Comparison of in vitro and in vivo effects of vincristine and vindesine on leukemic cells from patients with chronic granulocytic leukemia in blast crisis.

abstract：:Mantle cell lymphoma (MCL) is a distinct type of B cell malignancy and accounts for approximately 5-10% of non-Hodgkin's lymphomas (NHL). The characteristic cytogenetic aberration in MCL is the translocation (11;14)(q13;q32) present in virtually all cases. This rearrangement at the BCL1 locus at 11q13 dysregulates the...

journal_title：Leukemia research

authors： Drexler HG,MacLeod RA

更新日期：2002-09-01 00:00:00

abstract：:Fluorescent-labeled DNA probes were used to study 52 chronic lymphocytic leukemia (B-CLL) patients for (1) disease progression, (2) angiogenesis genes, (3) T-cell leukemia 1 gene (TCL1), (4) immunoglobulin heavy chain variable region (IGHv) and (5) chromosome 6q. Compared to stable disease, more patients with progress...

journal_title：Leukemia research

authors： Fink SR,Paternoster SF,Smoley SA,Flynn HC,Geyer SM,Shanafelt TD,Lee YK,Jelinek DF,Kay NE,Dewald GW

更新日期：2005-03-01 00:00:00

abstract：:A diagnosis of myelodysplastic syndrome was made in an 18-year-old patient with Warkany syndrome due to constitutional trisomy 8 mosaicism. The possible causal role of this particular chromosome constitution with respect to myelodysplasia and embryonal childhood tumors is discussed. ...

journal_title：Leukemia research

authors： Zollino M,Genuardi M,Bajer J,Tornesello A,Mastrangelo S,Zampino G,Mastrangelo R,Neri G

更新日期：1995-10-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t(15;17) (q22;q12), resulting in fusion of the genes promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA). With conventional cytogenetic methods, these translocations are detected in about 70-90% of patients, with most o...

journal_title：Leukemia research

authors： Han JY,Kim KE,Kim KH,Park JI,Kim JS

更新日期：2007-02-01 00:00:00

abstract：:This report describes a unique case of acute myeloid leukemia with hypergranular cytoplasm and t(X;11)(q24;q23). The breakpoint on 11q23 was identified within the MLL gene. The hypergranular cytoplasm of leukemic cells and the associated coagulopathy resembled a characteristic of acute promyelocytic leukemia, despite ...

journal_title：Leukemia research

authors： Nakata Y,Mori T,Yamazaki T,Suzuki T,Okazaki T,Kurosawa Y,Kinoshita A,Ohyashiki K,Nakazawa S

更新日期：1999-01-01 00:00:00

abstract：:To highlight dasatinib role in the elderly, 125 unselected patients with CP-CML aged >60 years resistant/intolerant to imatinib were retrospectively evaluated. Grade 3-4 haematological and extra-haematological toxicities were reported in 39 (31.2%) and 34 (27.2%) patients; grade 3-4 haematological toxicity was higher ...

journal_title：Leukemia research

authors： Latagliata R,Breccia M,Castagnetti F,Stagno F,Luciano L,Gozzini A,Ulisciani S,Cavazzini F,Annunziata M,Sorà F,Rossi AR,Pregno P,Montefusco E,Abruzzese E,Crisà E,Musto P,Tiribelli M,Binotto G,Occhini U,Feo C,Vigner

更新日期：2011-09-01 00:00:00

abstract：:Homoharringtonine combined aclarubicin and cytarabine (HAA) has been demonstrated to achieve a high remission rate and provide a survival advantage in acute myeloid leukemia (AML). To investigate whether HAA is an ideal induction regimen for t(8;21)AML, we retrospectively analyzed the data of 140 patients from the las...

journal_title：Leukemia research

authors： Zhu HH,Jiang H,Jiang Q,Jia JS,Qin YZ,Huang XJ

更新日期：2016-05-01 00:00:00

abstract：:When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. The concentration of IFN-gamma that effectively ...

journal_title：Leukemia research

authors： Niitsu N,Higashihara M,Honma Y

更新日期：2002-08-01 00:00:00

abstract：:GNAS1 gene is located at the long arm of chromosome 20 (q13.32). GNAS1 gene deletion has never been investigated in MDS. A GNAS1 activating mutation (R201) was recently found in MDS. We applied FISH and DHPLC plus sequencing to investigate GNAS1 gene in MDS cases with and without del(20q) at karyotype. ...

journal_title：Leukemia research

authors： Di Giacomo D,Lema Fernandez AG,Pierini T,Crescenzi B,Brandimarte L,Matteucci C,Testoni N,Mecucci C

更新日期：2014-07-01 00:00:00

abstract：:The treatment of acute leukemia is still challenging due in part to the development of resistance and relapse. This chemotherapeutics resistance is established by clonal selection of resistant variants of the cancer cells. Recently, a horizontal transfer of chemo-resistance among cancer cells via extracellular vesicle...

journal_title：Leukemia research

authors： Bouvy C,Wannez A,Laloy J,Chatelain C,Dogné JM

更新日期：2017-11-01 00:00:00

abstract：:Outcome of adult acute lymphoblastic leukemia (ALL) with central nervous system (CNS) involvement is not clearly defined. We studied 104 patients presenting with CNS involvement at diagnosis among 1493 patients (7%) included into the LALA trials, and 109 patients presenting CNS disease at the time of first relapse amo...

journal_title：Leukemia research

authors： Reman O,Pigneux A,Huguet F,Vey N,Delannoy A,Fegueux N,de Botton S,Stamatoullas A,Tournilhac O,Buzyn A,Charrin C,Boucheix C,Gabert J,Lhéritier V,Vernant JP,Fière D,Dombret H,Thomas X,GET-LALA group.

更新日期：2008-11-01 00:00:00

abstract：:Deletion in chromosome 9p involving the CDKN2A locus (9p21.3) is known in many malignancies. To detect this deletion in adolescent ALL patients we used oligo array CGH and studied 54 patients aged 10-25 years. Deletion rate was 25/54 (46%), of these 19/25 (76%) were homozygous. Small deletions (<200 kb) were found in ...

journal_title：Leukemia research

authors： Usvasalo A,Savola S,Räty R,Vettenranta K,Harila-Saari A,Koistinen P,Savolainen ER,Elonen E,Saarinen-Pihkala UM,Knuutila S

更新日期：2008-08-01 00:00:00

abstract：:Most clinicians caring for patients with AML do not use the word "cure" casually, since for many patients diagnosed with AML, a state of cure or even of long term survival remains elusive. Analysis of prognostic factors may aid in defining the chance for cure in various AML subtypes, and improvements are required at a...

journal_title：Leukemia research

authors： Liesveld J

更新日期：2012-12-01 00:00:00

abstract：:The effect of serum on the proliferation of human bone marrow pluripotent progenitor cells (CFU-GEMM), was compared to that of fresh frozen plasma (FFP). Serum significantly increased the number of mixed erythroid-granulocytic-megakaryocytic colonies (CFU-GEMM) and erythrocytic bursts (BFU-E) in this assay system (p l...

journal_title：Leukemia research

authors： Michalevicz R,Francis GE,Price GM,Hoffbrand AV

更新日期：1985-01-01 00:00:00

abstract：:Leukemia-prone AKR mice were exposed twice a week to a 6 mT, 12 Hz or 460 Hz pulsed magnetic field for 30 min. If we take into account the five consecutive generations of mice, the above exposure actually took place in utero and, or during their life span. There was no difference in the incidence of leukemia or in the...

journal_title：Leukemia research

authors： Bellossi A

更新日期：1991-01-01 00:00:00

abstract：:Philadelphia-positive chronic myeloid leukemia (Ph+ CML) patients who are resistant to imatinib are commonly treated with second-generation tyrosine kinase inhibitors (TKIs). Limited data exist on the possible effects of these drugs on subsequent allogeneic hematopoietic stem cell transplantation (allo-HSCT).The outco...

journal_title：Leukemia research

authors： Breccia M,Palandri F,Iori AP,Colaci E,Latagliata R,Castagnetti F,Torelli GF,Usai S,Valle V,Martinelli G,Rosti G,Foà R,Baccarani M,Alimena G

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:T- cell prolymphocytic leukemia (T- PLL) is a rare aggressive hematological malignancy. Alemtuzumab, an anti-CD52 humanized monoclonal antibody, is the treatment of choice for remission induction. Allogeneic hematopoietic cell transplantation (allo-HCT) has been described to induce durable remissions and imp...

journal_title：Leukemia research

authors： Dholaria BR,Ayala E,Sokol L,Nishihori T,Chavez JC,Hussaini M,Kumar A,Kharfan-Dabaja MA

更新日期：2018-04-01 00:00:00

abstract：:The frequency of chromosomal alterations was compared among four children groups: those with Down syndrome and acute leukemia (DS/AL), those with acute leukemia (AL), those with only Down syndrome (DS) and healthy children (NC). The frequency of acquired chromosome abnormalities was larger in the AL group, followed by...

journal_title：Leukemia research

authors： Valladares A,Palma-Padilla V,Mejía-Aranguré JM,Guevara-Yánez R,Lerma-Reyes A,Salamanca-Gómez F

更新日期：2005-11-01 00:00:00

abstract：:Bone marrow culture techniques and equilibrium density centrifugation of human bone marrow cells were used to analyse the neutrophil-granulocyte, macrophage and eosinophil-granulocyte progenitor hierarchy. The buoyant density of progenitor cells changes as cells differentiate down the granulocyte-macrophage pathway an...

journal_title：Leukemia research

authors： Guimaraes JE,Francis GE,Bol SJ,Berney JJ,Hoffbrand AV

更新日期：1982-01-01 00:00:00

abstract：:We reported the different clinical features between Japanese and German refractory anemia (RA) patients in FAB classification. We re-analyzed the clinical features by WHO classification revised in 2008. The frequencies of refractory cytopenia with unilineage dysplasia (RCUD) and myelodysplastic syndrome-unclassified (...

journal_title：Leukemia research

authors： Matsuda A,Germing U,Jinnai I,Araseki K,Kuendgen A,Strupp C,Iwanaga M,Miyazaki Y,Hata T,Bessho M,Gattermann N,Tomonaga M

更新日期：2010-08-01 00:00:00

abstract：:To determine the clinical significance of the T helper 1(Th1)/T helper 2 (Th2) ratio in multiple myeloma, the intracellular IFN-gamma and IL-4 were analyzed by flow cytometry in 56 patients with multiple myeloma. The mean Th1/Th2 ratio of cases in the initial diagnosis phase and the refractory phase were higher than t...

journal_title：Leukemia research

authors： Ogawara H,Handa H,Yamazaki T,Toda T,Yoshida K,Nishimoto N,Al-ma'Quol WH,Kaneko Y,Matsushima T,Tsukamoto N,Nojima Y,Matsumoto M,Sawamura M,Murakami H

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:The use of intensive pediatric protocols for the treatment of ALL is being extended to older adults. AIM OF THE STUDY:Analysis of the efficacy and toxicity results of pediatric DFCP vs. classic Hyper-CVAD protocol for the treatment of patients with ALL < 50 Y. PATIENTS AND METHODS:A retrospective single ce...

journal_title：Leukemia research

authors： Alabdulwahab AS,Elsayed HG,Sherisher MA,Zeeneldin A,Alghamdi K,Elbjeirami WM

更新日期：2017-09-01 00:00:00

abstract：:Brazil is a wide country with huge contrasts. Its peculiarities can highlight environmental factors that could influence the frequencies of different cancers. The standard treatment and results achieved from several different areas of the country may not be found in others. The establishment of a national cooperative ...

journal_title：Leukemia research

authors： Lopes LF,Lorand-Metze I,Niero-Melo L,Tone LG,Velloso E,Campanaro CM,Latorre Mdo R

更新日期：2002-07-01 00:00:00

abstract：:Although biological and clinical features differ between B-lineage acute lymphoblastic leukemia (ALL) and T-lineage ALL (T-ALL), there have been few reports that focused on the prognosis for T-ALL in adults, primarily due to its rarity. Here, we studied the long-term outcomes and prognostic factors specific for adult ...

journal_title：Leukemia research

authors： Yanada M,Jinnai I,Takeuchi J,Ueda T,Miyawaki S,Tsuzuki M,Hatta Y,Usui N,Wada H,Morii T,Matsuda M,Kiyoi H,Okada M,Honda S,Miyazaki Y,Ohno R,Naoe T

更新日期：2007-07-01 00:00:00

abstract：:Protein tyrosine kinase-7 (PTK7) was recently identified as a surface protein expressed on hematopoietic cells. To determine if PTK7 is a useful biomarker in clinical practice for acute leukemia immunophenotyping and detection, we examined the PTK7 expression in human bone marrow and thymic specimens. Our results show...

journal_title：Leukemia research

authors： Jiang G,Zhang M,Yue B,Yang M,Carter C,Al-Quran SZ,Li B,Li Y

更新日期：2012-11-01 00:00:00

abstract：:c-Myc has been implicated in a variety of hematologic malignancies including Burkitt's lymphoma. Targeting c-Myc driven growth pathways could be therapeutically useful but might require the identification of critical downstream proteins. Here we show that the serine-threonine kinase PBK/TOPK is frequently overexpresse...

journal_title：Leukemia research

authors： Hu F,Gartenhaus RB,Zhao XF,Fang HB,Minkove S,Poss DE,Rapoport AP

更新日期：2013-04-01 00:00:00

abstract：:Two white European males are reported with adult T-cell leukemia (ATL), a disease first described in Japan, but recently also in the U.K. and U.S.A. Both patients presented with lymphadenopathy, but without a mediastinal mass. In addition, one patient had skin infiltrates and the other had hepatosplenomegaly. Morpholo...

journal_title：Leukemia research

authors： Tricot GJ,Broeckaert-Van Orshoven A,den Ottolander GJ,de Wolf-Peeters C,Meyer CJ,Verwilghen RL,Jansen J

更新日期：1983-01-01 00:00:00

abstract：:Migration of eosinophil (Eo) into tissues is a hallmark of chronic eosinophilic leukaemia (CEL), but the exact mechanism involved in cell migration is unknown. We report on a patient with CEL who presented high expressions of VLA-4, LFA-1 and Mac-1 integrins on the Eo surface, increased chemotaxis of Eo to eotaxin, de...

journal_title：Leukemia research

authors： Lima CS,Franco-Penteado CF,Canalli AA,Conran N,Lorand-Metze I,Costa FF,Ferreira HH

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Current results regarding treatment outcomes in acute myeloid leukemia (AML) point to significant differences between low- and middle-income countries (LMIC) and high-income countries (HIC). Excluding well-known socioeconomic issues, genetic markers important for prognosis have not been properly incorporated...

journal_title：Leukemia research

authors： Benicio MTL,Ribeiro AFT,Américo AD,Furtado FM,Glória AB,Lima AS,Santos SM,Xavier SG,Lucena-Araujo AR,Fagundes EM,Rego EM

更新日期：2017-09-01 00:00:00

abstract：:The aim of this study was to elucidate the pathologic sequence changes and associated clinical phenotypes in 9 new patients showing homozygosity for perforin gene among a total of 37 (24%) Turkish FHL families studied by linkage analysis. These 9 unrelated patients (5M/4F) were coming from consanguineous families and ...

journal_title：Leukemia research

authors： Okur H,Balta G,Akarsu N,Oner A,Patiroglu T,Bay A,Sayli T,Unal S,Gurgey A

更新日期：2008-06-01 00:00:00