Clonality analysis of childhood ALL in remission: no evidence of clonal hematopoiesis.

abstract：:Discovering genetic predictors of childhood acute lymphoblastic leukemia (ALL) necessitates the evaluation of novel factors including maternal genetic effects, which are a proxy for the intrauterine environment, and robust epidemiologic study designs. Therefore, we evaluated five maternal and offspring xenobiotic meta...

journal_title：Leukemia research

authors： Nousome D,Lupo PJ,Okcu MF,Scheurer ME

更新日期：2013-05-01 00:00:00

abstract：:Outcomes in patients with secondary acute myeloid leukemia (sAML) (including therapy related myeloid neoplasms and AML with myelodysplasia related changes (MRC)) are poor. Patients treated with hypomethylating agents (HMAs) for antecedent hematological malignancy (AHM) have suboptimal responses to induction chemothera...

journal_title：Leukemia research

authors： Talati C,Goldberg AD,Przespolewski A,Chan O,Ali NA,Kim J,Famulare C,Sallman D,Padron E,Kuykendall A,Lancet JE,Wang E,Tallman MS,Komrokji R,Sweet K

更新日期：2020-06-01 00:00:00

abstract：:Checkpoint genes code for a family of proteins which sense DNA damage in eukaryotic cells. They play an important role in the control of the cell cycle. The human CHK2 is a homolog of the yeast G(2) checkpoint kinases known as CDS1 and RAD53. The CHK2 may be a tumor suppressor gene because it was found to be mutated i...

journal_title：Leukemia research

authors： Hofmann WK,Miller CW,Tsukasaki K,Tavor S,Ikezoe T,Hoelzer D,Takeuchi S,Koeffler HP

更新日期：2001-04-01 00:00:00

abstract：:Granulocytic sarcoma (GS) is a rare extra-medullary tumor and usually involves the skin, soft tissue, and lymph nodes. GS is found in 8% of acute myeloid leukemia (AML) patients, especially patients with t(8;21)AML. It has been suggested that GS is a poor prognostic factor in t(8;21)AML. Compared to t(8;21)AML, GS is ...

journal_title：Leukemia research

authors： Fujieda A,Nishii K,Tamaru T,Otsuki S,Kobayashi K,Monma F,Ohishi K,Nakase K,Katayama N,Shiku H

更新日期：2006-08-01 00:00:00

abstract：:Stem cell factor (SCF) is a growth factor that promotes the survival, proliferation, and differentiation of hematopoietic cells. SCF and its receptor, Kit, are normally present in both cell surface and soluble forms. Both forms of Kit can bind SCF. However, the function of soluble Kit is unknown. In order to determine...

journal_title：Leukemia research

authors： Dahlen DD,Lin NL,Liu YC,Broudy VC

更新日期：2001-05-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is an aggressive malignancy and new treatment modalities must be established to increase patient survival time. In the search for new therapeutic targets, reliable and well-characterised in vitro models are essential. In this study, we have characterised three MCL cell lines (SP53, Granta 51...

journal_title：Leukemia research

authors： Ek S,Ortega E,Borrebaeck CA

更新日期：2005-02-01 00:00:00

abstract：:Although the production of interleukin (IL) 2 and interferon (IFN) gamma by peripheral blood lymphocytes in patients with Hodgkin lymphoma (HL) is well documented, the synthesis of IL4 has not been investigated before. The present study examines the production of IL4 by 2-day phytohaemaglutinin (PHA)-stimulated periph...

journal_title：Leukemia research

authors： Mainou-Fowler T,Proctor SJ,Taylor PR

更新日期：2004-02-01 00:00:00

abstract：:We evaluated the efficacy of low-dose cytarabine and aclarubicin combined with granulocyte colony-stimulating factor (CAG) in elderly patients with previously untreated acute myeloid leukemia. Patients aged between 60 and 70 years who were not eligible for standard chemotherapy protocols and patients aged over 70 year...

journal_title：Leukemia research

authors： Suzushima H,Wada N,Yamasaki H,Eto K,Shimomura T,Kugimiya MH,Horikawa K,Nishimura S,Tsuda H,Mitsuya H,Asou N

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Current results regarding treatment outcomes in acute myeloid leukemia (AML) point to significant differences between low- and middle-income countries (LMIC) and high-income countries (HIC). Excluding well-known socioeconomic issues, genetic markers important for prognosis have not been properly incorporated...

journal_title：Leukemia research

authors： Benicio MTL,Ribeiro AFT,Américo AD,Furtado FM,Glória AB,Lima AS,Santos SM,Xavier SG,Lucena-Araujo AR,Fagundes EM,Rego EM

更新日期：2017-09-01 00:00:00

abstract：:The presence of intracellular cytoplasmic immunoglobulin M (IgM) in leukemic cells from patients with acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL) was investigated by flow cytometry. The objective of the study was to develop a reproducible flow cytometric method. A Burkitt's lymphoma-derived...

journal_title：Leukemia research

authors： Loftin KC,Reuben JM,Hersh EM,Sujansky D

更新日期：1985-01-01 00:00:00

abstract：:The CBFA2 gene on chromosome band 21q22 is one of the most commonly translocated genes in leukemia. As with other translocations, those involving CBFA2 are associated with specific disease phenotypes. Only one of the different translocations involving CBFA2, the t(12;21), has been associated with a non-myeloid lineage...

journal_title：Leukemia research

authors： Dann EJ,Fears S,Arád-Dann H,Nucifora G,Rowley JD

更新日期：2000-01-01 00:00:00

abstract：:The onset of acute myeloid leukemia following ionizing radiation or alkylating agent exposure is antedated months to years by the development of 'preleukemia', or secondary myelodysplastic syndrome (sMDS). Mitochondrial abnormalities induced by chloramphenicol and clonal deletions of mitochondrial DNA (mt DNA) in the ...

journal_title：Leukemia research

authors： Hatfill SJ,La Cock CJ,Laubscher R,Downing TG,Kirby R

更新日期：1993-11-01 00:00:00

abstract：:Despite the evolution of effective frontline treatment strategies, many patients with myeloma inevitably relapse. Treatment can be complicated by the interplay of disease-, treatment-, and patient-related factors. Unfortunately, many patients eventually develop disease that is refractory to lenalidomide and bortezomib...

journal_title：Leukemia research

authors： Mark TM,Coleman M,Niesvizky R

更新日期：2014-05-01 00:00:00

abstract：:The MTT cell viability assay is widely used in determining drug sensitivity profiles for patients with hematological malignancies and in primary screening of potential chemotherapeutic drugs. Because the multidrug resistance (MDR) phenotype is associated with these malignancies, and since many vital dyes are effluxed ...

journal_title：Leukemia research

authors： Marks DC,Belov L,Davey MW,Davey RA,Kidman AD

更新日期：1992-12-01 00:00:00

abstract：:We have established a new T-cell line (CL-8313) that produces interleukin-3 from the spleen cells of mice with a radiation-induced myeloproliferative disorder. IL-3 activity was detected at an extremely high level in the culture medium of the CL-8313 cell line in the absence of any exogenous stimulator. A large amount...

journal_title：Leukemia research

authors： Yoshida K,Seki M,Maeda M,Fujita J,Tadokoro K

更新日期：1988-01-01 00:00:00

abstract：:Treatment failure of patients with acute myelogenous leukemia (AML) is frequently due to the development of multidrug resistance phenotype blasts. We have expressed a fusion protein consisting of human granulocyte-macrophage colony stimulating factor (GMCSF) fused to the N-terminus of a lectin-deficient ricin toxin B ...

journal_title：Leukemia research

authors： Burbage C,Tagge EP,Harris B,Hall P,Fu T,Willingham MC,Frankel AE

更新日期：1997-07-01 00:00:00

abstract：:Leukemia-prone AKR mice were exposed twice a week to a 6 mT, 12 Hz or 460 Hz pulsed magnetic field for 30 min. If we take into account the five consecutive generations of mice, the above exposure actually took place in utero and, or during their life span. There was no difference in the incidence of leukemia or in the...

journal_title：Leukemia research

authors： Bellossi A

更新日期：1991-01-01 00:00:00

abstract：:In acute lymphoblastic leukemia (ALL) patients, automated fluorescence fragment analysis (ALF) has been reported to improve the monoclonality detection rate of immunoglobulin heavy chain genes (IgH) polymerase chain reaction (PCR) analysis. This study performed complementary determining region (CDR) I and III PCR on s...

journal_title：Leukemia research

authors： Gleissner B,Maurer J,Sindram A,Reinhard R,Thiel E

更新日期：2001-09-01 00:00:00

abstract：:Pericardial effusion is a rare but potentially life-threatening complication of chronic myelomonocytic leukemia. A case of a 70-year-old female with CMML is reported, who developed a severe pericardial effusion after an initially stable course of disease. She underwent pericardiocentesis and subsequent intracardial in...

journal_title：Leukemia research

authors： Strupp C,Germing U,Trommer I,Gattermann N,Aul C

更新日期：2000-12-01 00:00:00

abstract：:GNAS1 gene is located at the long arm of chromosome 20 (q13.32). GNAS1 gene deletion has never been investigated in MDS. A GNAS1 activating mutation (R201) was recently found in MDS. We applied FISH and DHPLC plus sequencing to investigate GNAS1 gene in MDS cases with and without del(20q) at karyotype. ...

journal_title：Leukemia research

authors： Di Giacomo D,Lema Fernandez AG,Pierini T,Crescenzi B,Brandimarte L,Matteucci C,Testoni N,Mecucci C

更新日期：2014-07-01 00:00:00

abstract：:The aims were to investigate the feasibility of imatinib mesylate (IM) discontinuation in chronic myeloid leukemia patients who were initially treated with IM and achieved complete molecular response (CMR). Fourteen patients were included. Ten were relapsed within 9.5 months after discontinuation of IM. All 7 patients...

journal_title：Leukemia research

authors： Yhim HY,Lee NR,Song EK,Yim CY,Jeon SY,Shin S,Kim JA,Kim HS,Cho EH,Kwak JY

更新日期：2012-06-01 00:00:00

abstract：:To increase our knowledge of the pathogenesis of tumour recurrence, cell membrane phenotypes were determined on bone marrow and extramedullary tumour cells at diagnosis and at relapse in 24 children with lymphoid malignancies. There were 19 patients with acute lymphoblastic leukemia and five with non-Hodgkin's lymphom...

journal_title：Leukemia research

authors： Lauer S,Piaskowski V,Camitta B,Casper J

更新日期：1982-01-01 00:00:00

abstract：:We examined the effect of deferasirox (DFX) on CD34+ hematopoietic progenitors from MDS patients. Progressive, dose-dependent suppression of MDS progenitor proliferation in culture was observed with DFX concentrations ranging from 5 μM to 20 μM. This effect was more pronounced in MDS compared to CD34+ progenitors isol...

journal_title：Leukemia research

authors： Pullarkat V,Sehgal A,Li L,Meng Z,Lin A,Forman S,Bhatia R

更新日期：2012-08-01 00:00:00

abstract：:Atypical chronic myeloid leukemia (aCML) and chronic neutrophilic leukemia (CNL) are rare BCR-ABL1 fusion gene-negative myeloid neoplasms with a predominance of neutrophils. Since no standard therapeutic strategy currently exists for these diseases, we retrospectively evaluated the outcomes of allogeneic hematopoietic...

journal_title：Leukemia research

authors： Itonaga H,Ota S,Ikeda T,Taji H,Amano I,Hasegawa Y,Ichinohe T,Fukuda T,Atsuta Y,Tanizawa A,Kondo T,Miyazaki Y

更新日期：2018-12-01 00:00:00

abstract：:CD200 is a relatively ubiquitously expressed molecule that plays a role in cancer immune evasion through interaction with its receptors. High expression levels of CD200 have been described in different human malignancies. For example, CD200 has been shown to be targeted after RAS/RAF/MEK/ERK activation in melanoma. He...

journal_title：Leukemia research

authors： Conticello C,Giuffrida R,Parrinello N,Buccheri S,Adamo L,Sciuto MR,Colarossi C,Aiello E,Chiarenza A,Romano A,Salomone E,Gulisano M,Giustolisi R,Di Raimondo F

更新日期：2013-12-01 00:00:00

abstract：:To characterize the molecular mechanisms involved in the transition from the chronic phase to blast crisis in chronic myelogenous leukemia (CML), gene expression profiles of leukemic cells from patients in the chronic and blast crisis phases were analyzed using an 8.7K cDNA chip and real-time PCR. A transient transfec...

journal_title：Leukemia research

authors： Kim KI,Park J,Ahn KS,Won NH,Kim BK,Shin WG,Yoon SS,Oh JM

更新日期：2010-08-01 00:00:00

abstract：:MicroRNA (miRNA) is an important regulator of cellular proliferation, differentiation and death. Leukemia-specific signature of miRNAs suggests that epigenetic dysregulation of miRNAs is important for leukemogenesis. We focused on the role of DNA methylation of miR-203 which targets BCR-ABL1 mRNA. The microarray analy...

journal_title：Leukemia research

authors： Shibuta T,Honda E,Shiotsu H,Tanaka Y,Vellasamy S,Shiratsuchi M,Umemura T

更新日期：2013-10-01 00:00:00

abstract：:The glycosylation of beta-hexosaminidase was investigated in the transformed cell-line, CCRF/CEM, derived from a human acute lymphoblastic leukaemia, and comparisons were made with enzyme from normal human skin fibroblasts. A series of studies including neuraminidase sensitivity, lectin chromatography, Biogel P4 chrom...

journal_title：Leukemia research

authors： Moss SE,Besley GT

更新日期：1988-01-01 00:00:00

abstract：:The ability of pH-sensitive liposomes and immunoliposomes to deliver synthetic antisense oligonucleotides (oligos) into human myeloid and lymphoid leukaemia cells was examined. The cellular uptake of an 18mer anti-myb oligonucleotide encapsulated in liposomes was from three- to five-fold higher than that of 32P-oligos...

journal_title：Leukemia research

authors： Ma DD,Wei AQ

更新日期：1996-11-01 00:00:00

abstract：:Leukemic cell apoptosis may be enhanced by appropriate oxidative stress. We report here the mechanism of Jurkat cell apoptosis by monochloramine (NH(2)Cl), a neutrophil-derived oxidant. NH(2)Cl induced caspase-dependent apoptosis, which was preceded by cytochrome c and Smac/Diablo release from mitochondria. Within 10m...

journal_title：Leukemia research

authors： Ogino T,Ozaki M,Hosako M,Omori M,Okada S,Matsukawa A

更新日期：2009-01-01 00:00:00