Abstract:
:Aberrant expression of tumor suppressor genes WT 1, RB 1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML 1, MLL-AF 4, E2A-PBX 1, SIL-TAL 1 were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblastic leukemia (ALL). In contrast to expression of chimeric oncogenes alterations in p16, WT 1, RB 1 and p53 expression were T/B-lineage-unrestricted. Significant association between expression of MLL-AF 4 and WT 1, E2A-PBX 1 and p53; SIL-TAL 1 and homozygous deletion of p16 has been demonstrated.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Kustanovich AM,Savitskaja TV,Bydanov OI,Belevtsev MV,Potapnev MPdoi
10.1016/j.leukres.2005.04.006keywords:
subject
Has Abstractpub_date
2005-11-01 00:00:00pages
1271-6issue
11eissn
0145-2126issn
1873-5835pii
S0145-2126(05)00168-2journal_volume
29pub_type
杂志文章abstract::The impact of genetic aberrations on rituximab-based therapeutic regimens has been intensely studied in chronic lymphocytic leukemia (CLL). According to the current consensus chemoimmunotherapy consisting of rituximab and DNA-damaging drugs is not suitable for patients with TP53 defects. In our study, we focused on CL...
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2016.08.013
更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Leukemia research
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更新日期:2001-12-01 00:00:00
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journal_title:Leukemia research
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更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0145-2126(93)90058-s
更新日期:1993-02-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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更新日期:2012-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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更新日期:2005-10-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2004.10.006
更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.leukres.2012.07.014
更新日期:2012-11-01 00:00:00
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更新日期:2015-12-01 00:00:00
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2004.08.008
更新日期:2005-04-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.11.012
更新日期:2006-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2005.10.014
更新日期:2006-08-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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