Molecular mechanisms of resistance of leukemia to imatinib mesylate.

abstract：:There is resurgent interest in glucocorticoids (GCs) in the treatment of poor prognosis chronic lymphocytic leukemia (CLL). Little is known however on how GCs induce apoptosis in CLL. Methylprednisolone (MP) induces apoptosis in ZAP-70 positive CLL more readily than in ZAP-70 negative CLL, which is in contrast to the ...

journal_title：Leukemia research

authors： Boelens J,Lust S,Van Bockstaele F,Van Gele M,Janssens A,Derycke L,Vanhoecke B,Philippé J,Bracke M,Offner F

更新日期：2009-10-01 00:00:00

abstract：:The active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (VD3), inhibits proliferation and induces differentiation of myelomonocytic leukemia cells, but its clinical use is limited by the adverse effect of hypercalcemia. VD3 mobilizes calcium stores from bone by inducing the dissolution of bone mineral and matrix. ...

journal_title：Leukemia research

authors： Honma Y,Tobe H,Makishima M,Yokoyama A,Okabe-Kado J

更新日期：1998-07-01 00:00:00

abstract：:Of 597 cases of acute leukaemia in adults (greater than 16 years) seen at St. Bartholomew's Hospital, London, between May 1973 and January 1982, 412 were diagnosed as AML, 103 as ALL and 58 as Philadelphia chromosome positive blast crisis of CML (13 presenting as acute leukaemia and 45 having a prior chronic phase). T...

journal_title：Leukemia research

authors： Greaves MF,Bell R,Amess J,Lister TA

更新日期：1983-01-01 00:00:00

abstract：:A novel Philadelphia (Ph1) chromosome positive cell line, designated KYO-1, was established from the peripheral blood of a patient with chronic myelogenous leukemia (CML) in blastic crisis. Although this line had a unique capacity to differentiate spontaneously along the erythroid and monocytoid lineages as evidenced ...

journal_title：Leukemia research

authors： Ohkubo T,Kamamoto T,Kita K,Hiraoka A,Yoshida Y,Uchino H

更新日期：1985-01-01 00:00:00

abstract：:We designed a pharmacokinetic and pharmacodynamic phase I study of sequential topotecan (2.55-6.3mg/m2) by 72h infusion followed by five daily doses of etoposide for patients with refractory acute leukemia based upon synergistic anti-tumor activity of topoisomerase I and II inhibitors in vitro. Eight of the 29 patient...

journal_title：Leukemia research

authors： Cooper BW,Donaher E,Lazarus HM,Green SB,Gosky DM,Rosenthal NS,Berger SJ,Li X,Ingalls ST,Hoppel CL,Gerson SL

更新日期：2003-01-01 00:00:00

abstract：:Despite initial remissions, most patients with Ph chromosome positive (Ph(+)) acute leukemia (AL) become refractory to tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib. This study was designed to determine if targeting the interleukin-3 receptor (IL-3R) with a diphtheria toxin fusion protein (DT(388)IL...

journal_title：Leukemia research

authors： Kim HP,Frankel AE,Hogge DE

更新日期：2010-08-01 00:00:00

abstract：:The effect of prostaglandin E2 (PGE2) on the reduction of c-myc expression during the differentiation of the human leukemic cell line, HL-60, was examined. PGE2, a potent inducer of intracellular cyclic AMP (cAMP) in HL-60 cells, augmented monocyte-associated cell surface antigens induced by human gamma-interferon (IF...

journal_title：Leukemia research

authors： Matsui T,Nakao Y,Koizumi T,Katakami Y,Takahashi R,Mihara K,Sugiyama T,Fujita T

更新日期：1988-01-01 00:00:00

abstract：:In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MD...

journal_title：Leukemia research

authors： Yasunami T,Wang YH,Tsuji K,Takanashi M,Yamada Y,Motoji T

更新日期：2007-04-01 00:00:00

abstract：:When spleen cells of mice grafted with STIL-3 C5 cells, a leukemic T-cell line producing IL-3, are cultured in vitro, a high IL-3 activity is detectable in the culture supernatant. However, when bone marrow cells of the same grafted mice are cultured under similar conditions, hardly any IL-3 activity is detectable. To...

journal_title：Leukemia research

authors： Sugimoto K,Taniguchi S,Ogata H,Ikehara S,Fujita J,Mori KJ

更新日期：1992-09-01 00:00:00

abstract：:We report the development and characterization of SJ-9A4, a monoclonal antibody (MoAb) produced against common acute lymphoblastic leukemia (C-ALL) cell lines. SJ-9A4 reacted with C-ALL, B-cell chronic lymphocytic leukemia (B-CLL), platelets and C-ALL neuroblastoma (NB) and the K562 cell lines. It had no significant r...

journal_title：Leukemia research

authors： Komada Y,Peiper SC,Melvin SL,Metzger DW,Tarnowski BH,Green AA

更新日期：1983-01-01 00:00:00

abstract：:Five patients from the Kyushu area in Japan with adult T-cell leukaemia (ATL) refractory to conventional chemotherapeutic agents were treated with 5 mg/m2 of the adenosine deaminase inhibitor, 2'-deoxycoformycin (DCF), intravenously (i.v.) for 3 consecutive days, followed by 5 mg/m2 i.v. weekly. Two patients showed a ...

journal_title：Leukemia research

authors： Yamaguchi K,Yul LS,Oda T,Maeda Y,Ishii M,Fujita K,Kagiyama S,Nagai K,Suzuki H,Takatsuki K

更新日期：1986-01-01 00:00:00

abstract：:We analysed the optimal conditions for autologous bone marrow purging using complement binding monoclonal antibodies (mAbs). Twelve mAbs belonging to four clusters (CD9, CD10, CD19, CD24), alone or combined were evaluated by using direct cytotoxicity and clonogenic assays. We observed the following data: (1) optimal c...

journal_title：Leukemia research

authors： Racadot E,Herve P,Lamy B,Peters A

更新日期：1987-01-01 00:00:00

abstract：:AG-013736 is an oral anti-angiogenesis agent with activity against a variety of receptor tyrosine kinases, including VEGFR-1, VEGFR-2, VEGFR-3, c-kit, and PDGFR-beta. A phase 2 study was conducted in patients with poor prognosis AML or MDS. Twelve patients (six AML; six MDS) were treated with AG-013736 at a dose of 10...

journal_title：Leukemia research

authors： Giles FJ,Bellamy WT,Estrov Z,O'Brien SM,Verstovsek S,Ravandi F,Beran M,Bycott P,Pithavala Y,Steinfeldt H,Reich SD,List AF,Yee KW

更新日期：2006-07-01 00:00:00

abstract：:We have demonstrated that constitutive signal transducer and activator of transcription (STAT) 3 activity, observed in approximately 50% of acute myeloid leukemia (AML) cases, is associated with adverse treatment outcome. Constitutive STAT3 activation may result from the expression of oncogenic protein tyrosine kinase...

journal_title：Leukemia research

authors： Ghoshal Gupta S,Baumann H,Wetzler M

更新日期：2008-07-01 00:00:00

abstract：:We have studied the survival of clonogenic neoplastic cells of a murine pre-B-lymphoma (BCl-1) of the spleen in culture. We have found quantitative deficiencies such as reduced surface adherence of stromal cells and impaired CFU-F (colony forming units-fibroblast) and pre-CFU-F colony and layer formation in stromal cu...

journal_title：Leukemia research

authors： Prindull G,Ben-Ishay Z,Bergholz M,Prindull B

更新日期：1993-07-01 00:00:00

abstract：:A synthetic pentadecapeptide preparation, env 406-420, with an amino acid sequence deduced from the envelope glycoprotein gene of human T cell leukemia virus type I (HTLV I), was used as the antigen in an enzyme immunoassay for immunoglobulin G antibodies, exploring its usefulness for seroepidemiological purposes. The...

journal_title：Leukemia research

authors： Blomberg J,Fölsch G,Nilsson I,Fäldt R

更新日期：1985-01-01 00:00:00

abstract：:Although the production of interleukin (IL) 2 and interferon (IFN) gamma by peripheral blood lymphocytes in patients with Hodgkin lymphoma (HL) is well documented, the synthesis of IL4 has not been investigated before. The present study examines the production of IL4 by 2-day phytohaemaglutinin (PHA)-stimulated periph...

journal_title：Leukemia research

authors： Mainou-Fowler T,Proctor SJ,Taylor PR

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...

journal_title：Leukemia research

authors： He H,Fu W,Jiang H,Du J,Zhou L,Zhang C,Xi H,Li R,Hou J

更新日期：2015-05-01 00:00:00

abstract：:Molecular epidemiological studies have found new insights into the etiology of myelodysplastic syndromes (MDS). We analyzed the polymorphisms of 5 genes in 275 patients with primary MDS and 354 healthy controls in an attempt to identify candidate genetic risk factors for primary MDS in Chinese Han population. There wa...

journal_title：Leukemia research

authors： Li L,Yang L,Zhang Y,Xu Z,Qin T,Hao Y,Xiao Z

更新日期：2011-06-01 00:00:00

abstract：:To characterize the molecular mechanisms involved in the transition from the chronic phase to blast crisis in chronic myelogenous leukemia (CML), gene expression profiles of leukemic cells from patients in the chronic and blast crisis phases were analyzed using an 8.7K cDNA chip and real-time PCR. A transient transfec...

journal_title：Leukemia research

authors： Kim KI,Park J,Ahn KS,Won NH,Kim BK,Shin WG,Yoon SS,Oh JM

更新日期：2010-08-01 00:00:00

abstract：:Hodgkin and Sternberg Reed (H and SR) cells, the putative malignant cells of Hodgkin's disease carry regularly T-cell activation antigens, like CD30 and CD25 (low affinity IL-2 receptor). We have investigated the Hodgkin cell line L540, bearing characteristic markers of H and SR cells for its expression of the low aff...

journal_title：Leukemia research

authors： Tesch H,Herrmann T,Abts H,Diamantstein T,Diehl V

更新日期：1990-01-01 00:00:00

abstract：:Introduction of the maturation index (MI) as a measure for the degree of maturation improved the subtyping of acute myeloid leukemia (AML). A comparison is made here between the MI and the results of surface marker analysis with a panel of monoclonal antibodies (McAb) in the immunofluorescence technique. The McAb appl...

journal_title：Leukemia research

authors： van Rhenen DJ,van der Reijden HJ,van't Veer MB,Engelfriet CP,von dem Borne AE,Langenhuijsen MM

更新日期：1983-01-01 00:00:00

abstract：:Malignant plasma cells exert osteoclast-like activity in vitro. We investigated the function of the calcitonin (CT) receptor (R) on myeloma cells from patients and in myeloma cell lines. Primary myeloma cells expressed high CTR levels whereas the cell lines uniformly exposed the CTR-2 variant expressed by osteoclasts....

journal_title：Leukemia research

authors： Silvestris F,Cafforio P,De Matteo M,Quatraro C,Dammacco F

更新日期：2008-04-01 00:00:00

abstract：:We hypothesized that the high early death rate (EDR) due to bleeding in acute promyelocytic leukemia (APL) is in part attributable to delays in all- trans retinoic acid (ATRA). We conducted a retrospective analysis of the timing of ATRA administration. 204 consecutive patients with newly diagnosed APL between 1992 and...

journal_title：Leukemia research

authors： Altman JK,Rademaker A,Cull E,Weitner BB,Ofran Y,Rosenblat TL,Haidau A,Park JH,Ram SL,Orsini JM Jr,Sandhu S,Catchatourian R,Trifilio SM,Adel NG,Frankfurt O,Stein EM,Mallios G,Deblasio T,Jurcic JG,Nimer S,Peterson L

更新日期：2013-09-01 00:00:00

abstract：:We have studied 35 adult patients with morphologically undifferentiated peroxidase-negative acute leukemia that failed to meet the criteria for acute lymphoblastic leukemia and compared them to patients with FAB M1-M7 seen by the same physicians. The diagnosis of minimally differentiated acute leukemia (MD-AL) was ass...

journal_title：Leukemia research

authors： Cadwell FJ,Burns CP,Dick FR,Jones MP,Heckman KD,Weiner GJ,Goeken JA

更新日期：1993-03-01 00:00:00

abstract：:Microtubular reorganisation contributing to apoptotic morphology occurs in normal and neoplastic cells undergoing apoptosis induced by cytotoxic drugs [1-3]. The aim of this study was to correlate the changes in the microtubules (MTs) with behavior of the centrosome in apoptotic cells, and to see whether post-translat...

journal_title：Leukemia research

authors： Pittman S,Geyp M,Fraser M,Ellem K,Peaston A,Ireland C

更新日期：1997-06-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) and 25% of adult onset acute lymphoblastic leukemia (ALL) are associated with the expression of Bcr-Abl, a constitutively activated protein tyrosine kinase. Bcr-Abl associated leukemias are characterized by a high degree of chromosomal and genomic instability. It is unclear if the ph...

journal_title：Leukemia research

authors： Brain J,Saksena A,Laneuville P

更新日期：2002-11-01 00:00:00

abstract：:We evaluated the effect of SCF on myeloid differentiation by correlating clonogenic potential (as CFU-GM), bone marrow (BM) plasma SCF levels and CD34/c-kit expression in 57 MDS samples. There was a significant correlation between low SCF levels and 'leukemic' in vitro growth, the number of clusters and the colony/clu...

journal_title：Leukemia research

authors： Cortelezzi A,Cattaneo C,Cristiani S,Sarina B,Pomati M,Silvestris I,Ibatici A,Maiolo AT

更新日期：1999-03-01 00:00:00

abstract：:We report the characterization of a novel human T-cell line, HPB-MLp-W, which was established from blastic cells of a lymph node specimen from a patient with non-Hodgkin's lymphoma. They demonstrated the T-cell association antigens, CD2 and CD4, but no CD3, CD8, CD1, CD5, CD7 nor T-cell antigen receptor on their cell ...

journal_title：Leukemia research

authors： Morikawa S,Morikawa K,Hara J,Nagasaki M,Nakano A,Oseko F

更新日期：1991-01-01 00:00:00

abstract：:The risk of second malignant neoplasms (SMN) in chronic myeloid leukemia (CML) survivors remains unclear. We utilized the Surveillance, Epidemiology and End Results 18 (SEER 18) registries to evaluate the risk and subsequent outcomes of SMN in CML survivors. There were 3407 patients included. Of these, 170 (4.99%) dev...

journal_title：Leukemia research

authors： Jamy O,Sarmad R,Costa L

更新日期：2019-07-01 00:00:00