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Differences in the distribution of subtypes according to the WHO classification 2008 between Japanese and German patients with refractory anemia according to the FAB classification in myelodysplastic syndromes.

Abstract：

:We reported the different clinical features between Japanese and German refractory anemia (RA) patients in FAB classification. We re-analyzed the clinical features by WHO classification revised in 2008. The frequencies of refractory cytopenia with unilineage dysplasia (RCUD) and myelodysplastic syndrome-unclassified (MDS-U) with pancytopenia in Japanese patients were higher than in German patients (p<0.001). Refractory cytopenia with multilineage dysplasia patients showed the most unfavorable prognosis in both countries. The higher frequencies of MDS-U with pancytopenia and RCUD in Japanese patients may influence the different clinical characteristics between Japanese and German FAB-RA patients.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Matsuda A,Germing U,Jinnai I,Araseki K,Kuendgen A,Strupp C,Iwanaga M,Miyazaki Y,Hata T,Bessho M,Gattermann N,Tomonaga M

doi

10.1016/j.leukres.2009.11.015

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

974-80

issue

8

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(09)00537-2

journal_volume

34

pub_type

杂志文章

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