Induction of mixed allogeneic chimerism for leukemia.

abstract：:The glycosylation of beta-hexosaminidase was investigated in the transformed cell-line, CCRF/CEM, derived from a human acute lymphoblastic leukaemia, and comparisons were made with enzyme from normal human skin fibroblasts. A series of studies including neuraminidase sensitivity, lectin chromatography, Biogel P4 chrom...

journal_title：Leukemia research

authors： Moss SE,Besley GT

更新日期：1988-01-01 00:00:00

abstract：:We investigated protracted low-dose oral Clofarabine for the treatment of myelodysplastic syndromes (MDS). Adults with an International Prognostic Scoring System (IPSS) score of INT-1 or higher who had failed first line therapy were eligible. INT-1 patients had to be transfusion-dependent. We started with oral Clofara...

journal_title：Leukemia research

authors： Rudrapatna VK,Morley K,Boucher KM,Pierson AS,Shull CT,Kushner JP,Shami PJ

更新日期：2015-08-01 00:00:00

abstract：:The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (VD3), inhibits proliferation and induces differentiation of myelomonocytic leukemia cells, but its clinical use is limited by the adverse effect of hypercalcemia. VD3 mobilizes calcium stores from bone by inducing the dissolution of bone mineral and matrix. ...

journal_title：Leukemia research

authors： Honma Y,Tobe H,Makishima M,Yokoyama A,Okabe-Kado J

更新日期：1998-07-01 00:00:00

abstract：:We investigated the role of Src family kinases (SFKs) in the regulation of STAT activation in myeloid leukemia cells. Two of 6 AML cell lines displayed constitutive STAT5 activation, whereas four cell lines had constitutive SFK activity. Treatment with the SFK inhibitors suppressed STAT5 activation and decreased viabi...

journal_title：Leukemia research

authors： Ozawa Y,Williams AH,Estes ML,Matsushita N,Boschelli F,Jove R,List AF

更新日期：2008-06-01 00:00:00

abstract：:We investigated the effects of two sex steroids (17beta estradiol and testosterone) on five human leukemia cell lines. We observed a statistically significant inhibition of proliferation, dose and time dependent, of the human monoblastic leukemia cell line U937. This inhibition was associated with a dose dependent dec...

journal_title：Leukemia research

authors： Mossuz P,Cousin F,Castinel A,Chauvet M,Sotto MF,Polack B,Sotto JJ,Kolodie L

更新日期：1998-11-01 00:00:00

abstract：:Compound 48 (C48) is a novel dual ligand for peroxisome proliferator-activated receptor alpha and gamma (PPAR alpha/gamma). Culture of imatinib-sensitive and -resistant CML cell lines with C48 resulted in a strong growth inhibition which associated with G0/G1 cell cycle arrest. However, it showed no obvious toxicity t...

journal_title：Leukemia research

authors： Bertz J,Zang C,Liu H,Wächter M,Possinger K,Koeffler HP,Elstner E

更新日期：2009-05-01 00:00:00

abstract：:We investigated Syk as a potential marker of CML progression. We observed a significant over-expression of Syk mRNA and constitutive phosphorylation of Syk Y348 in blast cells from six AP or BP-CML, but not in 15 CML in chronic phase. We could follow in vivo the recurrence of pSyk(348) throughout blast cell escape, de...

journal_title：Leukemia research

authors： Bourgne C,Janel A,Berger J,Rapatel C,Tournilhac O,Hermet E,Guerci A,Lioret F,Briançon A,Bamdad M,Boiret-Dupré N,Berger MG

更新日期：2015-03-01 00:00:00

abstract：:The risk of second malignant neoplasms (SMN) in chronic myeloid leukemia (CML) survivors remains unclear. We utilized the Surveillance, Epidemiology and End Results 18 (SEER 18) registries to evaluate the risk and subsequent outcomes of SMN in CML survivors. There were 3407 patients included. Of these, 170 (4.99%) dev...

journal_title：Leukemia research

authors： Jamy O,Sarmad R,Costa L

更新日期：2019-07-01 00:00:00

abstract：:As a part of our continuing efforts to develop gene therapy for acute myelogenous leukemia (AML), this study was undertaken to evaluate the possibility of using autologous bone marrow stromal fibroblasts (BMSFs) as a target cell population. Autologous BMSFs in AML were isolated from the stromal layers of long-term bon...

journal_title：Leukemia research

authors： Min YH,Li GX,Jang JH,Suh HC,Kim JS,Cheong JW,Lee ST,Hahn JS,Ko YW

更新日期：2002-04-01 00:00:00

abstract：:Ectopic expression of LMO2 occurs in approximately 45% of T-lineage acute lymphoblastic leukemias (T-ALL), sometimes in association with chromosomal translocations. Recently, a lymphoproliferative disorder developed in two participants in a gene therapy trial due to LMO2 activation via integration of the retroviral ve...

journal_title：Leukemia research

authors： Hammond SM,Crable SC,Anderson KP

更新日期：2005-01-01 00:00:00

abstract：:Cell-mediated natural cytotoxicity (CMNC) of fresh or long-term cultured lymphocytes collected from HTLV-positive patients or infected in vitro with the virus, was tested against K562 target cells. Severe depression of reactivity was found in fresh lymphocytes of three patients with advanced disease, in 12 in vitro es...

journal_title：Leukemia research

authors： De Vecchis L,Graziani G,Macchi B,Grandori C,Pastore S,Popovic M,Gallo RC,Bonmassar E

更新日期：1985-01-01 00:00:00

abstract：:This retrospective study of the thrombocythemia Italian registry (RIT) documented that 71 (30.6%) out of 232 ET patients experienced 88 cardiovascular adverse events (CV-AEs) during anagrelide treatment (522 pt-y). The rate of CV-AEs was: 24.1% for palpitations, 4.3% for angina, 3.5% for arterial hypertension, 3.0% fo...

journal_title：Leukemia research

authors： Gugliotta L,Tieghi A,Tortorella G,Scalzulli PR,Ciancia R,Lunghi M,Cacciola E,Cacciola R,Candoni A,Crugnola M,Codeluppi K,Usala E,Specchia G,Martinelli V,Palmieri F,Pierri I,Liberati AM,Iurlo A,Grossi A,Vannucchi AM

更新日期：2011-12-01 00:00:00

abstract：:T-cell leukemias were induced in adult BDF1 mice by a single i.v. injection of methylnitrosourea (MNU). Leukemogenesis was delayed by a single or repeated injections of hydrocortisone (HC) after MNU and also when HC was given one day before MNU. Enhancement of leukemogenesis was seen in experiments with 10 and 14 days...

journal_title：Leukemia research

authors： Seidel HJ,Kreja L

更新日期：1985-01-01 00:00:00

abstract：:A total of 854 patients with anti-HTLV-I antibody positive ATL, newly diagnosed from 1983 to 1987, were analyzed for prognostic factors. There were 466 males and 388 females with a mean age of 57.1. Of these 269 (31.5%) were alive with a median follow-up time of 14 months from diagnosis, while 585 (65.5%) were dead wi...

journal_title：Leukemia research

authors：

更新日期：1991-01-01 00:00:00

abstract：:A novel bivalent single chain fusion protein, Bic3, was assembled consisting of the catalytic and translocation domains of diphtheria toxin (DT(390)) fused to two repeating sFv molecules recognizing human CD3 epsilon of the human T-cell receptor. Historically, problems with these constructs include low yield, toxicity...

journal_title：Leukemia research

authors： Vallera DA,Todhunter D,Kuroki DW,Shu Y,Sicheneder A,Panoskaltsis-Mortari A,Vallera VD,Chen H

更新日期：2005-03-01 00:00:00

abstract：:Many elderly patients with newly diagnosed acute myeloid leukemia (AML) present with cardiac comorbidity precluding the use of anthracycline containing chemotherapy regimens. Amsacrine, a topoisomerase II inhibitor, has been proposed as possible alternative to anthracyclines. Here, we report about the combination of a...

journal_title：Leukemia research

authors： Kessler T,Mohr M,Müller-Tidow C,Krug U,Brunnberg U,Mohr B,Schliemann C,Sauerland C,Serve H,Büchner T,Berdel WE,Mesters RM

更新日期：2008-03-01 00:00:00

abstract：:Dasatinib was approved for the treatment of chronic phase (CP) chronic myeloid leukemia (CML) patients in first line therapy based on the demonstration of efficacy and safety reported in patients enrolled in clinical trials. We describe a multicentric Italian "real-life" experience of dasatinib used as frontline treat...

journal_title：Leukemia research

authors： Breccia M,Stagno F,Luciano L,Abruzzese E,Annunziata M,D'Adda M,Maggi A,Sgherza N,Russo-Rossi A,Pregno P,Castagnetti F,Iurlo A,Latagliata R,Cedrone M,Di Renzo N,Sorà F,Rege-Cambrin G,La Nasa G,Scortechini AR,Greco G

更新日期：2016-01-01 00:00:00

abstract：:During a 4-yr period, 292 patients with acute leukaemia were studied using morphology, cytochemistry and immunologic reagents to determine the cell lineage of the leukaemia. One hundred and sixty-three cases were shown to be acute lymphoblastic leukaemia (ALL), 127 acute myeloblastic leukaemia (AML) and two cases (0.6...

journal_title：Leukemia research

authors： Ruiz-Argüelles GJ,Lobato-Mendizábal E,Marín-López A

更新日期：1988-01-01 00:00:00

abstract：:The efficiency of gene transfer into human leukemia cell lines by electroporation was investigated. For both transient expression (beta-galactosidase gene) and stable transformation (neomycin resistance gene), the transfer efficiency into leukemia cell lines using a square wave pulse was superior to that using an expo...

journal_title：Leukemia research

authors： Takahashi M,Furukawa T,Saitoh H,Aoki A,Koike T,Moriyama Y,Shibata A

更新日期：1991-01-01 00:00:00

abstract：:We evaluated the efficacy of FISH to detect chromosome anomalies in the evaluation of young (<60 years) patients with AML. Patients were enrolled in E1900, an ECOG clinical trial for AML. The protocol was designed to collect bone marrow or blood for both cytogenetic and FISH studies at study entry (diagnosis). FISH fo...

journal_title：Leukemia research

authors： Vance GH,Kim H,Hicks GA,Cherry AM,Higgins R,Hulshizer RL,Tallman MS,Fernandez HF,Dewald GW

更新日期：2007-05-01 00:00:00

abstract：:We report a unique case of de novo acute promyelocytic leukemia (APL) with cryptic 15;17 rearrangements. Cytogenetically, structural rearrangements of the 6p23 region has been reported mainly in secondary leukemia. This patient had a karyotype of 46, XY, del(6)(p23) and no additional chromosomal abnormalities. Molecul...

journal_title：Leukemia research

authors： Nakase K,Wakita Y,Minamikawa K,Yamaguchi T,Shiku H

更新日期：2000-01-01 00:00:00

abstract：:miR-16, a miRNA involved in cell proliferation and apoptosis regulation, may interfere with either oncogenic or tumor-suppressor pathways and is implicated in leukemogenesis. We then explored its expression in 93 childhood acute lymphoblastic leukemia (ALL) cases. A high miR-16 expression was associated with hyperleuk...

journal_title：Leukemia research

authors： Kaddar T,Chien WW,Bertrand Y,Pages MP,Rouault JP,Salles G,Ffrench M,Magaud JP

更新日期：2009-09-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is frequently treated with induction and consolidation chemotherapy. Consolidation chemotherapy can be delivered on an ambulatory basis, requiring some patients to travel long distances for treatment at specialized centers. We developed a shared care model where patients receive consolidat...

journal_title：Leukemia research

authors： Hershenfeld SA,Maki K,Rothfels L,Murray CS,Nixon S,Schimmer AD,Doherty MC

更新日期：2017-08-01 00:00:00

abstract：:We report single institution outcome of brief, intensive ara-C-based chemotherapy using bone marrow transplantation as primary intensification for untreated adult patients with acute lymphoblastic leukemia (ALL). Overall disease-free and overall survival were inferior to those reported with prolonged chemotherapy mode...

journal_title：Leukemia research

authors： Sotomayor EM,Piantadosi S,Miller CB,Karp JE,Jones RJ,Rowley SD,Kaufmann SH,Braine H,Burke PJ,Gore SD

更新日期：2002-05-01 00:00:00

abstract：:Mitoxantrone, etoposide and prednisone (MEP)-based regimens using granulocyte colony-stimulating factor (G-CSF) were designed for relapsed and CHOP-resistant diffuse large B-cell lymphomas in a single institution, and the therapeutic effects and adverse reactions were studied. In a total of 49 patients, the MEP regime...

journal_title：Leukemia research

authors： Murohashi I,Kashimura T,Tominaga K,Wakao D,Takahashi T,Akiba M,Kishimoto K,Yoshida K,Yagasaki F,Itoh Y,Sakata T,Kawai N,Itoh K,Suzuki T,Matsuda A,Hirashima K,Bessho M

更新日期：2002-03-01 00:00:00

abstract：:ABCG2 encodes a transporter protein that is associated with multidrug-resistant phenotypes in many cancers, including acute myeloid leukemia (AML); high levels of expression are generally associated with a poor prognosis. To better understand how expression of ABCG2 is controlled in pediatric AML, we performed a detai...

journal_title：Leukemia research

authors： Campbell PK,Zong Y,Yang S,Zhou S,Rubnitz JE,Sorrentino BP

更新日期：2011-10-01 00:00:00

abstract：:Febrile neutropenia (FN) risk-assessment and granulocyte-colony stimulating factor (G-CSF) prophylaxis use in clinical practice was evaluated in patients with diffuse large B-cell lymphoma receiving R-CHOP-21. More G-CSF primary prophylaxis was used in patients assessed as high FN risk, but R-CHOP-21 was associated wi...

journal_title：Leukemia research

authors： Salar A,Haioun C,Rossi FG,Duehrsen U,Pettengell R,Johnsen HE,Jaeger U,Verhoef G,Schwenkglenks M,Bacon P,Bendall K,Lugtenburg PJ

更新日期：2012-05-01 00:00:00

abstract：:Leukotrienes and lipoxins are bioactive lipoxygenase products formed by leukocytes alone or in collaboration with other cells. While the physiological role of lipoxins remains to be clarified, accumulating evidence shows that leukotrienes are important mediators in asthma and inflammation. Consequently, recent clinica...

journal_title：Leukemia research

authors： Stenke L,Reizenstein P,Lindgren JA

更新日期：1994-10-01 00:00:00

abstract：:In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with ha...

journal_title：Leukemia research

authors： D'Amelio AM Jr,Monroy C,El-Zein R,Etzel CJ

更新日期：2012-11-01 00:00:00

abstract：:We have studied the survival of clonogenic neoplastic cells of a murine pre-B-lymphoma (BCl-1) of the spleen in culture. We have found quantitative deficiencies such as reduced surface adherence of stromal cells and impaired CFU-F (colony forming units-fibroblast) and pre-CFU-F colony and layer formation in stromal cu...

journal_title：Leukemia research

authors： Prindull G,Ben-Ishay Z,Bergholz M,Prindull B

更新日期：1993-07-01 00:00:00