Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation.

abstract：:In acute lymphoblastic leukemia (ALL) patients, automated fluorescence fragment analysis (ALF) has been reported to improve the monoclonality detection rate of immunoglobulin heavy chain genes (IgH) polymerase chain reaction (PCR) analysis. This study performed complementary determining region (CDR) I and III PCR on s...

journal_title：Leukemia research

authors： Gleissner B,Maurer J,Sindram A,Reinhard R,Thiel E

更新日期：2001-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) can induce a broad spectrum of hematological diseases, especially in immune deficient patients. We assayed for receptor for EBV (EBVR) using fluoresceinated viral particles on 44 human hematopoietic cell lines derived from patients with T, B, and non-T, non-B acute lymphocytic leukemia (ALL), ...

journal_title：Leukemia research

authors： Tatsumi E,Harada S,Kuszynski C,Volsky D,Minowada J,Purtilo DT

更新日期：1985-01-01 00:00:00

abstract：:With the application of adequately sensitive tests, it is now becoming evident that more than 90% of patients with conventionally-defined polycythemia vera (PV) carry the somatic JAK2V617F mutation in their granulocytes. However, the specific mutation is also found in other classic and atypical myeloproliferative diso...

journal_title：Leukemia research

authors： Tefferi A,Pardanani A

更新日期：2006-06-01 00:00:00

abstract：:Hemopoietic responses were studied in splenectomized mice after transplantation of the hemopoietic colony stimulating activity producing leukemia, L8313. In non-splenectomized mice, the number of peripheral leukocytes was elevated to 4 x 10(5)/mm3 after transplantation. In contrast, it was below 1.7 x 10(4)/mm3 in spl...

journal_title：Leukemia research

authors： Sawada H,Sugimoto K,Aramaki K,Mori KJ

更新日期：1989-01-01 00:00:00

abstract：:Secondary acute lymphoblastic leukemia (s-ALL) is rare and poorly defined and data regarding outcomes post-transplant are lacking. Here, we report a detailed analysis of s-ALL at our Institution. Among 211 eligible patients with ALL from 2006 to 2017, 30 (14%) were defined as s-ALL and the remaining as primary ALL (p-...

journal_title：Leukemia research

authors： Ferraro F,Gao F,Stockerl-Goldstein K,Westervelt P,DiPersio JF,Ghobadi A

更新日期：2018-09-01 00:00:00

abstract：:This study investigated radioresistance mechanisms in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100. AML-2/DX100 also showed resistance to radiation. AML-2/DX100 characterized by down-regulated catalase expression was supersensitive to exogenous hydrogen peroxide whereas they increased defense mec...

journal_title：Leukemia research

authors： Choi CH,Xu H,Bark H,Lee TB,Yun J,Kang SI,Oh YK

更新日期：2007-09-01 00:00:00

abstract：:The expression of various proto-oncogenes in primary culture of lymphocytes from peripheral blood of bovine with chronic lymphocytic leukemia (CLL) was studied. Cellular proto-oncogenes encode proteins that propagate growth, differentiation or apoptosis signals from cell membrane to nucleus. The proliferation and diff...

journal_title：Leukemia research

authors： Kalvelyte AV,Pabrezaite LC

更新日期：1998-02-01 00:00:00

abstract：:The presence of intracellular cytoplasmic immunoglobulin M (IgM) in leukemic cells from patients with acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL) was investigated by flow cytometry. The objective of the study was to develop a reproducible flow cytometric method. A Burkitt's lymphoma-derived...

journal_title：Leukemia research

authors： Loftin KC,Reuben JM,Hersh EM,Sujansky D

更新日期：1985-01-01 00:00:00

abstract：:Expression of p14(ARF) and p16(INK4a) tumor suppressor genes was investigated in 109 patients with chronic myeloid leukemia (CML). The p14(ARF) and p16(INK4a) mRNA levels were significantly low in patients in chronic phase (CP) at presentation and high in patients treated with interferon-alpha (IFN-alpha), especially ...

journal_title：Leukemia research

authors： Cividin M,Ayrault O,Sorel N,Séité P,Brizard F,Blanchet O,Mahon FX,Guilhot F,Larsen C,Chomel JC,Brizard A

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Chylomicrons carry in the bloodstream dietary fats absorbed the intestine for storage in the body tissues such as adipose and muscle. The two-step chylomicron metabolism consists in lipolysis by lipoprotein lipase on vessel walls and hepatic uptake of triglyceride-depleted remnants. Chylomicron metabolism is...

journal_title：Leukemia research

authors： Gonçalves RP,Hungria VT,Chiattone CS,Pozzi DB,Maranhão RC

更新日期：2003-02-01 00:00:00

abstract：:We evaluated the effect of SCF on myeloid differentiation by correlating clonogenic potential (as CFU-GM), bone marrow (BM) plasma SCF levels and CD34/c-kit expression in 57 MDS samples. There was a significant correlation between low SCF levels and 'leukemic' in vitro growth, the number of clusters and the colony/clu...

journal_title：Leukemia research

authors： Cortelezzi A,Cattaneo C,Cristiani S,Sarina B,Pomati M,Silvestris I,Ibatici A,Maiolo AT

更新日期：1999-03-01 00:00:00

abstract：:Leukaemic cells from the peripheral blood of 90 patients with acute leukaemia (54 non-lymphocytic (ANLL) 36 lymphocytic (ALL)) have been examined for the presence of the platelet/ALL-associated p24 membrane antigen by indirect immunofluorescence and flow cytometry using monoclonal antibody FMC8. Cells from 28 of the A...

journal_title：Leukemia research

authors： Ashman LK,White D,Zola H,Dart GW

更新日期：1987-01-01 00:00:00

abstract：:Thirty-nine patients with Philadelphia chromosome-positive (Ph1) chronic myelocytic leukemia (CML) were monitored using cytofluorometry and cytogenetics. During chronic phase, abnormal populations could be detected using commercially available monoclonal antibodies. Most of these abnormal populations had either an HLA...

journal_title：Leukemia research

authors： Ligler FS,Brodsky I,Schlam ML,Fuscaldo KE

更新日期：1985-01-01 00:00:00

abstract：:Appropriate treatment for nonreactive thrombocytosis resulting from a myeloproliferative disorder (MPD) is surrounded by controversy. Although few doubt the association of thrombocytosis with increased risk for life-threatening events such as thrombosis or hemorrhage, or the association between clonal myeloproliferati...

journal_title：Leukemia research

authors： Fruchtman SM,Petitt RM,Gilbert HS,Fiddler G,Lyne A,Anagrelide Study Group.

更新日期：2005-05-01 00:00:00

abstract：:Despite initial remissions, most patients with Ph chromosome positive (Ph(+)) acute leukemia (AL) become refractory to tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib. This study was designed to determine if targeting the interleukin-3 receptor (IL-3R) with a diphtheria toxin fusion protein (DT(388)IL...

journal_title：Leukemia research

authors： Kim HP,Frankel AE,Hogge DE

更新日期：2010-08-01 00:00:00

abstract：:miRNAs have been reported to be involved in the pathogenesis of many cancers. In this article, we investigated the role and the mechanisms of miR-15a/16 in the pathogenesis of multiple myeloma (MM). We found that miR-15a/16 was down-regulated in bone marrow-derived mononuclear cells (BM-MNCs) of newly diagnosed patien...

journal_title：Leukemia research

authors： Li Y,Zhang B,Li W,Wang L,Yan Z,Li H,Yao Y,Yao R,Xu K,Li Z

更新日期：2016-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is pathognomonically elevated in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome. However, its source of overproduction is unclear. As clinical improvement is almost always associated with VEGF reduction after...

journal_title：Leukemia research

authors： Wang C,Huang XF,Cai QQ,Cao XX,Cai H,Zhou D,Li J

更新日期：2016-11-01 00:00:00

abstract：:Although clinical experience and in vitro data provide evidence of an anti-leukemic activity of T cells, there are few examples of recognition of leukemic cells by tumor-specific T cells in vitro. Tumor antigens encoded by the MAGE genes are useful tools to study this recognition. We tested the sensitivity to recognit...

journal_title：Leukemia research

authors： Chambost H,Collette Y,Dutartre H,Thuret I,Olive D

更新日期：2000-10-01 00:00:00

abstract：:Spider venoms are a rich source of bioactive compounds with therapeutic potential. In traditional Chinese medicine, spiders and spider venoms have been used in the treatment of various ailments. In the present study, the venom of the spider Macrothele raveni potently suppressed cell growth in the myelogenous leukemia ...

journal_title：Leukemia research

authors： Liu Z,Zhao Y,Li J,Xu S,Liu C,Zhu Y,Liang S

更新日期：2012-08-01 00:00:00

abstract：:Several genetic polymorphisms in the genes coding folate-metabolizing enzymes have been associated with susceptibility to hematology malignancies. We conducted a Korean population-based case-control study to examine the relationship between the polymorphisms of folate-metabolizing enzymes and the risk of AML (acute my...

journal_title：Leukemia research

authors： Kim HN,Kim YK,Lee IK,Yang DH,Lee JJ,Shin MH,Park KS,Choi JS,Park MR,Jo DY,Won JH,Kwak JY,Kim HJ

更新日期：2009-01-01 00:00:00

abstract：:The capacity of human thymocytes and of differentiated lymphocytes circulating in peripheral blood to perform unscheduled DNA synthesis (a measure of nucleotide excision repair) after UV irradiation was measured by radioautographic analysis. Only 4% of immature T lymphocytes, but 68% of circulating lymphocytes exhibit...

journal_title：Leukemia research

authors： Gensler HL,Lindberg RE,Pinnas JL,Jones JF

更新日期：1985-01-01 00:00:00

abstract：:Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity. Several previous studies have suggested such differences between Asian and European/U...

journal_title：Leukemia research

authors： Miyazaki Y,Tuechler H,Sanz G,Schanz J,Garcia-Manero G,Solé F,Bennett JM,Bowen D,Fenaux P,Dreyfus F,Kantarjian H,Kuendgen A,Malcovati L,Cazzola M,Cermak J,Fonatsch C,Le Beau MM,Slovak ML,Santini V,Lübbert M,Macieje

更新日期：2018-10-01 00:00:00

abstract：:Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n=109), AML (n=47) ...

journal_title：Leukemia research

authors： Poloni A,Serrani F,Berardinelli E,Maurizi G,Mariani M,Costantini B,Trappolini S,Mancini S,Olivieri A,Leoni P

更新日期：2013-11-01 00:00:00

abstract：:Like CD19 or CD56, CD22 in non-lymphoid leukemia has been considered an aberrantly expressed antigen. CD22 had been believed to be restricted to B lymphoid, however, it was also found to be expressed in human basophils. Mature basophils are unique granulocytes expressing CD13, CD22 and CD25. To estimate whether the ex...

journal_title：Leukemia research

authors： Sato N,Kishi K,Toba K,Watanabe K,Itoh H,Narita M,Takahashi M,Aizawa Y

更新日期：2004-07-01 00:00:00

abstract：:A novel Philadelphia (Ph1) chromosome positive cell line, designated KYO-1, was established from the peripheral blood of a patient with chronic myelogenous leukemia (CML) in blastic crisis. Although this line had a unique capacity to differentiate spontaneously along the erythroid and monocytoid lineages as evidenced ...

journal_title：Leukemia research

authors： Ohkubo T,Kamamoto T,Kita K,Hiraoka A,Yoshida Y,Uchino H

更新日期：1985-01-01 00:00:00

abstract：:The sum of endogenous and food-derived antioxidants provides an estimate of the total antioxidant capacity (TAC) of the extracellular fluids, while corrected TAC (cTAC) is an estimation of the exogenously provided antioxidants. Similar values for TAC and cTAC were observed between cancer free children and children wit...

journal_title：Leukemia research

authors： Papageorgiou M,Stiakaki E,Dimitriou H,Malliaraki N,Notas G,Castanas E,Kalmanti M

更新日期：2005-01-01 00:00:00

abstract：:Increased DNA damage and alteration of the DNA damage response (DDR) are critical features of genetic instability presumably implicated in pathogenesis of myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). We used immunofluorescence staining of γH2AX and 53BP1 for analyzing DNA double-strand breaks (DS...

journal_title：Leukemia research

authors： Popp HD,Naumann N,Brendel S,Henzler T,Weiss C,Hofmann WK,Fabarius A

更新日期：2017-06-01 00:00:00

abstract：:Anti-MY9 is an IgG2b murine monoclonal antibody selected for reactivity with immature normal human myeloid cells. The MY9 antigen is expressed by blasts, promyelocytes and myelocytes in the bone marrow, and by monocytes in the peripheral blood. Erythrocytes, lymphocytes and platelets are MY9 negative. All myeloid colo...

journal_title：Leukemia research

authors： Griffin JD,Linch D,Sabbath K,Larcom P,Schlossman SF

更新日期：1984-01-01 00:00:00

abstract：:Chlorambucil-induced apoptosis was assessed by three different flow cytometric methods in B-cell chronic lymphocytic leukaemia (B-CLL) cells cultured in vitro and the results were compared with those derived from the morphological assessment of the same samples. Spontaneous apoptosis was consistently observed in the c...

journal_title：Leukemia research

authors： Pepper C,Thomas A,Tucker H,Hoy T,Bentley P

更新日期：1998-05-01 00:00:00

abstract：:Retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (D3) are well known for inducing differentiation in many leukemic cell lines. The nuclear signalling pathways of RA and D3 are mediated through their cognate receptors, the retinoic acid receptor (RAR) and vitamin D3 receptor (VDR), respectively. Retinoid X receptor (RXR...

journal_title：Leukemia research

authors： Nakajima H,Kizaki M,Ueno H,Muto A,Takayama N,Matsushita H,Sonoda A,Ikeda Y

更新日期：1996-08-01 00:00:00