Abstract:
:The development of risk-adapted therapy has improved the treatment results of acute lymphoblastic leukemia (ALL) especially in children. However, more accurate risk classifiers are warranted. In this study we aimed at defining a prognostic classifier based on DNA copy number alterations of adolescent and young adult (AYA) (10-25 yrs) ALL patients (n=60) determined by microarray CGH and the relapse status of the patients. As a result of prognostic model identification procedure, we got a model of four genes: BAK1, CDKN2C, GSTM1, and MT1F, the copy number profile combinations of which differentiated AYA ALL patients at diagnosis depending on their risk of relapse. The performance of the model was poorer on other age groups. We suggest that this kind of approach produces models simple and accurate enough for potential use in ALL routine classification.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Usvasalo A,Elonen E,Saarinen-Pihkala UM,Räty R,Harila-Saari A,Koistinen P,Savolainen ER,Knuutila S,Hollmén Jdoi
10.1016/j.leukres.2010.02.031subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1476-82issue
11eissn
0145-2126issn
1873-5835pii
S0145-2126(10)00114-1journal_volume
34pub_type
杂志文章abstract::MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression at the post-transcriptional level through its sequence complementation with target mRNAs. An individual miRNA species can simultaneously influence the expression of multiple genes and conversely, several miRNAs can synchronously contro...
journal_title:Leukemia research
pub_type: 杂志文章,评审
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-07-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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更新日期:2020-06-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90181-0
更新日期:1987-01-01 00:00:00
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更新日期:2010-11-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/j.leukres.2011.06.015
更新日期:2011-12-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(91)90169-t
更新日期:1991-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章,评审
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journal_title:Leukemia research
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Leukemia research
pub_type: 杂志文章
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