Abstract：
:We studied monosomy and deletions of chromosome 7 in 170 patients with myeloid disorders and we identified a minimal region of loss in 7q31.1 spanning between the D7S2554 and D7S2460 markers. The closest gene to our most deleted microsatellite, D7S2554, is the human I-mfa domain containing (HIC) gene, alias MyoD family inhibitor domain containing (MDFIC). We investigated the involvement of HIC in myeloid neoplasms by screening for mutations the coding regions and the intron-exon boundaries of this gene in 15 patients who presented chromosome 7 deletions in the region of HIC. No mutations were found in the coding region of this gene.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Cigognini D,Corneo G,Fermo E,Zanella A,Tripputi Pdoi
10.1016/j.leukres.2006.09.007subject
Has Abstractpub_date
2007-04-01 00:00:00pages
477-82issue
4eissn
0145-2126issn
1873-5835pii
S0145-2126(06)00345-6journal_volume
31pub_type
杂志文章abstract：:This study was aimed to illustrate the significance of minimal residual disease (MRD) assessment on day 22 in childhood acute lymphoblastic leukemia. MRD were measured on day 22, day 36, week 12, month 6 and month 12 by four-color flow cytometry. The 5-year cumulative incidence of relapse was significantly different f...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.leukres.2012.03.014
更新日期：2012-08-01 00:00:00
abstract：:Brazil is a wide country with huge contrasts. Its peculiarities can highlight environmental factors that could influence the frequencies of different cancers. The standard treatment and results achieved from several different areas of the country may not be found in others. The establishment of a national cooperative ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(01)00187-4
更新日期：2002-07-01 00:00:00
abstract：:We used a novel high-throughput drug screening assay, based on Luminex technology, to identify anti-myeloma agents capable of inhibiting cytokines and growth factors essential for multiple myeloma (MM) from a chemical library of 1120 compounds provided by MMRF. Tetracycline derivatives inhibited MM cell proliferation ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.12.002
更新日期：2010-07-01 00:00:00
abstract：:We wish to demonstrate new evidence for the in vivo production of interleukin-3 (IL-3). Syngeneic murine splenocytes were transplanted into lethally irradiated mice. The spleen cells in these transplant mice spontaneously produced IL-3 in cultures, and IL-3-like activity was detected in the serum. Chronological change...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(89)90138-0
更新日期：1989-01-01 00:00:00
abstract：:A national cooperative group trial was conducted in 153 patients with chronic myelogenous leukemia (CML) in chronic phase treated with oral pulse busulfan to determine if oral vitamin A can increase the time to blast crisis and enhance survival of patients. Patients diagnosed within 1 year and in the chronic phase of ...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/0145-2126(95)00032-j
更新日期：1995-09-01 00:00:00
abstract：:Induction of granulocyte maturation in HL-60 leukemic cells by DMSO (1.2%) or RA (1 microM) is accompanied by a 50-60% decrease in cellular thymidine kinase activity. Similarly, the differentiation of HL-60 cells into monocyte-macrophage phenotype by the addition of PMA is paralleled by a 60-80% suppression of thymidi...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90079-8
更新日期：1987-01-01 00:00:00
abstract：:Aneuploidy is a very common prognostic factor in multiple myeloma (MM). Nonhyperdiploidy including near-tetraploidy (NT) is a poor prognostic indicator, compared to hyperdiploidy in multiple myeloma (MM). NT results from endoduplication of hypodiploidy. We report of a 55-year-old female patient diagnosed with advanced...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2010.01.013
更新日期：2010-07-01 00:00:00
abstract：:The resistance to all trans retinoic acid (ATRA) differentiating treatment is a consequence, in most of the cases, of either increased catabolism or down regulation of ATRA uptake. Recently, we have shown that ATRA efficiency to differentiate HL-60 cells was enhanced about 30 times after its incorporation into Low Den...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(00)00019-9
更新日期：2000-06-01 00:00:00
abstract：:To examine the possibility that ETS family transcription factors, PU.1, SPI-B, ELF-1, ERG-3, ETS-1 and TEL, and homeodomain proteins, HOXA10, HOXC13, MEIS1 and PBX1B, function cooperatively, we investigated their interactions. In luciferase assays, HOXA10 and HOXC13 augmented the activity of PU.1 and SPI-B while dimin...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.07.002
更新日期：2009-03-01 00:00:00
abstract：:The efficiency of gene transfer into human leukemia cell lines by electroporation was investigated. For both transient expression (beta-galactosidase gene) and stable transformation (neomycin resistance gene), the transfer efficiency into leukemia cell lines using a square wave pulse was superior to that using an expo...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90062-x
更新日期：1991-01-01 00:00:00
abstract：:The treatment of acute myeloid leukemia (AML) did not evolve profoundly in the last decades. Some improvement has been made for acute lymphoblastic leukemia (ALL). Emerging new treatment modalities, such as immunotherapy, are now beginning to be available for acute leukemia, mostly for patients suffering from ALL. Thi...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2017.06.011
更新日期：2017-09-01 00:00:00
abstract：:The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-va...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.06.012
更新日期：2006-02-01 00:00:00
abstract：:CFW/D mice injected neonatally with a type B retrovirus, (DMBA-LV), rapidly develop thymic lymphomas. The present study examined simultaneously the karyotype and the expression of surface antigens on thymocytes from DMBA-LV treated mice at 28, 35 and 42 days of age during the development of lymphomas, and of cells fro...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(89)90122-7
更新日期：1989-01-01 00:00:00
abstract：:We determined the position of the breakpoint within the bcr gene in 22 patients with Philadelphia-positive chronic myelocytic leukemia using conventional Southern-blots and analyzed its relationship to thrombopoiesis. After DNA digestion with restriction endonucleases (Hind III, Bam HI and Bgl II), we localized the br...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90113-8
更新日期：1991-01-01 00:00:00
abstract：:The expression and release of adhesion molecules by acute myelogenous leukemia (AML) blasts was investigated in vitro. For most patients AML blasts expressed relatively low levels of membrane-bound L-selectin and Intercellular adhesion molecule 1 (ICAM-1), but their soluble forms were detected in the supernatants for ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(98)00156-8
更新日期：1999-02-01 00:00:00
abstract：:Increased DNA damage and alteration of the DNA damage response (DDR) are critical features of genetic instability presumably implicated in pathogenesis of myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). We used immunofluorescence staining of γH2AX and 53BP1 for analyzing DNA double-strand breaks (DS...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.03.011
更新日期：2017-06-01 00:00:00
abstract：:We examined the symptoms and referral rates to specialized palliative care and psychosocial oncology services of patients with acute leukemia. The Memorial Symptom Assessment Scale (MSAS) was completed by 249 adult patients with acute leukemia. Patients reported a median of 9 physical and 2 psychological symptoms, and...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.02.009
更新日期：2013-07-01 00:00:00
abstract：:A novel Philadelphia (Ph1) chromosome positive cell line, designated KYO-1, was established from the peripheral blood of a patient with chronic myelogenous leukemia (CML) in blastic crisis. Although this line had a unique capacity to differentiate spontaneously along the erythroid and monocytoid lineages as evidenced ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90314-5
更新日期：1985-01-01 00:00:00
abstract：:Oblimersen selectively targets Bcl-2 mRNA and has been shown to enhance the apoptotic activity of various antileukemic agents, including gemtuzumab ozogamicin (GO), in preclinical studies. We evaluated the efficacy and safety of oblimersen combined with GO in patients > or =60 years of age in first relapse with CD33+ ...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2005.10.025
更新日期：2006-07-01 00:00:00
abstract：:In this study we investigated the Ara-CTP-forming capacity of leukemic cells in different phases of the cell cycle. Cells from two leukemic cell lines and leukemic bone marrow cells from patients and rats (BNML model) with acute myelocytic leukemia were separated according to cell cycle phase by means of an albumin de...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(90)90164-5
更新日期：1990-01-01 00:00:00
abstract：:Among 17,633 U.S. white male insurance policy holders whose use of tobacco was characterized in a 1966 self-administered questionnaire, there were 49 deaths from non-Hodgkin's lymphoma (NHL) and 21 from multiple myeloma (MM) during a 20-year follow-up. Men who had ever smoked cigarettes had an elevated mortality from ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(92)90011-u
更新日期：1992-06-01 00:00:00
abstract：:Despite the evolution of effective frontline treatment strategies, many patients with myeloma inevitably relapse. Treatment can be complicated by the interplay of disease-, treatment-, and patient-related factors. Unfortunately, many patients eventually develop disease that is refractory to lenalidomide and bortezomib...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2014.02.008
更新日期：2014-05-01 00:00:00
abstract：:In AML, prevention of GvHD leads to better tolerance of myeloablative therapy. 66 individuals with AML in CR underwent myeloablative conditioning and transplantation with allogeneic PBPC grafts. Median presentation age was 44.5 years. Karyotyping was intermediate in 48% and of unfavourable risk in 36%. For GvHD prophy...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.leukres.2011.06.039
更新日期：2012-01-01 00:00:00
abstract：:CD200, a membrane glycoprotein of the immunoglobulin superfamily, is overexpressed in CLL. Soluble in serum CD200 (sCD200) is correlated with poor prognosis in CLL. ADAM (a disintegrin and metalloproteinase) enzymes are implicated in membrane protein shedding. ADAM28 mRNA expression in CLL was correlated with plasma s...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.04.014
更新日期：2013-07-01 00:00:00
abstract：:Although the earliest sites of hematopoietic cell and endothelial cell differentiation in the yolk sac blood islands were identified about 100 years ago, cells with hemangioblast properties have not yet been identified in vivo. Endothelial cells differentiate from angioblasts in the embryo and from endothelial progeni...
journal_title：Leukemia research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.leukres.2006.10.014
更新日期：2007-04-01 00:00:00
abstract：:Although recent advances in chemotherapy have markedly improved outcome of acute lymphoblastic leukemia (ALL), infantile ALL with MLL gene rearrangements (MLL+ALL) is refractory to chemotherapy. We have shown that specific cytokines FLT3 ligand and TGFβ1 both of which are produced from bone marrow stromal cells synerg...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2018.11.001
更新日期：2018-12-01 00:00:00
abstract：:Thermal stress induces expression of a family of heat shock proteins which may regulate the synthesis of various cellular genes. We investigated the effect of heat shock on polyadenylation in Epstein-Barr Virus (EBV) negative and EBV transformed human Burkitt's lymphoma (BL) B-cell lines. Incubation of the BL B-cell l...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(95)00063-1
更新日期：1995-11-01 00:00:00
abstract：:Despite high rates of hematologic and cytogenetic responses to imatinib therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of Ph-positive leukemia. The high frequency of BCR-ABL mutations and amplifications represents the high degree of heterogeneity in patients wi...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2003.10.007
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND/AIMS:Multiple myeloma (MM) is caused by proliferation of clonal plasma cells (cPCs) in bone marrow (BM), associated with numerical and functional defects in immune subsets. An impairment of B cell compartment is involved in onset/progression of the disease. METHODS:By flow cytometry, we studied distribution...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2016.08.008
更新日期：2016-10-01 00:00:00
abstract：:Molecular epidemiological studies have found new insights into the etiology of myelodysplastic syndromes (MDS). We analyzed the polymorphisms of 5 genes in 275 patients with primary MDS and 354 healthy controls in an attempt to identify candidate genetic risk factors for primary MDS in Chinese Han population. There wa...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2010.12.001
更新日期：2011-06-01 00:00:00
