Combined treatment of 3-hydroxyflavone and imatinib mesylate increases apoptotic cell death of imatinib mesylate-resistant leukemia cells.

abstract：:Secondary acute lymphoblastic leukemia (s-ALL) is rare and poorly defined and data regarding outcomes post-transplant are lacking. Here, we report a detailed analysis of s-ALL at our Institution. Among 211 eligible patients with ALL from 2006 to 2017, 30 (14%) were defined as s-ALL and the remaining as primary ALL (p-...

journal_title：Leukemia research

authors： Ferraro F,Gao F,Stockerl-Goldstein K,Westervelt P,DiPersio JF,Ghobadi A

更新日期：2018-09-01 00:00:00

abstract：:The prognosis of patients with advanced refractory lymphoma remains poor. We have carried out a Phase II study of continuous high dose intravenous recombinant interleukin 2 alone without LAK cells in this group of patients. Eight patients have so far been treated, 4 with non-Hodgkins lymphoma and 4 with Hodgkins disea...

journal_title：Leukemia research

authors： Lim SH,Worman CP,Callaghan T,Jewell A,Smith MP,Goldstone AH

更新日期：1991-01-01 00:00:00

abstract：:Concern has been expressed recently about apparent increases in the incidence of leukaemia amongst young people living in certain geographical areas. We analysed the incidence of childhood leukaemia in South-East Scotland (excluding North-East Fife) from 1970 to 1984. There was a significant geographical variation in ...

journal_title：Leukemia research

authors： Gerrard M,Eden OB,Stiller CA

更新日期：1986-01-01 00:00:00

abstract：:Standard chemotherapic approach for MZL is missing. We are presenting our monocenter experience with 2CdA+/-rituximab. Patients received 2CdA, 5mg/m(2), weekly, for 6 weeks. Patients receiving rituximab underwent to antibody administration in association with 2CdA, or after the end of chemotherapy. Global ORR was 89.3...

journal_title：Leukemia research

authors： Orciuolo E,Buda G,Sordi E,Baraté C,Galimberti S,Ciancia E,Petrini M

更新日期：2010-02-01 00:00:00

abstract：:In this study we investigated the Ara-CTP-forming capacity of leukemic cells in different phases of the cell cycle. Cells from two leukemic cell lines and leukemic bone marrow cells from patients and rats (BNML model) with acute myelocytic leukemia were separated according to cell cycle phase by means of an albumin de...

journal_title：Leukemia research

authors： Richel DJ,Colly LP,Arentsen-Honders MW,Starrenburg CW,Willemze R

更新日期：1990-01-01 00:00:00

abstract：:Human promyelocytic leukemia cells (HL-60) mature into functional granulocytes in response to in vitro treatment with several classes of chemical agents. Compounds that increase intracellular adenosine 3':5' -cyclic monophosphate induce a modified program of maturation in which the cells demonstrate functional propert...

journal_title：Leukemia research

authors： Chaplinski TJ,Sloan GJ,Niedel JE

更新日期：1985-01-01 00:00:00

abstract：:Promoter hypermethylation occurs early in leukemogenesis and seems to be associated with poor prognosis in acute lymphoblastic leukemia (ALL). The methylation status of the promoter region of six genes was analyzed in 71 children with ALL using methylation specific PCR (MSP). Calcitonin (CALCA) and E-cadherin (CDH1) w...

journal_title：Leukemia research

authors： Paixão VA,Vidal DO,Caballero OL,Vettore AL,Tone LG,Ribeiro KB,Lopes LF

更新日期：2006-07-01 00:00:00

abstract：:The involvement of histone lysine methyltransferases (HMT) in carcinogenesis is not well understood. Here, we describe a dose-dependent growth and survival inhibitory effects of BIX-01294, a specific inhibitor of euchromatic HMT2, in promyelocytic leukemia HL-60 and NB4 cells. BIX-01294 combined with all-trans retinoi...

journal_title：Leukemia research

authors： Savickiene J,Treigyte G,Stirblyte I,Valiuliene G,Navakauskiene R

更新日期：2014-07-01 00:00:00

abstract：:We report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. The cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at di...

journal_title：Leukemia research

authors： Dalla Torre CA,de Martino Lee ML,Yoshimoto M,Lopes LF,Melo LN,Caminada de Toledo SR,Duffles Andrade JA

更新日期：2002-06-01 00:00:00

abstract：:Aneuploidy is a very common prognostic factor in multiple myeloma (MM). Nonhyperdiploidy including near-tetraploidy (NT) is a poor prognostic indicator, compared to hyperdiploidy in multiple myeloma (MM). NT results from endoduplication of hypodiploidy. We report of a 55-year-old female patient diagnosed with advanced...

journal_title：Leukemia research

authors： Yuan J,Shah R,Kulharya A,Ustun C

更新日期：2010-07-01 00:00:00

abstract：:We determined the position of the breakpoint within the bcr gene in 22 patients with Philadelphia-positive chronic myelocytic leukemia using conventional Southern-blots and analyzed its relationship to thrombopoiesis. After DNA digestion with restriction endonucleases (Hind III, Bam HI and Bgl II), we localized the br...

journal_title：Leukemia research

authors： Inokuchi K,Futaki M,Yamada T,Tanabe Y,Dan K,Shinohara T,Kuriya S,Nomura T

更新日期：1991-01-01 00:00:00

abstract：:Recently, we identified a novel chromosomal rearrangement in Hodgkin lymphoma (HL), t(4;8)(q27;q24), which targets homeobox gene ZHX2 at the recurrent breakpoint 8q24. This aberration deletes the far upstream region of ZHX2 and results in silenced transcription pinpointing loss of activatory elements. Here, we have lo...

journal_title：Leukemia research

authors： Nagel S,Schneider B,Meyer C,Kaufmann M,Drexler HG,Macleod RA

更新日期：2012-05-01 00:00:00

abstract：:The pre-B lymphoma in SL/Kh mice is a polygenic trait involving a number of host genes. In prelymphoma-stage bone marrow, transient pre-B cell expansion is induced by a host locus, Bomb1, and later followed by the emergence of a monoclonal population with a similar phenotype. To determine whether these pre-B cells rep...

journal_title：Leukemia research

authors： Hiratsuka T,Tsuruyama T,Kaszynski R,Kometani K,Minato N,Nakamura T,Tamaki K,Hiai H

更新日期：2008-02-01 00:00:00

abstract：:It has become routine practice to culture bone marrow and/or unstimulated peripheral blood for cytogenetic analysis due to associations of consistent chromosomal abnormalities within specific subgroups of leukemias. Unfortunately, two leukemias for which numerous chromosomal aberrations have been recorded, acute myelo...

journal_title：Leukemia research

authors： Macera MJ,Szabo P,Verma RS

更新日期：1989-01-01 00:00:00

abstract：:We have previously shown that HL-60 cells exposed to all-trans retinoic acid (ATRA) after treatment with a non-cytotoxic concentration of vincristine (VCR) result in granulocytic maturation and differentiation, suggesting that VCR might exhibit a synergistic action with ATRA in the treatment of acute promyelocytic leu...

journal_title：Leukemia research

authors： Leung M,Wong K

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:For most cases of idiopathic acquired sideroblastic anemia (IASA), the molecular pathogenesis is unknown, despite the consistent morphological signature of abundant pathological ringed sideroblasts with their characteristic iron-engorged mitochondria. Moderately elevated free erythrocyte protoporphyrin (FEP)...

journal_title：Leukemia research

authors： Steensma DP,Hecksel KA,Porcher JC,Lasho TL

更新日期：2007-05-01 00:00:00

abstract：:The human cell line U-937 has many features suggestive of the monocyte. It may be stimulated in vitro to develop attributes of an activated macrophage with increased phagocytosis and enhanced Fc receptor expression. We describe the establishment of a subclone designated U-937 AG through the use of a mutagenic agent. T...

journal_title：Leukemia research

authors： Peacock TE,Kay NE,Ascensao JL,Kaplan ME

更新日期：1984-01-01 00:00:00

abstract：:We evaluated the efficacy of FISH to detect chromosome anomalies in the evaluation of young (<60 years) patients with AML. Patients were enrolled in E1900, an ECOG clinical trial for AML. The protocol was designed to collect bone marrow or blood for both cytogenetic and FISH studies at study entry (diagnosis). FISH fo...

journal_title：Leukemia research

authors： Vance GH,Kim H,Hicks GA,Cherry AM,Higgins R,Hulshizer RL,Tallman MS,Fernandez HF,Dewald GW

更新日期：2007-05-01 00:00:00

abstract：:Retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (D3) are well known for inducing differentiation in many leukemic cell lines. The nuclear signalling pathways of RA and D3 are mediated through their cognate receptors, the retinoic acid receptor (RAR) and vitamin D3 receptor (VDR), respectively. Retinoid X receptor (RXR...

journal_title：Leukemia research

authors： Nakajima H,Kizaki M,Ueno H,Muto A,Takayama N,Matsushita H,Sonoda A,Ikeda Y

更新日期：1996-08-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic malignancies characterized by ineffective hematopoiesis, progressive bone marrow (BM) failure, cytogenetic and molecular abnormalities, and variable risk of progression to acute myeloid leukemia (AML). The BM microenvironment in MDS plays ...

journal_title：Leukemia research

authors： Cogle CR,Saki N,Khodadi E,Li J,Shahjahani M,Azizidoost S

更新日期：2015-10-01 00:00:00

abstract：:We compared the efficacy and toxicity of BEAM (BCNU, etoposide, cytarabine and melphalan) and BuCyE (busulfan, cyclophosphamide and etoposide), given prior to autologous stem cell transplantation (ASCT), in 65 patients with non-Hodgkin's lymphoma. Of these 65 patients, 43 received BEAM and 22 received BuCyE. Their age...

journal_title：Leukemia research

authors： Kim JE,Lee DH,Yoo C,Kim S,Kim SW,Lee JS,Park CJ,Huh J,Suh C

更新日期：2011-02-01 00:00:00

abstract：:We have earlier shown that VP-16 combined with Cyclosporin A (CsA) produces tumor specific immunity to L1210 leukemia in BDF/1 mice [Slater LM, Sweet P, Stupecky M, Reynolds JT. Cyclosporin A/VP-16 produced immunity to L1210 leukemia: the participation of cytotoxic CD(8) T-lymphocytes, Clin Immunol Immunopathol 1995;7...

journal_title：Leukemia research

authors： Slater LM,Stupecky M,Sweet P,Osann KE

更新日期：2002-02-01 00:00:00

abstract：:Expression of p14(ARF) and p16(INK4a) tumor suppressor genes was investigated in 109 patients with chronic myeloid leukemia (CML). The p14(ARF) and p16(INK4a) mRNA levels were significantly low in patients in chronic phase (CP) at presentation and high in patients treated with interferon-alpha (IFN-alpha), especially ...

journal_title：Leukemia research

authors： Cividin M,Ayrault O,Sorel N,Séité P,Brizard F,Blanchet O,Mahon FX,Guilhot F,Larsen C,Chomel JC,Brizard A

更新日期：2006-10-01 00:00:00

abstract：:Up to 30% of patients with acute myeloid leukemia (AML) and abnormal cytogenetics have persistent cytogenetic abnormalities (pCytAbnl) at morphologic complete remission (mCR). We hypothesized that the prognostic significance of pCytAbnl in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) i...

journal_title：Leukemia research

authors： Rashidi A,Cashen AF

更新日期：2015-01-01 00:00:00

abstract：:Many patients with multiple myeloma (MM) are elderly (aged >65 years) or unfit, and therefore ineligible for stem-cell transplantation. The novel agents thalidomide, bortezomib, and lenalidomide have shown improved outcomes in these patients. This article discusses the role of continuous therapy in improving patient o...

journal_title：Leukemia research

authors： Palumbo A,Niesvizky R

更新日期：2012-11-01 00:00:00

abstract：:p23 is a heat shock protein 90 (Hsp90) cochaperone that plays a significant role in estrogen receptor (ER) alpha signal transduction and telomerase activity; it is up-regulated in several cancers. Recent studies have found that high level of p23 may promote tumor progression and poor prognosis in breast cancer patient...

journal_title：Leukemia research

authors： Liu X,Zou L,Zhu L,Zhang H,Du C,Li Z,Gao C,Zhao X,Bao S,Zheng H

更新日期：2012-09-01 00:00:00

abstract：:Normal human monocytes express Fas and are susceptible to Fas ligand (FasL)-induced apoptosis. Because the myeloid leukemia cell lines HL-60 and THP-1 can be differentiated into functional monocytes and macrophages, we studied their expression of Fas and Fas ligand (FasL) to determine whether there were differentiatio...

journal_title：Leukemia research

authors： Bremner TA,Chatterjee D,Han Z,Tsan MF,Wyche JH

更新日期：1999-10-01 00:00:00

abstract：:Outcome of adult acute lymphoblastic leukemia (ALL) with central nervous system (CNS) involvement is not clearly defined. We studied 104 patients presenting with CNS involvement at diagnosis among 1493 patients (7%) included into the LALA trials, and 109 patients presenting CNS disease at the time of first relapse amo...

journal_title：Leukemia research

authors： Reman O,Pigneux A,Huguet F,Vey N,Delannoy A,Fegueux N,de Botton S,Stamatoullas A,Tournilhac O,Buzyn A,Charrin C,Boucheix C,Gabert J,Lhéritier V,Vernant JP,Fière D,Dombret H,Thomas X,GET-LALA group.

更新日期：2008-11-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) may be underreported in cancer registries such as the Netherlands Cancer Registry (NCR). Analysis of Dutch medical claims can complement NCR data on MDS and CMML. We analyzed data on 3681 MDS patients and 235 CMML patients aged ≥18 years with i...

journal_title：Leukemia research

authors： Dinmohamed AG,van Norden Y,Visser O,Posthuma EF,Huijgens PC,Sonneveld P,van de Loosdrecht AA,Jongen-Lavrencic M

更新日期：2015-02-01 00:00:00

abstract：:Inosine 5'-monophosphate (IMP) dehydrogenase catalyzes the rate-limiting reaction of guanine nucleotide biosynthesis and has been implicated in the reaction of cell growth and differentiation. We investigated the ability of mycophenolate mofetil, a prodrug of mycophenolic acid, to induce differentiation in HL-60 and U...

journal_title：Leukemia research

authors： Inai K,Tsutani H,Yamauchi T,Fukushima T,Iwasaki H,Imamura S,Wano Y,Nemoto Y,Naiki H,Ueda T

更新日期：2000-09-01 00:00:00