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Combination of all-trans retinoic acid and lithium chloride surmounts a retinoid differentiation block induced by expression of Scl and Rbtn2 transcription factors in myeloid leukemia cells.

Abstract：

:We have previously shown that forced expression of the transcription factor Scl in WEHI-3B D(+) cells prevents ATRA-induced cell differentiation. We now find that the overexpression of Rbtn2 also interferes with induction of differentiation by ATRA. Addition of LiCl to ATRA treatment restored the capacity of both Scl- and Rbtn2-expressing cells to respond to the retinoid in a synergistic manner. Similar results were obtained with Scl-transfected HL60 cells where its expression diminished responsiveness to ATRA. These findings suggest that if Scl and/or Rbtn2 are involved in the non-responsiveness of AML patients to ATRA-induced differentiation, addition of LiCl may reverse insensitivity.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Rice AM,Li J,Sartorelli AC

doi

10.1016/j.leukres.2003.08.011

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

399-403

issue

4

eissn

0145-2126

issn

1873-5835

pii

S014521260300300X

journal_volume

28

pub_type

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