Abstract:
:Glycosylation of cytokines appears to be responsible for several differences in their activity, and focusing on G-CSF, several divergences between the non-glycosylated G-CSF, Filgrastim, and the glycosylated G-CSF, Lenograstim, have been reported. To verify the role of G-CSF glycosylation in mediating these differences we tested in vitro the effects on the RhoA activation of the different G-CSFs, including deglycosylated Lenograstim. The results showed that Filgrastim induced sustained-RhoA activation while Lenograstim did not do so. Deglycosylated Lenograstim mimicked Filgrastim, resulting in RhoA hyper-activation. These in vitro findings demonstrate that the glycosylation of G-CSF plays a crucial role in RhoA activation.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Mattii L,Battolla B,Azzarà A,D'Urso G,Montali U,Petrini Mdoi
10.1016/j.leukres.2010.05.027subject
Has Abstractpub_date
2011-02-01 00:00:00pages
265-7issue
2eissn
0145-2126issn
1873-5835pii
S0145-2126(10)00286-9journal_volume
35pub_type
杂志文章abstract::We have recently described that a variant of L1210 leukemia cell (L1210/LN-1) originally fused with Lesch-Nyhan fibroblast is highly immunogenic for inducing tumor-specific transplantation immunity in (BALB/cxDBA/2)F1 mice. This finding has clearly been confirmed in the present study by in-vitro cell-mediated cytotoxi...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(85)90316-9
更新日期:1985-01-01 00:00:00
abstract::The risk of second malignant neoplasms (SMN) in chronic myeloid leukemia (CML) survivors remains unclear. We utilized the Surveillance, Epidemiology and End Results 18 (SEER 18) registries to evaluate the risk and subsequent outcomes of SMN in CML survivors. There were 3407 patients included. Of these, 170 (4.99%) dev...
journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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abstract::Nasal-type natural killer/T-cell (NK/T-cell) lymphomas are subtypes of non-Hodgkin's lymphoma (NHL), which are typically more clinically aggressive. There is, however relatively little understanding of nasal-type NK/T-cell lymphoma molecular pathogenesis. Thus, in this study we applied RNA sequencing to systematically...
journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(95)00084-4
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journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2012.12.017
更新日期:2013-04-01 00:00:00
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2012.07.004
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2006.11.018
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journal_title:Leukemia research
pub_type: 信件
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2010.06.003
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1996-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00