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The aorta-gonad-mesonephros-derived stroma cell line DAS104-4 induces differentiation of leukemic cells.

Abstract：

:While critical steps in the regulation of leukemia cell development have been intensively studied in recent years, less is known about the interactions of leukemic cells with their stroma. Previously, we have shown that human acute myeloid leukemia (AML) cells differentiate upon injection into murine blastocysts. We here describe that human AML Kasumi-1 cells, cocultured with murine aorta-gonad-mesonephros (AGM) region-derived DAS104-4 stromal cells, decrease proliferation and colony formation efficiency; and up-regulate myelo-monocytic cell surface markers. Gene expression analysis showed decreased transcription of the AML1-ETO fusion gene and increased transcription of p16 (INK4A), p21 (WAF1) and C/EBPalpha genes. Coculture can induce myeloid differentiation also in patient-derived AML cells. Our findings strengthen the notion that the embryonic milieu can regulate the proliferation and differentiation of leukemic cells.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Pramanik K,Trüpschuch S,Greiner A,Ruthardt M,Henschler R,Müller AM

doi

10.1016/j.leukres.2007.09.014

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

781-9

issue

5

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(07)00348-7

journal_volume

32

pub_type

杂志文章

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