The combined differentiating effect of retinoic acid and vincristine on acute promyelocytic leukemia.

abstract：:Microtubular reorganisation contributing to apoptotic morphology occurs in normal and neoplastic cells undergoing apoptosis induced by cytotoxic drugs [1-3]. The aim of this study was to correlate the changes in the microtubules (MTs) with behavior of the centrosome in apoptotic cells, and to see whether post-translat...

journal_title：Leukemia research

authors： Pittman S,Geyp M,Fraser M,Ellem K,Peaston A,Ireland C

更新日期：1997-06-01 00:00:00

abstract：:The frequency of chromosomal alterations was compared among four children groups: those with Down syndrome and acute leukemia (DS/AL), those with acute leukemia (AL), those with only Down syndrome (DS) and healthy children (NC). The frequency of acquired chromosome abnormalities was larger in the AL group, followed by...

journal_title：Leukemia research

authors： Valladares A,Palma-Padilla V,Mejía-Aranguré JM,Guevara-Yánez R,Lerma-Reyes A,Salamanca-Gómez F

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Myeloid sarcoma is a tumor mass that consists of myeloblasts or immature myeloid cells at an extramedullary site. Pathological diagnosis is very difficult based on morphology if systemic signs of disease are absent. The subtype of myeloid sarcoma is also minimally identifiable in the histological picture. F...

journal_title：Leukemia research

authors： Xiao D,Shi Y,Fu C,Jia J,Pan Y,Jiang Y,Chen L,Liu S,Zhou W,Zhou J,Tao Y

更新日期：2016-03-01 00:00:00

abstract：:The process of B-cell development is characterized by the activation of the unfolded protein response. Under certain circumstances, the unfolded protein response can be manipulated in a cell death-inducing way. Therefore, tackling the unfolded protein response might be an attractive strategy in the treatment of diffus...

journal_title：Leukemia research

authors： Boelens J,Jais JP,Vanhoecke B,Beck I,Van Melckebeke H,Philippé J,Bracke M,Jardin F,Brière J,Leroy K,Offner F,Lust S

更新日期：2013-01-01 00:00:00

abstract：:The biochemical activity of terminal transferase (TdT) in the thymocytes of leukemic AKR mice has no relationship to cell cycle stage, unlike the activity of replicative DNA polymerase which increases during the period of DNA synthesis. Moreover, such assays of DNA polymerase alpha reveal a shift in enzyme activity fr...

journal_title：Leukemia research

authors： Barr RD,Barresi T,Koekebakker M,Sarin PS

更新日期：1984-01-01 00:00:00

abstract：:We investigated parental origin of rearranged chromosomes 9 and 22 (9q + and 22q -) in five patients with Ph-positive chronic myeloid leukemia (CML) using the C-banding and silver-staining methods of nucleolus organizer regions, respectively; of rearranged chromosome 21 (21q +) in seven patients with t(8;21)-positive ...

journal_title：Leukemia research

authors： Nakamura H,Itoyama T,Niikawa N,Sadamori N,Tomonaga M

更新日期：1998-09-01 00:00:00

abstract：:The aim of this study is to detect the biologic and/or prognostic significance of survivin (S) and effector protease receptor 1: EPR-1 (E) expression in acute leukemias (34 ALL and 40 AML) by using RT-PCR. S and E expressions were found in 83.8 and 20.3% of the cases, respectively. S was detected in 90%, 76.5% and E w...

journal_title：Leukemia research

authors： Oto OA,Paydas S,Tanriverdi K,Seydaoglu G,Yavuz S,Disel U

更新日期：2007-11-01 00:00:00

abstract：:We report a unique case of de novo acute promyelocytic leukemia (APL) with cryptic 15;17 rearrangements. Cytogenetically, structural rearrangements of the 6p23 region has been reported mainly in secondary leukemia. This patient had a karyotype of 46, XY, del(6)(p23) and no additional chromosomal abnormalities. Molecul...

journal_title：Leukemia research

authors： Nakase K,Wakita Y,Minamikawa K,Yamaguchi T,Shiku H

更新日期：2000-01-01 00:00:00

abstract：:In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MD...

journal_title：Leukemia research

authors： Yasunami T,Wang YH,Tsuji K,Takanashi M,Yamada Y,Motoji T

更新日期：2007-04-01 00:00:00

abstract：:A single patient who had a leukemic relapse six months after receiving a syngeneic bone marrow transplant was given "adoptive chemoimmunotherapy." Lymphocytes from the patients identical twin were alloactivated and grown in T cell growth factor in vitro. After receiving chemotherapy to reduce the number of relapsed le...

journal_title：Leukemia research

authors： Sondel PM,Kohler PC,Hank JA,Bozdech MJ,Lieberman LM,Hong R,Albertini R,Exten RE

更新日期：1984-01-01 00:00:00

abstract：:Five patients from the Kyushu area in Japan with adult T-cell leukaemia (ATL) refractory to conventional chemotherapeutic agents were treated with 5 mg/m2 of the adenosine deaminase inhibitor, 2'-deoxycoformycin (DCF), intravenously (i.v.) for 3 consecutive days, followed by 5 mg/m2 i.v. weekly. Two patients showed a ...

journal_title：Leukemia research

authors： Yamaguchi K,Yul LS,Oda T,Maeda Y,Ishii M,Fujita K,Kagiyama S,Nagai K,Suzuki H,Takatsuki K

更新日期：1986-01-01 00:00:00

abstract：:Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in folate metabolism and DNA methylation. Studies on MTHFR polymorphism in leukemia have largely focused on the protective role of MTHFR polymorphism in acute lymphoblastic leukemia (ALL). We evaluated the C677T and A1298C polymorphisms using the TaqMan...

journal_title：Leukemia research

authors： Moon HW,Kim TY,Oh BR,Min HC,Cho HI,Bang SM,Lee JH,Yoon SS,Lee DS

更新日期：2007-09-01 00:00:00

abstract：:We have earlier shown that VP-16 combined with Cyclosporin A (CsA) produces tumor specific immunity to L1210 leukemia in BDF/1 mice [Slater LM, Sweet P, Stupecky M, Reynolds JT. Cyclosporin A/VP-16 produced immunity to L1210 leukemia: the participation of cytotoxic CD(8) T-lymphocytes, Clin Immunol Immunopathol 1995;7...

journal_title：Leukemia research

authors： Slater LM,Stupecky M,Sweet P,Osann KE

更新日期：2002-02-01 00:00:00

abstract：:Patients with FLT3-ITD mutated (FLT3-ITD+) Acute Myeloid Leukemia (AML), have frequently relapsed or refractory disease and FLT3-ITD+ inhibitors have limited efficacy. Rho kinases (ROCK) are constitutively activated by FLT3-ITD+ in AML via PI3 kinase and Rho GTPase. Upon activation by ROCK, LIM kinases (LIMK) inactiva...

journal_title：Leukemia research

authors： Djamai H,Berrou J,Dupont M,Kaci A,Ehlert JE,Weber H,Baruchel A,Paublant F,Prudent R,Gardin C,Dombret H,Braun T

更新日期：2020-12-13 00:00:00

abstract：:When spleen cells of mice grafted with STIL-3 C5 cells, a leukemic T-cell line producing IL-3, are cultured in vitro, a high IL-3 activity is detectable in the culture supernatant. However, when bone marrow cells of the same grafted mice are cultured under similar conditions, hardly any IL-3 activity is detectable. To...

journal_title：Leukemia research

authors： Sugimoto K,Taniguchi S,Ogata H,Ikehara S,Fujita J,Mori KJ

更新日期：1992-09-01 00:00:00

abstract：:With Percoll density gradients, blasts from peripheral blood and bone marrow could be separated with a significant enrichment, and very often with a high degree of purity. This allowed a study of selected cases, where the separated sample exhibited chromosome abnormalities and/or an abnormal DNA content distribution (...

journal_title：Leukemia research

authors： Berneman ZN,De Bock R,Van Alsenoy L,Vingerhoets W,Van den Bergh M,Dumon J,Peetermans M

更新日期：1985-01-01 00:00:00

abstract：:We evaluated the effect of SCF on myeloid differentiation by correlating clonogenic potential (as CFU-GM), bone marrow (BM) plasma SCF levels and CD34/c-kit expression in 57 MDS samples. There was a significant correlation between low SCF levels and 'leukemic' in vitro growth, the number of clusters and the colony/clu...

journal_title：Leukemia research

authors： Cortelezzi A,Cattaneo C,Cristiani S,Sarina B,Pomati M,Silvestris I,Ibatici A,Maiolo AT

更新日期：1999-03-01 00:00:00

abstract：:We report on the clinico-biological characteristics of 20 cases of gammadelta T cell large granular lymphocyte (LGL) leukemia. All the data were compared to that of 196 cases with alphabeta T cell subtype, which represents the majority of T cell LGL leukemias. Clinical findings were quite similar in the two groups reg...

journal_title：Leukemia research

authors： Bourgault-Rouxel AS,Loughran TP Jr,Zambello R,Epling-Burnette PK,Semenzato G,Donadieu J,Amiot L,Fest T,Lamy T

更新日期：2008-01-01 00:00:00

abstract：:A clonal origin of hematopoiesis was studied by investigation of X-chromosome inactivation patterns (XCIP) in isolated granulocyte, CD14(+) and CD3(+) subpopulations obtained from bone marrow and peripheral blood of 36 female patients with primary myelodysplastic syndrome (MDS). Clonality was assessed by PCR amplifica...

journal_title：Leukemia research

authors： Cermák J,Belicková M,Krejcová H,Michalová K,Zilovcová S,Zemanová Z,Brezinová J,Sieglová Z

更新日期：2005-04-01 00:00:00

abstract：:In order to establish diagnostic criteria for hypocellular acute leukemia (HL), we have reviewed 32 cases selected on the basis of hypothetical 40% or less cellularity, by focusing on morphology, immunophenotype, karyotype and response to low dose Ara-C (LDAC) regimen and compared them with 40 cases of myelodysplastic...

journal_title：Leukemia research

authors： Nagai K,Kohno T,Chen YX,Tsushima H,Mori H,Nakamura H,Jinnai I,Matsuo T,Kuriyama K,Tomonaga M,Bennett JM

更新日期：1996-07-01 00:00:00

abstract：:In 2008 the first evidence-based Canadian consensus guideline addressing the diagnosis, monitoring and management of transfusional iron overload in patients with myelodysplastic syndromes (MDS) was published. The Canadian Consortium on MDS, comprised of hematologists from across Canada with a clinical and academic int...

journal_title：Leukemia research

authors： Leitch HA,Buckstein R,Zhu N,Nevill TJ,Yee KWL,Leber B,Keating MM,St Hilaire E,Kumar R,Delage R,Geddes M,Storring JM,Shamy A,Elemary M,Wells RA

更新日期：2018-11-01 00:00:00

abstract：:Overexpression of the Wilms' tumor gene 1 (WT1) was observed in most leukemia cells. In addition to four major isoforms of WT1, an N-terminally truncated isoforms (sWT1) has been identified. We separately quantified the transcript levels of sWT1 and full-length WT1 (fWT1) in 237 patients with acute myeloid leukemia (A...

journal_title：Leukemia research

authors： Ishikawa Y,Kiyoi H,Naoe T

更新日期：2011-05-01 00:00:00

abstract：:The levels of expression of the activation antigen CD98 were studied by mAB CAF7 in 51 newly diagnosed consecutive cases of childhood acute lymphoblastic leukemia aged from 1 to 13 years. The mean follow-up was 8 months. A wide range of CAF7 expression was observed, the highest mean fluorescence intensity exceeding th...

journal_title：Leukemia research

authors： Taskov H,Pashov A,ffmitrova E,Yordanova M,Serbinova M

更新日期：1996-01-01 00:00:00

abstract：:Chemosensitivity of purified AML blasts to daunomycin was examined under conditions of CSF stimulation and compared with clinical outcome of DNR combination chemotherapy. AML blasts from 16 patients were purified, incubated serum-free in the presence of optimal concentrations of a complete cocktail of IL-3, GM-CSF and...

journal_title：Leukemia research

authors： Santini V,Nooter K,Delwel R,Löwenberg B

更新日期：1990-01-01 00:00:00

abstract：:To examine the possibility that ETS family transcription factors, PU.1, SPI-B, ELF-1, ERG-3, ETS-1 and TEL, and homeodomain proteins, HOXA10, HOXC13, MEIS1 and PBX1B, function cooperatively, we investigated their interactions. In luciferase assays, HOXA10 and HOXC13 augmented the activity of PU.1 and SPI-B while dimin...

journal_title：Leukemia research

authors： Yamada T,Shimizu T,Sakurai T,Nanashima N,Kihara-Negishi F,Suzuki M,Fan Y,Akita M,Oikawa T,Tsuchida S

更新日期：2009-03-01 00:00:00

abstract：:The tumor microenvironment (TME) is critical to the longevity of tumor B cells in chronic lymphocytic leukemia (CLL). Bone marrow mesenchymal stem cells (BMMSCs) and the cytokines they produce including IL-6 are important components of the TME in CLL. We found BMMSCs supported the survival of CLL cells in vitro throug...

journal_title：Leukemia research

authors： Zhu F,McCaw L,Spaner DE,Gorczynski RM

更新日期：2018-03-01 00:00:00

abstract：:This study evaluated the association of -401C/T and +452C/T polymorphisms of gamma-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the -401C/T polymorphism and the risk...

journal_title：Leukemia research

authors： Organista-Nava J,Gómez-Gómez Y,Saavedra-Herrera MV,Rivera-Ramírez AB,Terán-Porcayo MA,Alarcón-Romero Ldel C,Illades-Aguiar B,Leyva-Vázquez MA

更新日期：2010-06-01 00:00:00

abstract：:Proliferative responses of mononuclear cells in liquid cultures to phytohemagglutinin, a T-cell mitogen, are depressed for a long time after allogeneic marrow transplantation. We examined the role of interleukin-2, a lymphokine important in T-cell mitogenesis, in the impaired phytohemagglutinin responses early after m...

journal_title：Leukemia research

authors： Elfenbein GJ,Adams JS,Bellis MM,Santos GW,Smith KA

更新日期：1984-01-01 00:00:00

abstract：:Malignant B-1 cells derived from NZB mice, a murine model of chronic lymphocytic leukemia, produce significantly higher levels of IL-10 mRNA than normal B-1 or B cells. IL-10 may act as an autocrine growth factor for malignant B-1 cells. By addition of antisense oligodeoxynucleotides specific for IL-10 mRNA, we were a...

journal_title：Leukemia research

authors： Peng B,Mehta NH,Fernandes H,Chou CC,Raveché E

更新日期：1995-03-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although several clinical characteristics can be associated with worse prognosis, more robust biological markers still remains uncovered. SMYD2, a member of SMYD protein family, regulates the activity of several proteins through methylation. I...

journal_title：Leukemia research

authors： Sakamoto LH,Andrade RV,Felipe MS,Motoyama AB,Pittella Silva F

更新日期：2014-04-01 00:00:00