Abstract：
:We examined the antineoplastic effects of the iron chelators, deferasirox and deferoxamine in multiple myeloma cell lines as well as primary myeloma cells. These iron chelators showed marked antiproliferative activity as well as cytotoxicity toward myeloma cell lines and deferasirox was cytotoxic to bone marrow plasma cells from myeloma patients. We also demonstrate that autophagy induced by iron deprivation is the dominant mechanism that mediates the cytotoxicity of iron chelators in multiple myeloma. Exposure to iron chelators led to repression of mTOR signaling as evidenced by decreased phosphorylation of its target p70S6 kinase. Iron chelation, in particular with deferasirox has the potential to be readily translated to a clinical trial for multiple myeloma.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Pullarkat V,Meng Z,Donohue C,Yamamoto VN,Tomassetti S,Bhatia R,Krishnan A,Forman SJ,Synold TWdoi
10.1016/j.leukres.2014.06.005subject
Has Abstractpub_date
2014-08-01 00:00:00pages
988-96issue
8eissn
0145-2126issn
1873-5835pii
S0145-2126(14)00184-2journal_volume
38pub_type
杂志文章abstract：:The incidence of B cell chronic lymphocytic leukemia (B-CLL) is lower in Asian countries, including India, when compared with Western countries. The bcl-2 gene rearrangement was restricted to the 5' region and seen in only one of the 20 Indian patients analyzed. The incidence remains similar to that reported from West...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(96)00036-7
更新日期：1996-09-01 00:00:00
abstract：:A novel Philadelphia (Ph1) chromosome positive cell line, designated KYO-1, was established from the peripheral blood of a patient with chronic myelogenous leukemia (CML) in blastic crisis. Although this line had a unique capacity to differentiate spontaneously along the erythroid and monocytoid lineages as evidenced ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90314-5
更新日期：1985-01-01 00:00:00
abstract：:In a patient affected with chronic lymphocytic leukemia with lymphocyte surface mu and kappa determinants and vacuolated bone marrow plasma cells, the serum contained polymers of a truncated mu chain and normal-sized kappa chains. These light chains were present as monomers and covalent dimers in studies performed und...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90129-9
更新日期：1993-06-01 00:00:00
abstract：:A permanent cell line, MN 60, was established from the peripheral blood of a patient with an acute lymphoblastic leukemia (ALL) classified morphologically as being of the L3 type. Cell growth started rapidly in vitro and no feeder cells were needed. Cells of the MN-60 line were identical to the original leukemic cells...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(82)90085-6
更新日期：1982-01-01 00:00:00
abstract：:Despite advances in understanding the complexities of acute myeloid leukaemia (AML), the treatment of refractory or relapsed AML (rrAML) remains a daunting clinical challenge. Numerous clinical trials have failed to identify new treatments or combinations of existing therapies that substantially improve outcomes and s...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2016.05.025
更新日期：2016-08-01 00:00:00
abstract：:We studied monosomy and deletions of chromosome 7 in 170 patients with myeloid disorders and we identified a minimal region of loss in 7q31.1 spanning between the D7S2554 and D7S2460 markers. The closest gene to our most deleted microsatellite, D7S2554, is the human I-mfa domain containing (HIC) gene, alias MyoD famil...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.09.007
更新日期：2007-04-01 00:00:00
abstract：:We compared 2-[fluorine-18] fluoro-2-deoxy-d-glucose PET-CT and contrast-enhanced computed tomography (CECT) in 62 consecutive patients with newly diagnosed Hodgkin Lymphoma (HL), aiming to provide evidences that may spare CECT from the staging procedures of HL patients. Among a total of 1448 nodal sites examined, dis...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2018.11.018
更新日期：2019-01-01 00:00:00
abstract：:We studied 98 female patients in remission (2-240 months) from childhood ALL to determine the clonality status of their hematopoiesis. Thirty-one (31.6%) were heterozygous at the PGK locus for the BstX1 endonuclease restriction site, permitting X-linked clonality assays to be performed. Two patients were in relapse at...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90121-x
更新日期：1994-02-01 00:00:00
abstract：:Occupational and industrial exposures have been implicated in the etiology of leukemia, yet uncertainty remains regarding potential high risk occupations. We examined the associations between self-reported occupations and hobbies and acute leukemia risk using data from 811 cases and 637 controls participating in a cas...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2005.03.002
更新日期：2005-10-01 00:00:00
abstract：:Malignant plasma cells exert osteoclast-like activity in vitro. We investigated the function of the calcitonin (CT) receptor (R) on myeloma cells from patients and in myeloma cell lines. Primary myeloma cells expressed high CTR levels whereas the cell lines uniformly exposed the CTR-2 variant expressed by osteoclasts....
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.07.009
更新日期：2008-04-01 00:00:00
abstract：:The colony-forming capacity of the peripheral blood stem/progenitor cells (PBSC) in different forms of myelodysplastic syndrome (MDS) was investigated. In most cases of refractory anemia (RA) the colony growth of PBSC was definitely reduced as compared to the controls. However, in RA with unfavorable chromosomal aberr...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(01)00064-9
更新日期：2001-11-01 00:00:00
abstract：:The peripheral blood lymphocyte to monocyte ratio (LMR) at diagnosis has been used to predict survival in diffuse large B-cell lymphoma (DLBCL) patients, but its prognostic significance with respect to different cell-of-origin (COO) subtypes remains unknown. We retrospectively analyzed 168 de novo DLBCL patients in th...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2014.03.013
更新日期：2014-06-01 00:00:00
abstract：:Little information is available about the risk factors and means to improve the survival rate of acute leukemia in a rare but often fatal complication after liver transplantation (LT). We report the development of AML-M2 in one of the 764 patients who underwent liver transplantation at our center, and review the liter...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.03.035
更新日期：2009-10-01 00:00:00
abstract：:The human cell line U-937 has many features suggestive of the monocyte. It may be stimulated in vitro to develop attributes of an activated macrophage with increased phagocytosis and enhanced Fc receptor expression. We describe the establishment of a subclone designated U-937 AG through the use of a mutagenic agent. T...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(84)90084-5
更新日期：1984-01-01 00:00:00
abstract：:Ml cells were labeled in vitro with [3H]thymidine and injected into the peritoneal cavity of syngeneic mice. After several days the peritoneal cells were harvested and [3H]labeled cells were determined by autoradiography. The inoculated isotope-labeled Ml cells differentiated in the peritoneal cavity and lipopolysacch...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(82)90050-9
更新日期：1982-01-01 00:00:00
abstract：:Aggressive chemotherapy of myelodysplastic syndromes is rarely feasible because these disorders predominantly occur in elderly patients who often have concurrent illnesses. Alternative treatment modalities must therefore be evaluated. This review summarizes the results that have been obtained with low-dose chemotherap...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/0145-2126(92)90058-f
更新日期：1992-01-01 00:00:00
abstract：:Acute myeloid leukemia (AML) is a heterogeneous disease. Until recently, treatment for patients with AML was limited to induction chemotherapy with cytarabine and anthracycline or hypomethylating agents, and, in some instances, allogeneic hematopoietic stem cell transplant. With the recent approval of new therapies-i....
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2018.09.001
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are associated with increases in janus kinase 2 (JAK2) signaling, often resulting from the JAK2 V617F mutation. LY2784544 (gandotinib) is a potent, selective, small-molecule inhibitor of JAK2 that has potential dose-dependent selectivit...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2018.06.014
更新日期：2018-08-01 00:00:00
abstract：:p23 is a heat shock protein 90 (Hsp90) cochaperone that plays a significant role in estrogen receptor (ER) alpha signal transduction and telomerase activity; it is up-regulated in several cancers. Recent studies have found that high level of p23 may promote tumor progression and poor prognosis in breast cancer patient...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.05.003
更新日期：2012-09-01 00:00:00
abstract：:The results of allogeneic marrow transplantation in 75 patients with acute lymphoblastic leukemia and 63 patients with acute non-lymphoblastic leukemia in relapse are reviewed. The effects of various chemotherapeutic regimens added to the basic regimen of cyclophosphamide (Cy) 60 mg/kg given on each of two successive ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(82)90101-1
更新日期：1982-01-01 00:00:00
abstract：:We monitored DLI treatment of 13 post-SCT relapses using quantitative competitive (QC) RT-PCR for BCR-ABL (sensitivity 10(-5)) and compared responses to DLI alone and DLI in combination with interferon-alpha (IFN). Ten relapses (one blast crisis, five cytogenetic and four molecular) were treated with DLI+IFN, three re...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(02)00280-1
更新日期：2003-08-01 00:00:00
abstract：:We studied differentiation inducing effects of retinoic acid (RA), 1 alpha, 25-dihydroxyvitamin D3 (D3) and interferons (IFNs), alone and in combination, on fresh myeloid leukemic cells from 8 patients. RA not only induced the differentiation of leukemic cells in 5/8 cases, but potentiated differentiation by IFNs eith...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(90)90072-h
更新日期：1990-01-01 00:00:00
abstract：:Bcr-Abl tyrosine kinase inhibitor induces apoptosis and erythroid differentiation of K562 cells. During this erythroid differentiation, c-Myc and cyclin D1 transcripts are transiently downregulated. Accordingly, we studied the effect of cyclin D1 overexpression on erythroid differentiation. After treatment with 250 nM...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2003.10.022
更新日期：2004-06-01 00:00:00
abstract：:Using the human erythroleukaemic cell line K562 cl.6 and its daunorubicin-resistant subline K/DAU600, and the human T-lymphoblastic leukaemic cell line CCRF-CEM and its vinblastine-resistant subline CEM/VLB100, we have shown that the drug-resistant cell lines were more sensitive to cytotoxicity induced by tumour necro...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)00149-5
更新日期：1995-03-01 00:00:00
abstract：:A number of inborn errors of purine metabolism have been associated with immunodeficiency diseases. From studies to the possible mechanism(s) leading to the defects in the immune system, it appeared that the accumulation of deoxyATP and deoxyGTP and the subsequent inhibition of ribonucleotide reductase played an impor...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/0145-2126(83)90042-5
更新日期：1983-01-01 00:00:00
abstract：:Changes of phosphoprotein patterns in HL-60 cells were studied during short exposures to 1 alpha, 25-dihydroxyvitamin D3 [1,25(OH)2D3]. One hundred nanometers 1,25(OH)2D3 dephosphorylated at least three proteins in 6 h: phosphoproteins with molecular weights of 82 kD (pp82), 33 kD (pp33), and 31 kD (pp31). Phosphoryla...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90169-t
更新日期：1991-01-01 00:00:00
abstract：:As sensitization of leukemia cells with granulocyte colony-stimulating factor (G-CSF) can enhance the cytotoxicity of chemotherapy in myeloid malignancies, a pilot study was conducted in order to evaluate the effect of G-CSF priming combined with low-dose chemotherapy in patients with higher risk myelodysplastic syndr...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2016.07.005
更新日期：2016-09-01 00:00:00
abstract：:The present study explored the effects of Forkhead box Q1 (FOXQ1) on cell proliferation, cell cycle and apoptosis via the Sonic hedgehog (Shh) pathway in Natural killer/T-cell lymphoma (NKTCL). Quantitative real time-polymerase chain reaction (qRT-PCR) was performed to detect FOXQ1 expression in 117 NKTCL patients and...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.11.001
更新日期：2018-01-01 00:00:00
abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.01.006
更新日期：2009-02-20 00:00:00
abstract：:A method using avidin-biotin complex (ABC) to detect the presence of the enzyme terminal deoxynucleotidyl transferase (TdT) is described and compared with a proven indirect immunofluorescence method. The material studied consisted of: (1) peripheral blood and bone marrow smears from 17 patients with leukemia (ALL, 8; ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(83)90107-8
更新日期：1983-01-01 00:00:00
