Effect of granulocyte colony-stimulating factor priming combined with low-dose cytarabine and homoharringtonine in higher risk myelodysplastic syndrome patients.

abstract：:Vinorelbine chemotherapy with G-CSF stimulation is the standard mobilization regimen in Switzerland for multiple myeloma patients. However, with the increasing use of bortezomib during induction treatment, adding the neurotoxic compound vinorelbine for mobilization may aggravate bortezomib-induced polyneuropathy. In t...

journal_title：Leukemia research

authors： Keller S,Seipel K,Novak U,Mueller BU,Taleghani BM,Leibundgut K,Pabst T

更新日期：2015-07-01 00:00:00

abstract：:A new cell line, designated MO1043, was established from the peripheral blood (PB) of a patient with B-cell chronic lymphocytic leukemia (CLL). Both the PB leukemia cells and MO1043 were found to have an abnormal cytogenetic marker of trisomy 12, the most common cytogenetic abnormality in CLL. In addition, both the PB...

journal_title：Leukemia research

authors： Kawata A,Han T,Dadey B,Weier HU,Okazaki M,Yokota S,Fukiage T,Xiao H,Block AM,Barcos M

更新日期：1993-10-01 00:00:00

abstract：:In acute lymphoblastic leukemia (ALL) patients, automated fluorescence fragment analysis (ALF) has been reported to improve the monoclonality detection rate of immunoglobulin heavy chain genes (IgH) polymerase chain reaction (PCR) analysis. This study performed complementary determining region (CDR) I and III PCR on s...

journal_title：Leukemia research

authors： Gleissner B,Maurer J,Sindram A,Reinhard R,Thiel E

更新日期：2001-09-01 00:00:00

abstract：:In vivo infection by HTLV-I is characterized by the lack of virus expression in the host's infected cells and in most cases it is clinically inapparent. The present study shows that exposure of HTLV-I-infected human T-cells to a maximal non-toxic dose of 3-MC remarkably enhances virus expression. This stimulatory effe...

journal_title：Leukemia research

authors： Feldman G,Aboud M

更新日期：1993-05-01 00:00:00

abstract：:Exogenous expression of the transcription factor Scl (Tal1) in WEHI-3B D+ myelomonocytic leukemia cells interferes with their capacity to respond to all-trans retinoic acid (ATRA) induced differentiation; combination of ATRA with LiCl, however, circumvents the inhibition of differentiation produced by Scl. To gain inf...

journal_title：Leukemia research

authors： Rice AM,Holtz KM,Karp J,Rollins S,Sartorelli AC

更新日期：2004-11-01 00:00:00

abstract：:Pro-apoptotic signalling upon toll-like receptor (TLR) stimulation in myeloid cells is normally antagonized by the simultaneous activation of anti-apoptotic pathways. We have previously reported that IFN-alpha can sensitize human monocytes to apoptosis induction by lipopolysaccharide (LPS). Based on these results we i...

journal_title：Leukemia research

authors： Lehner M,Bailo M,Stachel D,Roesler W,Parolini O,Holter W

更新日期：2007-12-01 00:00:00

abstract：:MicroRNA (miRNA) is an important regulator of cellular proliferation, differentiation and death. Leukemia-specific signature of miRNAs suggests that epigenetic dysregulation of miRNAs is important for leukemogenesis. We focused on the role of DNA methylation of miR-203 which targets BCR-ABL1 mRNA. The microarray analy...

journal_title：Leukemia research

authors： Shibuta T,Honda E,Shiotsu H,Tanaka Y,Vellasamy S,Shiratsuchi M,Umemura T

更新日期：2013-10-01 00:00:00

abstract：:The acid phosphatase (AP), beta-glucuronidase (BG), and alpha-naphthyl-acetate esterase (ANAE) distribution and the morphology of stage 0 B-CLL lymphocytes were studied. The results were compared with the same hydrolase equipment and morphology of normal B-cell populations showing the B-CLL-like phenotype, and thus re...

journal_title：Leukemia research

authors： Palestro G,Novero D,Godio L,Micca FB,Resegotti L,Stramignon A

更新日期：1987-01-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) in children has been reported to be associated with various constitutional anomalies; however, it has not been described previously in patients with Griscelli syndrome (GS). In this report, we present a case with GS and refractory anemia with an excess of blasts. We believe that careful ...

journal_title：Leukemia research

authors： Cetin M,Hiçsönmez G,Göğüş S

更新日期：1998-09-01 00:00:00

abstract：:Hybrid (C56BL/6 x DBA) (BDF1; H-2b/H-2d) mice bearing the P815 leukemia (H-2d) were grafted with a (CBA x C57BL/6)F1 (CBF1; H-2k/H-2b) cell suspension, comprising bone marrow cells (BMC; 25 x 10(6)/mouse) and spleen cells (SC; 55 x 10(6)/mouse) on day-4, then treated with cyclophosphamide (200 mg/kg) on day-2 and fina...

journal_title：Leukemia research

authors： Seledtsov VI,Seledtsova GV,Avdeev EV,Samarin DM,Kozlov VA

更新日期：1997-10-01 00:00:00

abstract：:It is generally accepted that morphologically recognizable bone marrow (BM) cells are derived from progenitor cells committed to a specific line of haematopoietic differentiation [51]. The origin and morphological identity of such progenitor cells is not yet known and the question, whether there is a single pluripoten...

journal_title：Leukemia research

authors： Islam A

更新日期：1985-01-01 00:00:00

abstract：:The serum levels of interleukin 6 (IL6) are known to be elevated in two diseases of the elderly age, myelodysplastic syndrome (MDS) and multiple myeloma (MM). Authors suppose that one of the possible causes of this elevation could be a difference between these patients and healthy subjects in the frequency of polymorp...

journal_title：Leukemia research

authors： Aladzsity I,Kovács M,Semsei A,Falus A,Szilágyi A,Karádi I,Varga G,Füst G,Várkonyi J

更新日期：2009-11-01 00:00:00

abstract：:Assessment of treatment response in acute leukemia is routinely performed after therapy via bone marrow biopsy. We investigated the use of positron emission tomography (PET) for early assessment of treatment response in patients with acute myeloid leukemia (AML), using the proliferation marker 3'-deoxy-3'-[(18)F]fluor...

journal_title：Leukemia research

authors： Vanderhoek M,Juckett MB,Perlman SB,Nickles RJ,Jeraj R

更新日期：2011-03-01 00:00:00

abstract：:It has been suggested that acidic isoferritins play a major role in the regulation of human granulocyte-macrophage (CFU-GM) proliferation. Such regulatory isoferritins are said to occur in some human tissues including both leukaemic and normal leucocytes, and certain established cell lines. They are glycosylated and b...

journal_title：Leukemia research

authors： Wyllie F,Jacobs A,Waradanukul K,Worwood M,Wagstaff M

更新日期：1984-01-01 00:00:00

abstract：:The onset of acute myeloid leukemia following ionizing radiation or alkylating agent exposure is antedated months to years by the development of 'preleukemia', or secondary myelodysplastic syndrome (sMDS). Mitochondrial abnormalities induced by chloramphenicol and clonal deletions of mitochondrial DNA (mt DNA) in the ...

journal_title：Leukemia research

authors： Hatfill SJ,La Cock CJ,Laubscher R,Downing TG,Kirby R

更新日期：1993-11-01 00:00:00

abstract：:Amsacrine is an acridine derivative that has been extensively evaluated for its antitumor activity in recent years. Amsacrine is active in the treatment of acute leukemias and lymphomas but largely ineffective in solid tumors. In acute myelogenous leukemia, amsacrine is as effective as the two most active drugs, cytar...

journal_title：Leukemia research

authors： Cassileth PA,Gale RP

更新日期：1986-01-01 00:00:00

abstract：:In order to establish diagnostic criteria for hypocellular acute leukemia (HL), we have reviewed 32 cases selected on the basis of hypothetical 40% or less cellularity, by focusing on morphology, immunophenotype, karyotype and response to low dose Ara-C (LDAC) regimen and compared them with 40 cases of myelodysplastic...

journal_title：Leukemia research

authors： Nagai K,Kohno T,Chen YX,Tsushima H,Mori H,Nakamura H,Jinnai I,Matsuo T,Kuriyama K,Tomonaga M,Bennett JM

更新日期：1996-07-01 00:00:00

abstract：:Two AML patients, whose leukemic clonogenic cells totally reacted to the anti-lactofucopentaose III S4-7 monoclonal antibody (MoAb), underwent autologous bone marrow transplantation, in first complete remission, after in-vitro purging with S4-7 MoAb and complement. After ablative chemotherapy (BAVC regimen) and reinfu...

journal_title：Leukemia research

authors： Ferrero D,De Fabritiis P,Amadori S,De Felice L,Gallo E,Meloni G,Pregno P,Pulsoni A,Simone F,Tarella C

更新日期：1987-01-01 00:00:00

abstract：:Inosine 5'-monophosphate (IMP) dehydrogenase catalyzes the rate-limiting reaction of guanine nucleotide biosynthesis and has been implicated in the reaction of cell growth and differentiation. We investigated the ability of mycophenolate mofetil, a prodrug of mycophenolic acid, to induce differentiation in HL-60 and U...

journal_title：Leukemia research

authors： Inai K,Tsutani H,Yamauchi T,Fukushima T,Iwasaki H,Imamura S,Wano Y,Nemoto Y,Naiki H,Ueda T

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Chromosomal aberrations at the ETV6 gene locus on 12p13.2 are common in bone marrow samples involved by blastic plasmacytoid dendritic cell neoplasm (BPDCN). However, their pathogenic role, incidence in cutaneous BPDCN lesions, and clinical significance have not been assessed systematically. RESULTS:The stu...

journal_title：Leukemia research

authors： Tang Z,Li Y,Wang W,Yin CC,Tang G,Aung PP,Hu S,Lu X,Toruner GA,Medeiros LJ,Khoury JD

更新日期：2018-10-01 00:00:00

abstract：:Anti-MY9 is an IgG2b murine monoclonal antibody selected for reactivity with immature normal human myeloid cells. The MY9 antigen is expressed by blasts, promyelocytes and myelocytes in the bone marrow, and by monocytes in the peripheral blood. Erythrocytes, lymphocytes and platelets are MY9 negative. All myeloid colo...

journal_title：Leukemia research

authors： Griffin JD,Linch D,Sabbath K,Larcom P,Schlossman SF

更新日期：1984-01-01 00:00:00

abstract：:Ten patients with acute nonlymphocytic leukemia (ANLL) received bromodeoxyuridine (BrdU) at 100 mg/M2 intravenously over 1 h. BrdU is incorporated into the DNA by S-phase cells and was detected by using a monoclonal anti-BrdU antibody in the bone marrow aspirate (BM) and biopsy specimens obtained at the end of the inf...

journal_title：Leukemia research

authors： Raza A,Maheshwari Y,Yasin Z,Mandava N,Mayers G,Preisler HD

更新日期：1987-01-01 00:00:00

abstract：:Incorporation of ABL-targeted oral tyrosine kinase inhibitors (TKIs) into frontline therapeutic regimens has improved outcomes for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). However, patients with persistent minimal residual disease (MRD) exhibit increased risk of relapse. Co...

journal_title：Leukemia research

authors： King AC,Pappacena JJ,Tallman MS,Park JH,Geyer MB

更新日期：2019-04-01 00:00:00

abstract：:Bone marrow specimens from 185 patients with plasma cell disorders (PCD) were investigated by fluorescence in situ hybridization (FISH) in order to determine the temporal sequence of cytogenetic aberrations. In 25 cases combined FISH analysis has also been performed at single cell level. Clonal evolution was observed ...

journal_title：Leukemia research

authors： Nagy Z,Kajtár B,Jáksó P,Dávid M,Kosztolányi S,Hermesz J,Kereskai L,Pajor L,Alpár D

更新日期：2011-08-01 00:00:00

abstract：:Determination of T-cell clonality has an important additional value for diagnosis of T-cell lymphomas. Various molecular methods have been developed, including polymerase chain reaction (PCR) of T-cell receptor γ (TCRγ). The detection of PCR products usually relies commonly on either GeneScan (GS) analysis or heterodu...

journal_title：Leukemia research

authors： Beaufils N,Ben Lassoued A,Essaydi A,Dales JP,Formisano-Tréziny C,Bonnet N,Grob JJ,Gabert J

更新日期：2012-09-01 00:00:00

abstract：:Multiple myeloma patients may develop extraosseous involvement in the course of the disease making prognosis very poor and new drugs clearly needed. The PD-1/PD-L1 axis has emerged as a master immune checkpoint in antitumor responses and recent studies investigated the role of PD-L1 in multiple myeloma cells; no data ...

journal_title：Leukemia research

authors： Crescenzi A,Annibali O,Bianchi A,Pagano A,Donati M,Grifoni A,Avvisati G

更新日期：2016-10-01 00:00:00

abstract：:To elucidate the biological characteristics of chronic myelogenous leukemia (CML) cells, we observed morphological and functional changes of CML cells during primary long-term culture, in which their morphology changed to that of myofibroblasts with similar molecular characteristics to the parental CML cells including...

journal_title：Leukemia research

authors： Shirasaki R,Tashiro H,Mizutani-Noguchi M,Kawasugi K,Shirafuji N

更新日期：2011-05-01 00:00:00

abstract：:The technology of array comparative genomic hybridization (array-CGH/aCGH) enabled the identification of novel genomic aberrations in chronic lymphocytic leukemia (CLL) including the monoallelic and biallelic deletions affecting 22q11 locus. In contrast to previous publications, we hypothesized that the described 22q1...

journal_title：Leukemia research

authors： Mraz M,Stano Kozubik K,Plevova K,Musilova K,Tichy B,Borsky M,Kuglik P,Doubek M,Brychtova Y,Mayer J,Pospisilova S

更新日期：2013-07-01 00:00:00

abstract：:We studied monosomy and deletions of chromosome 7 in 170 patients with myeloid disorders and we identified a minimal region of loss in 7q31.1 spanning between the D7S2554 and D7S2460 markers. The closest gene to our most deleted microsatellite, D7S2554, is the human I-mfa domain containing (HIC) gene, alias MyoD famil...

journal_title：Leukemia research

authors： Cigognini D,Corneo G,Fermo E,Zanella A,Tripputi P

更新日期：2007-04-01 00:00:00

abstract：:We analysed the optimal conditions for autologous bone marrow purging using complement binding monoclonal antibodies (mAbs). Twelve mAbs belonging to four clusters (CD9, CD10, CD19, CD24), alone or combined were evaluated by using direct cytotoxicity and clonogenic assays. We observed the following data: (1) optimal c...

journal_title：Leukemia research

authors： Racadot E,Herve P,Lamy B,Peters A

更新日期：1987-01-01 00:00:00