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Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production.

Abstract：

:Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration with a mitochondrial membrane depolarization. Cytochrome c release to cytoplasm, superoxide anion overproduction and ATP depletion in NB4 cells induce, 16 h later, apoptosis by a typical caspase-9/caspase-3-dependent intrinsic pathway. K562 cells were more resistant to the DQA effect than NB4 cells, remaining viable for longer time periods.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Sancho P,Galeano E,Nieto E,Delgado MD,García-Pérez AI

doi

10.1016/j.leukres.2006.11.018

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

969-78

issue

7

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(06)00462-0

journal_volume

31

pub_type

杂志文章

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