Dephosphorylation of specific proteins in HL-60 cells by 1 alpha, 25-dihydroxyvitamin D3: possible involvement of cAMP-dependent protein kinase.

Abstract:

:Changes of phosphoprotein patterns in HL-60 cells were studied during short exposures to 1 alpha, 25-dihydroxyvitamin D3 [1,25(OH)2D3]. One hundred nanometers 1,25(OH)2D3 dephosphorylated at least three proteins in 6 h: phosphoproteins with molecular weights of 82 kD (pp82), 33 kD (pp33), and 31 kD (pp31). Phosphorylation of pp33 and pp31 was also suppressed by 1 mM dbcAMP, and dephosphorylation of the two protein by 1,25(OH)2D3 was inhibited by 8 microM H-8, an inhibitor of cAMP-dependent protein kinase (PKA). Furthermore, 8 microM H-8 inhibited dephosphorylation of the two proteins when it was added with 1,25(OH)2D3. On the other hand, 10 nM TPA gave no significant change to these two phosphoproteins. These results suggest the possibility that PKA is involved in the early stages of 1,25(OH)2D3-induced HL-60 cell differentiation through specific protein dephosphorylation.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Ueda T,Sawada H,Okuda T,Yumoto Y,Kato Y,Ogawa K,Tashima M,Yoshida Y,Okuma M

doi

10.1016/0145-2126(91)90169-t

keywords:

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

927-34

issue

10

eissn

0145-2126

issn

1873-5835

pii

0145-2126(91)90169-T

journal_volume

15

pub_type

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