当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > A role for mitochondrial DNA in the pathogenesis of radiation-induced myelodysplasia and secondary leukemia.

A role for mitochondrial DNA in the pathogenesis of radiation-induced myelodysplasia and secondary leukemia.

Abstract：

:The onset of acute myeloid leukemia following ionizing radiation or alkylating agent exposure is antedated months to years by the development of 'preleukemia', or secondary myelodysplastic syndrome (sMDS). Mitochondrial abnormalities induced by chloramphenicol and clonal deletions of mitochondrial DNA (mt DNA) in the bone marrow create hematological defects similar to sMDS, and abnormal dimers of mt DNA are observed in acute leukemia. This suggests a role for mt DNA in the pathogenesis of sMDS and secondary leukemia. We outline disparate experimental evidence to support this concept and suggest a role for select protease inhibitors in the clinical management of this disorder.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Hatfill SJ,La Cock CJ,Laubscher R,Downing TG,Kirby R

doi

10.1016/0145-2126(93)90036-k

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

907-13

issue

11

eissn

0145-2126

issn

1873-5835

journal_volume

17

pub_type

杂志文章,评审

相关文献

LEUKEMIA RESEARCH文献大全
  • Comparison of 24-month outcomes in chelated and non-chelated lower-risk patients with myelodysplastic syndromes in a prospective registry.

    abstract：:This 5-year, prospective registry enrolled 600 lower-risk MDS patients (pts) with transfusional iron overload. Clinical outcomes were compared between chelated and nonchelated pts. At baseline, cardiovascular comorbidities were more common in non-chelated pts, and MDS therapy was more common in chelated pts. At 24 mon...

    journal_title：Leukemia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.leukres.2013.11.004

    authors： Lyons RM,Marek BJ,Paley C,Esposito J,Garbo L,DiBella N,Garcia-Manero G

    更新日期：2014-02-01 00:00:00

  • Semenogelin I expression in myeloma cells can be upregulated pharmacologically.

    abstract：:Semenogelin (SEMG) I is a Cancer-Testis (CT) antigen that we have found to be expressed in myeloma cells. In this study, we set out to determine whether the expression of SEMG I could be upregulated pharmacologically. We found that SEMG I expression in myeloma cells can be upregulated by 5-azacytidine, IL-4 and IL-6. ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2008.03.036

    authors： Zhang Y,Wang Z,Zhang J,Farmer B,Lim SH

    更新日期：2008-12-01 00:00:00

  • ATP-binding cassette sub-family C member 4 (ABCC4) is overexpressed in human NK/T-cell lymphoma and regulates chemotherapy sensitivity: Potential as a functional therapeutic target.

    abstract：:Nasal-type natural killer/T-cell (NK/T-cell) lymphomas are subtypes of non-Hodgkin's lymphoma (NHL), which are typically more clinically aggressive. There is, however relatively little understanding of nasal-type NK/T-cell lymphoma molecular pathogenesis. Thus, in this study we applied RNA sequencing to systematically...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2015.10.001

    authors： Zhang X,Zhao L,Li X,Wang X,Li L,Fu X,Sun Z,Li Z,Nan F,Chang Y,Zhang M

    更新日期：2015-12-01 00:00:00

  • A coordinated proto-oncogene expression characterizes MCF 247 murine leukemia virus-induced T-cell lymphomas irrespectively of proviral insertion affecting myc loci.

    abstract：:Proto-oncogene transcriptional activation was analyzed in a group of MCF 247 MuLv-induced T-cell lymphomas to identify transformation-specific gene activations and determine whether the proviral insertion near a myc gene could promote a peculiar mechanism of transformation through a differential proto-oncogene express...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(90)90007-v

    authors： Boiocchi M,Dolcetti R,Maestro R,Feriotto G,Rizzo S,De Re V,Sonego F

    更新日期：1990-01-01 00:00:00

  • Relationship between cyclin D1 and p21(Waf1/Cip1) during differentiation of human myeloid leukemia cell lines.

    abstract：:Expression of cell cycle-regulating genes was studied in human myeloid leukemia cell lines ML-1, ML-2 and ML-3 during induction of differentiation in vitro. Myelomonocytic differentiation was induced by phorbol ester (12-o-Tetradecanoyl-phorbol-13-acetate, TPA), tumor necrosis factor alpha (TNFalpha) or interferon gam...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(03)00103-6

    authors： Ullmannová V,Stöckbauer P,Hradcová M,Soucek J,Haskovec C

    更新日期：2003-12-01 00:00:00

  • Variations in incidence of childhood leukaemia in South East Scotland (1970-1984).

    abstract：:Concern has been expressed recently about apparent increases in the incidence of leukaemia amongst young people living in certain geographical areas. We analysed the incidence of childhood leukaemia in South-East Scotland (excluding North-East Fife) from 1970 to 1984. There was a significant geographical variation in ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(86)90091-3

    authors： Gerrard M,Eden OB,Stiller CA

    更新日期：1986-01-01 00:00:00

  • Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents.

    abstract：:We used a novel high-throughput drug screening assay, based on Luminex technology, to identify anti-myeloma agents capable of inhibiting cytokines and growth factors essential for multiple myeloma (MM) from a chemical library of 1120 compounds provided by MMRF. Tetracycline derivatives inhibited MM cell proliferation ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.12.002

    authors： Feng R,Rios JA,Onishi T,Lokshin A,Gorelik E,Lentzsch S

    更新日期：2010-07-01 00:00:00

  • Difference in effects of interferon-alpha and interferon-gamma on the induction of differentiation of retinoic acid-treated acute myeloid leukemia cells in primary culture.

    abstract：:We studied differentiation inducing effects of retinoic acid (RA), 1 alpha, 25-dihydroxyvitamin D3 (D3) and interferons (IFNs), alone and in combination, on fresh myeloid leukemic cells from 8 patients. RA not only induced the differentiation of leukemic cells in 5/8 cases, but potentiated differentiation by IFNs eith...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(90)90072-h

    authors： Nakamaki T,Sakashita A,Hino K,Suzuki K,Tomoyasu S,Tsuruoka N,Honma Y,Hozumi M

    更新日期：1990-01-01 00:00:00

  • Bone and bone marrow interactions: hematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide. II. Action on human hematopoietic stem cells.

    abstract：:Osteogenic growth peptide (OGP) is a peptide exerting regulatory effects on the bone and on bone marrow. The carboxy-terminal pentapeptide (OGP10-14) is the biologically active portion of OGP. We evaluated OGP10-14 hematopoietic activity performing colony-forming tests on human stem cells derived by bone marrow, perip...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(02)00008-5

    authors： Fazzi R,Galimberti S,Testi R,Pacini S,Trasciatti S,Rosini S,Petrini M

    更新日期：2002-09-01 00:00:00

  • The intracellular location of terminal transferase does not vary with cell cycle stage.

    abstract：:The biochemical activity of terminal transferase (TdT) in the thymocytes of leukemic AKR mice has no relationship to cell cycle stage, unlike the activity of replicative DNA polymerase which increases during the period of DNA synthesis. Moreover, such assays of DNA polymerase alpha reveal a shift in enzyme activity fr...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(84)90082-1

    authors： Barr RD,Barresi T,Koekebakker M,Sarin PS

    更新日期：1984-01-01 00:00:00

  • Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.

    abstract：:We retrospectively analyzed allogenic stem cell transplantation (allo-SCT) outcomes in 82 patients with AML or MDS were conditioned with fludarabine, idarubicin, intravenous-busulfan and cytarabine (FIBA) or busulfan and cyclophosphamide (BuCy). Compared to BuCy regimen, reduced intensity conditioning (RIC) with FIBA ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.08.016

    authors： Gao L,Gao L,Gong Y,Zhang C,Chen XH,Zhang X

    更新日期：2013-11-01 00:00:00

  • Over-expression of Flt3 induces NF-kappaB pathway and increases the expression of IL-6.

    abstract：:Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-kappaB), which is a target molecule of these kin...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.01.008

    authors： Takahashi S,Harigae H,Ishii KK,Inomata M,Fujiwara T,Yokoyama H,Ishizawa K,Kameoka J,Licht JD,Sasaki T,Kaku M

    更新日期：2005-08-01 00:00:00

  • Bone marrow niche in the myelodysplastic syndromes.

    abstract：:The myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic malignancies characterized by ineffective hematopoiesis, progressive bone marrow (BM) failure, cytogenetic and molecular abnormalities, and variable risk of progression to acute myeloid leukemia (AML). The BM microenvironment in MDS plays ...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.leukres.2015.06.017

    authors： Cogle CR,Saki N,Khodadi E,Li J,Shahjahani M,Azizidoost S

    更新日期：2015-10-01 00:00:00

  • MCP-1 in the cerebrospinal fluid of children with acute lymphoblastic leukemia.

    abstract：BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokines. MCP-1 has been previously shown to have a major role in the migration of monocytes towards human leukemic cells, yet it cannot increase cytotoxic effects of monocytes on human leukemic cells. AIM:To determine levels of MCP-1 in the...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2006.01.017

    authors： Eisenkraft A,Keidan I,Bielorai B,Keller N,Toren A,Paret G

    更新日期：2006-10-01 00:00:00

  • Evaluation of tolerability and efficacy of imatinib mesylate in elderly patients with chronic phase CML: ELDERGLI study.

    abstract：:Imatinib mesylate (IM) is the treatment of choice in patients with newly diagnosed chronic myeloid leukemia (CML), irrespectively of their age. Nevertheless, information regarding tolerability and responses in advanced-age patients, a subgroup in which co-morbidities and other factors may influence outcome, is scarce,...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.leukres.2011.01.017

    authors： Sánchez-Guijo FM,Durán S,Galende J,Boqué C,Nieto JB,Balanzat J,Gracia A,García I,Avellaneda-Molina C,Moreno MV,Luño-Fernandez E,Hermosilla M,Sanchez-Varela JM,Dios A,López-Garrido P,Giraldo P,Bargay J,Domingo JM,Soler

    更新日期：2011-09-01 00:00:00

  • The role of hematopoietic cell transplantation in adult ALL: clinical equipoise persists.

    abstract：:Adults with acute lymphoblastic leukemia (ALL) in first complete remission (CR1) may be treated either with ongoing systemic chemotherapy or with allogeneic hematopoietic cell transplantation (alloHCT). Despite the presence of phase III trials to support clinical decision-making, we hypothesized that physicians who tr...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.10.021

    authors： Paulson K,Szwajcer D,Raymond CB,Seftel MD

    更新日期：2014-02-01 00:00:00

  • Non-Hodgkin's lymphoma: case control epidemiological study in Yorkshire.

    abstract：:This paper reports the results of a case control study of non-Hodgkin's lymphoma in the Yorkshire Health Region. In all, 437 cases and 724 controls were interviewed. Risk factors associated with past skin conditions, family history of cancer and infectious mononucleosis, aspects of social life and contact with wood du...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(98)80012-x

    authors： Cartwright RA,McKinney PA,O'Brien C,Richards ID,Roberts B,Lauder I,Darwin CM,Bernard SM,Bird CC

    更新日期：1988-01-01 00:00:00

  • Minimally differentiated acute leukemia.

    abstract：:We have studied 35 adult patients with morphologically undifferentiated peroxidase-negative acute leukemia that failed to meet the criteria for acute lymphoblastic leukemia and compared them to patients with FAB M1-M7 seen by the same physicians. The diagnosis of minimally differentiated acute leukemia (MD-AL) was ass...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(93)90002-3

    authors： Cadwell FJ,Burns CP,Dick FR,Jones MP,Heckman KD,Weiner GJ,Goeken JA

    更新日期：1993-03-01 00:00:00

  • Bone marrow B lymphocytes in multiple myeloma and MGUS: Focus on distribution of naïve cells and memory subsets.

    abstract：BACKGROUND/AIMS:Multiple myeloma (MM) is caused by proliferation of clonal plasma cells (cPCs) in bone marrow (BM), associated with numerical and functional defects in immune subsets. An impairment of B cell compartment is involved in onset/progression of the disease. METHODS:By flow cytometry, we studied distribution...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2016.08.008

    authors： Pojero F,Casuccio A,Giambanco C,Bulati M,Buffa S,Di Bassiano F,Gervasi F,Caruso C,Colonna Romano G

    更新日期：2016-10-01 00:00:00

  • STAT6 and the regulation of CD23 expression in B-chronic lymphocytic leukemia.

    abstract：:High CD23 expression is a hallmark of B-CLL cells. It is lost during in vitro culture and can be reinduced by IL-4, albeit to a lower extent than in normal B cells. To elucidate the events controlling CD23 expression in B-CLL cells, the IL-4 mediated induction of STAT6 was investigated. Western-blot analysis demonstra...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(99)00191-5

    authors： Kneitz C,Goller M,Seggewiss R,Yaman A,Serfling E,Tony HP

    更新日期：2000-04-01 00:00:00

  • Regulation of topoisomerase II expression during the VM-26 induced differentiation of IW32 murine erythroleukemia cells.

    abstract：:The effect of VM-26, a topoisomerase II targeting drug, on IW32 murine erythroleukemia cells was investigated. The VM-26 induced IW32 cells to differentiate at a non-toxic but cytostatic concentration (0.01 microgram/ml). More than 40% of the cells were induced to synthesize hemoglobin, and cells were arrested in G2/M...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(95)00144-1

    authors： Tan SK,Tang SJ,Wang MC,Hwang J,Wang FF

    更新日期：1996-03-01 00:00:00

  • Response to intermediate and standard doses of IFN-beta in hairy-cell leukaemia.

    abstract：:Thirteen hairy-cell leukaemia patients were treated with IFN-beta (6 X 10(6) IU/m2) for 7 days, alternate weeks, for three cycles. IFN-beta was then continued at the same dose twice a week for 24 weeks. Treatment was discontinued in 2 non-responders and 2 partial responders (1 haem PR, 1 path PR) because of complicati...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(90)90071-g

    authors： Liberati AM,Fizzotti M,Di Clemente F,Senatore M,Berruto P,Falini B,Martelli MF,Grignani F

    更新日期：1990-01-01 00:00:00

  • In vivo efficacy of griseofulvin against multiple myeloma.

    abstract：:We recently confirmed that ciclopirox olamine inhibits Wnt/beta catenin signalling in myeloma. Griseofulvin (GF) has similar chemical features as compared to ciclopirox olamine. In this study the anti-tumor effect of GF was investigated. GF demonstrated a major apoptotic activity in various human and murine myeloma an...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2010.10.008

    authors： Kim Y,Alpmann P,Blaum-Feder S,Krämer S,Endo T,Lu D,Carson D,Schmidt-Wolf IG

    更新日期：2011-08-01 00:00:00

  • Reversine triggers mitotic catastrophe and apoptosis in K562 cells.

    abstract：:Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm of the hematopoietic stem cell characterized by presence of the oncoprotein BCR-ABL1, which have constitutive tyrosine kinase activity. BCR-ABL1 activation induces aurora kinase A (AURKA) and aurora kinase B (AURKB) expression, which are serine-thr...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2016.06.011

    authors： Rodrigues Alves AP,Machado-Neto JA,Scheucher PS,Paiva HH,Simões BP,Rego EM,Traina F

    更新日期：2016-09-01 00:00:00

  • The role of platelet-derived growth factor on human pluripotent progenitor (CFU-GEMM) growth in vitro.

    abstract：:The effect of serum on the proliferation of human bone marrow pluripotent progenitor cells (CFU-GEMM), was compared to that of fresh frozen plasma (FFP). Serum significantly increased the number of mixed erythroid-granulocytic-megakaryocytic colonies (CFU-GEMM) and erythrocytic bursts (BFU-E) in this assay system (p l...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(85)90062-1

    authors： Michalevicz R,Francis GE,Price GM,Hoffbrand AV

    更新日期：1985-01-01 00:00:00

  • Biochemical mechanisms of deoxycoformycin toxicity in chronic leukemias.

    abstract：:The in-vitro effects of deoxycoformycin (dCF) on dATP, NAD, ATP and DNA strand breaks have been evaluated in the cells from 42 patients with various types of chronic lymphoid leukemia. These included 18 with B-cell chronic lymphoid leukemias of different types (BCL); 10 with hairy cell leukemia (HCL) and 14 with T-cel...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(87)90140-8

    authors： Ganeshaguru K,Ho AD,Piga A,Catovsky D,Hoffbrand AV

    更新日期：1987-01-01 00:00:00

  • Leukemias associated with Turner syndrome: report of three cases and review of the literature.

    abstract：:Cases of leukemia associated with Turner syndrome (TS) are rare. Here we report three TS patients with leukemia including one case of T-large granular lymphocyte leukemia (T-LGL), one rare case of coexistence of chronic lymphocytic leukemia (CLL) and idiopathic myelofibrosis (IMF) and one case of a patient with AML-M2...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.leukres.2007.06.004

    authors： Manola KN,Sambani C,Karakasis D,Kalliakosta G,Harhalakis N,Papaioannou M

    更新日期：2008-03-01 00:00:00

  • No parental origin bias for the rearranged chromosomes in myeloid leukemias associated with t(9;22), t(8;21) and t(15;17).

    abstract：:We investigated parental origin of rearranged chromosomes 9 and 22 (9q + and 22q -) in five patients with Ph-positive chronic myeloid leukemia (CML) using the C-banding and silver-staining methods of nucleolus organizer regions, respectively; of rearranged chromosome 21 (21q +) in seven patients with t(8;21)-positive ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(98)00069-1

    authors： Nakamura H,Itoyama T,Niikawa N,Sadamori N,Tomonaga M

    更新日期：1998-09-01 00:00:00

  • Susceptibility of mantle cell lymphomas to reovirus oncolysis.

    abstract：:Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro, we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras acti...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.05.020

    authors： Alain T,Muzik H,Otsuka S,Chan S,Magliocco T,Diaz R,Forsyth PA,Morris D,Bebb G

    更新日期：2010-01-01 00:00:00

  • Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia.

    abstract：:FLT3 is a receptor tyrosine kinase involved in the survival of hematopoietic stem cells, and mutations of FLT3 have been reported to be of prognostic significance. This is the first study of FLT3 mutations in pediatric non-promyelocytic AML patients that received the same treatment scheme in single institute. FLT3 int...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2004.11.006

    authors： Kang HJ,Hong SH,Kim IH,Park BK,Han KS,Cho HI,Shin HY,Ahn HS

    更新日期：2005-06-01 00:00:00