当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Compound 48, a novel dual PPAR alpha/gamma ligand, inhibits the growth of human CML cell lines and enhances the anticancer-effects of imatinib.

Compound 48, a novel dual PPAR alpha/gamma ligand, inhibits the growth of human CML cell lines and enhances the anticancer-effects of imatinib.

Abstract：

:Compound 48 (C48) is a novel dual ligand for peroxisome proliferator-activated receptor alpha and gamma (PPAR alpha/gamma). Culture of imatinib-sensitive and -resistant CML cell lines with C48 resulted in a strong growth inhibition which associated with G0/G1 cell cycle arrest. However, it showed no obvious toxicity to normal CD34(+) hematopoietic stem cells. Decrease of pSTATs and pAKT were noticed suggesting that interference of AKT and STATs signaling may be the mechanisms for the effects of PPAR alpha/gamma ligands. Of more clinical importance, this ligand strongly enhanced the anticancer-effects of imatinib. Overall, our data suggest that the PPAR alpha/gamma ligands may have potentials in the treatment of CML in an adjuvant setting either before or after the development of imatinib resistance.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Bertz J,Zang C,Liu H,Wächter M,Possinger K,Koeffler HP,Elstner E

doi

10.1016/j.leukres.2008.11.023

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

686-92

issue

5

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(08)00525-0

journal_volume

33

pub_type

杂志文章

相关文献

LEUKEMIA RESEARCH文献大全
  • Phosphorylation of spleen tyrosine kinase at tyrosine 348 (pSyk³⁴⁸) may be a marker of advanced phase of Chronic Myeloid Leukemia (CML).

    abstract：:We investigated Syk as a potential marker of CML progression. We observed a significant over-expression of Syk mRNA and constitutive phosphorylation of Syk Y348 in blast cells from six AP or BP-CML, but not in 15 CML in chronic phase. We could follow in vivo the recurrence of pSyk(348) throughout blast cell escape, de...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2014.11.014

    authors： Bourgne C,Janel A,Berger J,Rapatel C,Tournilhac O,Hermet E,Guerci A,Lioret F,Briançon A,Bamdad M,Boiret-Dupré N,Berger MG

    更新日期：2015-03-01 00:00:00

  • Soluble Kit receptor blocks stem cell factor bioactivity in vitro.

    abstract：:Stem cell factor (SCF) is a growth factor that promotes the survival, proliferation, and differentiation of hematopoietic cells. SCF and its receptor, Kit, are normally present in both cell surface and soluble forms. Both forms of Kit can bind SCF. However, the function of soluble Kit is unknown. In order to determine...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(00)00122-3

    authors： Dahlen DD,Lin NL,Liu YC,Broudy VC

    更新日期：2001-05-01 00:00:00

  • Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo.

    abstract：:Many evidences have shown that dietary intake of cruciferous vegetables could protect against the risk of various types of malignancies. Benzyl isothiocyanate (BITC), one of the compounds from cruciferous vegetables, had shown induced cell cycle arrest and apoptosis in cancer cells. However, there is no available info...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.01.030

    authors： Tsou MF,Peng CT,Shih MC,Yang JS,Lu CC,Chiang JH,Wu CL,Lin JP,Lo C,Fan MJ,Chung JG

    更新日期：2009-11-01 00:00:00

  • TNF-mediated killing of human leukaemic cells: effects of endogenous antioxidant levels and TNF alpha expression in leukaemic cell lines.

    abstract：:Using the human erythroleukaemic cell line K562 cl.6 and its daunorubicin-resistant subline K/DAU600, and the human T-lymphoblastic leukaemic cell line CCRF-CEM and its vinblastine-resistant subline CEM/VLB100, we have shown that the drug-resistant cell lines were more sensitive to cytotoxicity induced by tumour necro...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(94)00149-5

    authors： Jia L,Jiang XR,Razak K,Wu YL,Newland AC,Kelsey SM

    更新日期：1995-03-01 00:00:00

  • Immunologic cell markers of peripheral blood and lymph node lymphocytes in chronic lymphocytic leukemia.

    abstract：:The immunologic phenotype of the lymphocytes of 100 patients with chronic lymphocytic leukaemia (CLL) was investigated. Peripheral blood lymphocytes (PBL) were examined in all cases; in 46 patients with lymphadenopathy, a lymph node was biopsied and the histologic and immunologic patterns were assessed: 24 had a lymph...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(87)90063-4

    authors： Resegotti L,Palestro G,Novero D,Micca FB,Godio L,Pistone M,Garnero M,Levis A,Stramignoni A

    更新日期：1987-01-01 00:00:00

  • Cytogenetics and cell surface marker analysis in CML--1. Prediction of phenotype of acute phase transformation.

    abstract：:Thirty-nine patients with Philadelphia chromosome-positive (Ph1) chronic myelocytic leukemia (CML) were monitored using cytofluorometry and cytogenetics. During chronic phase, abnormal populations could be detected using commercially available monoclonal antibodies. Most of these abnormal populations had either an HLA...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(85)90097-9

    authors： Ligler FS,Brodsky I,Schlam ML,Fuscaldo KE

    更新日期：1985-01-01 00:00:00

  • Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: not sufficient for lymphomagenesis.

    abstract：:The pre-B lymphoma in SL/Kh mice is a polygenic trait involving a number of host genes. In prelymphoma-stage bone marrow, transient pre-B cell expansion is induced by a host locus, Bomb1, and later followed by the emergence of a monoclonal population with a similar phenotype. To determine whether these pre-B cells rep...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2007.05.013

    authors： Hiratsuka T,Tsuruyama T,Kaszynski R,Kometani K,Minato N,Nakamura T,Tamaki K,Hiai H

    更新日期：2008-02-01 00:00:00

  • Fluorescent-labeled DNA probes applied to novel biological aspects of B-cell chronic lymphocytic leukemia.

    abstract：:Fluorescent-labeled DNA probes were used to study 52 chronic lymphocytic leukemia (B-CLL) patients for (1) disease progression, (2) angiogenesis genes, (3) T-cell leukemia 1 gene (TCL1), (4) immunoglobulin heavy chain variable region (IGHv) and (5) chromosome 6q. Compared to stable disease, more patients with progress...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2004.07.012

    authors： Fink SR,Paternoster SF,Smoley SA,Flynn HC,Geyer SM,Shanafelt TD,Lee YK,Jelinek DF,Kay NE,Dewald GW

    更新日期：2005-03-01 00:00:00

  • Comparison of ethidium bromide-stained agarose gel electrophoresis and automated fragment analysis for evaluation of IgH gene products.

    abstract：:In acute lymphoblastic leukemia (ALL) patients, automated fluorescence fragment analysis (ALF) has been reported to improve the monoclonality detection rate of immunoglobulin heavy chain genes (IgH) polymerase chain reaction (PCR) analysis. This study performed complementary determining region (CDR) I and III PCR on s...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(01)00025-x

    authors： Gleissner B,Maurer J,Sindram A,Reinhard R,Thiel E

    更新日期：2001-09-01 00:00:00

  • Transfer of the cytidine deaminase cDNA into hematopoietic cells.

    abstract：:In order to investigate whether transfer of the cytidine deaminase (CDD) cDNA would increase chemotherapy resistance to cytosine arabinoside (ara-C) we used a retroviral vector expressing both, neomycin phosphotransferase and the CDD cDNA, to transduce hematopoietic cells from cell lines and from murine bone marrow (B...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(99)00128-9

    authors： Flasshove M,Frings W,Schröder JK,Moritz T,Schütte J,Seeber S

    更新日期：1999-11-01 00:00:00

  • STAT6 and the regulation of CD23 expression in B-chronic lymphocytic leukemia.

    abstract：:High CD23 expression is a hallmark of B-CLL cells. It is lost during in vitro culture and can be reinduced by IL-4, albeit to a lower extent than in normal B cells. To elucidate the events controlling CD23 expression in B-CLL cells, the IL-4 mediated induction of STAT6 was investigated. Western-blot analysis demonstra...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(99)00191-5

    authors： Kneitz C,Goller M,Seggewiss R,Yaman A,Serfling E,Tony HP

    更新日期：2000-04-01 00:00:00

  • Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia.

    abstract：:TCL-1 expression is variable in CLL, and no study has examined its association with treatment response. We measured TCL-1 protein in CLL cells from 51 patients who then received pentostatin, cyclophosphamide, and rituximab. TCL-1 expression did not correlate with any pre-treatment characteristics. Lower TCL-1 levels w...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2007.05.020

    authors： Browning RL,Geyer SM,Johnson AJ,Jelinek DF,Tschumper RC,Call TG,Shanafelt TD,Zent CS,Bone ND,Dewald GW,Lin TS,Heerema NA,Grever MR,Kay NE,Byrd JC,Lucas DM

    更新日期：2007-12-01 00:00:00

  • Efficacy of hypomethylating agents in therapy-related myelodysplastic syndromes.

    abstract：:We retrospectively assessed morphologic and cytogenetic responses to 5-azacytidine and decitabine in a cohort of 42 adult therapy-related myelodysplastic syndromes (tMDS) patients treated at Memorial Sloan-Kettering Cancer Center and in 2 industry-sponsored decitabine trials (D0007 and DACO-020). The overall response ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.04.025

    authors： Klimek VM,Dolezal EK,Tees MT,Devlin SM,Stein K,Romero A,Nimer SD

    更新日期：2012-09-01 00:00:00

  • Therapy-related myelodysplastic syndrome with inv(16)(p13q22) and I type CBFbeta/MYH11 after autologous transplantation: undetectable fusion transcript in pretransplant progenitor cells.

    abstract：:We describe here a unique case of therapy-related myelodysplastic syndrome (t-MDS) with inv(16)(p13q22) after autologous stem cell transplantation for lymphoma. The rare and smallest I type CBFbeta/MYH11 fusion transcript with a breakpoint at nucleotide 399 of CBFbeta and at nucleotide 2134 of MYH11 was detected in th...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.08.001

    authors： Yamamoto K,Nishikawa S,Minagawa K,Yakushijin K,Okamura A,Matsui T

    更新日期：2006-03-01 00:00:00

  • Comparative analysis of IL6 promoter and receptor polymorphisms in myelodysplasia and multiple myeloma.

    abstract：:The serum levels of interleukin 6 (IL6) are known to be elevated in two diseases of the elderly age, myelodysplastic syndrome (MDS) and multiple myeloma (MM). Authors suppose that one of the possible causes of this elevation could be a difference between these patients and healthy subjects in the frequency of polymorp...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.03.009

    authors： Aladzsity I,Kovács M,Semsei A,Falus A,Szilágyi A,Karádi I,Varga G,Füst G,Várkonyi J

    更新日期：2009-11-01 00:00:00

  • Flow cytometric detection of aneuploid CD38(++) plasmacells and CD19(+) B-lymphocytes in bone marrow, peripheral blood and PBSC harvest in multiple myeloma patients.

    abstract：:DNA aneuploidy has been used as a genetic marker of malignancy in multiple myeloma (MM). CD38 and CD138 expression and absence of CD22 and CD19 may define plasmacells (PC). Several authors support evidences of circulating plasmacells, and their role in relapse after autologous stem cell transplantation has been hypoth...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2003.09.015

    authors： Santonocito AM,Consoli U,Bagnato S,Milone G,Palumbo GA,Di Raimondo F,Stagno F,Guglielmo P,Giustolisi R

    更新日期：2004-05-01 00:00:00

  • A novel Ph1 chromosome positive cell line established from a patient with chronic myelogenous leukemia in blastic crisis.

    abstract：:A novel Philadelphia (Ph1) chromosome positive cell line, designated KYO-1, was established from the peripheral blood of a patient with chronic myelogenous leukemia (CML) in blastic crisis. Although this line had a unique capacity to differentiate spontaneously along the erythroid and monocytoid lineages as evidenced ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(85)90314-5

    authors： Ohkubo T,Kamamoto T,Kita K,Hiraoka A,Yoshida Y,Uchino H

    更新日期：1985-01-01 00:00:00

  • Dephosphorylation of specific proteins in HL-60 cells by 1 alpha, 25-dihydroxyvitamin D3: possible involvement of cAMP-dependent protein kinase.

    abstract：:Changes of phosphoprotein patterns in HL-60 cells were studied during short exposures to 1 alpha, 25-dihydroxyvitamin D3 [1,25(OH)2D3]. One hundred nanometers 1,25(OH)2D3 dephosphorylated at least three proteins in 6 h: phosphoproteins with molecular weights of 82 kD (pp82), 33 kD (pp33), and 31 kD (pp31). Phosphoryla...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(91)90169-t

    authors： Ueda T,Sawada H,Okuda T,Yumoto Y,Kato Y,Ogawa K,Tashima M,Yoshida Y,Okuma M

    更新日期：1991-01-01 00:00:00

  • The need for improved neutropenia risk assessment in DLBCL patients receiving R-CHOP-21: findings from clinical practice.

    abstract：:Febrile neutropenia (FN) risk-assessment and granulocyte-colony stimulating factor (G-CSF) prophylaxis use in clinical practice was evaluated in patients with diffuse large B-cell lymphoma receiving R-CHOP-21. More G-CSF primary prophylaxis was used in patients assessed as high FN risk, but R-CHOP-21 was associated wi...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.02.002

    authors： Salar A,Haioun C,Rossi FG,Duehrsen U,Pettengell R,Johnsen HE,Jaeger U,Verhoef G,Schwenkglenks M,Bacon P,Bendall K,Lugtenburg PJ

    更新日期：2012-05-01 00:00:00

  • Decreased microRNA-30a levels are associated with enhanced ABL1 and BCR-ABL1 expression in chronic myeloid leukemia.

    abstract：:Chronic myeloid leukemia (CML) is associated with overexpression of BCR-ABL1, a nonreceptor tyrosine kinase critical for malignant transformation. We investigated whether non-coding microRNAs (miRNAs) targeting BCR-ABL1 mRNA contribute to the pathogenesis of CML. Indeed, miR-30a targeted BCR-ABL1 and was underexpresse...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.12.003

    authors： Liu Y,Song Y,Ma W,Zheng W,Yin H

    更新日期：2013-03-01 00:00:00

  • Comparison of 18F FDG PET-CT AND CECT in pretreatment staging of adults with Hodgkin's lymphoma.

    abstract：:We compared 2-[fluorine-18] fluoro-2-deoxy-d-glucose PET-CT and contrast-enhanced computed tomography (CECT) in 62 consecutive patients with newly diagnosed Hodgkin Lymphoma (HL), aiming to provide evidences that may spare CECT from the staging procedures of HL patients. Among a total of 1448 nodal sites examined, dis...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2018.11.018

    authors： Panebianco M,Bagni O,Cenfra N,Mecarocci S,Ortu La Barbera E,Filippi L,Codacci-Pisanelli G,Biondi T,Laghi A,Cimino G

    更新日期：2019-01-01 00:00:00

  • Monoclonal origin of B cells producing k, lambda and k lambda immunoglobulin light chains in a patient with chronic lymphocytic leukemia.

    abstract：:Immunoglobulin gene rearrangements can be used as genetic markers of clonality in the study of B-cell populations [4]. We have therefore analysed the structure and expression of heavy and light chain immunoglobulin genes in lymphocytes of a patient with chronic lymphocytic leukemia, where we found both k and lambda pr...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(87)90162-7

    authors： del Senno L,Gandini D,Gambari R,Lanza F,Tomasi P,Castoldi G

    更新日期：1987-01-01 00:00:00

  • Myelodysplastic syndrome with transformation to acute monocytic leukemia with FLT3-ITD mutation following orthotopic liver transplantation.

    abstract：:A rare case of a 46-year-old man who underwent myelodysplastic syndrome, acute monocytic leukemia with FLT3-ITD mutation and splenic disruption following orthotopic liver transplantation is reported. The study of this case may be helpful to understand both the pathogenesis of acute leukemia and new complication of liv...

    journal_title：Leukemia research

    pub_type： 信件

    doi：10.1016/j.leukres.2005.11.025

    authors： Zhang GS,Dai CW,Peng HL,Xu YX,Pei MF

    更新日期：2006-07-01 00:00:00

  • Histone deacetylase inhibition restores cisplatin sensitivity of Hodgkin's lymphoma cells.

    abstract：:Increasing evidence suggest that epigenetic mechanisms (e.g. histone modification by histone deacetylases) play a major role in the pathogenesis of Hodgkin's lymphoma (HL). We treated HL cell lines with the histone deacetylase inhibitor vorinostat and investigated the gene expression profile of these cells by using DN...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2012.02.021

    authors： Kewitz S,Bernig T,Staege MS

    更新日期：2012-06-01 00:00:00

  • Assessment of proteasome concentration and chymotrypsin-like activity in plasma of patients with newly diagnosed multiple myeloma.

    abstract：:The ubiquitin-proteasome pathway is implicated in the pathogenesis of many haematologic malignancies, including multiple myeloma. Under conditions of rapid cell turnover and growth rate, proteasomes are returned into circulation. The measurement of their levels or activity could offer a new approach to diagnosis, prog...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2014.05.008

    authors： Oldziej A,Bolkun L,Galar M,Kalita J,Ostrowska H,Romaniuk W,Kloczko J

    更新日期：2014-08-01 00:00:00

  • miR-155 regulative network in FLT3 mutated acute myeloid leukemia.

    abstract：BACKGROUND:Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2015.04.017

    authors： Salemi D,Cammarata G,Agueli C,Augugliaro L,Corrado C,Bica MG,Raimondo S,Marfia A,Randazzo V,Dragotto P,Di Raimondo F,Alessandro R,Fabbiano F,Santoro A

    更新日期：2015-08-01 00:00:00

  • Monoclonal gammopathies in B-cell non-Hodgkin's lymphomas.

    abstract：:The association of monoclonal gammopathy (MG) with B-cell non-Hodgkin's lymphomas (NHL) is a well known phenomenon. The aim of the present work was to study the incidence, type of monoclonal component and prognostic significance of MG in a population of 255 cases with B-cell NHL. Among 255 evaluable patients with B-ce...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(02)00277-1

    authors： Economopoulos T,Papageorgiou S,Pappa V,Papageorgiou E,Valsami S,Kalantzis D,Xiros N,Dervenoulas J,Raptis S

    更新日期：2003-06-01 00:00:00

  • Tumor associated macrophages in relapsed and refractory Hodgkin lymphoma.

    abstract：BACKGROUND:Growing evidence demonstrates that an increased number of CD68 positive tumor-associated macrophages (TAM) is associated with decreased survival in patients with newly diagnosed classic Hodgkin lymphoma (HL). However, the impact of TAM in relapsed and refractory disease is unknown. DESIGN AND METHODS:To inv...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.03.021

    authors： Casulo C,Arcila M,Bohn OL,Teruya-Feldstein J,Maragulia J,Moskowitz CH

    更新日期：2013-09-01 00:00:00

  • Ph-negative acute lymphocytic leukemia occurring after interferon therapy for Ph-positive chronic myelocytic leukemia.

    abstract：:We report a unique case of chronic myelocytic leukemia (CML) with the Philadelphia (Ph) chromosome. The patient obtained cytogenetic complete remission (CR) after treatment with interferon (IFN). When he transformed to acute lymphocytic leukemia (ALL), cytogenetic analysis showed that the karyotype was normal and fluo...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(02)00175-3

    authors： Zhang X,Ji L,Liu S,Wang J

    更新日期：2003-04-01 00:00:00

  • Increased peripheral stem cell pool in MDS: an indication of disease progression?

    abstract：:The colony-forming capacity of the peripheral blood stem/progenitor cells (PBSC) in different forms of myelodysplastic syndrome (MDS) was investigated. In most cases of refractory anemia (RA) the colony growth of PBSC was definitely reduced as compared to the controls. However, in RA with unfavorable chromosomal aberr...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(01)00064-9

    authors： Vehmeyer K,Haase D,Alves F

    更新日期：2001-11-01 00:00:00