Ectodomain shedding of CD200 from the B-CLL cell surface is regulated by ADAM28 expression.

abstract：:The concurrent development of chronic myeloid (CML) or myelomonocytic (CMML) leukemia in patients with systemic mastocytosis (SM) is a well recognized phenomenon. Although the leukemia often resembles CML in morphological and in clinical terms, a Ph-Chromosome-positive variant has not been reported in SM so far. We he...

journal_title：Leukemia research

authors： Agis H,Sotlar K,Valent P,Horny HP

更新日期：2005-10-01 00:00:00

abstract：:HSP90 is a multi-client chaperone involved in regulating a large array of cellular processes and is commonly overexpressed in many different cancer types including hematological malignancies. Inhibition of HSP90 holds promise for targeting multiple molecular abnormalities and is therefore an attractive target for hete...

journal_title：Leukemia research

authors： Lazenby M,Hills R,Burnett AK,Zabkiewicz J

更新日期：2015-06-01 00:00:00

abstract：:The tumor microenvironment (TME) is critical to the longevity of tumor B cells in chronic lymphocytic leukemia (CLL). Bone marrow mesenchymal stem cells (BMMSCs) and the cytokines they produce including IL-6 are important components of the TME in CLL. We found BMMSCs supported the survival of CLL cells in vitro throug...

journal_title：Leukemia research

authors： Zhu F,McCaw L,Spaner DE,Gorczynski RM

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to elucidate the pathologic sequence changes and associated clinical phenotypes in 9 new patients showing homozygosity for perforin gene among a total of 37 (24%) Turkish FHL families studied by linkage analysis. These 9 unrelated patients (5M/4F) were coming from consanguineous families and ...

journal_title：Leukemia research

authors： Okur H,Balta G,Akarsu N,Oner A,Patiroglu T,Bay A,Sayli T,Unal S,Gurgey A

更新日期：2008-06-01 00:00:00

abstract：:Homoharringtonine combined aclarubicin and cytarabine (HAA) has been demonstrated to achieve a high remission rate and provide a survival advantage in acute myeloid leukemia (AML). To investigate whether HAA is an ideal induction regimen for t(8;21)AML, we retrospectively analyzed the data of 140 patients from the las...

journal_title：Leukemia research

authors： Zhu HH,Jiang H,Jiang Q,Jia JS,Qin YZ,Huang XJ

更新日期：2016-05-01 00:00:00

abstract：:Imatinib is a tyrosine kinase inhibitor and is now used regularly in chronic myeloid leukaemia therapy in chronic phase with great success. This drug due its very nature of action is suspected to be teratogenic hence the patients are counseled not to get pregnant while on this drug. However in world literature few nor...

journal_title：Leukemia research

authors： Meera V,Jijina F,Shrikande M,Madkaikar M,Ghosh K

更新日期：2008-10-01 00:00:00

abstract：:Up to 30% of patients with acute myeloid leukemia (AML) and abnormal cytogenetics have persistent cytogenetic abnormalities (pCytAbnl) at morphologic complete remission (mCR). We hypothesized that the prognostic significance of pCytAbnl in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) i...

journal_title：Leukemia research

authors： Rashidi A,Cashen AF

更新日期：2015-01-01 00:00:00

abstract：:A nonsteroidal anti-inflammatory drug (NSAID)--indomethacin (IN), was found to induce apoptosis and inhibit proliferation of K562 cells and primary culture bone marrow cells from six chronic myelogenous leukemia (CML) patients. IN induced cells apoptosis and inhibited cells proliferation in a dose-and time-dependent m...

journal_title：Leukemia research

authors： Zhang G,Tu C,Zhang G,Zhou G,Zheng W

更新日期：2000-05-01 00:00:00

abstract：:We investigated Syk as a potential marker of CML progression. We observed a significant over-expression of Syk mRNA and constitutive phosphorylation of Syk Y348 in blast cells from six AP or BP-CML, but not in 15 CML in chronic phase. We could follow in vivo the recurrence of pSyk(348) throughout blast cell escape, de...

journal_title：Leukemia research

authors： Bourgne C,Janel A,Berger J,Rapatel C,Tournilhac O,Hermet E,Guerci A,Lioret F,Briançon A,Bamdad M,Boiret-Dupré N,Berger MG

更新日期：2015-03-01 00:00:00

abstract：:When exposed to the anthracycline doxorubicin, K562 cells undergo differentiation which is characterized by arrested cell division, an increased mean cell diameter, and the production of hemoglobin. The influence of expression of p28, a low-molecular weight stress protein, on the differentiation of K562 cells was exam...

journal_title：Leukemia research

authors： Kodym R,Calkins PR,Story MD

更新日期：2001-02-01 00:00:00

abstract：:The effect of VM-26, a topoisomerase II targeting drug, on IW32 murine erythroleukemia cells was investigated. The VM-26 induced IW32 cells to differentiate at a non-toxic but cytostatic concentration (0.01 microgram/ml). More than 40% of the cells were induced to synthesize hemoglobin, and cells were arrested in G2/M...

journal_title：Leukemia research

authors： Tan SK,Tang SJ,Wang MC,Hwang J,Wang FF

更新日期：1996-03-01 00:00:00

abstract：:The immunologic phenotype of the lymphocytes of 100 patients with chronic lymphocytic leukaemia (CLL) was investigated. Peripheral blood lymphocytes (PBL) were examined in all cases; in 46 patients with lymphadenopathy, a lymph node was biopsied and the histologic and immunologic patterns were assessed: 24 had a lymph...

journal_title：Leukemia research

authors： Resegotti L,Palestro G,Novero D,Micca FB,Godio L,Pistone M,Garnero M,Levis A,Stramignoni A

更新日期：1987-01-01 00:00:00

abstract：:Treatment of CMML remains a clinical challenge, with no drug demonstrating clear clinical benefit. Even if azacitidine is approved in the treatment of CMML, its role remains disputed. We report a cohort of 76 CMML patients (according to WHO classification) treated with azacitidine in 3 programs (French AZA compassiona...

journal_title：Leukemia research

authors： Adès L,Sekeres MA,Wolfromm A,Teichman ML,Tiu RV,Itzykson R,Maciejewski JP,Dreyfus F,List AF,Fenaux P,Komrokji RS

更新日期：2013-06-01 00:00:00

abstract：:The aim of this study was to describe the presenting features, the frequency and outcome of myeloid sarcoma (MS) diagnosed in our Institution from January 1995 to December 2000. Twelve MS were seen and the frequency account for only 2% of all acute myeloid leukemia (AML) patients observed in our department in the same...

journal_title：Leukemia research

authors： Breccia M,Mandelli F,Petti MC,D'Andrea M,Pescarmona E,Pileri SA,Carmosino I,Russo E,De Fabritiis P,Alimena G

更新日期：2004-11-01 00:00:00

abstract：:Although there has been much progress in the treatment of acute lymphoblastic leukemia (ALL), decreased sensitivity to chemotherapy remains a significant issue. Recent studies have shown how interactions with the bone marrow microenvironment can protect ALL cells from chemotherapy and allow for the persistence of the ...

journal_title：Leukemia research

authors： Quagliano A,Gopalakrishnapillai A,Barwe SP

更新日期：2017-05-01 00:00:00

abstract：:This study investigated radioresistance mechanisms in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100. AML-2/DX100 also showed resistance to radiation. AML-2/DX100 characterized by down-regulated catalase expression was supersensitive to exogenous hydrogen peroxide whereas they increased defense mec...

journal_title：Leukemia research

authors： Choi CH,Xu H,Bark H,Lee TB,Yun J,Kang SI,Oh YK

更新日期：2007-09-01 00:00:00

abstract：:The culture supernatants from 43 human cell lines obtained during log phase and from purified normal peripheral blood B-lymphocytes cultured at 10(6) cells ml-1 for 48 h in RPMI 1640-5% fetal calf serum were examined for interleukin-8 (IL-8) using Elisa kits. Constitutive IL-8 production was found for 14/15 B-cell lin...

journal_title：Leukemia research

authors： Srivastava MD,Srivastava R,Srivastava BI

更新日期：1993-12-01 00:00:00

abstract：:During a 4-yr period, 292 patients with acute leukaemia were studied using morphology, cytochemistry and immunologic reagents to determine the cell lineage of the leukaemia. One hundred and sixty-three cases were shown to be acute lymphoblastic leukaemia (ALL), 127 acute myeloblastic leukaemia (AML) and two cases (0.6...

journal_title：Leukemia research

authors： Ruiz-Argüelles GJ,Lobato-Mendizábal E,Marín-López A

更新日期：1988-01-01 00:00:00

abstract：:The prognostic impact of combined NPM1+/FLT3- genotype is not well defined in elderly patients with acute myeloid leukemia (AML), and in the setting of different treatments, such as cytotoxic chemotherapy (Chemo), hematopoietic cell transplantation (HCT), or hypomethylating agents (HMA). Eighty-two elderly (age >60 ye...

journal_title：Leukemia research

authors： Hefazi M,Siddiqui M,Patnaik M,Wolanskyj A,Alkhateeb H,Zblewski D,Elliott M,Hogan W,Litzow M,Al-Kali A

更新日期：2015-09-03 00:00:00

abstract：:Experimental data are in keeping with the finding that megakaryocytes isolated from normal human bone marrow may promote fibroblast growth. This effect can be significantly enhanced by interleukin (IL)-3. In this context it has been demonstrated that IL-3 induces the release of platelet-derived growth factor (PDGF) an...

journal_title：Leukemia research

authors： Schmitz B,Wickenhauser C,Thiele J,Frimpong S,Brockbals C,Selbach B,Mueller C,Fischer R

更新日期：1999-08-01 00:00:00

abstract：:Although biological and clinical features differ between B-lineage acute lymphoblastic leukemia (ALL) and T-lineage ALL (T-ALL), there have been few reports that focused on the prognosis for T-ALL in adults, primarily due to its rarity. Here, we studied the long-term outcomes and prognostic factors specific for adult ...

journal_title：Leukemia research

authors： Yanada M,Jinnai I,Takeuchi J,Ueda T,Miyawaki S,Tsuzuki M,Hatta Y,Usui N,Wada H,Morii T,Matsuda M,Kiyoi H,Okada M,Honda S,Miyazaki Y,Ohno R,Naoe T

更新日期：2007-07-01 00:00:00

abstract：:p23 is a heat shock protein 90 (Hsp90) cochaperone that plays a significant role in estrogen receptor (ER) alpha signal transduction and telomerase activity; it is up-regulated in several cancers. Recent studies have found that high level of p23 may promote tumor progression and poor prognosis in breast cancer patient...

journal_title：Leukemia research

authors： Liu X,Zou L,Zhu L,Zhang H,Du C,Li Z,Gao C,Zhao X,Bao S,Zheng H

更新日期：2012-09-01 00:00:00

abstract：:In acute lymphoblastic leukemia (ALL) patients, automated fluorescence fragment analysis (ALF) has been reported to improve the monoclonality detection rate of immunoglobulin heavy chain genes (IgH) polymerase chain reaction (PCR) analysis. This study performed complementary determining region (CDR) I and III PCR on s...

journal_title：Leukemia research

authors： Gleissner B,Maurer J,Sindram A,Reinhard R,Thiel E

更新日期：2001-09-01 00:00:00

abstract：:Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. We report here that OPN gene is transactivated by Tax protein of human T-cell leukemia virus type 1 (HTLV-1). Northern blot showed enhanced OPN gene expression in cells stably expressing Tax....

journal_title：Leukemia research

authors： Zhang J,Yamada O,Matsushita Y,Chagan-Yasutan H,Hattori T

更新日期：2010-06-01 00:00:00

abstract：:We performed a systematic review and meta-analysis of all trials comparing MMF and methotrexate as GVHD prophylaxis. Our search yielded 11 studies; 3 were randomized-control trials (RCTs). While the incidence of grades 2-4 acute GVHD was comparable, the incidence of grades 3 and 4 acute GVHD was higher in patients giv...

journal_title：Leukemia research

authors： Ram R,Yeshurun M,Vidal L,Shpilberg O,Gafter-Gvili A

更新日期：2014-03-01 00:00:00

abstract：:Survivin is a newly discovered inhibitor of the apoptosis protein, IAP, expressed during development and in human cancers. The effector cell protease receptor-1 (EPR-1) gene is oriented in the opposite direction on the same DNA double strand. Thus, the Survivin and EPR-1 (Survivin/EPR-1) genes exist in a head-to-head ...

journal_title：Leukemia research

authors： Shinozawa I,Inokuchi K,Wakabayashi I,Dan K

更新日期：2000-11-01 00:00:00

abstract：:We investigated the role of Src family kinases (SFKs) in the regulation of STAT activation in myeloid leukemia cells. Two of 6 AML cell lines displayed constitutive STAT5 activation, whereas four cell lines had constitutive SFK activity. Treatment with the SFK inhibitors suppressed STAT5 activation and decreased viabi...

journal_title：Leukemia research

authors： Ozawa Y,Williams AH,Estes ML,Matsushita N,Boschelli F,Jove R,List AF

更新日期：2008-06-01 00:00:00

abstract：:Imatinib mesylate, a Bcr/Abl tyrosine kinase inhibitor, is widely used in treating chronic myeloid leukemia. However, drug-resistance of leukemia cells becomes an emergent problem. Herein, various flavonoids were screened for applicability in leukemia treatment, and 3-hydroxyflavone (3-HF) was found to be most effecti...

journal_title：Leukemia research

authors： Kim JH,Song M,Kang GH,Lee ER,Choi HY,Lee C,Kim JH,Kim Y,Koo BN,Cho SG

更新日期：2012-09-01 00:00:00

abstract：:This study examined the immunoregulatory role of recombinant interleukin 4 (IL-4), also known as B-cell stimulating factor 1, on the generation of cytotoxic effector cells from normal and leukaemic human blood mononuclear cells. When tested on cells from normal individuals, the addition of IL-4 to mixed lymphocyte cul...

journal_title：Leukemia research

authors： Jin BQ,Lopez AF,Gillis S,Juttner CA,Vadas MA,Burns GF

更新日期：1989-01-01 00:00:00

abstract：:Heterogeneity for 5'nucleotidase has been demonstrated in chronic lymphocytic leukemia [12]. The enzyme is not detectable in the lymphocytes from the majority of patients with this disorder, but normal and even supranormal levels are found in some cases [17]. In the present studies, the properties of this ecto-nucleot...

journal_title：Leukemia research

authors： Conklyn MJ,Silber R

更新日期：1982-01-01 00:00:00