Increased peripheral stem cell pool in MDS: an indication of disease progression?

abstract：:This study was conducted to determine the frequency of the most common fusion genes in Mexican pediatric patients with acute lymphoblastic leukemia (ALL). Molecular analysis using RT-PCR was carried out in 53-blood samples: 52 patients with de novo ALL and one with relapsed ALL. The ETV6-RUNX1 fusion was found in 7 ca...

journal_title：Leukemia research

authors： Jiménez-Morales S,Miranda-Peralta E,Saldaña-Alvarez Y,Perez-Vera P,Paredes-Aguilera R,Rivera-Luna R,Velázquez-Cruz R,Ramírez-Bello J,Carnevale A,Orozco L

更新日期：2008-10-01 00:00:00

abstract：:TCL-1 expression is variable in CLL, and no study has examined its association with treatment response. We measured TCL-1 protein in CLL cells from 51 patients who then received pentostatin, cyclophosphamide, and rituximab. TCL-1 expression did not correlate with any pre-treatment characteristics. Lower TCL-1 levels w...

journal_title：Leukemia research

authors： Browning RL,Geyer SM,Johnson AJ,Jelinek DF,Tschumper RC,Call TG,Shanafelt TD,Zent CS,Bone ND,Dewald GW,Lin TS,Heerema NA,Grever MR,Kay NE,Byrd JC,Lucas DM

更新日期：2007-12-01 00:00:00

abstract：:In order to investigate whether transfer of the cytidine deaminase (CDD) cDNA would increase chemotherapy resistance to cytosine arabinoside (ara-C) we used a retroviral vector expressing both, neomycin phosphotransferase and the CDD cDNA, to transduce hematopoietic cells from cell lines and from murine bone marrow (B...

journal_title：Leukemia research

authors： Flasshove M,Frings W,Schröder JK,Moritz T,Schütte J,Seeber S

更新日期：1999-11-01 00:00:00

abstract：:Glycosylation of cytokines appears to be responsible for several differences in their activity, and focusing on G-CSF, several divergences between the non-glycosylated G-CSF, Filgrastim, and the glycosylated G-CSF, Lenograstim, have been reported. To verify the role of G-CSF glycosylation in mediating these difference...

journal_title：Leukemia research

authors： Mattii L,Battolla B,Azzarà A,D'Urso G,Montali U,Petrini M

更新日期：2011-02-01 00:00:00

abstract：:Chromosomal changes are necessary in determining the classification, prognosis and using the appropriate therapeutic regimen in acute leukemia. Isochromosomes are uncommon chromosome aberations in childhood acute lymphoblastic leukemia (ALL) and the effect of i(9q) is not well established. We present an 8-year-old mal...

journal_title：Leukemia research

authors： Cogulu O,Karapinar DY,Karaca E,Aydinok Y,Ozkinay F

更新日期：2006-11-01 00:00:00

abstract：:Nucleic acid and protein synthesis was determined in immature myeloid cells isolated from seven normal bone marrow samples and compared to blasts from nine patients with fullblown acute non-lymphocytic leukemia. Samples obtained from normal bone marrow contained a mean of 82% immature myeloid cells with 29.9% S-phase ...

journal_title：Leukemia research

authors： Burghouts JT,Plas AM,Salden MH,Wessels HM

更新日期：1982-01-01 00:00:00

abstract：:The development of risk-adapted therapy has improved the treatment results of acute lymphoblastic leukemia (ALL) especially in children. However, more accurate risk classifiers are warranted. In this study we aimed at defining a prognostic classifier based on DNA copy number alterations of adolescent and young adult (...

journal_title：Leukemia research

authors： Usvasalo A,Elonen E,Saarinen-Pihkala UM,Räty R,Harila-Saari A,Koistinen P,Savolainen ER,Knuutila S,Hollmén J

更新日期：2010-11-01 00:00:00

abstract：:The use of low density lipoprotein (LDL) as drug carrier in acute myeloblastic leukemia chemotherapy is attractive due to high LDL uptake by leukemic cells. Lipid-based formulations, such as liposomes or microemulsions are promising alternatives. In the current study, we incorporated N-trifluoroacetyl-adriamycin-14-va...

journal_title：Leukemia research

authors： Masquelier M,Lundberg B,Peterson C,Vitols S

更新日期：2006-02-01 00:00:00

abstract：:MDS is primarily a disease of the elderly. Cases who give a history of exposure to X-rays, cytotoxic drugs or leukaemogenic chemicals may be younger. Many cases of MDS present because of an incidental blood count. The most prominent clinical features are those of anaemia, neutropenia, thrombocytopenia. Because haemopo...

journal_title：Leukemia research

authors： Hamblin T

更新日期：1992-01-01 00:00:00

abstract：:Molecular epidemiological studies have found new insights into the etiology of myelodysplastic syndromes (MDS). We analyzed the polymorphisms of 5 genes in 275 patients with primary MDS and 354 healthy controls in an attempt to identify candidate genetic risk factors for primary MDS in Chinese Han population. There wa...

journal_title：Leukemia research

authors： Li L,Yang L,Zhang Y,Xu Z,Qin T,Hao Y,Xiao Z

更新日期：2011-06-01 00:00:00

abstract：:Thermal stress induces expression of a family of heat shock proteins which may regulate the synthesis of various cellular genes. We investigated the effect of heat shock on polyadenylation in Epstein-Barr Virus (EBV) negative and EBV transformed human Burkitt's lymphoma (BL) B-cell lines. Incubation of the BL B-cell l...

journal_title：Leukemia research

authors： Kumar A,Kurl RN,Kryworuchko M,Diaz-Mitoma F,Sharma S

更新日期：1995-11-01 00:00:00

abstract：:Stromal cells from pediatric myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) associated with MDS (MDS-AML) present high expression of leukemia inhibitor factor (LIF). We demonstrated using mitogen-activated protein kinase (MAPK) inhibitors that in stromal cells from pediatric MDS and MDS-AML, p38MAPK ...

journal_title：Leukemia research

authors： da Costa SV,Roela RA,Junqueira MS,Arantes C,Brentani MM

更新日期：2010-04-01 00:00:00

abstract：:Hodgkin and Sternberg Reed (H and SR) cells, the putative malignant cells of Hodgkin's disease carry regularly T-cell activation antigens, like CD30 and CD25 (low affinity IL-2 receptor). We have investigated the Hodgkin cell line L540, bearing characteristic markers of H and SR cells for its expression of the low aff...

journal_title：Leukemia research

authors： Tesch H,Herrmann T,Abts H,Diamantstein T,Diehl V

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To study whether institutional clinical trial accrual volume affects clinical outcomes of younger (age less than 61 years) patients with acute myeloid leukemia. PATIENTS AND METHODS:We investigated the impact of clinical trial accrual on response rates, early mortality and survival in patients with AML enrolle...

journal_title：Leukemia research

authors： Medeiros BC,Othus M,Tallman MS,Sun Z,Fernandez HF,Rowe JM,Lazarus HM,Appelbaum FR,Luger SM,Litzow MR,Erba HP

更新日期：2019-03-01 00:00:00

abstract：:ABCG2 encodes a transporter protein that is associated with multidrug-resistant phenotypes in many cancers, including acute myeloid leukemia (AML); high levels of expression are generally associated with a poor prognosis. To better understand how expression of ABCG2 is controlled in pediatric AML, we performed a detai...

journal_title：Leukemia research

authors： Campbell PK,Zong Y,Yang S,Zhou S,Rubnitz JE,Sorrentino BP

更新日期：2011-10-01 00:00:00

abstract：:Philadelphia-positive chronic myeloid leukemia (Ph+ CML) patients who are resistant to imatinib are commonly treated with second-generation tyrosine kinase inhibitors (TKIs). Limited data exist on the possible effects of these drugs on subsequent allogeneic hematopoietic stem cell transplantation (allo-HSCT).The outco...

journal_title：Leukemia research

authors： Breccia M,Palandri F,Iori AP,Colaci E,Latagliata R,Castagnetti F,Torelli GF,Usai S,Valle V,Martinelli G,Rosti G,Foà R,Baccarani M,Alimena G

更新日期：2010-02-01 00:00:00

abstract：:N-Propyl-N-nitrosourea (PNU) was proved to be a strong leukemogen, which induces myelogenous leukemia or thymic lymphoma in rats. BUF/Mna rats and F344 rats were the strain most susceptible to thymic lymphomagenic activity of PNU. In addition, F1 rats between BUF/Mna and WKY rats were also susceptible to PNU-lymphomag...

journal_title：Leukemia research

authors： Ogiu T,Utsumi KR,Fukami H,Matsuyama M

更新日期：1988-01-01 00:00:00

abstract：:The prognostic relevance of 12p deletion is controversial in multiple myeloma (MM) and the status of 12p deletion is unknown in other plasma cell disorders. We investigated 12p deletion in 88 patients with MM, 19 patients with monoclonal gammopathy of undetermined significance (MGUS), and 17 patients with plasma cell ...

journal_title：Leukemia research

authors： Jiang N,Qi C,Yu L,Ning Y,An G,Qiu L,Chang H

更新日期：2012-01-01 00:00:00

abstract：:Older patients with acute myelogenous leukemia (AML) have overexpression of P-glycoprotein (Pgp+), and this has been shown to correlate quantitatively with therapeutic outcome. Since Pgp-mediated efflux of cytotoxic drugs can be inhibited by the cyclosporine analogue, PSC 833, we investigated the use of this agent wit...

journal_title：Leukemia research

authors： Chauncey TR,Rankin C,Anderson JE,Chen I,Kopecky KJ,Godwin JE,Kalaycio ME,Moore DF,Shurafa MS,Petersdorf SH,Kraut EH,Leith CP,Head DR,Luthardt FW,Willman CL,Appelbaum FR

更新日期：2000-07-01 00:00:00

abstract：:Higher-risk myelodysplastic syndromes (MDS) are rarely curable and have a poor prognosis. We investigated the accuracy of physicians' perception of patients' health status and the patients' preferences for involvement in treatment decisions. We examined 280 newly diagnosed higher-risk elderly MDS patients paired with ...

journal_title：Leukemia research

authors： Caocci G,Voso MT,Angelucci E,Stauder R,Cottone F,Abel G,Nguyen K,Platzbecker U,Beyne-Rauzy O,Gaidano G,Invernizzi R,Molica S,Criscuolo M,Breccia M,Lübbert M,Sanpaolo G,Buccisano F,Ricco A,Palumbo GA,Niscola P,Zhan

更新日期：2015-08-01 00:00:00

abstract：:Nasal-type natural killer/T-cell (NK/T-cell) lymphomas are subtypes of non-Hodgkin's lymphoma (NHL), which are typically more clinically aggressive. There is, however relatively little understanding of nasal-type NK/T-cell lymphoma molecular pathogenesis. Thus, in this study we applied RNA sequencing to systematically...

journal_title：Leukemia research

authors： Zhang X,Zhao L,Li X,Wang X,Li L,Fu X,Sun Z,Li Z,Nan F,Chang Y,Zhang M

更新日期：2015-12-01 00:00:00

abstract：:Although there has been much progress in the treatment of acute lymphoblastic leukemia (ALL), decreased sensitivity to chemotherapy remains a significant issue. Recent studies have shown how interactions with the bone marrow microenvironment can protect ALL cells from chemotherapy and allow for the persistence of the ...

journal_title：Leukemia research

authors： Quagliano A,Gopalakrishnapillai A,Barwe SP

更新日期：2017-05-01 00:00:00

abstract：:Mitoxantrone, etoposide and prednisone (MEP)-based regimens using granulocyte colony-stimulating factor (G-CSF) were designed for relapsed and CHOP-resistant diffuse large B-cell lymphomas in a single institution, and the therapeutic effects and adverse reactions were studied. In a total of 49 patients, the MEP regime...

journal_title：Leukemia research

authors： Murohashi I,Kashimura T,Tominaga K,Wakao D,Takahashi T,Akiba M,Kishimoto K,Yoshida K,Yagasaki F,Itoh Y,Sakata T,Kawai N,Itoh K,Suzuki T,Matsuda A,Hirashima K,Bessho M

更新日期：2002-03-01 00:00:00

abstract：:A new cell line, designated MO1043, was established from the peripheral blood (PB) of a patient with B-cell chronic lymphocytic leukemia (CLL). Both the PB leukemia cells and MO1043 were found to have an abnormal cytogenetic marker of trisomy 12, the most common cytogenetic abnormality in CLL. In addition, both the PB...

journal_title：Leukemia research

authors： Kawata A,Han T,Dadey B,Weier HU,Okazaki M,Yokota S,Fukiage T,Xiao H,Block AM,Barcos M

更新日期：1993-10-01 00:00:00

abstract：:miR-16, a miRNA involved in cell proliferation and apoptosis regulation, may interfere with either oncogenic or tumor-suppressor pathways and is implicated in leukemogenesis. We then explored its expression in 93 childhood acute lymphoblastic leukemia (ALL) cases. A high miR-16 expression was associated with hyperleuk...

journal_title：Leukemia research

authors： Kaddar T,Chien WW,Bertrand Y,Pages MP,Rouault JP,Salles G,Ffrench M,Magaud JP

更新日期：2009-09-01 00:00:00

abstract：:The effect of serum on the proliferation of human bone marrow pluripotent progenitor cells (CFU-GEMM), was compared to that of fresh frozen plasma (FFP). Serum significantly increased the number of mixed erythroid-granulocytic-megakaryocytic colonies (CFU-GEMM) and erythrocytic bursts (BFU-E) in this assay system (p l...

journal_title：Leukemia research

authors： Michalevicz R,Francis GE,Price GM,Hoffbrand AV

更新日期：1985-01-01 00:00:00

abstract：:The aberrant changes of tumor suppressor genes (TSGs) are now recognized as an important mechanism contributing to the development of acute myeloid leukemia (AML). CCAAT/enhancer binding protein zeta (C/EBPζ), a candidate TSG, has been found to be involved in cancers including AML. We detected the methylation status o...

journal_title：Leukemia research

authors： Yao DM,Qian J,Lin J,Wang YL,Chen Q,Qian Z,Li Y,Wang CZ,Yang J

更新日期：2011-07-01 00:00:00

abstract：:We investigated protracted low-dose oral Clofarabine for the treatment of myelodysplastic syndromes (MDS). Adults with an International Prognostic Scoring System (IPSS) score of INT-1 or higher who had failed first line therapy were eligible. INT-1 patients had to be transfusion-dependent. We started with oral Clofara...

journal_title：Leukemia research

authors： Rudrapatna VK,Morley K,Boucher KM,Pierson AS,Shull CT,Kushner JP,Shami PJ

更新日期：2015-08-01 00:00:00

abstract：:In vivo infection by HTLV-I is characterized by the lack of virus expression in the host's infected cells and in most cases it is clinically inapparent. The present study shows that exposure of HTLV-I-infected human T-cells to a maximal non-toxic dose of 3-MC remarkably enhances virus expression. This stimulatory effe...

journal_title：Leukemia research

authors： Feldman G,Aboud M

更新日期：1993-05-01 00:00:00

abstract：:The tumor microenvironment (TME) is critical to the longevity of tumor B cells in chronic lymphocytic leukemia (CLL). Bone marrow mesenchymal stem cells (BMMSCs) and the cytokines they produce including IL-6 are important components of the TME in CLL. We found BMMSCs supported the survival of CLL cells in vitro throug...

journal_title：Leukemia research

authors： Zhu F,McCaw L,Spaner DE,Gorczynski RM

更新日期：2018-03-01 00:00:00