Synergy of FLT3 inhibitors and the small molecule inhibitor of LIM kinase1/2 CEL_Amide in FLT3-ITD mutated Acute Myeloblastic Leukemia (AML) cells.

abstract：:In AML, prevention of GvHD leads to better tolerance of myeloablative therapy. 66 individuals with AML in CR underwent myeloablative conditioning and transplantation with allogeneic PBPC grafts. Median presentation age was 44.5 years. Karyotyping was intermediate in 48% and of unfavourable risk in 36%. For GvHD prophy...

journal_title：Leukemia research

authors： Novitzky N,Thomas V

更新日期：2012-01-01 00:00:00

abstract：:The human lymphoblastoid leukemic cell line (CCRF-CEM) was induced to differentiate with phorbol 12-myristate 13-acetate (PMA). During differentiation, assessed by monitoring the cluster of differentiation (CD) profile, the prosome (proteasomes, multi-catalytic proteinase) distribution and composition were studied by ...

journal_title：Leukemia research

authors： Baz A,Henry L,Chateau MT,Scherrer K,Bureau JP

更新日期：1997-11-01 00:00:00

abstract：:MicroRNA (miRNA) is an important regulator of cellular proliferation, differentiation and death. Leukemia-specific signature of miRNAs suggests that epigenetic dysregulation of miRNAs is important for leukemogenesis. We focused on the role of DNA methylation of miR-203 which targets BCR-ABL1 mRNA. The microarray analy...

journal_title：Leukemia research

authors： Shibuta T,Honda E,Shiotsu H,Tanaka Y,Vellasamy S,Shiratsuchi M,Umemura T

更新日期：2013-10-01 00:00:00

abstract：:We employed a liquid culture system to examine the in vitro effects of vincristine and vindesine on cellular incorporation of 35SO4 into leukemic cells obtained from 5 patients with chronic granulocytic leukemia in blast crisis. The per cent of 35SO4 into drug-treated as compared to saline-treated leukemic cells was c...

journal_title：Leukemia research

authors： Theodorakis ME,Goldberg J

更新日期：1984-01-01 00:00:00

abstract：:This paper reports the results of a case control study of non-Hodgkin's lymphoma in the Yorkshire Health Region. In all, 437 cases and 724 controls were interviewed. Risk factors associated with past skin conditions, family history of cancer and infectious mononucleosis, aspects of social life and contact with wood du...

journal_title：Leukemia research

authors： Cartwright RA,McKinney PA,O'Brien C,Richards ID,Roberts B,Lauder I,Darwin CM,Bernard SM,Bird CC

更新日期：1988-01-01 00:00:00

abstract：:In order to establish diagnostic criteria for hypocellular acute leukemia (HL), we have reviewed 32 cases selected on the basis of hypothetical 40% or less cellularity, by focusing on morphology, immunophenotype, karyotype and response to low dose Ara-C (LDAC) regimen and compared them with 40 cases of myelodysplastic...

journal_title：Leukemia research

authors： Nagai K,Kohno T,Chen YX,Tsushima H,Mori H,Nakamura H,Jinnai I,Matsuo T,Kuriyama K,Tomonaga M,Bennett JM

更新日期：1996-07-01 00:00:00

abstract：:We have analysed the configuration of immunoassociated genes and the karyotypes of 30 patients with acute myelocytic leukemia (AML) and 10 with chronic myelocytic leukemia in blast crisis (CML-BC). In AML, the frequencies of T-cell receptor (TcR) beta, gamma, and delta chain and immunoglobulin heavy and light chain ge...

journal_title：Leukemia research

authors： Akiyoshi TT,Kimura N,Uike N,Kozuru M,Tamura K,Takihara Y,Hisano S,Nishimura J,Kikuchi M

更新日期：1991-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is rare in Asians living in Asia and possibly in US Asians. In contrast, CLL is the most common leukemia in whites. The basis for this ethnic and geographic variation is unknown. We compared average annual age-adjusted incidence rates (AAIR) of CLL diagnosed from 1972 to 1995 among L...

journal_title：Leukemia research

authors： Gale RP,Cozen W,Goodman MT,Wang FF,Bernstein L

更新日期：2000-08-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 (1,25D) induces differentiation of myeloid leukemia cells, but resistant cells are also encountered. We studied the mechanistic basis for the resistance in a model system using enhancers of 1,25D, the antioxidant carnosic acid and a kinase inhibitor SB202190. Knock-down (KD) of JNK2p54 unexpec...

journal_title：Leukemia research

authors： Chen-Deutsch X,Garay E,Zhang J,Harrison JS,Studzinski GP

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIMS:Jumping translocations are rare cytogenetic aberrations in haematological malignancies, the pathogenesis of which remains to be fully characterised. We investigated the mechanism of formation of jumping translocations in a case of adult common acute lymphoblastic leukaemia (ALL) positive for the Ph tran...

journal_title：Leukemia research

authors： Wan TS,Ma SK,Chow EY,Li YH,Lin SY,Chan LC

更新日期：2004-10-01 00:00:00

abstract：:The inaugural meeting of the International Working Group on MDS cytogenetics convened 22-23 October 2007 in Chicago, IL. Under the sponsorship of the Myelodysplastic Syndromes Foundation, the group was organized to address the substantial need for worldwide standardized cytogenetic testing for MDS in clinical practice...

journal_title：Leukemia research

authors： Slovak ML,Dewald GW,International Working Group on MDS cytogenetics.

更新日期：2008-09-01 00:00:00

abstract：:In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MD...

journal_title：Leukemia research

authors： Yasunami T,Wang YH,Tsuji K,Takanashi M,Yamada Y,Motoji T

更新日期：2007-04-01 00:00:00

abstract：:Mutation of the tumor suppressor PTEN results in loss of its PI3-kinase counteracting function. PI3-kinase stimulates tumor formation by PKB/Akt-mediated cell proliferation and prevention of apoptosis. PI3-kinase may also activate Rho-GTPases and their regulatory GEFs to promote invasion. Here we have analyzed the fun...

journal_title：Leukemia research

authors： Strumane K,Song JY,Baas I,Collard JG

更新日期：2008-01-01 00:00:00

abstract：:FcRIII (CD16) expression on neutrophils from 17 patients with chronic myeloid leukemia (CML) was studied by flow cytometry using monoclonal antibodies. A variable proportion of CD16-negative neutrophils were found both in CML patients in chronic phase (3 out of 8 patients) and in CML patients in hematological remissio...

journal_title：Leukemia research

authors： Carulli G,Gianfaldoni ML,Azzara A,Papineschi F,Vanacore R,Minnucci S,Testi R,Ambrogi F

更新日期：1992-12-01 00:00:00

abstract：:High CD23 expression is a hallmark of B-CLL cells. It is lost during in vitro culture and can be reinduced by IL-4, albeit to a lower extent than in normal B cells. To elucidate the events controlling CD23 expression in B-CLL cells, the IL-4 mediated induction of STAT6 was investigated. Western-blot analysis demonstra...

journal_title：Leukemia research

authors： Kneitz C,Goller M,Seggewiss R,Yaman A,Serfling E,Tony HP

更新日期：2000-04-01 00:00:00

abstract：:Higher-risk myelodysplastic syndromes (MDS) are rarely curable and have a poor prognosis. We investigated the accuracy of physicians' perception of patients' health status and the patients' preferences for involvement in treatment decisions. We examined 280 newly diagnosed higher-risk elderly MDS patients paired with ...

journal_title：Leukemia research

authors： Caocci G,Voso MT,Angelucci E,Stauder R,Cottone F,Abel G,Nguyen K,Platzbecker U,Beyne-Rauzy O,Gaidano G,Invernizzi R,Molica S,Criscuolo M,Breccia M,Lübbert M,Sanpaolo G,Buccisano F,Ricco A,Palumbo GA,Niscola P,Zhan

更新日期：2015-08-01 00:00:00

abstract：:Nasal-type natural killer/T-cell (NK/T-cell) lymphomas are subtypes of non-Hodgkin's lymphoma (NHL), which are typically more clinically aggressive. There is, however relatively little understanding of nasal-type NK/T-cell lymphoma molecular pathogenesis. Thus, in this study we applied RNA sequencing to systematically...

journal_title：Leukemia research

authors： Zhang X,Zhao L,Li X,Wang X,Li L,Fu X,Sun Z,Li Z,Nan F,Chang Y,Zhang M

更新日期：2015-12-01 00:00:00

abstract：:A prospective case-control study of the aetiologic factors involved in the production of lymphoid malignancies has been conducted within a defined geographical area covering six health districts in the Yorkshire Region. Among the aspects investigated were past medical events, occupations and certain social factors. A ...

journal_title：Leukemia research

authors： Bernard SM,Cartwright RA,Bird CC,Richards ID,Lauder I,Roberts BE

更新日期：1984-01-01 00:00:00

abstract：:We have previously shown that HL-60 cells exposed to all-trans retinoic acid (ATRA) after treatment with a non-cytotoxic concentration of vincristine (VCR) result in granulocytic maturation and differentiation, suggesting that VCR might exhibit a synergistic action with ATRA in the treatment of acute promyelocytic leu...

journal_title：Leukemia research

authors： Leung M,Wong K

更新日期：1997-01-01 00:00:00

abstract：:Most clinicians caring for patients with AML do not use the word "cure" casually, since for many patients diagnosed with AML, a state of cure or even of long term survival remains elusive. Analysis of prognostic factors may aid in defining the chance for cure in various AML subtypes, and improvements are required at a...

journal_title：Leukemia research

authors： Liesveld J

更新日期：2012-12-01 00:00:00

abstract：:p23 is a heat shock protein 90 (Hsp90) cochaperone that plays a significant role in estrogen receptor (ER) alpha signal transduction and telomerase activity; it is up-regulated in several cancers. Recent studies have found that high level of p23 may promote tumor progression and poor prognosis in breast cancer patient...

journal_title：Leukemia research

authors： Liu X,Zou L,Zhu L,Zhang H,Du C,Li Z,Gao C,Zhao X,Bao S,Zheng H

更新日期：2012-09-01 00:00:00

abstract：:Mononuclear cells from a bone marrow infiltrated by plasmacytoma cells were examined by electron microscopy. An analysis was performed according to different cytoarchitectural forms of the endoplasmic reticulum (ER). Six types of plasma cells could be distinguished. The bone marrow cells were treated with an anti-idio...

journal_title：Leukemia research

authors： Renau-Piqueras J,Wetter O,Miragall F,Brandhorst D,Martinez-Ramon A

更新日期：1984-01-01 00:00:00

abstract：:The ability of A-MuLV to transform bone marrow cells on in vitro culture in agarose is enhanced by inclusion of conditioned media during infection and culture. The conditioned medium of a non-virus producing A-MuLV transformed fibroblast cell line was synergistic with medium from Whitlock-Witte long-term bone marrow c...

journal_title：Leukemia research

authors： Palumbo GJ,Ozanne B,Kettman JR

更新日期：1991-01-01 00:00:00

abstract：:The continuous human promyeloid cell line HL60 may be induced to differentiate into neutrophils by the presence of 1.25% dimethylsulphoxide (DMSO) and related compounds [4]. When treated with 12-O-tetradecanoylphorbol-13-acetate (TPA), the cells exhibit may features characteristic of monocytes/macrophages [13]. In bot...

journal_title：Leukemia research

authors： Toksoz D,Bunce CM,Stone PC,Michell RH,Brown G

更新日期：1982-01-01 00:00:00

abstract：:We studied 98 female patients in remission (2-240 months) from childhood ALL to determine the clonality status of their hematopoiesis. Thirty-one (31.6%) were heterozygous at the PGK locus for the BstX1 endonuclease restriction site, permitting X-linked clonality assays to be performed. Two patients were in relapse at...

journal_title：Leukemia research

authors： Busque L,Ilaria R Jr,Tantravahi R,Weinstein H,Gilliland DG

更新日期：1994-02-01 00:00:00

abstract：:Information about the expression of some myelomonocytic markers in lymphocytes of patients with B-CLL is scarce. We studied the CD13, CD14, CD11c and CD68 surface antigens in 42 controls and in 38 patients with B-CLL to detect their possible reactivity. Eighty-nine percent of B-CLL expressed very strongly the CD14 ant...

journal_title：Leukemia research

authors： Woessner S,Florensa L,Besses C,Vilà RM,Gallés C,Palou L,Sabrafen JS

更新日期：1992-01-01 00:00:00

abstract：:The PRAME gene encodes an antigen recognized by autologous T lymphocytes and is expressed in trophoblasts, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detecting MRD. We demonstrate expression of PRAME by RT-PCR in the peripheral blood or bone marrow...

journal_title：Leukemia research

authors： Proto-Siqueira R,Falcão RP,de Souza CA,Ismael SJ,Zago MA

更新日期：2003-05-01 00:00:00

abstract：:Immunophenotypic classification of the acute leukemias (AcL) is of well documented value in those of lymphoid or uncertain origin and of increasing importance in those of nonlymphoid origin. Most of these studies have been performed on viable cell suspensions. To study the efficacy of a simpler immunohistochemical app...

journal_title：Leukemia research

authors： Vago JF,Hurtubise PE,Martelo OJ,Swerdlow SH

更新日期：1987-01-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to be cytotoxic for normal and transformed cell lines. One of the intracellular targets for NO action is glutathione (GSH). GSH determinates cellular redox potential and modulates several biological events. During oxidative and nitrosative stress, glutathione system imbalance is associ...

journal_title：Leukemia research

authors： Santos-Silva MC,Freitas MS,Assreuy J

更新日期：2006-02-01 00:00:00

abstract：:Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p<0.001) and do...

journal_title：Leukemia research

authors： Lönnerholm G,Thörn I,Sundström C,Frost BM,Abrahamsson J,Behrendtz M,Heldrup J,Jacobsson S,Li A,Olofsson T,Porwit A,Söderhäll S,Larsson R,Forestier E

更新日期：2009-01-01 00:00:00