Abstract:
BACKGROUND:T- cell prolymphocytic leukemia (T- PLL) is a rare aggressive hematological malignancy. Alemtuzumab, an anti-CD52 humanized monoclonal antibody, is the treatment of choice for remission induction. Allogeneic hematopoietic cell transplantation (allo-HCT) has been described to induce durable remissions and improve survival, but data is limited. PATIENTS AND METHODS:We evaluated clinical outcomes of 11 patients, median age of 56 (range, 43-71) years who underwent allo-HCT for T-PLL. The majority of cases were in the first complete remission (CR1 = 9, CR2 = 1, second partial response PR2 = 1) at time of allo-HCT. Myeloablative conditioning was the most commonly prescribed preparative regimen (n = 8, 73%) and tacrolimus plus sirolimus was most commonly prescribed regimen for graft-versus-host disease prophylaxis (n = 5, 46%). RESULTS:The median follow-up for surviving patients was 48 (range, 6-123) months. The 4-year progression-free survival (PFS) and overall survival (OS) were 45% (95% confidence interval (CI) = 13-78%) and 56% (95% CI = 24-89%), respectively. Cumulative incidence of non-relapse mortality (NRM) at 4-year post-transplantation was 34% (95%CI = 14-85%). The 4-year cumulative incidence of relapse/progression was 21% (95% CI = 6-71%). CONCLUSION:Allo-HCT is an effective treatment for T-PLL. Patients must be evaluated for their candidacy for allo-HCT as soon as the diagnosis is confirmed. Efforts are needed to decrease NRM and relapse.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Dholaria BR,Ayala E,Sokol L,Nishihori T,Chavez JC,Hussaini M,Kumar A,Kharfan-Dabaja MAdoi
10.1016/j.leukres.2018.01.009subject
Has Abstractpub_date
2018-04-01 00:00:00pages
1-5eissn
0145-2126issn
1873-5835pii
S0145-2126(18)30015-8journal_volume
67pub_type
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2012.12.003
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2014.06.018
更新日期:2014-10-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00083-6
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/s0145-2126(03)00005-5
更新日期:2003-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0145-2126(88)90005-7
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(83)90072-3
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90140-7
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2019.106225
更新日期:2019-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.10.006
更新日期:2005-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1997-11-01 00:00:00