Imatinib induces demethylation of miR-203 gene: an epigenetic mechanism of anti-tumor effect of imatinib.

abstract：PURPOSE:The study aims to develop a prognostic scoring system based on prognostic lncRNAs for acute myeloid leukemia (AML). METHODS:Based on lncRNA expression profiles downloaded from The Cancer Genome Atlas (TCGA), differentially expressed long noncoding RNAs (DELs) between good prognosis and bad prognosis samples we...

journal_title：Leukemia research

authors： Zeng H,Wu H,Yan M,Tang L,Guo X,Zhao X

更新日期：2020-01-01 00:00:00

abstract：:We reported the different clinical features between Japanese and German refractory anemia (RA) patients in FAB classification. We re-analyzed the clinical features by WHO classification revised in 2008. The frequencies of refractory cytopenia with unilineage dysplasia (RCUD) and myelodysplastic syndrome-unclassified (...

journal_title：Leukemia research

authors： Matsuda A,Germing U,Jinnai I,Araseki K,Kuendgen A,Strupp C,Iwanaga M,Miyazaki Y,Hata T,Bessho M,Gattermann N,Tomonaga M

更新日期：2010-08-01 00:00:00

abstract：:Fractionation of mononuclear cells from human fetal liver provides a cell population at early stages of myeloid differentiation which, when cultured, generates neutrophils and macrophages for up to a month. These studies describe the further purification of an undifferentiated myeloid blast cell population by rosette ...

journal_title：Leukemia research

authors： Bunce CM,Patton WN,Pound JD,Lord JM,Brown G

更新日期：1990-01-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Leukemia research

authors： Zengwang,Zhou HJ,Li A,Zhang JL

更新日期：2009-02-20 00:00:00

abstract：:We conducted an analysis of the effect of monocytosis at diagnosis of CLL on subsequent overall (OS) and treatment-free survival (TFS). Monocyte counts were performed using the Sysmex XE2100 analyser. A monocyte count >0.9 × 10(9)L(-1) at the time of diagnosis was associated with a shortened OS and TFS. Monocytosis at...

journal_title：Leukemia research

authors： Mazumdar R,Evans P,Culpin R,Bailey J,Allsup D

更新日期：2013-06-01 00:00:00

abstract：:We report the case of an elderly patient affected by Philadelphia positive Acute Lymphoblastic Leukaemia (Ph(+) ALL) who developed meningeal leukaemia during imatinib monotherapy, despite bone marrow molecular remission. Aggressive central nervous system (CNS)-directed therapy in combination with continued imatinib tr...

journal_title：Leukemia research

authors： Mele G,Pinna S,Melpignano A,Romano A,Brocca MC,Coppi MR,Quarta G

更新日期：2007-10-01 00:00:00

abstract：:In vivo infection by HTLV-I is characterized by the lack of virus expression in the host's infected cells and in most cases it is clinically inapparent. The present study shows that exposure of HTLV-I-infected human T-cells to a maximal non-toxic dose of 3-MC remarkably enhances virus expression. This stimulatory effe...

journal_title：Leukemia research

authors： Feldman G,Aboud M

更新日期：1993-05-01 00:00:00

abstract：:Glycosylation of cytokines appears to be responsible for several differences in their activity, and focusing on G-CSF, several divergences between the non-glycosylated G-CSF, Filgrastim, and the glycosylated G-CSF, Lenograstim, have been reported. To verify the role of G-CSF glycosylation in mediating these difference...

journal_title：Leukemia research

authors： Mattii L,Battolla B,Azzarà A,D'Urso G,Montali U,Petrini M

更新日期：2011-02-01 00:00:00

abstract：:While critical steps in the regulation of leukemia cell development have been intensively studied in recent years, less is known about the interactions of leukemic cells with their stroma. Previously, we have shown that human acute myeloid leukemia (AML) cells differentiate upon injection into murine blastocysts. We h...

journal_title：Leukemia research

authors： Pramanik K,Trüpschuch S,Greiner A,Ruthardt M,Henschler R,Müller AM

更新日期：2008-05-01 00:00:00

abstract：:A nonsteroidal anti-inflammatory drug (NSAID)--indomethacin (IN), was found to induce apoptosis and inhibit proliferation of K562 cells and primary culture bone marrow cells from six chronic myelogenous leukemia (CML) patients. IN induced cells apoptosis and inhibited cells proliferation in a dose-and time-dependent m...

journal_title：Leukemia research

authors： Zhang G,Tu C,Zhang G,Zhou G,Zheng W

更新日期：2000-05-01 00:00:00

abstract：:We performed a comprehensive cost calculation identifying the main cost drivers of treatment of chronic lymphocytic leukaemia in daily practice. In our observational study 160 patient charts were reviewed repeatedly to assess the treatment strategies from diagnosis till the study end. Ninety-seven patients (61%) recei...

journal_title：Leukemia research

authors： Holtzer-Goor KM,Bouwmans-Frijters CA,Schaafsma MR,de Weerdt O,Joosten P,Posthuma EF,Wittebol S,Huijgens PC,Mattijssen EJ,Vreugdenhil G,Visser H,Peters WG,Erjavec Z,Wijermans PW,Daenen SM,van der Hem KG,van Oers MH,Groot

更新日期：2014-01-01 00:00:00

abstract：:In-vitro infection of normal human lymphocytes with HTLV-I (human T-cell lymphotropic retrovirus type I) has been carried out to study the target cell specificity and the kinetics of infection. Cord blood (CBL) and adult peripheral blood lymphocytes (PBL) have been co-cultivated with irradiated HTLV-I donor cells (MT2...

journal_title：Leukemia research

authors： Del Mistro A,De Rossi A,Aldovini A,Salmi R,Chieco-Bianchi L

更新日期：1986-01-01 00:00:00

abstract：:Older patients with acute myelogenous leukemia (AML) have overexpression of P-glycoprotein (Pgp+), and this has been shown to correlate quantitatively with therapeutic outcome. Since Pgp-mediated efflux of cytotoxic drugs can be inhibited by the cyclosporine analogue, PSC 833, we investigated the use of this agent wit...

journal_title：Leukemia research

authors： Chauncey TR,Rankin C,Anderson JE,Chen I,Kopecky KJ,Godwin JE,Kalaycio ME,Moore DF,Shurafa MS,Petersdorf SH,Kraut EH,Leith CP,Head DR,Luthardt FW,Willman CL,Appelbaum FR

更新日期：2000-07-01 00:00:00

abstract：:A single patient who had a leukemic relapse six months after receiving a syngeneic bone marrow transplant was given "adoptive chemoimmunotherapy." Lymphocytes from the patients identical twin were alloactivated and grown in T cell growth factor in vitro. After receiving chemotherapy to reduce the number of relapsed le...

journal_title：Leukemia research

authors： Sondel PM,Kohler PC,Hank JA,Bozdech MJ,Lieberman LM,Hong R,Albertini R,Exten RE

更新日期：1984-01-01 00:00:00

abstract：:Heterogeneity for 5'nucleotidase has been demonstrated in chronic lymphocytic leukemia [12]. The enzyme is not detectable in the lymphocytes from the majority of patients with this disorder, but normal and even supranormal levels are found in some cases [17]. In the present studies, the properties of this ecto-nucleot...

journal_title：Leukemia research

authors： Conklyn MJ,Silber R

更新日期：1982-01-01 00:00:00

abstract：:Recent studies indicate that lipid metabolic changes affect the survival of multiple myeloma (MM) cells. Time-of-flight secondary ion mass spectrometry (TOF-SIMS), an imaging mass spectrometry technique, is used to visualize the subcellular distribution of biomolecules including lipids. We therefore applied this metho...

journal_title：Leukemia research

authors： Nagata Y,Ishizaki I,Waki M,Ide Y,Hossen MA,Ohnishi K,Miyayama T,Setou M

更新日期：2015-06-01 00:00:00

abstract：:We have recently described that a variant of L1210 leukemia cell (L1210/LN-1) originally fused with Lesch-Nyhan fibroblast is highly immunogenic for inducing tumor-specific transplantation immunity in (BALB/cxDBA/2)F1 mice. This finding has clearly been confirmed in the present study by in-vitro cell-mediated cytotoxi...

journal_title：Leukemia research

authors： Kawashima K,Isobe K,Nagase F,Yokochi T,Nagura E,Hasegawa Y,Morishita H,Yamada K,Nakashima I

更新日期：1985-01-01 00:00:00

abstract：:The study was undertaken to elucidate the regulatory roles of GMP reductase (GMPR) and IMP dehydrogenase (IMPDH) on purine interconversion during differentiation. Treatment of HL-60 cells with retinoic acid (1 microM) induced granulocytic differentiation which was accompanied with a 2.4-fold increase in GMPR and 55% d...

journal_title：Leukemia research

authors： Nakamura H,Natsumeda Y,Nagai M,Takahara J,Irino S,Weber G

更新日期：1992-06-01 00:00:00

abstract：:We analyzed the function of a SEPT9-ABL1 fusion identified in a case of T-prolymphocytic leukemia with tyrosine kinase inhibitor (TKI) resistance. Five isoforms with different N-termini, including SEPT9a-ABL1, SEPT9b-ABL1, SEPT9d-ABL1, SEPT9e-ABL1 and SEPT9f-ABL1, were detected in the leukemic cells. All isoforms exce...

journal_title：Leukemia research

authors： Kawai H,Matsushita H,Suzuki R,Sheng Y,Lu J,Matsuzawa H,Yahata T,Tsuma-Kaneko M,Tsukamoto H,Kawada H,Ogawa Y,Ando K

更新日期：2014-12-01 00:00:00

abstract：:The human lymphoblastoid leukemic cell line (CCRF-CEM) was induced to differentiate with phorbol 12-myristate 13-acetate (PMA). During differentiation, assessed by monitoring the cluster of differentiation (CD) profile, the prosome (proteasomes, multi-catalytic proteinase) distribution and composition were studied by ...

journal_title：Leukemia research

authors： Baz A,Henry L,Chateau MT,Scherrer K,Bureau JP

更新日期：1997-11-01 00:00:00

abstract：:In 141 adult patients with diagnosis of acute myeloid leukemia the overall expression and intensity of expression of CD34 antigen on leukemic cells was investigated. Myeloid blasts were tested by applying direct immunofluorescence staining using anti-CD34 fluorescein monoclonal antibody in flow cytometry. CD34 antigen...

journal_title：Leukemia research

authors： Raspadori D,Lauria F,Ventura MA,Rondelli D,Visani G,de Vivo A,Tura S

更新日期：1997-07-01 00:00:00

abstract：:The revised IPSS (IPSS-R) was developed aiming at a better prognostication, taking into account patients treated with best supportive care. We herein validated this model on the basis of data from 1314 patients who received BSC only as well as patients who underwent induction chemotherapy (n=214) or allogeneic transpl...

journal_title：Leukemia research

authors： Neukirchen J,Lauseker M,Blum S,Giagounidis A,Lübbert M,Martino S,Siragusa S,Schlenk RF,Platzbecker U,Hofmann WK,Götze K,Palumbo GA,Magrin S,Kündgen A,Aul C,Hildebrandt B,Hasford J,Kobbe G,Haas R,Germing U

更新日期：2014-01-01 00:00:00

abstract：:CD13/aminopeptidase-N, an enzyme expressed by myeloid cells, may be important in the regulation and signalling pathways that control myeloid growth and differentiation. In this study we have used the myeloid leukaemic cell line HL60, and its ability to differentiate when induced by all-trans-retinoic acid (ATRA), to s...

journal_title：Leukemia research

authors： Razak K,Allen PD,Kelsey SM,Gutteridge CN,Newland AC

更新日期：1994-08-01 00:00:00

abstract：:Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxicity in human acute promyelocytic leukemia NB4 cells by early disturbance in mitochondrial function and oxidative stres...

journal_title：Leukemia research

authors： García-Pérez AI,Galeano E,Nieto E,Estañ MC,Sancho P

更新日期：2014-07-01 00:00:00

abstract：:miR-16, a miRNA involved in cell proliferation and apoptosis regulation, may interfere with either oncogenic or tumor-suppressor pathways and is implicated in leukemogenesis. We then explored its expression in 93 childhood acute lymphoblastic leukemia (ALL) cases. A high miR-16 expression was associated with hyperleuk...

journal_title：Leukemia research

authors： Kaddar T,Chien WW,Bertrand Y,Pages MP,Rouault JP,Salles G,Ffrench M,Magaud JP

更新日期：2009-09-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t(15;17) (q22;q12), resulting in fusion of the genes promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA). With conventional cytogenetic methods, these translocations are detected in about 70-90% of patients, with most o...

journal_title：Leukemia research

authors： Han JY,Kim KE,Kim KH,Park JI,Kim JS

更新日期：2007-02-01 00:00:00

abstract：:Standard chemotherapic approach for MZL is missing. We are presenting our monocenter experience with 2CdA+/-rituximab. Patients received 2CdA, 5mg/m(2), weekly, for 6 weeks. Patients receiving rituximab underwent to antibody administration in association with 2CdA, or after the end of chemotherapy. Global ORR was 89.3...

journal_title：Leukemia research

authors： Orciuolo E,Buda G,Sordi E,Baraté C,Galimberti S,Ciancia E,Petrini M

更新日期：2010-02-01 00:00:00

abstract：:GNAS1 gene is located at the long arm of chromosome 20 (q13.32). GNAS1 gene deletion has never been investigated in MDS. A GNAS1 activating mutation (R201) was recently found in MDS. We applied FISH and DHPLC plus sequencing to investigate GNAS1 gene in MDS cases with and without del(20q) at karyotype. ...

journal_title：Leukemia research

authors： Di Giacomo D,Lema Fernandez AG,Pierini T,Crescenzi B,Brandimarte L,Matteucci C,Testoni N,Mecucci C

更新日期：2014-07-01 00:00:00

abstract：:We compared 2-[fluorine-18] fluoro-2-deoxy-d-glucose PET-CT and contrast-enhanced computed tomography (CECT) in 62 consecutive patients with newly diagnosed Hodgkin Lymphoma (HL), aiming to provide evidences that may spare CECT from the staging procedures of HL patients. Among a total of 1448 nodal sites examined, dis...

journal_title：Leukemia research

authors： Panebianco M,Bagni O,Cenfra N,Mecarocci S,Ortu La Barbera E,Filippi L,Codacci-Pisanelli G,Biondi T,Laghi A,Cimino G

更新日期：2019-01-01 00:00:00

abstract：:Ras proteins are frequently over-expressed in leukemia and contribute to leukemogenesis. We evaluated the anti-leukemic efficacy of a new third-generation bisphosphonate, ONO5920/YM529 (YM529). YM529 prevents the prenylation of Ras proteins and inhibited the growth of leukemic cells including a P-glycoprotein (P-gp) o...

journal_title：Leukemia research

authors： Segawa H,Kimura S,Kuroda J,Sato K,Nogawa M,Yuasa T,Yokota A,Hodohara K,Fujiyama Y,Maekawa T

更新日期：2005-04-01 00:00:00