Abstract：
:There is resurgent interest in glucocorticoids (GCs) in the treatment of poor prognosis chronic lymphocytic leukemia (CLL). Little is known however on how GCs induce apoptosis in CLL. Methylprednisolone (MP) induces apoptosis in ZAP-70 positive CLL more readily than in ZAP-70 negative CLL, which is in contrast to the effects of radiation and chemotherapy. The increased GC sensitivity of ZAP-70+ CLL was studied in relation to the expression status of ZAP-70 and the related signal transducing tyrosine kinase SYK. Both ZAP-70 and SYK were downregulated by GC treatment. Moreover, SYK was dephosphorylated by the phosphatase PTP1B of which the expression and translation levels were induced by GCs. Inhibition of PTP1B successfully restored ZAP-70 expression and SYK phosphorylation but did not interfere with GC-induced apoptosis. Therefore, the downregulation of ZAP-70 and P-SYK per se during treatment with GCs is not sufficient to induce apoptosis, and different mechanisms must therefore be responsible for the increased steroid sensitivity of ZAP-70+ CLL.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Boelens J,Lust S,Van Bockstaele F,Van Gele M,Janssens A,Derycke L,Vanhoecke B,Philippé J,Bracke M,Offner Fdoi
10.1016/j.leukres.2009.02.022subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1335-43issue
10eissn
0145-2126issn
1873-5835pii
S0145-2126(09)00095-2journal_volume
33pub_type
杂志文章abstract：:Exogenous expression of the transcription factor Scl (Tal1) in WEHI-3B D+ myelomonocytic leukemia cells interferes with their capacity to respond to all-trans retinoic acid (ATRA) induced differentiation; combination of ATRA with LiCl, however, circumvents the inhibition of differentiation produced by Scl. To gain inf...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2004.03.017
更新日期：2004-11-01 00:00:00
abstract：:We determined the position of the breakpoint within the bcr gene in 22 patients with Philadelphia-positive chronic myelocytic leukemia using conventional Southern-blots and analyzed its relationship to thrombopoiesis. After DNA digestion with restriction endonucleases (Hind III, Bam HI and Bgl II), we localized the br...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90113-8
更新日期：1991-01-01 00:00:00
abstract：:Most clinicians caring for patients with AML do not use the word "cure" casually, since for many patients diagnosed with AML, a state of cure or even of long term survival remains elusive. Analysis of prognostic factors may aid in defining the chance for cure in various AML subtypes, and improvements are required at a...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2012.08.006
更新日期：2012-12-01 00:00:00
abstract：:Although the earliest sites of hematopoietic cell and endothelial cell differentiation in the yolk sac blood islands were identified about 100 years ago, cells with hemangioblast properties have not yet been identified in vivo. Endothelial cells differentiate from angioblasts in the embryo and from endothelial progeni...
journal_title：Leukemia research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.leukres.2006.10.014
更新日期：2007-04-01 00:00:00
abstract：:This study investigated radioresistance mechanisms in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100. AML-2/DX100 also showed resistance to radiation. AML-2/DX100 characterized by down-regulated catalase expression was supersensitive to exogenous hydrogen peroxide whereas they increased defense mec...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.11.006
更新日期：2007-09-01 00:00:00
abstract：:Analgesic use has been implicated in the chemoprevention of a number of solid tumors, but to date no previous research has focused on the role of analgesics in the etiology of multiple myeloma (MM). We conducted a hospital-based case-control study of 117 patients with primary, incident MM and 483 age and residence mat...
journal_title：Leukemia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.leukres.2006.07.027
更新日期：2007-04-01 00:00:00
abstract：:Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) were measured in normal human and in malignant lymphoid cells. Thymocytes had high ADA activity (21.2 +/- 6.8 10(3) nM/h/mg) and low PNP activity (1.2 +/- 0.6), whereas T peripheral blood lymphocytes (PBL) had low ADA activity (1.20 +/- 0.22) and high...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(82)90027-3
更新日期：1982-01-01 00:00:00
abstract：:Incidence and outcomes of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are not well established at the population level, especially since the widespread use of immunophenotyping. We studied the epidemiology of CLL in Manitoba (Canada) by combining data from a centralized flow cytometry facility and th...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.06.013
更新日期：2009-11-01 00:00:00
abstract：:Acute monocytic leukemia (M5) is a subtype of acute myeloid leukemia (AML) with two distinct morphologic subcategories, M5a and M5b. We compared the immunophenotype, cytogenetics and clinical outcome of AML M5 with non-M5 AML and also compared M5a with M5b. One hundred and twelve M5 (76 M5a, 36 M5b) and 726 non-M5 cas...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.06.019
更新日期：2008-02-01 00:00:00
abstract：:We examined polymorphisms of glutathione S-transferase (GST) genes in 159 Japanese patients with myelodysplasia and compared the incidence with that in 43 normal individuals to clarify their pathogenetic significance in myelodysplasia. In individuals with the GSTT1 null genotype, the odds ratios for disease risk were ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(99)00119-8
更新日期：1999-11-01 00:00:00
abstract：INTRODUCTION:The seven in absentia homolog 2 (SIAH2) protein plays a significant role in human cancer by regulating hypoxia-inducible factor-a (HIF-1α); however, its role in T-cell acute lymphoblastic leukemia (T-ALL) is less clear. METHODS:Immunofluorescence evaluation of SIAH2 protein expression and location were co...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2016.01.013
更新日期：2016-03-01 00:00:00
abstract：:We recently confirmed that ciclopirox olamine inhibits Wnt/beta catenin signalling in myeloma. Griseofulvin (GF) has similar chemical features as compared to ciclopirox olamine. In this study the anti-tumor effect of GF was investigated. GF demonstrated a major apoptotic activity in various human and murine myeloma an...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2010.10.008
更新日期：2011-08-01 00:00:00
abstract：:We wondered whether there was any association between the extent of increased angiogenesis and IgV(H) gene mutational status, expression of CD38 and ZAP-70 in early B-cell chronic lymphocytic leukemia (CLL) patients. Circulating levels of vascular endothelial growth factor (VEGF) correlated positively with ZAP-70-expr...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.03.009
更新日期：2007-11-01 00:00:00
abstract：:The prognosis of patients with advanced refractory lymphoma remains poor. We have carried out a Phase II study of continuous high dose intravenous recombinant interleukin 2 alone without LAK cells in this group of patients. Eight patients have so far been treated, 4 with non-Hodgkins lymphoma and 4 with Hodgkins disea...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/0145-2126(91)90053-v
更新日期：1991-01-01 00:00:00
abstract：:The purpose of this study was to determine the relationship between platinum-DNA adducts in leukemic cells and the success of remission induction therapy in adult patients with acute nonlymphocytic leukemia (ANLL). Freshly isolated cells from pre-treatment bone marrow aspirates of 14 patients were incubated with cispl...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/0145-2126(94)90064-7
更新日期：1994-09-01 00:00:00
abstract：:We report a unique case of de novo acute promyelocytic leukemia (APL) with cryptic 15;17 rearrangements. Cytogenetically, structural rearrangements of the 6p23 region has been reported mainly in secondary leukemia. This patient had a karyotype of 46, XY, del(6)(p23) and no additional chromosomal abnormalities. Molecul...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(99)00139-3
更新日期：2000-01-01 00:00:00
abstract：:The surface marker phenotype of lymphocytes derived from 12 patients with B-CLL was compared to that of lymphocytes from 10 patients with an other monoclonal but clinical benign form of B-cell proliferative disorder termed monoclonal B-cell lymphocytosis of undetermined significance (B-MLUS). A panel of well character...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(89)90028-3
更新日期：1989-01-01 00:00:00
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journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2011.06.015
更新日期：2011-12-01 00:00:00
abstract：:Hematopoiesis is regulated by several cytokines with pleiotropic activity. Several evidences have clearly demonstrated that these molecules, formerly regarded as specific for the hematopoietic system, also affect certain endothelial cell functions and that hematopoietic factors clearly influence angiogenesis. This rev...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2012.02.003
更新日期：2012-05-01 00:00:00
abstract：:We report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. The cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at di...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(01)00152-7
更新日期：2002-06-01 00:00:00
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journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90058-s
更新日期：1993-02-01 00:00:00
abstract：:Infant leukemia cells with 46XY,t(11; 17)(q23; p13) karyotype and a hybrid pre B myeloid phenotype (HLA-DR, (Ia), B4 and My7-positive and CALLA and T11-negative) and immunoglobulin heavy chain gene rearrangement were maintained in long-term culture for over 10 months. The in-vitro survival and growth of the leukemia c...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(86)90253-5
更新日期：1986-01-01 00:00:00
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journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2009.03.035
更新日期：2009-10-01 00:00:00
abstract：:Outcome of adult acute lymphoblastic leukemia (ALL) with central nervous system (CNS) involvement is not clearly defined. We studied 104 patients presenting with CNS involvement at diagnosis among 1493 patients (7%) included into the LALA trials, and 109 patients presenting CNS disease at the time of first relapse amo...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2008.04.011
更新日期：2008-11-01 00:00:00
abstract：:An insertion (10;11)(p11;q23q24) was found in bone marrow metaphase cells from two children with acute monocytic leukemia (AMoL-M5b). This rearrangement involves a small chromosomal segment of 11q and may be misinterpreted as a deletion of 11q. Insertion (10;11) may represent a new recurring abnormality involving 11q ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90140-7
更新日期：1985-01-01 00:00:00
abstract：:Fractionation of mononuclear cells from human fetal liver provides a cell population at early stages of myeloid differentiation which, when cultured, generates neutrophils and macrophages for up to a month. These studies describe the further purification of an undifferentiated myeloid blast cell population by rosette ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(90)90114-o
更新日期：1990-01-01 00:00:00
abstract：:Treatment failure of patients with acute myelogenous leukemia (AML) is frequently due to the development of multidrug resistance phenotype blasts. We have expressed a fusion protein consisting of human granulocyte-macrophage colony stimulating factor (GMCSF) fused to the N-terminus of a lectin-deficient ricin toxin B ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(97)00043-x
更新日期：1997-07-01 00:00:00
abstract：:Chromosomal changes are necessary in determining the classification, prognosis and using the appropriate therapeutic regimen in acute leukemia. Isochromosomes are uncommon chromosome aberations in childhood acute lymphoblastic leukemia (ALL) and the effect of i(9q) is not well established. We present an 8-year-old mal...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.02.018
更新日期：2006-11-01 00:00:00
abstract：:We studied 98 female patients in remission (2-240 months) from childhood ALL to determine the clonality status of their hematopoiesis. Thirty-one (31.6%) were heterozygous at the PGK locus for the BstX1 endonuclease restriction site, permitting X-linked clonality assays to be performed. Two patients were in relapse at...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(94)90121-x
更新日期：1994-02-01 00:00:00
abstract：:Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2004.11.015
更新日期：2005-05-01 00:00:00
