Abstract：
:The immunologic phenotype of the lymphocytes of 100 patients with chronic lymphocytic leukaemia (CLL) was investigated. Peripheral blood lymphocytes (PBL) were examined in all cases; in 46 patients with lymphadenopathy, a lymph node was biopsied and the histologic and immunologic patterns were assessed: 24 had a lymphocytic-lymphoplasmocytoid histology and 22 the follicular variant of lymphocytic lymphoma (mantle zone lymphoma, MZL). For comparison, lymph node suspensions from 19 patients with non-leukemic centrocytic lymphoma (CCL) were also studied. Significant differences in the PBL immunologic features were found between stage O and stage I patients. The phenotype of the lymphocytes of patients with lymphocytic histology was similar to that of stage 0 CLL patients, whereas major differences were found between these patients and those with mantle zone histology. This enables these patients to be recognized easily on immunologic grounds.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Resegotti L,Palestro G,Novero D,Micca FB,Godio L,Pistone M,Garnero M,Levis A,Stramignoni Adoi
10.1016/0145-2126(87)90063-4subject
Has Abstractpub_date
1987-01-01 00:00:00pages
789-95issue
9eissn
0145-2126issn
1873-5835journal_volume
11pub_type
杂志文章abstract：:Human lymphocyte antigen-G (HLA-G) is an immunosuppressive molecule that induces functional silencing of immune component cells and can be responsible for immunosuppression in patients with multiple myeloma (MM). Immune dysfunction is an important feature of MM and leads to infections as well as may promote disease pr...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.02.015
更新日期：2012-07-01 00:00:00
abstract：:We have previously shown that forced expression of the transcription factor Scl in WEHI-3B D(+) cells prevents ATRA-induced cell differentiation. We now find that the overexpression of Rbtn2 also interferes with induction of differentiation by ATRA. Addition of LiCl to ATRA treatment restored the capacity of both Scl-...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2003.08.011
更新日期：2004-04-01 00:00:00
abstract：:Philadelphia-positive chronic myeloid leukemia (Ph+ CML) patients who are resistant to imatinib are commonly treated with second-generation tyrosine kinase inhibitors (TKIs). Limited data exist on the possible effects of these drugs on subsequent allogeneic hematopoietic stem cell transplantation (allo-HSCT).The outco...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2009.04.036
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Telomerase disfunction leads to short telometric overhangs, potentially resulting in chromosome instability. AIMS:To better understand the role of overhang length in the progression of myelodysplastic syndrome (MDS). METHODS:Bone marrow samples of 62 Chinese MDS patients were screened for TERT and TERC gen...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2013.06.011
更新日期：2013-10-01 00:00:00
abstract：:We used a novel high-throughput drug screening assay, based on Luminex technology, to identify anti-myeloma agents capable of inhibiting cytokines and growth factors essential for multiple myeloma (MM) from a chemical library of 1120 compounds provided by MMRF. Tetracycline derivatives inhibited MM cell proliferation ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.12.002
更新日期：2010-07-01 00:00:00
abstract：:TCL-1 expression is variable in CLL, and no study has examined its association with treatment response. We measured TCL-1 protein in CLL cells from 51 patients who then received pentostatin, cyclophosphamide, and rituximab. TCL-1 expression did not correlate with any pre-treatment characteristics. Lower TCL-1 levels w...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.05.020
更新日期：2007-12-01 00:00:00
abstract：:We evaluated the effect of SCF on myeloid differentiation by correlating clonogenic potential (as CFU-GM), bone marrow (BM) plasma SCF levels and CD34/c-kit expression in 57 MDS samples. There was a significant correlation between low SCF levels and 'leukemic' in vitro growth, the number of clusters and the colony/clu...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(98)00175-1
更新日期：1999-03-01 00:00:00
abstract：:A double monoclonal component (MC) detected in the serum and/or urine represents a very rare occurrence (2-6% of monoclonal gammopathies). In this study, we report 34 patients with double serum MCs, focusing on the associated diseases. The diagnosis was made using high-resolution serum protein electrophoresis and immu...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.05.008
更新日期：2012-10-01 00:00:00
abstract：:In vivo infection by HTLV-I is characterized by the lack of virus expression in the host's infected cells and in most cases it is clinically inapparent. The present study shows that exposure of HTLV-I-infected human T-cells to a maximal non-toxic dose of 3-MC remarkably enhances virus expression. This stimulatory effe...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90098-6
更新日期：1993-05-01 00:00:00
abstract：:Cytogenetic analysis provides important diagnostic and prognostic information for patients with myelodysplastic syndromes (MDS). Prior studies, mostly comprised of small sample sizes, have reported conflicting results while evaluating the usefulness of FISH in addition to G-band karyotyping in MDS. In the current stud...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.09.013
更新日期：2010-04-01 00:00:00
abstract：:Adult T-cell leukemia/lymphoma is a distinct clinical entity characterized by a clonal proliferation of malignant T-lymphocytes. The etiologic agent of the disease is a Human T-cell lymphotropic virus type I. It occurs almost exclusively in areas where the virus is endemic; however the disease develops only in the min...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2010.02.011
更新日期：2010-12-01 00:00:00
abstract：:All-trans-retinoic acid (ATRA) has been proven active against a range of malignancies in isolated tissue culture systems and in human clinical trials, but the duration of its effects has been transient. Recent evidence indicates that the basis for the limited duration of ATRA's activity, at least in one form of leukem...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90040-x
更新日期：1994-08-01 00:00:00
abstract：:Chronic Lymphocytic Leukemia B cells (CLL) are malignant cells which retain at least some functions of normal B cells. Paramount amongst the latter is that when such cells are appropriately stimulated, they are able to present antigens, including any potential tumor antigens, making them excellent choices as a candida...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2018.03.002
更新日期：2018-05-01 00:00:00
abstract：:Infant leukemia cells with 46XY,t(11; 17)(q23; p13) karyotype and a hybrid pre B myeloid phenotype (HLA-DR, (Ia), B4 and My7-positive and CALLA and T11-negative) and immunoglobulin heavy chain gene rearrangement were maintained in long-term culture for over 10 months. The in-vitro survival and growth of the leukemia c...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(86)90253-5
更新日期：1986-01-01 00:00:00
abstract：:Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration wit...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.11.018
更新日期：2007-07-01 00:00:00
abstract：:The aim of this study was to elucidate the pathologic sequence changes and associated clinical phenotypes in 9 new patients showing homozygosity for perforin gene among a total of 37 (24%) Turkish FHL families studied by linkage analysis. These 9 unrelated patients (5M/4F) were coming from consanguineous families and ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.11.033
更新日期：2008-06-01 00:00:00
abstract：:Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) were measured in normal human and in malignant lymphoid cells. Thymocytes had high ADA activity (21.2 +/- 6.8 10(3) nM/h/mg) and low PNP activity (1.2 +/- 0.6), whereas T peripheral blood lymphocytes (PBL) had low ADA activity (1.20 +/- 0.22) and high...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(82)90027-3
更新日期：1982-01-01 00:00:00
abstract：:Imatinib mesylate (IM) is the treatment of choice in patients with newly diagnosed chronic myeloid leukemia (CML), irrespectively of their age. Nevertheless, information regarding tolerability and responses in advanced-age patients, a subgroup in which co-morbidities and other factors may influence outcome, is scarce,...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.leukres.2011.01.017
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:The skin is the common extranasal sites in extranodal natural killer (NK) / T - cell lymphoma, (ENKTL). However, data regarding cutaneous ENKTL are relatively scarce. Thus, we performed a large retrospective study to analyze clinical features and treatment outcomes of cutaneous ENKTL. PATIENTS AND METHODS:S...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2019.106284
更新日期：2020-01-01 00:00:00
abstract：:Recently, we identified a novel chromosomal rearrangement in Hodgkin lymphoma (HL), t(4;8)(q27;q24), which targets homeobox gene ZHX2 at the recurrent breakpoint 8q24. This aberration deletes the far upstream region of ZHX2 and results in silenced transcription pinpointing loss of activatory elements. Here, we have lo...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2011.10.019
更新日期：2012-05-01 00:00:00
abstract：:With Percoll density gradients, blasts from peripheral blood and bone marrow could be separated with a significant enrichment, and very often with a high degree of purity. This allowed a study of selected cases, where the separated sample exhibited chromosome abnormalities and/or an abnormal DNA content distribution (...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90037-2
更新日期：1985-01-01 00:00:00
abstract：:Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2004.11.015
更新日期：2005-05-01 00:00:00
abstract：:Although the production of interleukin (IL) 2 and interferon (IFN) gamma by peripheral blood lymphocytes in patients with Hodgkin lymphoma (HL) is well documented, the synthesis of IL4 has not been investigated before. The present study examines the production of IL4 by 2-day phytohaemaglutinin (PHA)-stimulated periph...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(03)00216-9
更新日期：2004-02-01 00:00:00
abstract：:Although there has been much progress in the treatment of acute lymphoblastic leukemia (ALL), decreased sensitivity to chemotherapy remains a significant issue. Recent studies have shown how interactions with the bone marrow microenvironment can protect ALL cells from chemotherapy and allow for the persistence of the ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.01.030
更新日期：2017-05-01 00:00:00
abstract：:A panel of human leukemia cell lines from various lineages (T-cell, pre B- and Non-T/Non-B cell, myelomonocytic and erythroleukemia cell lines) were utilised as model systems of the distant effects of differentiation-inducing activity (DIA) produced by the T-leukemia cell line HUT-102. DIA inhibited cell proliferation...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90108-1
更新日期：1987-01-01 00:00:00
abstract：:Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. We report here that OPN gene is transactivated by Tax protein of human T-cell leukemia virus type 1 (HTLV-1). Northern blot showed enhanced OPN gene expression in cells stably expressing Tax....
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.08.028
更新日期：2010-06-01 00:00:00
abstract：:The simultaneous occurrence of two specific acquired chromosomal abnormalities in chronic or acute leukaemias is rare. Inherited chromosomal abnormalities are also rare events in the general population. In chronic myeloid leukaemia (CML), characterised by the t(9;22)(q34;q11), the inv(16)(p13q22) has been described as...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2005.06.003
更新日期：2006-01-01 00:00:00
abstract：:Recent studies indicate that lipid metabolic changes affect the survival of multiple myeloma (MM) cells. Time-of-flight secondary ion mass spectrometry (TOF-SIMS), an imaging mass spectrometry technique, is used to visualize the subcellular distribution of biomolecules including lipids. We therefore applied this metho...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.02.011
更新日期：2015-06-01 00:00:00
abstract：:Higher-risk myelodysplastic syndromes (MDS) are rarely curable and have a poor prognosis. We investigated the accuracy of physicians' perception of patients' health status and the patients' preferences for involvement in treatment decisions. We examined 280 newly diagnosed higher-risk elderly MDS patients paired with ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2015.05.012
更新日期：2015-08-01 00:00:00
abstract：:Feulgen-DNA cytophotometry and 3H-thymidine autoradiography were used to evaluate therapeutic cytapheresis effects on cell cycle distributions of peripheral blood leukemic cells in 15 acute leukemia, 5 CML and 8 CLL patients and of bone marrow erythroblasts in 18 PV patients. Both individual cytapheresis procedures an...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90186-x
更新日期：1987-01-01 00:00:00
