当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Management of AML: who do we really cure?

Management of AML: who do we really cure?

Abstract：

:Most clinicians caring for patients with AML do not use the word "cure" casually, since for many patients diagnosed with AML, a state of cure or even of long term survival remains elusive. Analysis of prognostic factors may aid in defining the chance for cure in various AML subtypes, and improvements are required at all stages of AML treatment if cure is to be realized in a higher proportion of patients. In order to improve outcome, requirements will include targeting the mutation responsible for the leukemia emergence, suppressing the stem or progenitor cell which acquires the mutation, and the capability to deliver therapy to patients who themselves have adverse co-morbidities.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Liesveld J

doi

10.1016/j.leukres.2012.08.006

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1475-80

issue

12

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(12)00339-6

journal_volume

36

pub_type

杂志文章,评审

相关文献

LEUKEMIA RESEARCH文献大全
  • Ph-Chromosome-positive chronic myeloid leukemia with associated bone marrow mastocytosis.

    abstract：:The concurrent development of chronic myeloid (CML) or myelomonocytic (CMML) leukemia in patients with systemic mastocytosis (SM) is a well recognized phenomenon. Although the leukemia often resembles CML in morphological and in clinical terms, a Ph-Chromosome-positive variant has not been reported in SM so far. We he...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.04.004

    authors： Agis H,Sotlar K,Valent P,Horny HP

    更新日期：2005-10-01 00:00:00

  • Analysis of chromosome 12p deletion in plasma cell dyscrasias.

    abstract：:The prognostic relevance of 12p deletion is controversial in multiple myeloma (MM) and the status of 12p deletion is unknown in other plasma cell disorders. We investigated 12p deletion in 88 patients with MM, 19 patients with monoclonal gammopathy of undetermined significance (MGUS), and 17 patients with plasma cell ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2011.07.030

    authors： Jiang N,Qi C,Yu L,Ning Y,An G,Qiu L,Chang H

    更新日期：2012-01-01 00:00:00

  • Circulating myeloid dendritic cell directly isolated from patients with chronic myelogenous leukemia are functional and carry the bcr-abl translocation.

    abstract：:Leukemic bcr-abl positive dendritic cells (DCs) are likely to be present in vivo in chronic myelogenous leukemia (CML) patients, but no data are available on their functional qualities. We analyzed the circulating BDCA-1+ myeloid DC compartment in 15 chronic phase CML patients. Phenotypic features of CML DCs were comp...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2005.11.028

    authors： Orsini E,Calabrese E,Maggio R,Pasquale A,Nanni M,Trasarti S,Tafuri A,Guarini A,Foa R

    更新日期：2006-07-01 00:00:00

  • Simultaneous development of humoral and cellular tumor-specific immunity against L1210 mouse leukemia.

    abstract：:We have recently described that a variant of L1210 leukemia cell (L1210/LN-1) originally fused with Lesch-Nyhan fibroblast is highly immunogenic for inducing tumor-specific transplantation immunity in (BALB/cxDBA/2)F1 mice. This finding has clearly been confirmed in the present study by in-vitro cell-mediated cytotoxi...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(85)90316-9

    authors： Kawashima K,Isobe K,Nagase F,Yokochi T,Nagura E,Hasegawa Y,Morishita H,Yamada K,Nakashima I

    更新日期：1985-01-01 00:00:00

  • Aspiration biopsy-nucleic acid diagnosis of thyroid malignant lymphoma by vectorette PCR: experience of eight cases.

    abstract：:The usefulness of a new method to detect B-cell monoclonality named VR, which is a combination of the digestion with restriction enzymes and vectorette PCR, in aspiration biopsy-nucleic acid diagnosis (ABND) of thyroid malignant lymphoma was investigated. ABND was performed in 12 patients in whom malignant lymphoma wa...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2007.03.019

    authors： Takano T,Asahi S,Matsuzuka F,Hidaka Y,Yoshida H,Miyauchi A

    更新日期：2008-01-01 00:00:00

  • Expression of IL-18 and its receptor in human leukemia cells.

    abstract：:The importance of IL-18, although clearly established in solid tumors, has not been fully elucidated in human hematopoietic neoplasms. Here we examined the mRNA and protein for IL-18 in eight human hematopoietic cell lines representing different lineages and neoplasms including leukemia, lymphoma and others. Our resul...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(03)00005-5

    authors： Zhang B,Ma XT,Zheng GG,Li G,Rao Q,Wu KF

    更新日期：2003-09-01 00:00:00

  • Expression of a 215,000-dalton nuclear envelope protein decreases during cell maturation.

    abstract：:The monoclonal antibody AGF2.3 identifies a nuclear envelope protein expressed at high levels in most transformed cell lines and weakly expressed in or absent from normal tissues and primary cell cultures. Here we report that expression of AGF2.3 antigen relates to the maturation status of cells. When HL60 cells were ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(86)90235-3

    authors： Brown G,Bunce CM,Johnson GD,Lord JM

    更新日期：1986-01-01 00:00:00

  • Effect of granulocyte colony-stimulating factor priming combined with low-dose cytarabine and homoharringtonine in higher risk myelodysplastic syndrome patients.

    abstract：:As sensitization of leukemia cells with granulocyte colony-stimulating factor (G-CSF) can enhance the cytotoxicity of chemotherapy in myeloid malignancies, a pilot study was conducted in order to evaluate the effect of G-CSF priming combined with low-dose chemotherapy in patients with higher risk myelodysplastic syndr...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2016.07.005

    authors： Wang FX,Zhang WG,He AL,Cao XM,Chen YX,Zhao WH,Yang Y,Wang JL,Zhang PY,Gu LF

    更新日期：2016-09-01 00:00:00

  • Flow cytometric detection of cytoplasmic antigens in acute leukemias: implications for lineage assignment.

    abstract：:This study aimed at optimizing the conditions for flow cytometric detection of myeloperoxidase (MPO), cytoplasmic CD3 (cCD3), and cytoplasmic CD22 (cCD22), which seem to be more reliable lineage-associated markers in acute leukemia than surface antigens. Fixation methods employing saponin as detergent resulted in accu...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(93)90102-q

    authors： Drach D,Drach J,Glassl H,Gattringer C,Huber H

    更新日期：1993-05-01 00:00:00

  • Infectious feline leukaemia virus is erythrosuppressive in vitro.

    abstract：:The direct effect of the feline leukaemia virus (FeLV) on erythroid colony formation in vitro was investigated. Bone marrow mononuclear cells (BMMC) from FeLV-naïve, specific-pathogen-free (SPF), adult cats were inoculated with FeLVs of characterized strains and biologically cloned subgroups and the subsequent develop...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(86)90237-7

    authors： Rojko JL,Cheney CM,Gasper PW,Hamilton KL,Hoover EA,Mathes LE,Kociba GJ

    更新日期：1986-01-01 00:00:00

  • All-trans and 9-cis retinoic acid enhance 1,25-dihydroxyvitamin D3-induced monocytic differentiation of U937 cells.

    abstract：:Retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (D3) are well known for inducing differentiation in many leukemic cell lines. The nuclear signalling pathways of RA and D3 are mediated through their cognate receptors, the retinoic acid receptor (RAR) and vitamin D3 receptor (VDR), respectively. Retinoid X receptor (RXR...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(96)00020-3

    authors： Nakajima H,Kizaki M,Ueno H,Muto A,Takayama N,Matsushita H,Sonoda A,Ikeda Y

    更新日期：1996-08-01 00:00:00

  • Endothelial cell receptors on leukemic plasma cells.

    abstract：:The binding of peripheral blood mononuclear cells of 7 patients with plasma cell leukemia to rat lymph node high endothelial venules has been studied in vitro. The mononuclear cells adhered selectively to the high endothelial venules. Their neoplastic origin was proved by in situ demonstration of their monoclonal cyto...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(89)90100-8

    authors： Kalász V,Pap T,Csanaky G,Kelényi G

    更新日期：1989-01-01 00:00:00

  • Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia.

    abstract：:Discovering genetic predictors of childhood acute lymphoblastic leukemia (ALL) necessitates the evaluation of novel factors including maternal genetic effects, which are a proxy for the intrauterine environment, and robust epidemiologic study designs. Therefore, we evaluated five maternal and offspring xenobiotic meta...

    journal_title：Leukemia research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.leukres.2013.01.020

    authors： Nousome D,Lupo PJ,Okcu MF,Scheurer ME

    更新日期：2013-05-01 00:00:00

  • Bone marrow niche in the myelodysplastic syndromes.

    abstract：:The myelodysplastic syndromes (MDS) are a diverse group of clonal hematopoietic malignancies characterized by ineffective hematopoiesis, progressive bone marrow (BM) failure, cytogenetic and molecular abnormalities, and variable risk of progression to acute myeloid leukemia (AML). The BM microenvironment in MDS plays ...

    journal_title：Leukemia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.leukres.2015.06.017

    authors： Cogle CR,Saki N,Khodadi E,Li J,Shahjahani M,Azizidoost S

    更新日期：2015-10-01 00:00:00

  • Effects of recombinant G-CSF and GM-CSF on the growth in methylcellulose and suspension of the blast cells in acute myeloblastic leukemia.

    abstract：:The effects of two recombinant human CSFs (G-CSF and GM-CSF) on the growth of blast progenitors from 36 acute myeloblastic leukemia patients were studied in methylcellulose and suspension cultures. Blast colony formation in methylcellulose and the growth of blast progenitors in suspension were stimulated by G-CSF or G...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(88)90063-x

    authors： Murohashi I,Nagata K,Suzuki T,Maruyama Y,Nara N

    更新日期：1988-01-01 00:00:00

  • BCL2 gene polymorphism could predict the treatment outcomes in acute myeloid leukemia patients.

    abstract：:The Bcl-2 protein inhibits apoptosis (programmed cell death) of hematopoietic stem cells induced by a variety of noxious stimuli, thus mediating chemoresistance and decreasing chemosensitivity. Higher Bcl-2 expression correlates to an adverse outcome following therapy for acute myeloid leukemia (AML). The current stud...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2009.05.009

    authors： Moon JH,Sohn SK,Lee MH,Jang JH,Kim K,Jung CW,Kim DH

    更新日期：2010-02-01 00:00:00

  • Comparison of 18F FDG PET-CT AND CECT in pretreatment staging of adults with Hodgkin's lymphoma.

    abstract：:We compared 2-[fluorine-18] fluoro-2-deoxy-d-glucose PET-CT and contrast-enhanced computed tomography (CECT) in 62 consecutive patients with newly diagnosed Hodgkin Lymphoma (HL), aiming to provide evidences that may spare CECT from the staging procedures of HL patients. Among a total of 1448 nodal sites examined, dis...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2018.11.018

    authors： Panebianco M,Bagni O,Cenfra N,Mecarocci S,Ortu La Barbera E,Filippi L,Codacci-Pisanelli G,Biondi T,Laghi A,Cimino G

    更新日期：2019-01-01 00:00:00

  • Good riddance to the term "refractory anemia" in myelodysplastic syndromes.

    abstract：:The term "refractory anemia" was used in 1937 by Cornelius Parker Rhoads to describe patients whose anemia did not improve after treatment with liver extract or iron salts, and this term has been used to denote patients with certain subtypes of myelodysplastic syndromes (MDS) since the 1976 and 1982 French-American-Br...

    journal_title：Leukemia research

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.leukres.2016.10.007

    authors： Steensma DP

    更新日期：2016-12-01 00:00:00

  • Low impact of cardiovascular adverse events on anagrelide treatment discontinuation in a cohort of 232 patients with essential thrombocythemia.

    abstract：:This retrospective study of the thrombocythemia Italian registry (RIT) documented that 71 (30.6%) out of 232 ET patients experienced 88 cardiovascular adverse events (CV-AEs) during anagrelide treatment (522 pt-y). The rate of CV-AEs was: 24.1% for palpitations, 4.3% for angina, 3.5% for arterial hypertension, 3.0% fo...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2011.06.030

    authors： Gugliotta L,Tieghi A,Tortorella G,Scalzulli PR,Ciancia R,Lunghi M,Cacciola E,Cacciola R,Candoni A,Crugnola M,Codeluppi K,Usala E,Specchia G,Martinelli V,Palmieri F,Pierri I,Liberati AM,Iurlo A,Grossi A,Vannucchi AM

    更新日期：2011-12-01 00:00:00

  • Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma.

    abstract：:Recently, we identified a novel chromosomal rearrangement in Hodgkin lymphoma (HL), t(4;8)(q27;q24), which targets homeobox gene ZHX2 at the recurrent breakpoint 8q24. This aberration deletes the far upstream region of ZHX2 and results in silenced transcription pinpointing loss of activatory elements. Here, we have lo...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2011.10.019

    authors： Nagel S,Schneider B,Meyer C,Kaufmann M,Drexler HG,Macleod RA

    更新日期：2012-05-01 00:00:00

  • Expressions of the VLA-4, LFA-1 and Mac-1 integrins in eosinophil migration in a case of chronic eosinophilic leukaemia.

    abstract：:Migration of eosinophil (Eo) into tissues is a hallmark of chronic eosinophilic leukaemia (CEL), but the exact mechanism involved in cell migration is unknown. We report on a patient with CEL who presented high expressions of VLA-4, LFA-1 and Mac-1 integrins on the Eo surface, increased chemotaxis of Eo to eotaxin, de...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2006.07.025

    authors： Lima CS,Franco-Penteado CF,Canalli AA,Conran N,Lorand-Metze I,Costa FF,Ferreira HH

    更新日期：2007-05-01 00:00:00

  • miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia.

    abstract：:microRNA profiling of acute myeloid leukemia patient samples identified miR-125a as being decreased. Current literature has investigated miR-125a's role in normal hematopoiesis but not within acute myeloid leukemia. Analysis of the upstream region of miR-125a identified several CpG islands. Both precursor and mature m...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.12.021

    authors： Ufkin ML,Peterson S,Yang X,Driscoll H,Duarte C,Sathyanarayana P

    更新日期：2014-03-01 00:00:00

  • Multidrug resistance protein expression of adult T-cell leukemia/lymphoma.

    abstract：:In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MD...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2006.10.012

    authors： Yasunami T,Wang YH,Tsuji K,Takanashi M,Yamada Y,Motoji T

    更新日期：2007-04-01 00:00:00

  • The morphological subcategories of acute monocytic leukemia (M5a and M5b) share similar immunophenotypic and cytogenetic features and clinical outcomes.

    abstract：:Acute monocytic leukemia (M5) is a subtype of acute myeloid leukemia (AML) with two distinct morphologic subcategories, M5a and M5b. We compared the immunophenotype, cytogenetics and clinical outcome of AML M5 with non-M5 AML and also compared M5a with M5b. One hundred and twelve M5 (76 M5a, 36 M5b) and 726 non-M5 cas...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2007.06.019

    authors： Villeneuve P,Kim DT,Xu W,Brandwein J,Chang H

    更新日期：2008-02-01 00:00:00

  • A model system in haematology and immunology: the human monocytic cell line MONO-MAC-1.

    abstract：:MONO-MAC-1 is a human cell line with properties of blood monocytes, which can be used as a model system to study monocytic functions in vitro. In the present study, we prepared a karyotype of MONO-MAC-1, analysed the growth behaviour, determined the presence of differentiation-associated antigens and studied the expre...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/s0145-2126(96)00129-4

    authors： Steube KG,Teepe D,Meyer C,Zaborski M,Drexler HG

    更新日期：1997-04-01 00:00:00

  • Impaired cell-mediated immunity to cytomegalovirus (CMV) in leukemic children with prolonged CMV viruria.

    abstract：:To determine the role of cell-mediated immunity (CMI) to cytomegalovirus (CMV) in leukemic children after CMV infection, CMI to CMV antigen was studied using CMV-specific lymphocyte blastogenic responses (LBR) and interferon (IFN) production. Four children, who continuously secreted CMV in urine more than 2 years afte...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(94)90086-8

    authors： Ihara T,Yasuda N,Isaji M,Torigoe S,Ito M,Kamiya H,Sakurai M

    更新日期：1994-07-01 00:00:00

  • Effects of c-KIT mutations on expression of the RUNX1/RUNX1T1 fusion transcript in t(8;21)-positive acute myeloid leukemia patients.

    abstract：:The aim of this study was to evaluate effect of c-KIT mutations on RUNX1/RUNX1T1 fusion transcript expression in patients with t(8;21)-positive AML. Fifty patients diagnosed with t(8;21)-positive AML for recent 10 years were enrolled. Patients with c-KIT mutations tended to achieve a greater than 3-log reduction in RU...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.02.010

    authors： Park SH,Chi HS,Cho YU,Jang S,Park CJ

    更新日期：2013-07-01 00:00:00

  • Reduced-intensity conditioning therapy with fludarabine, idarubicin, busulfan and cytarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.

    abstract：:We retrospectively analyzed allogenic stem cell transplantation (allo-SCT) outcomes in 82 patients with AML or MDS were conditioned with fludarabine, idarubicin, intravenous-busulfan and cytarabine (FIBA) or busulfan and cyclophosphamide (BuCy). Compared to BuCy regimen, reduced intensity conditioning (RIC) with FIBA ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2013.08.016

    authors： Gao L,Gao L,Gong Y,Zhang C,Chen XH,Zhang X

    更新日期：2013-11-01 00:00:00

  • Catalogue of Epstein-Barr virus (EBV) receptors on human malignant and non-malignant hematopoietic cell lines.

    abstract：:Epstein-Barr virus (EBV) can induce a broad spectrum of hematological diseases, especially in immune deficient patients. We assayed for receptor for EBV (EBVR) using fluoresceinated viral particles on 44 human hematopoietic cell lines derived from patients with T, B, and non-T, non-B acute lymphocytic leukemia (ALL), ...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/0145-2126(85)90085-2

    authors： Tatsumi E,Harada S,Kuszynski C,Volsky D,Minowada J,Purtilo DT

    更新日期：1985-01-01 00:00:00

  • Physical and functional interactions between hematopoietic cell-specific ETS transcription factors and homeodomain proteins.

    abstract：:To examine the possibility that ETS family transcription factors, PU.1, SPI-B, ELF-1, ERG-3, ETS-1 and TEL, and homeodomain proteins, HOXA10, HOXC13, MEIS1 and PBX1B, function cooperatively, we investigated their interactions. In luciferase assays, HOXA10 and HOXC13 augmented the activity of PU.1 and SPI-B while dimin...

    journal_title：Leukemia research

    pub_type： 杂志文章

    doi：10.1016/j.leukres.2008.07.002

    authors： Yamada T,Shimizu T,Sakurai T,Nanashima N,Kihara-Negishi F,Suzuki M,Fan Y,Akita M,Oikawa T,Tsuchida S

    更新日期：2009-03-01 00:00:00