) proliferation kinetics by humoral factors is now well documented. However, the mechanism of choice of CFU-S differentiation pathways is still a controversial issue. We suggest that long-range humoral factors (pluripoietins) are capable of preferentially channelling CFU-S tow...

journal_title：Leukemia research

authors： Frindel E,Vendrely C

更新日期：1984-01-01 00:00:00

abstract：:Exogenous expression of the transcription factor Scl (Tal1) in WEHI-3B D+ myelomonocytic leukemia cells interferes with their capacity to respond to all-trans retinoic acid (ATRA) induced differentiation; combination of ATRA with LiCl, however, circumvents the inhibition of differentiation produced by Scl. To gain inf...

journal_title：Leukemia research

authors： Rice AM,Holtz KM,Karp J,Rollins S,Sartorelli AC

更新日期：2004-11-01 00:00:00

abstract：:We examined the effect of deferasirox (DFX) on CD34+ hematopoietic progenitors from MDS patients. Progressive, dose-dependent suppression of MDS progenitor proliferation in culture was observed with DFX concentrations ranging from 5 μM to 20 μM. This effect was more pronounced in MDS compared to CD34+ progenitors isol...

journal_title：Leukemia research

authors： Pullarkat V,Sehgal A,Li L,Meng Z,Lin A,Forman S,Bhatia R

更新日期：2012-08-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to be cytotoxic for normal and transformed cell lines. One of the intracellular targets for NO action is glutathione (GSH). GSH determinates cellular redox potential and modulates several biological events. During oxidative and nitrosative stress, glutathione system imbalance is associ...

journal_title：Leukemia research

authors： Santos-Silva MC,Freitas MS,Assreuy J

更新日期：2006-02-01 00:00:00

abstract：:To elucidate the biological characteristics of chronic myelogenous leukemia (CML) cells, we observed morphological and functional changes of CML cells during primary long-term culture, in which their morphology changed to that of myofibroblasts with similar molecular characteristics to the parental CML cells including...

journal_title：Leukemia research

authors： Shirasaki R,Tashiro H,Mizutani-Noguchi M,Kawasugi K,Shirafuji N

更新日期：2011-05-01 00:00:00

abstract：:It has become routine practice to culture bone marrow and/or unstimulated peripheral blood for cytogenetic analysis due to associations of consistent chromosomal abnormalities within specific subgroups of leukemias. Unfortunately, two leukemias for which numerous chromosomal aberrations have been recorded, acute myelo...

journal_title：Leukemia research

authors： Macera MJ,Szabo P,Verma RS

更新日期：1989-01-01 00:00:00

abstract：:The continuous human promyeloid cell line HL60 may be induced to differentiate into neutrophils by the presence of 1.25% dimethylsulphoxide (DMSO) and related compounds [4]. When treated with 12-O-tetradecanoylphorbol-13-acetate (TPA), the cells exhibit may features characteristic of monocytes/macrophages [13]. In bot...

journal_title：Leukemia research

authors： Toksoz D,Bunce CM,Stone PC,Michell RH,Brown G

更新日期：1982-01-01 00:00:00

abstract：:Deregulated myc, bcl-2 and/or TP53 gene expression is associated with non-Hodgkin's B cell lymphomas (B-NHLs). Emu-N-myc transgenic mice that misexpress N-myc protein and carry a non-disrupted bcl-2 gene develop indolent B cell lymphomas reminiscent of the B-NHL, follicular lymphoma. Tumors from mice with end-stage di...

journal_title：Leukemia research

authors： Samant SA,Sheppard RD

更新日期：1999-10-01 00:00:00

abstract：:Although mutations in RNA splicing genes occur frequently in patients with clonal cytopenias of unknown significance (CCUS) and myelodysplastic syndromes (MDS), very often additional common myeloid gene driver mutations are present at diagnosis. Thus, the clinical significance of isolated mutations in the most commonl...

journal_title：Leukemia research

authors： Fleischman RA,Stockton SS,Cogle CR

更新日期：2017-10-01 00:00:00

abstract：:Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-kappaB), which is a target molecule of these kin...

journal_title：Leukemia research

authors： Takahashi S,Harigae H,Ishii KK,Inomata M,Fujiwara T,Yokoyama H,Ishizawa K,Kameoka J,Licht JD,Sasaki T,Kaku M

更新日期：2005-08-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) are a heterogeneous group of clonal disease characterized by insufficiency of bone marrow, increase of apoptosis and increased risk of acute leukemia progression. Proteins related to the mitotic spindle (AURKA, AURKB, TPX2), to the mitotic checkpoint (MAD2, CDC20) and the regulation of t...

journal_title：Leukemia research

authors： Borges DP,Dos Santos AWA,Paier CRK,Ribeiro HL Júnior,Costa MB,Farias IR,de Oliveira RTG,França IGDF,Cavalcante GM,Magalhães SMM,Pinheiro RF

更新日期：2018-01-01 00:00:00

abstract：:Hybrid (C56BL/6 x DBA) (BDF1; H-2b/H-2d) mice bearing the P815 leukemia (H-2d) were grafted with a (CBA x C57BL/6)F1 (CBF1; H-2k/H-2b) cell suspension, comprising bone marrow cells (BMC; 25 x 10(6)/mouse) and spleen cells (SC; 55 x 10(6)/mouse) on day-4, then treated with cyclophosphamide (200 mg/kg) on day-2 and fina...

journal_title：Leukemia research

authors： Seledtsov VI,Seledtsova GV,Avdeev EV,Samarin DM,Kozlov VA

更新日期：1997-10-01 00:00:00