Human B-cell lymphoma cell lines are highly sensitive to apoptosis induced by all-trans retinoic acid and interferon-gamma.

Abstract:

:When cells were incubated in the presence of both interferon-gamma (IFN-gamma) and all-trans retinoic acid (ATRA), the concentration of IFN-gamma required to induce apoptosis of B-cell lymphoma cells was much lower than that required for myeloid or erythroid cell lines. The concentration of IFN-gamma that effectively inhibited the proliferation of BALM-3 cells was 1/40 of that required for BALM-1 cells. STAT-1 phosphorylation, IRF-1 mRNA and protein expression and RAR-beta expression were enhanced to a greater degree in BALM-3 cells treated with IFN-gamma and ATRA than in BALM-1 cells treated with IFN-gamma and ATRA, suggesting that these IFN-gamma related genes were involved in the induction of apoptosis of BALM-3 cells.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Niitsu N,Higashihara M,Honma Y

doi

10.1016/s0145-2126(01)00202-8

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

745-55

issue

8

eissn

0145-2126

issn

1873-5835

pii

S0145212601002028

journal_volume

26

pub_type

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