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Chronic myelogenous leukemia cells convert to myofibroblasts in vitro: effect of vascular endothelial growth factor on development of the microenvironment.

Abstract：

:To elucidate the biological characteristics of chronic myelogenous leukemia (CML) cells, we observed morphological and functional changes of CML cells during primary long-term culture, in which their morphology changed to that of myofibroblasts with similar molecular characteristics to the parental CML cells including BCR-ABL fusion gene, and produced cytokines such as granulocyte colony-stimulating factor, interleukin-6, and vascular endothelial growth factor (VEGF)-A. When cultured on the CML-derived myofibroblasts, parental non-adherent CML cells significantly proliferated. When anti-VEGF-A-neutralizing antibody was added to the cultures, non-adherent CML cell proliferation was significantly inhibited. These observations indicate that CML cells can convert their morphology and function to adherent myofibroblasts, and produce a significant amount of cytokine to give a growth-promotion activity to CML cells.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Shirasaki R,Tashiro H,Mizutani-Noguchi M,Kawasugi K,Shirafuji N

doi

10.1016/j.leukres.2010.09.019

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

663-9

issue

5

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(10)00467-4

journal_volume

35

pub_type

杂志文章

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