Abstract：
:The WHO classification of hematological malignancies includes 5q-syndrome as a separate category within myelodysplastic syndromes (MDS). Clinically, patients with 5q-syndrome have a milder disease than patients with other MDS. The basis for this difference is not known. Identifying 5q-syndrome can be difficult because some of its morphologic and cytogenetic features are similar to those of other MDS. We compared apoptosis between 5q-syndrome and other refractory anemias. We found lower levels of apoptosis in 5q-syndrome as detected by less disruption of mitochondrial potential (P=0.008) and decreased annexin V positivity (P=0.01). Our results suggest that lower apoptosis in 5q-syndrome may explain the milder clinical course of the disease and distinguish 5q-syndrome from other MDS.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Washington LT,Jilani I,Estey E,Albitar Mdoi
10.1016/s0145-2126(02)00039-5keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
899-902issue
10eissn
0145-2126issn
1873-5835pii
S0145212602000395journal_volume
26pub_type
杂志文章abstract：:In a patient affected with chronic lymphocytic leukemia with lymphocyte surface mu and kappa determinants and vacuolated bone marrow plasma cells, the serum contained polymers of a truncated mu chain and normal-sized kappa chains. These light chains were present as monomers and covalent dimers in studies performed und...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90129-9
更新日期：1993-06-01 00:00:00
abstract：:A panel of human leukemia cell lines from various lineages (T-cell, pre B- and Non-T/Non-B cell, myelomonocytic and erythroleukemia cell lines) were utilised as model systems of the distant effects of differentiation-inducing activity (DIA) produced by the T-leukemia cell line HUT-102. DIA inhibited cell proliferation...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90108-1
更新日期：1987-01-01 00:00:00
abstract：:The development of the leukemia-lymphoma complex was studied in AKR/J (H-2k) mice using flow cytometry and staining with acridine orange. Investigation of cytokinetics and of cellular RNA content showed that during the neonatal period all mice had a significant increase of S phase cells in the thymus, bone marrow, lym...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90158-4
更新日期：1985-01-01 00:00:00
abstract：:A double monoclonal component (MC) detected in the serum and/or urine represents a very rare occurrence (2-6% of monoclonal gammopathies). In this study, we report 34 patients with double serum MCs, focusing on the associated diseases. The diagnosis was made using high-resolution serum protein electrophoresis and immu...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.05.008
更新日期：2012-10-01 00:00:00
abstract：:Inhibition of cyclooxygenase 2 (COX-2) by the selective COX-2 inhibitor celecoxib has been suggested as potentially useful for B-cell lymphoma therapy. However, additional pharmacological activities of celecoxib have been discovered and have challenged the notion that its antitumor effects are mediated primarily via t...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.09.028
更新日期：2010-02-01 00:00:00
abstract：:Based on Bcl-X(L) overexpression studies we identified type I and type II follicular lymphoma cell lines in response to TRAIL. We demonstrate here that either amount of caspase-8 activation or Bid cleavage could not define the dependence on mitochondria. Furthermore, an inhibitor of NF-kappaB, PDTC, enabled TRAIL to a...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.09.025
更新日期：2009-06-01 00:00:00
abstract：:The human cell line U-937 has many features suggestive of the monocyte. It may be stimulated in vitro to develop attributes of an activated macrophage with increased phagocytosis and enhanced Fc receptor expression. We describe the establishment of a subclone designated U-937 AG through the use of a mutagenic agent. T...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(84)90084-5
更新日期：1984-01-01 00:00:00
abstract：:Our retrospective analysis explored the role of leukemia cutis (LC) in disease progression of chronic myelomonocytic leukemia (CMML). Of 108 patients with CMML, 11 patients (10.2%) had LC including its equivalent (2 patients). Four of these patients developed acute myeloid leukemia (AML) within 0-4 months. The remaini...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2011.05.003
更新日期：2012-01-01 00:00:00
abstract：:Bi-specific anti-CD33 x anti-CD64 antibodies (BsAb) mediated more potent and longer-lasting inhibition of proliferation of human leukemia cell lines and primary acute myeloid leukemia (AML) samples compared to mono-specific anti-CD33 mAb. There were no differences between these two antibodies in cellular internalizati...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2003.12.001
更新日期：2004-08-01 00:00:00
abstract：:Quantitative differences in HLe-1 expression were studied on normal lymphocytes and lymphoblasts of patients with acute lymphoblastic leukemia (ALL). A relationship was found between quantitative antigen expression and therapeutic outcome. Alterations in fluorescence intensity (FI) were demonstrated using quantitative...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90110-x
更新日期：1987-01-01 00:00:00
abstract：:We employed a liquid culture system to examine the in vitro effects of vincristine and vindesine on cellular incorporation of 35SO4 into leukemic cells obtained from 5 patients with chronic granulocytic leukemia in blast crisis. The per cent of 35SO4 into drug-treated as compared to saline-treated leukemic cells was c...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(84)90062-6
更新日期：1984-01-01 00:00:00
abstract：:Adult T-cell leukemia (ATL) is an aggressive malignancy of peripheral T cells infected with human T-cell leukemia virus type 1 (HTLV-1). The prognosis of patients with aggressive ATL remains poor because ATL cells acquire resistance to conventional cytotoxic agents. Therefore, development of novel agents is urgently n...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.10.012
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:For most cases of idiopathic acquired sideroblastic anemia (IASA), the molecular pathogenesis is unknown, despite the consistent morphological signature of abundant pathological ringed sideroblasts with their characteristic iron-engorged mitochondria. Moderately elevated free erythrocyte protoporphyrin (FEP)...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.06.005
更新日期：2007-05-01 00:00:00
abstract：:The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-va...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.06.012
更新日期：2006-02-01 00:00:00
abstract：:Despite advances in understanding the complexities of acute myeloid leukaemia (AML), the treatment of refractory or relapsed AML (rrAML) remains a daunting clinical challenge. Numerous clinical trials have failed to identify new treatments or combinations of existing therapies that substantially improve outcomes and s...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2016.05.025
更新日期：2016-08-01 00:00:00
abstract：:Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n=109), AML (n=47) ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.07.022
更新日期：2013-11-01 00:00:00
abstract：:Ml cells were labeled in vitro with [3H]thymidine and injected into the peritoneal cavity of syngeneic mice. After several days the peritoneal cells were harvested and [3H]labeled cells were determined by autoradiography. The inoculated isotope-labeled Ml cells differentiated in the peritoneal cavity and lipopolysacch...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(82)90050-9
更新日期：1982-01-01 00:00:00
abstract：:The human lymphoblastoid leukemic cell line (CCRF-CEM) was induced to differentiate with phorbol 12-myristate 13-acetate (PMA). During differentiation, assessed by monitoring the cluster of differentiation (CD) profile, the prosome (proteasomes, multi-catalytic proteinase) distribution and composition were studied by ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(97)00091-x
更新日期：1997-11-01 00:00:00
abstract：:Activating mutations of the c-kit gene are frequently found in CBF (core binding factor) leukemias. We evaluated the effect of tyrosine kinase inhibitor dasatinib in leukemic cell lines bearing or not c-kit mutations. Our data demonstrate that in the AML Kasumi-1 cell line, bearing the N822K c-kit mutation, dasatinib ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.10.011
更新日期：2013-02-01 00:00:00
abstract：:The biological progression of chronic myeloid leukaemia is often associated with secondary cytogenetic abnormalities but the molecular mechanisms underlying this progression are poorly understood. This study explores the association of c-myc gene amplification with the progression of chronic myeloid leukaemia in fourt...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(98)00097-6
更新日期：1998-10-01 00:00:00
abstract：:We monitored DLI treatment of 13 post-SCT relapses using quantitative competitive (QC) RT-PCR for BCR-ABL (sensitivity 10(-5)) and compared responses to DLI alone and DLI in combination with interferon-alpha (IFN). Ten relapses (one blast crisis, five cytogenetic and four molecular) were treated with DLI+IFN, three re...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(02)00280-1
更新日期：2003-08-01 00:00:00
abstract：:The expression of various proto-oncogenes in primary culture of lymphocytes from peripheral blood of bovine with chronic lymphocytic leukemia (CLL) was studied. Cellular proto-oncogenes encode proteins that propagate growth, differentiation or apoptosis signals from cell membrane to nucleus. The proliferation and diff...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(97)00128-8
更新日期：1998-02-01 00:00:00
abstract：:The peripheral blood lymphocyte to monocyte ratio (LMR) at diagnosis has been used to predict survival in diffuse large B-cell lymphoma (DLBCL) patients, but its prognostic significance with respect to different cell-of-origin (COO) subtypes remains unknown. We retrospectively analyzed 168 de novo DLBCL patients in th...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2014.03.013
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.02.010
更新日期：2015-05-01 00:00:00
abstract：:To characterize the molecular mechanisms involved in the transition from the chronic phase to blast crisis in chronic myelogenous leukemia (CML), gene expression profiles of leukemic cells from patients in the chronic and blast crisis phases were analyzed using an 8.7K cDNA chip and real-time PCR. A transient transfec...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.11.008
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND/AIMS:Jumping translocations are rare cytogenetic aberrations in haematological malignancies, the pathogenesis of which remains to be fully characterised. We investigated the mechanism of formation of jumping translocations in a case of adult common acute lymphoblastic leukaemia (ALL) positive for the Ph tran...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2004.01.021
更新日期：2004-10-01 00:00:00
abstract：:Septins are proteins associated with crucial steps in cell division and cellular integrity. In humans, 14 septin genes have been identified, of which five (SEPT2, SEPT5, SEPT6, SEPT9, and SEPT11) are known to participate in reciprocal translocations with the MLL gene in myeloid neoplasias. We have recently shown a sig...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.08.018
更新日期：2010-05-01 00:00:00
abstract：:MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression at the post-transcriptional level through its sequence complementation with target mRNAs. An individual miRNA species can simultaneously influence the expression of multiple genes and conversely, several miRNAs can synchronously contro...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2013.08.020
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The skin is the common extranasal sites in extranodal natural killer (NK) / T - cell lymphoma, (ENKTL). However, data regarding cutaneous ENKTL are relatively scarce. Thus, we performed a large retrospective study to analyze clinical features and treatment outcomes of cutaneous ENKTL. PATIENTS AND METHODS:S...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2019.106284
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Most patients with myelodysplastic syndromes (MDS) require transfusions at the risk of iron overload and associated organ damage, and death. Emerging evidence indicates that iron chelation therapy (ICT) could reduce mortality and improve survival in transfusion-dependent MDS patients, especially those classi...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2014.02.003
更新日期：2014-05-01 00:00:00
