Abstract：
:1,25-Dihydroxyvitamin D3 (1,25D) induces differentiation of myeloid leukemia cells, but resistant cells are also encountered. We studied the mechanistic basis for the resistance in a model system using enhancers of 1,25D, the antioxidant carnosic acid and a kinase inhibitor SB202190. Knock-down (KD) of JNK2p54 unexpectedly increased the intensity of differentiation induced by the 1,25D, carnosic acid and SB202190 (DCS) combination. This was associated with upregulation of activated JNK1p46, and the transcription factors regulated by the JNK pathway, c-Jun, ATF2 and JunB, as well as C/EBP beta. In contrast, KD of JNK1p46 reduced the intensity of DCS-induced differentiation, and partially abrogated activation of c-Jun/AP-1 transcription factors.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Chen-Deutsch X,Garay E,Zhang J,Harrison JS,Studzinski GPdoi
10.1016/j.leukres.2009.03.003subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1372-8issue
10eissn
0145-2126issn
1873-5835pii
S0145-2126(09)00112-Xjournal_volume
33pub_type
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