The automated monocyte count is independently predictive of overall survival from diagnosis in chronic lymphocytic leukaemia and of survival following first-line chemotherapy.

abstract：:We report a unique case of de novo acute promyelocytic leukemia (APL) with cryptic 15;17 rearrangements. Cytogenetically, structural rearrangements of the 6p23 region has been reported mainly in secondary leukemia. This patient had a karyotype of 46, XY, del(6)(p23) and no additional chromosomal abnormalities. Molecul...

journal_title：Leukemia research

authors： Nakase K,Wakita Y,Minamikawa K,Yamaguchi T,Shiku H

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) represents a heterogeneous disorder with recurrent chromosomal alterations and molecular abnormalities. Among AML with normal karyotype (NK-AML) FLT3 activating mutation, internal tandem duplication (FLT3-ITD), is present in about 30% of patients, conferring unfavorable outcome. ...

journal_title：Leukemia research

authors： Salemi D,Cammarata G,Agueli C,Augugliaro L,Corrado C,Bica MG,Raimondo S,Marfia A,Randazzo V,Dragotto P,Di Raimondo F,Alessandro R,Fabbiano F,Santoro A

更新日期：2015-08-01 00:00:00

abstract：:We report the characterization of a novel human T-cell line, HPB-MLp-W, which was established from blastic cells of a lymph node specimen from a patient with non-Hodgkin's lymphoma. They demonstrated the T-cell association antigens, CD2 and CD4, but no CD3, CD8, CD1, CD5, CD7 nor T-cell antigen receptor on their cell ...

journal_title：Leukemia research

authors： Morikawa S,Morikawa K,Hara J,Nagasaki M,Nakano A,Oseko F

更新日期：1991-01-01 00:00:00

abstract：:We report a case of Ph1-negative, bcr-negative CML-BC, in which the primary leukemic cells displayed T-related antigens (CD7, CD4) in addition to HLA-DR and CD25 determinants. No B-lymphoid, myeloid and megakaryoblastic surface antigens were detected. In spite of this phenotype, DNA analysis revealed a germ-line confi...

journal_title：Leukemia research

authors： Callea V,Morabito F,Lista P,Pegoraro L,Cambrin GR,Guerrasio A,Saglio G,Tassinari A,Fierro MT,Iacopino P

更新日期：1988-01-01 00:00:00

abstract：:The amplified myeloma centrosome has been identified as a therapeutic target. The present study explored the expression and prognostic significance of the centrosome-associated protein PLK1 in myeloma and the effect of BI 2536, a potent and selective inhibitor of PLK1, on myeloma cells. High plasma cell expression of ...

journal_title：Leukemia research

authors： Evans RP,Dueck G,Sidhu R,Ghosh S,Toman I,Loree J,Bahlis N,Klimowicz AC,Fung J,Jung M,Lai R,Pilarski LM,Belch AR,Reiman T

更新日期：2011-12-01 00:00:00

abstract：:In a recent phase I study, a combination of gemcitabine at 10 mg/(m(2)min) for 12 h and mitoxantrone 12 mg/m(2) daily for 3 days, achieved a complete remission (CR) in 3 of 12 (25%) patients with refractory leukemia. A pilot assessment of this regimen was conducted to determine its tolerability in patients with refrac...

journal_title：Leukemia research

authors： Apostolidou E,Estey E,Cortes J,Garcia-Manero G,Faderl S,Thomas D,Tsimberidou A,Kantarjian H,Giles FJ

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Current results regarding treatment outcomes in acute myeloid leukemia (AML) point to significant differences between low- and middle-income countries (LMIC) and high-income countries (HIC). Excluding well-known socioeconomic issues, genetic markers important for prognosis have not been properly incorporated...

journal_title：Leukemia research

authors： Benicio MTL,Ribeiro AFT,Américo AD,Furtado FM,Glória AB,Lima AS,Santos SM,Xavier SG,Lucena-Araujo AR,Fagundes EM,Rego EM

更新日期：2017-09-01 00:00:00

abstract：:Recent studies have identified SOX11 as a novel diagnostic marker for mantle cell lymphoma (MCL). We quantified SOX11 by a truly mRNA specific qPCR assay in longitudinal peripheral blood samples from 20 patients and evidenced a close relationship of SOX11 expression and clinical status of the patients. In eight patien...

journal_title：Leukemia research

authors： Simonsen AT,Sørensen CD,Ebbesen LH,Bødker JS,Bentzen HH,Nyvold CG

更新日期：2014-08-01 00:00:00

abstract：:Human promyelocytic leukemia cells (HL-60) mature into functional granulocytes in response to in vitro treatment with several classes of chemical agents. Compounds that increase intracellular adenosine 3':5' -cyclic monophosphate induce a modified program of maturation in which the cells demonstrate functional propert...

journal_title：Leukemia research

authors： Chaplinski TJ,Sloan GJ,Niedel JE

更新日期：1985-01-01 00:00:00

abstract：:In-vitro infection of normal human lymphocytes with HTLV-I (human T-cell lymphotropic retrovirus type I) has been carried out to study the target cell specificity and the kinetics of infection. Cord blood (CBL) and adult peripheral blood lymphocytes (PBL) have been co-cultivated with irradiated HTLV-I donor cells (MT2...

journal_title：Leukemia research

authors： Del Mistro A,De Rossi A,Aldovini A,Salmi R,Chieco-Bianchi L

更新日期：1986-01-01 00:00:00

abstract：:Checkpoint genes code for a family of proteins which sense DNA damage in eukaryotic cells. They play an important role in the control of the cell cycle. The human CHK2 is a homolog of the yeast G(2) checkpoint kinases known as CDS1 and RAD53. The CHK2 may be a tumor suppressor gene because it was found to be mutated i...

journal_title：Leukemia research

authors： Hofmann WK,Miller CW,Tsukasaki K,Tavor S,Ikezoe T,Hoelzer D,Takeuchi S,Koeffler HP

更新日期：2001-04-01 00:00:00

abstract：:Leukotrienes and lipoxins are bioactive lipoxygenase products formed by leukocytes alone or in collaboration with other cells. While the physiological role of lipoxins remains to be clarified, accumulating evidence shows that leukotrienes are important mediators in asthma and inflammation. Consequently, recent clinica...

journal_title：Leukemia research

authors： Stenke L,Reizenstein P,Lindgren JA

更新日期：1994-10-01 00:00:00

abstract：:Treatment failure of patients with acute myelogenous leukemia (AML) is frequently due to the development of multidrug resistance phenotype blasts. We have expressed a fusion protein consisting of human granulocyte-macrophage colony stimulating factor (GMCSF) fused to the N-terminus of a lectin-deficient ricin toxin B ...

journal_title：Leukemia research

authors： Burbage C,Tagge EP,Harris B,Hall P,Fu T,Willingham MC,Frankel AE

更新日期：1997-07-01 00:00:00

abstract：:We hypothesized that the lipid second messenger, ceramide, and microtubule-directed chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our studies demonstrated that simultaneous treatment of Jurkat cells with paclitaxel and ceramide enhanced paclitaxel-induced cell growth inhibition. Cell ...

journal_title：Leukemia research

authors： Myrick D,Blackinton D,Klostergaard J,Kouttab N,Maizel A,Wanebo H,Mehta S

更新日期：1999-06-01 00:00:00

abstract：:The basis of intrinsic resistance of blasts from patients with acute non-lymphocytic leukemia (ANLL) to methotrexate was studied. MTX polyglutamate formation was measured in blast cells from 19 patients with ANLL and in 7 pediatric patients with acute lymphocytic leukemia (ALL), after in vitro incubation for 24 h with...

journal_title：Leukemia research

authors： Lin JT,Tong WP,Trippett TM,Niedzwiecki D,Tao Y,Tan C,Steinherz P,Schweitzer BI,Bertino JR

更新日期：1991-01-01 00:00:00

abstract：:Mononuclear cells from a bone marrow infiltrated by plasmacytoma cells were examined by electron microscopy. An analysis was performed according to different cytoarchitectural forms of the endoplasmic reticulum (ER). Six types of plasma cells could be distinguished. The bone marrow cells were treated with an anti-idio...

journal_title：Leukemia research

authors： Renau-Piqueras J,Wetter O,Miragall F,Brandhorst D,Martinez-Ramon A

更新日期：1984-01-01 00:00:00

abstract：:An acute promyelocytic leukemia in the rat (BNML) has been used in model studies on pathogenesis and therapy of human acute myeloid leukemia. The blood supply to bone marrow during BNML development has hitherto not been examined, even though in general, blood flow to hematopoietic tissues might affect drug treatment a...

journal_title：Leukemia research

authors： Iversen PO,Thing-Mortensen B,Nicolaysen G,Benestad HB

更新日期：1993-08-01 00:00:00

abstract：:Recombinant TNF was capable of inducing differentiation of human leukemic ML-1 cells in the monocytic pathway. Recombinant interleukin 6 did not have the activity but it could significantly increase the activity of recombinant TNF. Both of these molecules were found to play a similar role in PWM-induced conditioned me...

journal_title：Leukemia research

authors： Samal B,Stearns G,Crandall C,Arakawa T,Boone T

更新日期：1990-01-01 00:00:00

abstract：:Increased DNA damage and alteration of the DNA damage response (DDR) are critical features of genetic instability presumably implicated in pathogenesis of myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). We used immunofluorescence staining of γH2AX and 53BP1 for analyzing DNA double-strand breaks (DS...

journal_title：Leukemia research

authors： Popp HD,Naumann N,Brendel S,Henzler T,Weiss C,Hofmann WK,Fabarius A

更新日期：2017-06-01 00:00:00

abstract：:Fusion tyrosine kinases (FTKs) such as BCR/ABL, TEL/ABL, TEL/JAK2, TEL/PDGF beta R and NPM/ALK arise from reciprocal chromosomal translocations and cause acute and chronic myelogenous leukemias and non-Hodgkin's lymphoma. Murine hematopoietic growth factor dependent BaF3 cells and cells transformed by FTK (BaF3-FTK) w...

journal_title：Leukemia research

authors： Hoser G,Majsterek I,Romana DL,Slupianek A,Blasiak J,Skorski T

更新日期：2003-03-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is frequently treated with induction and consolidation chemotherapy. Consolidation chemotherapy can be delivered on an ambulatory basis, requiring some patients to travel long distances for treatment at specialized centers. We developed a shared care model where patients receive consolidat...

journal_title：Leukemia research

authors： Hershenfeld SA,Maki K,Rothfels L,Murray CS,Nixon S,Schimmer AD,Doherty MC

更新日期：2017-08-01 00:00:00

abstract：:The effect of mesna on intracellular accumulation of cytosine arabinoside (Ara-C) in murine normal and neoplastic lymphocytes was studied. Simultaneous exposure of cells to mesna at concentrations ranging from 0.25 to 1.0 mM and 3H-Ara-C (40.0 nM) resulted in a strong inhibition of Ara-C uptake in normal lymphocytes. ...

journal_title：Leukemia research

authors： Jastrzebski Z,Czyzewska-Szafran H,Remiszewska M,Côte-Rozanes C

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokines. MCP-1 has been previously shown to have a major role in the migration of monocytes towards human leukemic cells, yet it cannot increase cytotoxic effects of monocytes on human leukemic cells. AIM:To determine levels of MCP-1 in the...

journal_title：Leukemia research

authors： Eisenkraft A,Keidan I,Bielorai B,Keller N,Toren A,Paret G

更新日期：2006-10-01 00:00:00

abstract：:The aim of this study is to detect the biologic and/or prognostic significance of survivin (S) and effector protease receptor 1: EPR-1 (E) expression in acute leukemias (34 ALL and 40 AML) by using RT-PCR. S and E expressions were found in 83.8 and 20.3% of the cases, respectively. S was detected in 90%, 76.5% and E w...

journal_title：Leukemia research

authors： Oto OA,Paydas S,Tanriverdi K,Seydaoglu G,Yavuz S,Disel U

更新日期：2007-11-01 00:00:00

abstract：:The simultaneous occurrence of two specific acquired chromosomal abnormalities in chronic or acute leukaemias is rare. Inherited chromosomal abnormalities are also rare events in the general population. In chronic myeloid leukaemia (CML), characterised by the t(9;22)(q34;q11), the inv(16)(p13q22) has been described as...

journal_title：Leukemia research

authors： Silva PM,Lourenço GJ,Bognone RA,Delamain MT,Pinto-Junior W,Lima CS

更新日期：2006-01-01 00:00:00

abstract：:Essential thrombocythemia (ET) is an uncommon chronic myeloproliferative disorder with no cure. Patients with ET are at risk of different complications, and currently there are no optimal prognostic standards to predict severe post-diagnosis complications such as thrombosis and hemorrhage. In this study, we retrospect...

journal_title：Leukemia research

authors： Zhou D,Chen W,Cheng H,Qiao JL,Zhu LL,Li ZY,Xu KL

更新日期：2018-06-01 00:00:00

abstract：:Vinorelbine chemotherapy with G-CSF stimulation is the standard mobilization regimen in Switzerland for multiple myeloma patients. However, with the increasing use of bortezomib during induction treatment, adding the neurotoxic compound vinorelbine for mobilization may aggravate bortezomib-induced polyneuropathy. In t...

journal_title：Leukemia research

authors： Keller S,Seipel K,Novak U,Mueller BU,Taleghani BM,Leibundgut K,Pabst T

更新日期：2015-07-01 00:00:00

abstract：:Leukemic bcr-abl positive dendritic cells (DCs) are likely to be present in vivo in chronic myelogenous leukemia (CML) patients, but no data are available on their functional qualities. We analyzed the circulating BDCA-1+ myeloid DC compartment in 15 chronic phase CML patients. Phenotypic features of CML DCs were comp...

journal_title：Leukemia research

authors： Orsini E,Calabrese E,Maggio R,Pasquale A,Nanni M,Trasarti S,Tafuri A,Guarini A,Foa R

更新日期：2006-07-01 00:00:00

abstract：:Some peripheral blood clonogenic T-cells from patients with T-cell malignancies can generate colonies in methylcellulose in the absence of added growth factors or mitogen stimulation (T-CFCs). T-CFC from these patients were also able to form colonies in semi-solid media in the presence of added growth factors (T-CFCi)...

journal_title：Leukemia research

authors： Georgoulias V,Auclair H,Jasmin C

更新日期：1984-01-01 00:00:00

abstract：:Forty-three patients were studied to determine whether light chain gene rearrangements may occur in hematopoietic cells not pertaining to the B-lineage. In only one patient, affected by T-cell lymphoblastic lymphoma, one kappa light chain allele was rearranged. Neither at the protein level nor at the RNA level the rea...

journal_title：Leukemia research

authors： Moretti L,Mariano MT,Donelli A,Montagnani G,Sarti M,Grantini M,Di Prisco U,Torelli U,Narni F

更新日期：1991-01-01 00:00:00